Amino acid dipepetide frequency for Theileria orientalis strain Shintoku

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.942AlaAla: 2.942 ± 0.076	0.636AlaCys: 0.636 ± 0.02	2.419AlaAsp: 2.419 ± 0.036	3.016AlaGlu: 3.016 ± 0.044	1.902AlaPhe: 1.902 ± 0.037	2.7AlaGly: 2.7 ± 0.072	1.171AlaHis: 1.171 ± 0.027	2.569AlaIle: 2.569 ± 0.039	3.689AlaLys: 3.689 ± 0.057	4.692AlaLeu: 4.692 ± 0.058	1.04AlaMet: 1.04 ± 0.025	2.801AlaAsn: 2.801 ± 0.042	1.942AlaPro: 1.942 ± 0.064	1.636AlaGln: 1.636 ± 0.045	2.193AlaArg: 2.193 ± 0.037	4.44AlaSer: 4.44 ± 0.063	3.117AlaThr: 3.117 ± 0.056	3.024AlaVal: 3.024 ± 0.051	0.286AlaTrp: 0.286 ± 0.013	1.636AlaTyr: 1.636 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	0.712CysAla: 0.712 ± 0.021	0.422CysCys: 0.422 ± 0.021	0.852CysAsp: 0.852 ± 0.022	0.893CysGlu: 0.893 ± 0.02	0.771CysPhe: 0.771 ± 0.022	0.888CysGly: 0.888 ± 0.024	0.334CysHis: 0.334 ± 0.013	1.079CysIle: 1.079 ± 0.026	1.348CysLys: 1.348 ± 0.035	1.641CysLeu: 1.641 ± 0.032	0.33CysMet: 0.33 ± 0.012	1.004CysAsn: 1.004 ± 0.023	0.591CysPro: 0.591 ± 0.026	0.393CysGln: 0.393 ± 0.015	0.801CysArg: 0.801 ± 0.022	1.502CysSer: 1.502 ± 0.037	0.933CysThr: 0.933 ± 0.022	1.208CysVal: 1.208 ± 0.025	0.148CysTrp: 0.148 ± 0.008	0.712CysTyr: 0.712 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	2.788AspAla: 2.788 ± 0.042	0.799AspCys: 0.799 ± 0.024	3.743AspAsp: 3.743 ± 0.053	4.572AspGlu: 4.572 ± 0.056	2.602AspPhe: 2.602 ± 0.04	3.028AspGly: 3.028 ± 0.058	1.179AspHis: 1.179 ± 0.023	3.158AspIle: 3.158 ± 0.053	4.243AspLys: 4.243 ± 0.048	5.692AspLeu: 5.692 ± 0.064	1.257AspMet: 1.257 ± 0.025	2.966AspAsn: 2.966 ± 0.047	2.416AspPro: 2.416 ± 0.045	1.719AspGln: 1.719 ± 0.037	2.428AspArg: 2.428 ± 0.038	5.086AspSer: 5.086 ± 0.068	2.77AspThr: 2.77 ± 0.044	3.781AspVal: 3.781 ± 0.045	0.427AspTrp: 0.427 ± 0.015	2.476AspTyr: 2.476 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	3.491GluAla: 3.491 ± 0.055	1.015GluCys: 1.015 ± 0.025	4.317GluAsp: 4.317 ± 0.056	6.413GluGlu: 6.413 ± 0.113	2.908GluPhe: 2.908 ± 0.038	3.479GluGly: 3.479 ± 0.06	1.504GluHis: 1.504 ± 0.029	3.65GluIle: 3.65 ± 0.05	5.023GluLys: 5.023 ± 0.069	6.555GluLeu: 6.555 ± 0.075	1.625GluMet: 1.625 ± 0.032	4.105GluAsn: 4.105 ± 0.054	2.258GluPro: 2.258 ± 0.045	2.148GluGln: 2.148 ± 0.044	3.196GluArg: 3.196 ± 0.058	5.959GluSer: 5.959 ± 0.069	3.296GluThr: 3.296 ± 0.044	4.194GluVal: 4.194 ± 0.049	0.527GluTrp: 0.527 ± 0.016	3.029GluTyr: 3.029 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	1.834PheAla: 1.834 ± 0.037	0.787PheCys: 0.787 ± 0.02	2.856PheAsp: 2.856 ± 0.042	2.877PheGlu: 2.877 ± 0.043	1.972PhePhe: 1.972 ± 0.044	2.425PheGly: 2.425 ± 0.048	0.935PheHis: 0.935 ± 0.022	2.77PheIle: 2.77 ± 0.048	3.701PheLys: 3.701 ± 0.044	4.083PheLeu: 4.083 ± 0.054	1.107PheMet: 1.107 ± 0.025	3.119PheAsn: 3.119 ± 0.045	1.394PhePro: 1.394 ± 0.027	1.168PheGln: 1.168 ± 0.03	1.954PheArg: 1.954 ± 0.031	3.637PheSer: 3.637 ± 0.048	2.514PheThr: 2.514 ± 0.04	3.124PheVal: 3.124 ± 0.042	0.405PheTrp: 0.405 ± 0.015	2.038PheTyr: 2.038 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	2.871GlyAla: 2.871 ± 0.063	0.82GlyCys: 0.82 ± 0.022	2.978GlyAsp: 2.978 ± 0.044	3.148GlyGlu: 3.148 ± 0.05	2.343GlyPhe: 2.343 ± 0.043	3.297GlyGly: 3.297 ± 0.073	1.151GlyHis: 1.151 ± 0.03	2.843GlyIle: 2.843 ± 0.044	3.597GlyLys: 3.597 ± 0.051	4.264GlyLeu: 4.264 ± 0.049	1.083GlyMet: 1.083 ± 0.022	2.912GlyAsn: 2.912 ± 0.049	1.682GlyPro: 1.682 ± 0.034	1.519GlyGln: 1.519 ± 0.05	2.464GlyArg: 2.464 ± 0.043	5.086GlySer: 5.086 ± 0.074	3.352GlyThr: 3.352 ± 0.079	3.443GlyVal: 3.443 ± 0.048	0.44GlyTrp: 0.44 ± 0.014	2.178GlyTyr: 2.178 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	0.88HisAla: 0.88 ± 0.024	0.371HisCys: 0.371 ± 0.014	1.082HisAsp: 1.082 ± 0.025	1.365HisGlu: 1.365 ± 0.029	1.121HisPhe: 1.121 ± 0.025	1.179HisGly: 1.179 ± 0.034	0.549HisHis: 0.549 ± 0.018	1.308HisIle: 1.308 ± 0.027	1.587HisLys: 1.587 ± 0.026	2.321HisLeu: 2.321 ± 0.036	0.522HisMet: 0.522 ± 0.016	1.237HisAsn: 1.237 ± 0.024	0.946HisPro: 0.946 ± 0.026	0.722HisGln: 0.722 ± 0.023	1.212HisArg: 1.212 ± 0.023	1.829HisSer: 1.829 ± 0.034	1.296HisThr: 1.296 ± 0.027	1.443HisVal: 1.443 ± 0.031	0.199HisTrp: 0.199 ± 0.01	0.944HisTyr: 0.944 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	2.636IleAla: 2.636 ± 0.04	1.077IleCys: 1.077 ± 0.025	3.285IleAsp: 3.285 ± 0.049	3.516IleGlu: 3.516 ± 0.049	2.613IlePhe: 2.613 ± 0.049	2.617IleGly: 2.617 ± 0.047	1.304IleHis: 1.304 ± 0.026	3.434IleIle: 3.434 ± 0.056	4.594IleLys: 4.594 ± 0.059	5.616IleLeu: 5.616 ± 0.079	1.222IleMet: 1.222 ± 0.024	4.034IleAsn: 4.034 ± 0.06	2.313IlePro: 2.313 ± 0.036	1.723IleGln: 1.723 ± 0.031	2.649IleArg: 2.649 ± 0.04	4.918IleSer: 4.918 ± 0.066	3.043IleThr: 3.043 ± 0.045	3.646IleVal: 3.646 ± 0.049	0.603IleTrp: 0.603 ± 0.022	2.523IleTyr: 2.523 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	3.497LysAla: 3.497 ± 0.055	1.352LysCys: 1.352 ± 0.035	4.016LysAsp: 4.016 ± 0.05	5.453LysGlu: 5.453 ± 0.074	3.316LysPhe: 3.316 ± 0.047	3.498LysGly: 3.498 ± 0.045	1.862LysHis: 1.862 ± 0.032	4.627LysIle: 4.627 ± 0.06	6.018LysLys: 6.018 ± 0.086	7.984LysLeu: 7.984 ± 0.079	2.005LysMet: 2.005 ± 0.034	4.825LysAsn: 4.825 ± 0.058	2.639LysPro: 2.639 ± 0.05	2.36LysGln: 2.36 ± 0.037	4.188LysArg: 4.188 ± 0.048	6.153LysSer: 6.153 ± 0.059	4.042LysThr: 4.042 ± 0.053	4.852LysVal: 4.852 ± 0.063	0.712LysTrp: 0.712 ± 0.019	3.732LysTyr: 3.732 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	4.318LeuAla: 4.318 ± 0.059	1.69LeuCys: 1.69 ± 0.038	5.603LeuAsp: 5.603 ± 0.055	6.331LeuGlu: 6.331 ± 0.075	4.658LeuPhe: 4.658 ± 0.06	4.235LeuGly: 4.235 ± 0.057	2.047LeuHis: 2.047 ± 0.038	5.555LeuIle: 5.555 ± 0.072	7.916LeuLys: 7.916 ± 0.076	9.92LeuLeu: 9.92 ± 0.121	2.303LeuMet: 2.303 ± 0.038	6.383LeuAsn: 6.383 ± 0.089	3.26LeuPro: 3.26 ± 0.05	2.848LeuGln: 2.848 ± 0.044	4.518LeuArg: 4.518 ± 0.064	8.597LeuSer: 8.597 ± 0.079	5.07LeuThr: 5.07 ± 0.062	6.296LeuVal: 6.296 ± 0.079	0.824LeuTrp: 0.824 ± 0.021	4.034LeuTyr: 4.034 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.325MetAla: 1.325 ± 0.027	0.479MetCys: 0.479 ± 0.017	1.52MetAsp: 1.52 ± 0.028	1.721MetGlu: 1.721 ± 0.04	1.108MetPhe: 1.108 ± 0.02	1.179MetGly: 1.179 ± 0.027	0.354MetHis: 0.354 ± 0.013	1.217MetIle: 1.217 ± 0.025	1.672MetLys: 1.672 ± 0.03	2.2MetLeu: 2.2 ± 0.036	0.603MetMet: 0.603 ± 0.018	1.452MetAsn: 1.452 ± 0.03	0.9MetPro: 0.9 ± 0.028	0.522MetGln: 0.522 ± 0.02	0.984MetArg: 0.984 ± 0.024	1.9MetSer: 1.9 ± 0.035	1.12MetThr: 1.12 ± 0.025	1.439MetVal: 1.439 ± 0.027	0.151MetTrp: 0.151 ± 0.008	0.985MetTyr: 0.985 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.803AsnAla: 2.803 ± 0.046	0.997AsnCys: 0.997 ± 0.024	3.326AsnAsp: 3.326 ± 0.048	4.283AsnGlu: 4.283 ± 0.057	2.644AsnPhe: 2.644 ± 0.037	3.285AsnGly: 3.285 ± 0.085	1.225AsnHis: 1.225 ± 0.024	3.934AsnIle: 3.934 ± 0.061	5.02AsnLys: 5.02 ± 0.06	5.893AsnLeu: 5.893 ± 0.065	1.529AsnMet: 1.529 ± 0.031	4.115AsnAsn: 4.115 ± 0.07	2.19AsnPro: 2.19 ± 0.039	1.885AsnGln: 1.885 ± 0.032	3.0AsnArg: 3.0 ± 0.042	5.106AsnSer: 5.106 ± 0.06	3.706AsnThr: 3.706 ± 0.06	4.238AsnVal: 4.238 ± 0.052	0.503AsnTrp: 0.503 ± 0.013	2.868AsnTyr: 2.868 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	1.854ProAla: 1.854 ± 0.07	0.511ProCys: 0.511 ± 0.02	1.94ProAsp: 1.94 ± 0.037	3.083ProGlu: 3.083 ± 0.055	1.618ProPhe: 1.618 ± 0.032	2.098ProGly: 2.098 ± 0.056	0.68ProHis: 0.68 ± 0.02	1.99ProIle: 1.99 ± 0.033	2.957ProLys: 2.957 ± 0.056	3.37ProLeu: 3.37 ± 0.05	0.741ProMet: 0.741 ± 0.023	2.283ProAsn: 2.283 ± 0.037	1.96ProPro: 1.96 ± 0.059	1.322ProGln: 1.322 ± 0.041	1.756ProArg: 1.756 ± 0.039	3.178ProSer: 3.178 ± 0.055	2.059ProThr: 2.059 ± 0.05	2.545ProVal: 2.545 ± 0.065	0.283ProTrp: 0.283 ± 0.014	1.399ProTyr: 1.399 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	1.492GlnAla: 1.492 ± 0.037	0.471GlnCys: 0.471 ± 0.019	1.426GlnAsp: 1.426 ± 0.037	1.938GlnGlu: 1.938 ± 0.045	1.379GlnPhe: 1.379 ± 0.027	1.441GlnGly: 1.441 ± 0.034	0.671GlnHis: 0.671 ± 0.017	2.003GlnIle: 2.003 ± 0.037	2.143GlnLys: 2.143 ± 0.038	3.3GlnLeu: 3.3 ± 0.052	0.884GlnMet: 0.884 ± 0.025	1.835GlnAsn: 1.835 ± 0.03	1.389GlnPro: 1.389 ± 0.065	1.422GlnGln: 1.422 ± 0.054	1.408GlnArg: 1.408 ± 0.027	2.418GlnSer: 2.418 ± 0.04	1.622GlnThr: 1.622 ± 0.038	2.008GlnVal: 2.008 ± 0.037	0.246GlnTrp: 0.246 ± 0.011	1.26GlnTyr: 1.26 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	2.248ArgAla: 2.248 ± 0.043	0.875ArgCys: 0.875 ± 0.024	2.613ArgAsp: 2.613 ± 0.041	3.217ArgGlu: 3.217 ± 0.055	2.249ArgPhe: 2.249 ± 0.035	2.38ArgGly: 2.38 ± 0.04	1.133ArgHis: 1.133 ± 0.028	2.83ArgIle: 2.83 ± 0.045	3.565ArgLys: 3.565 ± 0.053	4.681ArgLeu: 4.681 ± 0.063	1.176ArgMet: 1.176 ± 0.029	2.898ArgAsn: 2.898 ± 0.039	1.72ArgPro: 1.72 ± 0.042	1.437ArgGln: 1.437 ± 0.029	3.187ArgArg: 3.187 ± 0.054	4.016ArgSer: 4.016 ± 0.054	2.414ArgThr: 2.414 ± 0.037	3.08ArgVal: 3.08 ± 0.039	0.406ArgTrp: 0.406 ± 0.015	2.005ArgTyr: 2.005 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.975SerAla: 3.975 ± 0.059	1.385SerCys: 1.385 ± 0.033	5.079SerAsp: 5.079 ± 0.055	5.814SerGlu: 5.814 ± 0.063	3.745SerPhe: 3.745 ± 0.05	4.95SerGly: 4.95 ± 0.067	1.945SerHis: 1.945 ± 0.034	4.958SerIle: 4.958 ± 0.066	6.717SerLys: 6.717 ± 0.068	7.981SerLeu: 7.981 ± 0.082	1.801SerMet: 1.801 ± 0.031	5.491SerAsn: 5.491 ± 0.07	2.956SerPro: 2.956 ± 0.051	2.908SerGln: 2.908 ± 0.049	4.215SerArg: 4.215 ± 0.062	8.63SerSer: 8.63 ± 0.114	5.271SerThr: 5.271 ± 0.074	5.424SerVal: 5.424 ± 0.062	0.615SerTrp: 0.615 ± 0.018	3.162SerTyr: 3.162 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	2.763ThrAla: 2.763 ± 0.06	0.908ThrCys: 0.908 ± 0.027	2.844ThrAsp: 2.844 ± 0.049	3.299ThrGlu: 3.299 ± 0.053	2.443ThrPhe: 2.443 ± 0.041	3.3ThrGly: 3.3 ± 0.076	1.471ThrHis: 1.471 ± 0.035	3.099ThrIle: 3.099 ± 0.039	4.04ThrLys: 4.04 ± 0.054	5.244ThrLeu: 5.244 ± 0.055	1.182ThrMet: 1.182 ± 0.027	3.504ThrAsn: 3.504 ± 0.051	2.662ThrPro: 2.662 ± 0.075	1.832ThrGln: 1.832 ± 0.036	2.561ThrArg: 2.561 ± 0.036	5.135ThrSer: 5.135 ± 0.076	3.621ThrThr: 3.621 ± 0.081	3.541ThrVal: 3.541 ± 0.048	0.423ThrTrp: 0.423 ± 0.015	2.026ThrTyr: 2.026 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	3.278ValAla: 3.278 ± 0.057	1.151ValCys: 1.151 ± 0.029	4.263ValAsp: 4.263 ± 0.057	4.543ValGlu: 4.543 ± 0.06	2.926ValPhe: 2.926 ± 0.045	3.077ValGly: 3.077 ± 0.049	1.424ValHis: 1.424 ± 0.028	3.369ValIle: 3.369 ± 0.052	5.162ValLys: 5.162 ± 0.064	6.147ValLeu: 6.147 ± 0.073	1.273ValMet: 1.273 ± 0.029	4.16ValAsn: 4.16 ± 0.053	2.771ValPro: 2.771 ± 0.05	1.804ValGln: 1.804 ± 0.039	2.725ValArg: 2.725 ± 0.041	5.24ValSer: 5.24 ± 0.058	3.76ValThr: 3.76 ± 0.066	4.516ValVal: 4.516 ± 0.059	0.622ValTrp: 0.622 ± 0.021	2.876ValTyr: 2.876 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.379TrpAla: 0.379 ± 0.014	0.139TrpCys: 0.139 ± 0.01	0.478TrpAsp: 0.478 ± 0.015	0.546TrpGlu: 0.546 ± 0.019	0.347TrpPhe: 0.347 ± 0.014	0.296TrpGly: 0.296 ± 0.011	0.21TrpHis: 0.21 ± 0.012	0.518TrpIle: 0.518 ± 0.017	0.741TrpLys: 0.741 ± 0.022	0.758TrpLeu: 0.758 ± 0.022	0.195TrpMet: 0.195 ± 0.01	0.552TrpAsn: 0.552 ± 0.018	0.243TrpPro: 0.243 ± 0.012	0.231TrpGln: 0.231 ± 0.014	0.439TrpArg: 0.439 ± 0.016	0.675TrpSer: 0.675 ± 0.019	0.472TrpThr: 0.472 ± 0.019	0.582TrpVal: 0.582 ± 0.019	0.083TrpTrp: 0.083 ± 0.006	0.348TrpTyr: 0.348 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.765TyrAla: 1.765 ± 0.031	0.68TyrCys: 0.68 ± 0.021	2.489TyrAsp: 2.489 ± 0.041	2.665TyrGlu: 2.665 ± 0.04	2.036TyrPhe: 2.036 ± 0.038	2.122TyrGly: 2.122 ± 0.039	0.963TyrHis: 0.963 ± 0.024	2.456TyrIle: 2.456 ± 0.04	3.396TyrLys: 3.396 ± 0.047	4.062TyrLeu: 4.062 ± 0.052	0.954TyrMet: 0.954 ± 0.02	2.873TyrAsn: 2.873 ± 0.037	1.393TyrPro: 1.393 ± 0.036	1.158TyrGln: 1.158 ± 0.028	2.252TyrArg: 2.252 ± 0.034	3.517TyrSer: 3.517 ± 0.048	2.423TyrThr: 2.423 ± 0.039	2.701TyrVal: 2.701 ± 0.039	0.327TyrTrp: 0.327 ± 0.013	2.208TyrTyr: 2.208 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3989 proteins (2048270 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---