Amino acid dipepetide frequency for Sewage-associated circular DNA virus-10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.626AlaAla: 5.626 ± 4.716
0.0AlaCys: 0.0 ± 0.0
4.219AlaAsp: 4.219 ± 3.537
1.406AlaGlu: 1.406 ± 1.179
2.813AlaPhe: 2.813 ± 0.316
2.813AlaGly: 2.813 ± 0.316
2.813AlaHis: 2.813 ± 2.358
8.439AlaIle: 8.439 ± 3.136
5.626AlaLys: 5.626 ± 2.674
2.813AlaLeu: 2.813 ± 0.316
2.813AlaMet: 2.813 ± 2.358
4.219AlaAsn: 4.219 ± 0.547
2.813AlaPro: 2.813 ± 1.726
1.406AlaGln: 1.406 ± 0.863
5.626AlaArg: 5.626 ± 1.41
0.0AlaSer: 0.0 ± 0.0
1.406AlaThr: 1.406 ± 0.863
5.626AlaVal: 5.626 ± 1.41
1.406AlaTrp: 1.406 ± 1.179
4.219AlaTyr: 4.219 ± 1.495
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
1.406CysPhe: 1.406 ± 1.179
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
1.406CysLys: 1.406 ± 1.179
0.0CysLeu: 0.0 ± 0.0
1.406CysMet: 1.406 ± 1.179
0.0CysAsn: 0.0 ± 0.0
1.406CysPro: 1.406 ± 0.863
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
1.406CysSer: 1.406 ± 0.863
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
1.406CysTyr: 1.406 ± 0.863
0.0CysXaa: 0.0 ± 0.0
Asp
2.813AspAla: 2.813 ± 2.358
0.0AspCys: 0.0 ± 0.0
1.406AspAsp: 1.406 ± 0.863
1.406AspGlu: 1.406 ± 1.179
1.406AspPhe: 1.406 ± 0.863
1.406AspGly: 1.406 ± 0.863
1.406AspHis: 1.406 ± 1.179
7.032AspIle: 7.032 ± 0.231
2.813AspLys: 2.813 ± 2.358
4.219AspLeu: 4.219 ± 3.537
2.813AspMet: 2.813 ± 0.316
1.406AspAsn: 1.406 ± 0.863
1.406AspPro: 1.406 ± 0.863
1.406AspGln: 1.406 ± 1.179
7.032AspArg: 7.032 ± 1.811
4.219AspSer: 4.219 ± 0.547
2.813AspThr: 2.813 ± 2.358
5.626AspVal: 5.626 ± 1.41
2.813AspTrp: 2.813 ± 1.726
4.219AspTyr: 4.219 ± 0.547
0.0AspXaa: 0.0 ± 0.0
Glu
2.813GluAla: 2.813 ± 2.358
0.0GluCys: 0.0 ± 0.0
2.813GluAsp: 2.813 ± 2.358
4.219GluGlu: 4.219 ± 3.537
0.0GluPhe: 0.0 ± 0.0
5.626GluGly: 5.626 ± 0.632
0.0GluHis: 0.0 ± 0.0
0.0GluIle: 0.0 ± 0.0
1.406GluLys: 1.406 ± 1.179
2.813GluLeu: 2.813 ± 0.316
1.406GluMet: 1.406 ± 0.863
2.813GluAsn: 2.813 ± 1.726
1.406GluPro: 1.406 ± 1.179
2.813GluGln: 2.813 ± 0.316
4.219GluArg: 4.219 ± 3.537
4.219GluSer: 4.219 ± 3.537
2.813GluThr: 2.813 ± 0.316
1.406GluVal: 1.406 ± 1.179
1.406GluTrp: 1.406 ± 0.863
2.813GluTyr: 2.813 ± 0.316
0.0GluXaa: 0.0 ± 0.0
Phe
2.813PheAla: 2.813 ± 2.358
2.813PheCys: 2.813 ± 1.726
1.406PheAsp: 1.406 ± 1.179
4.219PheGlu: 4.219 ± 1.495
0.0PhePhe: 0.0 ± 0.0
2.813PheGly: 2.813 ± 0.316
0.0PheHis: 0.0 ± 0.0
1.406PheIle: 1.406 ± 0.863
1.406PheLys: 1.406 ± 1.179
0.0PheLeu: 0.0 ± 0.0
0.0PheMet: 0.0 ± 0.0
2.813PheAsn: 2.813 ± 0.316
1.406PhePro: 1.406 ± 1.179
2.813PheGln: 2.813 ± 0.316
0.0PheArg: 0.0 ± 0.0
5.626PheSer: 5.626 ± 1.41
5.626PheThr: 5.626 ± 1.41
0.0PheVal: 0.0 ± 0.0
1.406PheTrp: 1.406 ± 0.863
1.406PheTyr: 1.406 ± 1.179
0.0PheXaa: 0.0 ± 0.0
Gly
8.439GlyAla: 8.439 ± 0.948
0.0GlyCys: 0.0 ± 0.0
1.406GlyAsp: 1.406 ± 0.863
4.219GlyGlu: 4.219 ± 0.547
2.813GlyPhe: 2.813 ± 0.316
7.032GlyGly: 7.032 ± 0.231
0.0GlyHis: 0.0 ± 0.0
4.219GlyIle: 4.219 ± 0.547
5.626GlyLys: 5.626 ± 4.716
0.0GlyLeu: 0.0 ± 0.0
2.813GlyMet: 2.813 ± 1.726
4.219GlyAsn: 4.219 ± 0.547
2.813GlyPro: 2.813 ± 2.358
1.406GlyGln: 1.406 ± 0.863
2.813GlyArg: 2.813 ± 0.316
4.219GlySer: 4.219 ± 0.547
4.219GlyThr: 4.219 ± 1.495
4.219GlyVal: 4.219 ± 0.547
1.406GlyTrp: 1.406 ± 0.863
2.813GlyTyr: 2.813 ± 2.358
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
1.406HisGlu: 1.406 ± 1.179
1.406HisPhe: 1.406 ± 1.179
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
1.406HisIle: 1.406 ± 1.179
0.0HisLys: 0.0 ± 0.0
1.406HisLeu: 1.406 ± 0.863
0.0HisMet: 0.0 ± 0.0
1.406HisAsn: 1.406 ± 1.179
2.813HisPro: 2.813 ± 1.726
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
1.406HisSer: 1.406 ± 1.179
0.0HisThr: 0.0 ± 0.0
1.406HisVal: 1.406 ± 1.179
1.406HisTrp: 1.406 ± 1.179
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.626IleAla: 5.626 ± 2.674
0.0IleCys: 0.0 ± 0.0
4.219IleAsp: 4.219 ± 0.547
5.626IleGlu: 5.626 ± 0.632
1.406IlePhe: 1.406 ± 1.179
0.0IleGly: 0.0 ± 0.0
1.406IleHis: 1.406 ± 1.179
0.0IleIle: 0.0 ± 0.0
4.219IleLys: 4.219 ± 1.495
5.626IleLeu: 5.626 ± 1.41
1.406IleMet: 1.406 ± 0.863
5.626IleAsn: 5.626 ± 1.41
1.406IlePro: 1.406 ± 1.179
1.406IleGln: 1.406 ± 1.179
1.406IleArg: 1.406 ± 0.863
4.219IleSer: 4.219 ± 1.495
5.626IleThr: 5.626 ± 1.41
5.626IleVal: 5.626 ± 0.632
0.0IleTrp: 0.0 ± 0.0
1.406IleTyr: 1.406 ± 0.863
0.0IleXaa: 0.0 ± 0.0
Lys
0.0LysAla: 0.0 ± 0.0
0.0LysCys: 0.0 ± 0.0
2.813LysAsp: 2.813 ± 0.316
1.406LysGlu: 1.406 ± 1.179
4.219LysPhe: 4.219 ± 1.495
1.406LysGly: 1.406 ± 0.863
0.0LysHis: 0.0 ± 0.0
2.813LysIle: 2.813 ± 0.316
2.813LysLys: 2.813 ± 1.726
0.0LysLeu: 0.0 ± 0.0
4.219LysMet: 4.219 ± 1.495
1.406LysAsn: 1.406 ± 1.179
2.813LysPro: 2.813 ± 2.358
0.0LysGln: 0.0 ± 0.0
9.845LysArg: 9.845 ± 1.957
8.439LysSer: 8.439 ± 3.136
5.626LysThr: 5.626 ± 1.41
5.626LysVal: 5.626 ± 1.41
1.406LysTrp: 1.406 ± 1.179
8.439LysTyr: 8.439 ± 2.99
0.0LysXaa: 0.0 ± 0.0
Leu
5.626LeuAla: 5.626 ± 0.632
1.406LeuCys: 1.406 ± 1.179
5.626LeuAsp: 5.626 ± 1.41
4.219LeuGlu: 4.219 ± 0.547
0.0LeuPhe: 0.0 ± 0.0
1.406LeuGly: 1.406 ± 0.863
2.813LeuHis: 2.813 ± 1.726
0.0LeuIle: 0.0 ± 0.0
7.032LeuLys: 7.032 ± 0.231
2.813LeuLeu: 2.813 ± 0.316
1.406LeuMet: 1.406 ± 0.863
1.406LeuAsn: 1.406 ± 0.863
4.219LeuPro: 4.219 ± 1.495
5.626LeuGln: 5.626 ± 3.452
7.032LeuArg: 7.032 ± 2.273
1.406LeuSer: 1.406 ± 1.179
1.406LeuThr: 1.406 ± 0.863
2.813LeuVal: 2.813 ± 2.358
0.0LeuTrp: 0.0 ± 0.0
2.813LeuTyr: 2.813 ± 1.726
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
1.406MetAsp: 1.406 ± 0.863
1.406MetGlu: 1.406 ± 1.179
1.406MetPhe: 1.406 ± 0.863
1.406MetGly: 1.406 ± 0.863
0.0MetHis: 0.0 ± 0.0
4.219MetIle: 4.219 ± 3.537
4.219MetLys: 4.219 ± 2.589
1.406MetLeu: 1.406 ± 1.179
1.406MetMet: 1.406 ± 0.863
1.406MetAsn: 1.406 ± 0.863
1.406MetPro: 1.406 ± 0.863
0.0MetGln: 0.0 ± 0.0
2.813MetArg: 2.813 ± 0.316
4.219MetSer: 4.219 ± 1.495
0.0MetThr: 0.0 ± 0.0
1.406MetVal: 1.406 ± 0.863
0.0MetTrp: 0.0 ± 0.0
1.406MetTyr: 1.406 ± 0.863
0.0MetXaa: 0.0 ± 0.0
Asn
5.626AsnAla: 5.626 ± 1.41
0.0AsnCys: 0.0 ± 0.0
4.219AsnAsp: 4.219 ± 2.589
0.0AsnGlu: 0.0 ± 0.0
7.032AsnPhe: 7.032 ± 0.231
4.219AsnGly: 4.219 ± 3.537
0.0AsnHis: 0.0 ± 0.0
5.626AsnIle: 5.626 ± 1.41
2.813AsnLys: 2.813 ± 1.726
2.813AsnLeu: 2.813 ± 0.316
0.0AsnMet: 0.0 ± 0.0
4.219AsnAsn: 4.219 ± 1.495
2.813AsnPro: 2.813 ± 1.726
0.0AsnGln: 0.0 ± 0.0
5.626AsnArg: 5.626 ± 3.452
0.0AsnSer: 0.0 ± 0.0
4.219AsnThr: 4.219 ± 2.589
2.813AsnVal: 2.813 ± 0.316
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
2.813ProAla: 2.813 ± 0.316
0.0ProCys: 0.0 ± 0.0
1.406ProAsp: 1.406 ± 1.179
0.0ProGlu: 0.0 ± 0.0
1.406ProPhe: 1.406 ± 0.863
4.219ProGly: 4.219 ± 0.547
1.406ProHis: 1.406 ± 1.179
0.0ProIle: 0.0 ± 0.0
0.0ProLys: 0.0 ± 0.0
4.219ProLeu: 4.219 ± 0.547
0.0ProMet: 0.0 ± 0.0
2.813ProAsn: 2.813 ± 1.726
0.0ProPro: 0.0 ± 0.0
2.813ProGln: 2.813 ± 2.358
5.626ProArg: 5.626 ± 0.632
4.219ProSer: 4.219 ± 2.589
5.626ProThr: 5.626 ± 3.452
2.813ProVal: 2.813 ± 1.726
1.406ProTrp: 1.406 ± 1.179
1.406ProTyr: 1.406 ± 1.179
0.0ProXaa: 0.0 ± 0.0
Gln
5.626GlnAla: 5.626 ± 1.41
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
2.813GlnGlu: 2.813 ± 0.316
0.0GlnPhe: 0.0 ± 0.0
4.219GlnGly: 4.219 ± 3.537
1.406GlnHis: 1.406 ± 1.179
1.406GlnIle: 1.406 ± 0.863
0.0GlnLys: 0.0 ± 0.0
2.813GlnLeu: 2.813 ± 0.316
0.0GlnMet: 0.0 ± 0.0
2.813GlnAsn: 2.813 ± 0.316
2.813GlnPro: 2.813 ± 1.726
1.406GlnGln: 1.406 ± 0.863
2.813GlnArg: 2.813 ± 0.316
2.813GlnSer: 2.813 ± 1.726
4.219GlnThr: 4.219 ± 0.547
1.406GlnVal: 1.406 ± 0.863
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
2.813ArgAla: 2.813 ± 0.316
0.0ArgCys: 0.0 ± 0.0
1.406ArgAsp: 1.406 ± 1.179
4.219ArgGlu: 4.219 ± 3.537
7.032ArgPhe: 7.032 ± 0.231
4.219ArgGly: 4.219 ± 1.495
0.0ArgHis: 0.0 ± 0.0
4.219ArgIle: 4.219 ± 1.495
11.252ArgLys: 11.252 ± 4.863
5.626ArgLeu: 5.626 ± 3.452
0.0ArgMet: 0.0 ± 0.0
1.406ArgAsn: 1.406 ± 0.863
0.0ArgPro: 0.0 ± 0.0
2.813ArgGln: 2.813 ± 0.316
15.471ArgArg: 15.471 ± 3.368
9.845ArgSer: 9.845 ± 1.957
5.626ArgThr: 5.626 ± 3.452
5.626ArgVal: 5.626 ± 0.632
0.0ArgTrp: 0.0 ± 0.0
4.219ArgTyr: 4.219 ± 1.495
0.0ArgXaa: 0.0 ± 0.0
Ser
4.219SerAla: 4.219 ± 0.547
0.0SerCys: 0.0 ± 0.0
8.439SerAsp: 8.439 ± 0.948
0.0SerGlu: 0.0 ± 0.0
1.406SerPhe: 1.406 ± 0.863
5.626SerGly: 5.626 ± 0.632
1.406SerHis: 1.406 ± 0.863
5.626SerIle: 5.626 ± 2.674
4.219SerLys: 4.219 ± 0.547
7.032SerLeu: 7.032 ± 4.316
0.0SerMet: 0.0 ± 0.0
1.406SerAsn: 1.406 ± 0.863
2.813SerPro: 2.813 ± 1.726
1.406SerGln: 1.406 ± 1.179
5.626SerArg: 5.626 ± 1.41
8.439SerSer: 8.439 ± 3.136
9.845SerThr: 9.845 ± 4.0
4.219SerVal: 4.219 ± 0.547
0.0SerTrp: 0.0 ± 0.0
2.813SerTyr: 2.813 ± 0.316
0.0SerXaa: 0.0 ± 0.0
Thr
4.219ThrAla: 4.219 ± 2.589
1.406ThrCys: 1.406 ± 0.863
4.219ThrAsp: 4.219 ± 1.495
2.813ThrGlu: 2.813 ± 1.726
1.406ThrPhe: 1.406 ± 0.863
4.219ThrGly: 4.219 ± 2.589
1.406ThrHis: 1.406 ± 1.179
1.406ThrIle: 1.406 ± 0.863
4.219ThrLys: 4.219 ± 1.495
4.219ThrLeu: 4.219 ± 2.589
5.626ThrMet: 5.626 ± 0.389
7.032ThrAsn: 7.032 ± 2.273
4.219ThrPro: 4.219 ± 0.547
5.626ThrGln: 5.626 ± 1.41
2.813ThrArg: 2.813 ± 0.316
2.813ThrSer: 2.813 ± 1.726
2.813ThrThr: 2.813 ± 0.316
4.219ThrVal: 4.219 ± 2.589
0.0ThrTrp: 0.0 ± 0.0
5.626ThrTyr: 5.626 ± 1.41
0.0ThrXaa: 0.0 ± 0.0
Val
4.219ValAla: 4.219 ± 2.589
0.0ValCys: 0.0 ± 0.0
7.032ValAsp: 7.032 ± 3.853
2.813ValGlu: 2.813 ± 2.358
1.406ValPhe: 1.406 ± 1.179
5.626ValGly: 5.626 ± 0.632
0.0ValHis: 0.0 ± 0.0
5.626ValIle: 5.626 ± 2.674
2.813ValLys: 2.813 ± 1.726
4.219ValLeu: 4.219 ± 0.547
1.406ValMet: 1.406 ± 0.863
2.813ValAsn: 2.813 ± 1.726
2.813ValPro: 2.813 ± 1.726
2.813ValGln: 2.813 ± 1.726
4.219ValArg: 4.219 ± 1.495
5.626ValSer: 5.626 ± 3.452
5.626ValThr: 5.626 ± 1.41
8.439ValVal: 8.439 ± 1.094
1.406ValTrp: 1.406 ± 1.179
4.219ValTyr: 4.219 ± 1.495
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
1.406TrpCys: 1.406 ± 1.179
0.0TrpAsp: 0.0 ± 0.0
1.406TrpGlu: 1.406 ± 1.179
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
2.813TrpLeu: 2.813 ± 0.316
0.0TrpMet: 0.0 ± 0.0
1.406TrpAsn: 1.406 ± 0.863
0.0TrpPro: 0.0 ± 0.0
2.813TrpGln: 2.813 ± 0.316
1.406TrpArg: 1.406 ± 0.863
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
2.813TrpVal: 2.813 ± 0.316
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.813TyrAla: 2.813 ± 2.358
1.406TyrCys: 1.406 ± 1.179
5.626TyrAsp: 5.626 ± 1.41
1.406TyrGlu: 1.406 ± 1.179
1.406TyrPhe: 1.406 ± 1.179
8.439TyrGly: 8.439 ± 0.948
0.0TyrHis: 0.0 ± 0.0
2.813TyrIle: 2.813 ± 0.316
1.406TyrLys: 1.406 ± 0.863
4.219TyrLeu: 4.219 ± 0.547
1.406TyrMet: 1.406 ± 0.863
1.406TyrAsn: 1.406 ± 1.179
2.813TyrPro: 2.813 ± 0.316
0.0TyrGln: 0.0 ± 0.0
1.406TyrArg: 1.406 ± 0.863
1.406TyrSer: 1.406 ± 0.863
4.219TyrThr: 4.219 ± 0.547
7.032TyrVal: 7.032 ± 3.853
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (712 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski