Amino acid dipepetide frequency for Pseudooceanicola algae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.538AlaAla: 16.538 ± 0.164
1.083AlaCys: 1.083 ± 0.032
7.018AlaAsp: 7.018 ± 0.071
8.266AlaGlu: 8.266 ± 0.096
4.172AlaPhe: 4.172 ± 0.065
11.076AlaGly: 11.076 ± 0.101
2.205AlaHis: 2.205 ± 0.044
5.767AlaIle: 5.767 ± 0.07
3.032AlaLys: 3.032 ± 0.061
14.351AlaLeu: 14.351 ± 0.14
3.887AlaMet: 3.887 ± 0.063
2.507AlaAsn: 2.507 ± 0.046
6.405AlaPro: 6.405 ± 0.085
4.426AlaGln: 4.426 ± 0.063
9.293AlaArg: 9.293 ± 0.117
5.936AlaSer: 5.936 ± 0.067
6.091AlaThr: 6.091 ± 0.075
8.042AlaVal: 8.042 ± 0.087
1.465AlaTrp: 1.465 ± 0.036
2.462AlaTyr: 2.462 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.101CysAla: 1.101 ± 0.03
0.123CysCys: 0.123 ± 0.01
0.647CysAsp: 0.647 ± 0.023
0.437CysGlu: 0.437 ± 0.021
0.33CysPhe: 0.33 ± 0.018
0.921CysGly: 0.921 ± 0.031
0.281CysHis: 0.281 ± 0.018
0.401CysIle: 0.401 ± 0.021
0.189CysLys: 0.189 ± 0.011
0.992CysLeu: 0.992 ± 0.027
0.178CysMet: 0.178 ± 0.013
0.213CysAsn: 0.213 ± 0.014
0.496CysPro: 0.496 ± 0.021
0.218CysGln: 0.218 ± 0.014
0.6CysArg: 0.6 ± 0.024
0.459CysSer: 0.459 ± 0.021
0.441CysThr: 0.441 ± 0.02
0.569CysVal: 0.569 ± 0.02
0.125CysTrp: 0.125 ± 0.01
0.197CysTyr: 0.197 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.914AspAla: 6.914 ± 0.074
0.502AspCys: 0.502 ± 0.021
3.295AspAsp: 3.295 ± 0.07
3.367AspGlu: 3.367 ± 0.053
2.541AspPhe: 2.541 ± 0.049
5.641AspGly: 5.641 ± 0.087
1.405AspHis: 1.405 ± 0.032
3.067AspIle: 3.067 ± 0.046
1.564AspLys: 1.564 ± 0.04
7.05AspLeu: 7.05 ± 0.091
1.796AspMet: 1.796 ± 0.037
1.278AspAsn: 1.278 ± 0.034
4.079AspPro: 4.079 ± 0.073
2.008AspGln: 2.008 ± 0.041
4.613AspArg: 4.613 ± 0.065
2.519AspSer: 2.519 ± 0.053
2.855AspThr: 2.855 ± 0.058
3.919AspVal: 3.919 ± 0.057
1.217AspTrp: 1.217 ± 0.033
1.513AspTyr: 1.513 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
8.305GluAla: 8.305 ± 0.089
0.346GluCys: 0.346 ± 0.017
3.65GluAsp: 3.65 ± 0.059
3.373GluGlu: 3.373 ± 0.07
1.618GluPhe: 1.618 ± 0.041
4.86GluGly: 4.86 ± 0.072
0.986GluHis: 0.986 ± 0.031
3.671GluIle: 3.671 ± 0.057
2.009GluLys: 2.009 ± 0.045
4.725GluLeu: 4.725 ± 0.066
1.904GluMet: 1.904 ± 0.04
1.62GluAsn: 1.62 ± 0.042
2.394GluPro: 2.394 ± 0.047
1.886GluGln: 1.886 ± 0.042
3.652GluArg: 3.652 ± 0.064
2.23GluSer: 2.23 ± 0.037
4.047GluThr: 4.047 ± 0.073
4.275GluVal: 4.275 ± 0.061
0.639GluTrp: 0.639 ± 0.023
1.037GluTyr: 1.037 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.386PheAla: 4.386 ± 0.055
0.414PheCys: 0.414 ± 0.018
2.707PheAsp: 2.707 ± 0.049
1.938PheGlu: 1.938 ± 0.039
1.398PhePhe: 1.398 ± 0.04
3.692PheGly: 3.692 ± 0.063
0.766PheHis: 0.766 ± 0.024
1.576PheIle: 1.576 ± 0.038
0.815PheLys: 0.815 ± 0.029
3.486PheLeu: 3.486 ± 0.069
0.836PheMet: 0.836 ± 0.029
0.989PheAsn: 0.989 ± 0.03
1.647PhePro: 1.647 ± 0.036
1.048PheGln: 1.048 ± 0.03
2.253PheArg: 2.253 ± 0.05
2.184PheSer: 2.184 ± 0.046
2.038PheThr: 2.038 ± 0.04
2.499PheVal: 2.499 ± 0.044
0.567PheTrp: 0.567 ± 0.025
0.879PheTyr: 0.879 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
10.251GlyAla: 10.251 ± 0.115
0.85GlyCys: 0.85 ± 0.028
4.898GlyAsp: 4.898 ± 0.08
4.622GlyGlu: 4.622 ± 0.061
3.554GlyPhe: 3.554 ± 0.055
7.513GlyGly: 7.513 ± 0.176
1.931GlyHis: 1.931 ± 0.043
4.614GlyIle: 4.614 ± 0.063
2.97GlyLys: 2.97 ± 0.059
9.897GlyLeu: 9.897 ± 0.1
2.8GlyMet: 2.8 ± 0.054
2.125GlyAsn: 2.125 ± 0.054
4.032GlyPro: 4.032 ± 0.056
3.446GlyGln: 3.446 ± 0.056
5.932GlyArg: 5.932 ± 0.085
4.482GlySer: 4.482 ± 0.075
4.933GlyThr: 4.933 ± 0.069
6.153GlyVal: 6.153 ± 0.085
1.488GlyTrp: 1.488 ± 0.033
2.308GlyTyr: 2.308 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.293HisAla: 2.293 ± 0.05
0.228HisCys: 0.228 ± 0.015
1.315HisAsp: 1.315 ± 0.036
1.027HisGlu: 1.027 ± 0.03
0.842HisPhe: 0.842 ± 0.024
1.876HisGly: 1.876 ± 0.044
0.54HisHis: 0.54 ± 0.023
0.826HisIle: 0.826 ± 0.026
0.434HisLys: 0.434 ± 0.019
2.131HisLeu: 2.131 ± 0.046
0.571HisMet: 0.571 ± 0.019
0.42HisAsn: 0.42 ± 0.02
1.391HisPro: 1.391 ± 0.039
0.56HisGln: 0.56 ± 0.019
1.329HisArg: 1.329 ± 0.039
0.975HisSer: 0.975 ± 0.035
0.732HisThr: 0.732 ± 0.027
1.488HisVal: 1.488 ± 0.04
0.339HisTrp: 0.339 ± 0.017
0.514HisTyr: 0.514 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.981IleAla: 6.981 ± 0.076
0.657IleCys: 0.657 ± 0.023
3.3IleAsp: 3.3 ± 0.053
3.258IleGlu: 3.258 ± 0.051
1.858IlePhe: 1.858 ± 0.044
4.982IleGly: 4.982 ± 0.072
0.933IleHis: 0.933 ± 0.031
2.121IleIle: 2.121 ± 0.046
1.147IleLys: 1.147 ± 0.036
5.127IleLeu: 5.127 ± 0.067
1.044IleMet: 1.044 ± 0.034
1.205IleAsn: 1.205 ± 0.034
2.445IlePro: 2.445 ± 0.041
1.202IleGln: 1.202 ± 0.032
3.482IleArg: 3.482 ± 0.058
3.127IleSer: 3.127 ± 0.058
2.919IleThr: 2.919 ± 0.052
3.495IleVal: 3.495 ± 0.051
0.736IleTrp: 0.736 ± 0.022
1.171IleTyr: 1.171 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.495LysAla: 3.495 ± 0.068
0.154LysCys: 0.154 ± 0.011
1.583LysAsp: 1.583 ± 0.038
1.325LysGlu: 1.325 ± 0.039
0.801LysPhe: 0.801 ± 0.027
2.43LysGly: 2.43 ± 0.046
0.495LysHis: 0.495 ± 0.022
1.55LysIle: 1.55 ± 0.04
0.972LysLys: 0.972 ± 0.04
2.638LysLeu: 2.638 ± 0.047
0.759LysMet: 0.759 ± 0.03
0.613LysAsn: 0.613 ± 0.021
1.637LysPro: 1.637 ± 0.039
0.786LysGln: 0.786 ± 0.027
1.93LysArg: 1.93 ± 0.047
1.674LysSer: 1.674 ± 0.047
1.72LysThr: 1.72 ± 0.038
2.208LysVal: 2.208 ± 0.049
0.323LysTrp: 0.323 ± 0.019
0.547LysTyr: 0.547 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
13.644LeuAla: 13.644 ± 0.134
1.039LeuCys: 1.039 ± 0.028
6.307LeuAsp: 6.307 ± 0.075
5.254LeuGlu: 5.254 ± 0.07
3.533LeuPhe: 3.533 ± 0.061
9.026LeuGly: 9.026 ± 0.093
1.991LeuHis: 1.991 ± 0.044
5.218LeuIle: 5.218 ± 0.076
3.035LeuLys: 3.035 ± 0.052
9.884LeuLeu: 9.884 ± 0.115
2.746LeuMet: 2.746 ± 0.048
2.527LeuAsn: 2.527 ± 0.048
6.159LeuPro: 6.159 ± 0.078
2.993LeuGln: 2.993 ± 0.05
7.417LeuArg: 7.417 ± 0.088
6.962LeuSer: 6.962 ± 0.085
6.358LeuThr: 6.358 ± 0.075
7.105LeuVal: 7.105 ± 0.087
1.33LeuTrp: 1.33 ± 0.035
1.956LeuTyr: 1.956 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
3.556MetAla: 3.556 ± 0.053
0.166MetCys: 0.166 ± 0.012
1.442MetAsp: 1.442 ± 0.039
1.352MetGlu: 1.352 ± 0.037
0.813MetPhe: 0.813 ± 0.027
2.217MetGly: 2.217 ± 0.043
0.425MetHis: 0.425 ± 0.018
1.648MetIle: 1.648 ± 0.045
1.029MetLys: 1.029 ± 0.033
2.813MetLeu: 2.813 ± 0.051
0.774MetMet: 0.774 ± 0.024
0.88MetAsn: 0.88 ± 0.026
1.578MetPro: 1.578 ± 0.037
1.13MetGln: 1.13 ± 0.028
1.9MetArg: 1.9 ± 0.039
1.771MetSer: 1.771 ± 0.041
2.245MetThr: 2.245 ± 0.041
1.976MetVal: 1.976 ± 0.042
0.216MetTrp: 0.216 ± 0.015
0.345MetTyr: 0.345 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.021AsnAla: 3.021 ± 0.054
0.253AsnCys: 0.253 ± 0.013
1.37AsnAsp: 1.37 ± 0.043
1.052AsnGlu: 1.052 ± 0.036
0.906AsnPhe: 0.906 ± 0.028
2.212AsnGly: 2.212 ± 0.042
0.468AsnHis: 0.468 ± 0.018
1.285AsnIle: 1.285 ± 0.032
0.547AsnLys: 0.547 ± 0.022
2.499AsnLeu: 2.499 ± 0.048
0.664AsnMet: 0.664 ± 0.022
0.578AsnAsn: 0.578 ± 0.025
1.682AsnPro: 1.682 ± 0.039
0.696AsnGln: 0.696 ± 0.026
1.661AsnArg: 1.661 ± 0.042
1.18AsnSer: 1.18 ± 0.033
1.223AsnThr: 1.223 ± 0.03
1.682AsnVal: 1.682 ± 0.036
0.409AsnTrp: 0.409 ± 0.017
0.622AsnTyr: 0.622 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
6.415ProAla: 6.415 ± 0.094
0.389ProCys: 0.389 ± 0.018
4.22ProAsp: 4.22 ± 0.059
4.539ProGlu: 4.539 ± 0.067
1.894ProPhe: 1.894 ± 0.031
5.112ProGly: 5.112 ± 0.079
1.047ProHis: 1.047 ± 0.033
2.205ProIle: 2.205 ± 0.041
1.439ProLys: 1.439 ± 0.037
5.084ProLeu: 5.084 ± 0.067
1.422ProMet: 1.422 ± 0.035
1.121ProAsn: 1.121 ± 0.03
2.44ProPro: 2.44 ± 0.06
1.813ProGln: 1.813 ± 0.037
3.085ProArg: 3.085 ± 0.057
2.591ProSer: 2.591 ± 0.041
2.434ProThr: 2.434 ± 0.045
4.47ProVal: 4.47 ± 0.065
0.701ProTrp: 0.701 ± 0.024
1.153ProTyr: 1.153 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.195GlnAla: 4.195 ± 0.053
0.201GlnCys: 0.201 ± 0.014
2.041GlnAsp: 2.041 ± 0.04
1.631GlnGlu: 1.631 ± 0.038
1.001GlnPhe: 1.001 ± 0.03
2.704GlnGly: 2.704 ± 0.053
0.559GlnHis: 0.559 ± 0.024
2.131GlnIle: 2.131 ± 0.037
0.99GlnLys: 0.99 ± 0.031
2.838GlnLeu: 2.838 ± 0.047
1.078GlnMet: 1.078 ± 0.027
0.87GlnAsn: 0.87 ± 0.027
1.708GlnPro: 1.708 ± 0.042
1.217GlnGln: 1.217 ± 0.036
2.257GlnArg: 2.257 ± 0.049
1.918GlnSer: 1.918 ± 0.048
1.841GlnThr: 1.841 ± 0.042
2.518GlnVal: 2.518 ± 0.048
0.385GlnTrp: 0.385 ± 0.019
0.561GlnTyr: 0.561 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
8.382ArgAla: 8.382 ± 0.095
0.523ArgCys: 0.523 ± 0.021
4.572ArgAsp: 4.572 ± 0.062
3.634ArgGlu: 3.634 ± 0.061
2.496ArgPhe: 2.496 ± 0.038
4.816ArgGly: 4.816 ± 0.064
1.586ArgHis: 1.586 ± 0.036
4.133ArgIle: 4.133 ± 0.059
2.172ArgLys: 2.172 ± 0.046
7.698ArgLeu: 7.698 ± 0.103
2.02ArgMet: 2.02 ± 0.044
1.81ArgAsn: 1.81 ± 0.038
3.554ArgPro: 3.554 ± 0.059
2.465ArgGln: 2.465 ± 0.044
5.27ArgArg: 5.27 ± 0.083
3.441ArgSer: 3.441 ± 0.058
2.901ArgThr: 2.901 ± 0.046
4.543ArgVal: 4.543 ± 0.066
0.86ArgTrp: 0.86 ± 0.028
1.542ArgTyr: 1.542 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.223SerAla: 6.223 ± 0.075
0.491SerCys: 0.491 ± 0.021
3.356SerAsp: 3.356 ± 0.057
2.828SerGlu: 2.828 ± 0.049
2.257SerPhe: 2.257 ± 0.052
5.868SerGly: 5.868 ± 0.083
1.124SerHis: 1.124 ± 0.03
2.438SerIle: 2.438 ± 0.046
1.27SerLys: 1.27 ± 0.033
5.47SerLeu: 5.47 ± 0.084
1.438SerMet: 1.438 ± 0.037
1.284SerAsn: 1.284 ± 0.034
2.701SerPro: 2.701 ± 0.049
1.712SerGln: 1.712 ± 0.037
3.513SerArg: 3.513 ± 0.06
2.735SerSer: 2.735 ± 0.064
2.594SerThr: 2.594 ± 0.058
3.842SerVal: 3.842 ± 0.06
0.709SerTrp: 0.709 ± 0.023
1.367SerTyr: 1.367 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
6.275ThrAla: 6.275 ± 0.07
0.526ThrCys: 0.526 ± 0.022
3.142ThrAsp: 3.142 ± 0.047
3.197ThrGlu: 3.197 ± 0.052
2.013ThrPhe: 2.013 ± 0.039
5.773ThrGly: 5.773 ± 0.072
1.087ThrHis: 1.087 ± 0.032
2.601ThrIle: 2.601 ± 0.045
1.203ThrLys: 1.203 ± 0.035
6.251ThrLeu: 6.251 ± 0.08
1.357ThrMet: 1.357 ± 0.034
1.199ThrAsn: 1.199 ± 0.034
3.65ThrPro: 3.65 ± 0.058
1.559ThrGln: 1.559 ± 0.035
3.7ThrArg: 3.7 ± 0.065
2.876ThrSer: 2.876 ± 0.056
2.853ThrThr: 2.853 ± 0.053
3.845ThrVal: 3.845 ± 0.064
0.745ThrTrp: 0.745 ± 0.029
1.239ThrTyr: 1.239 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
8.42ValAla: 8.42 ± 0.089
0.602ValCys: 0.602 ± 0.024
3.944ValAsp: 3.944 ± 0.058
4.208ValGlu: 4.208 ± 0.059
2.699ValPhe: 2.699 ± 0.046
5.084ValGly: 5.084 ± 0.066
1.185ValHis: 1.185 ± 0.033
4.281ValIle: 4.281 ± 0.065
1.867ValLys: 1.867 ± 0.041
7.623ValLeu: 7.623 ± 0.104
2.102ValMet: 2.102 ± 0.039
1.842ValAsn: 1.842 ± 0.04
3.731ValPro: 3.731 ± 0.052
2.116ValGln: 2.116 ± 0.044
3.889ValArg: 3.889 ± 0.063
4.201ValSer: 4.201 ± 0.061
4.979ValThr: 4.979 ± 0.069
5.206ValVal: 5.206 ± 0.077
0.855ValTrp: 0.855 ± 0.027
1.331ValTyr: 1.331 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.234TrpAla: 1.234 ± 0.036
0.135TrpCys: 0.135 ± 0.01
0.753TrpAsp: 0.753 ± 0.025
0.624TrpGlu: 0.624 ± 0.025
0.493TrpPhe: 0.493 ± 0.021
0.912TrpGly: 0.912 ± 0.032
0.32TrpHis: 0.32 ± 0.017
0.74TrpIle: 0.74 ± 0.024
0.465TrpLys: 0.465 ± 0.02
1.675TrpLeu: 1.675 ± 0.038
0.422TrpMet: 0.422 ± 0.018
0.388TrpAsn: 0.388 ± 0.019
0.736TrpPro: 0.736 ± 0.026
0.706TrpGln: 0.706 ± 0.027
1.081TrpArg: 1.081 ± 0.024
0.832TrpSer: 0.832 ± 0.026
0.782TrpThr: 0.782 ± 0.026
0.859TrpVal: 0.859 ± 0.022
0.215TrpTrp: 0.215 ± 0.013
0.287TrpTyr: 0.287 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.396TyrAla: 2.396 ± 0.041
0.236TyrCys: 0.236 ± 0.015
1.583TyrAsp: 1.583 ± 0.034
1.294TyrGlu: 1.294 ± 0.032
0.899TyrPhe: 0.899 ± 0.023
2.082TyrGly: 2.082 ± 0.039
0.499TyrHis: 0.499 ± 0.021
0.921TyrIle: 0.921 ± 0.023
0.491TyrLys: 0.491 ± 0.02
2.252TyrLeu: 2.252 ± 0.044
0.478TyrMet: 0.478 ± 0.021
0.544TyrAsn: 0.544 ± 0.022
1.105TyrPro: 1.105 ± 0.029
0.658TyrGln: 0.658 ± 0.024
1.562TyrArg: 1.562 ± 0.038
1.126TyrSer: 1.126 ± 0.036
1.104TyrThr: 1.104 ± 0.031
1.471TyrVal: 1.471 ± 0.032
0.332TyrTrp: 0.332 ± 0.017
0.541TyrTyr: 0.541 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3817 proteins (1216675 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski