Amino acid dipepetide frequency for Cellulosimicrobium sp. CUA-896

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.276AlaAla: 23.276 ± 0.312	0.928AlaCys: 0.928 ± 0.04	9.099AlaAsp: 9.099 ± 0.139	8.08AlaGlu: 8.08 ± 0.13	3.45AlaPhe: 3.45 ± 0.073	14.481AlaGly: 14.481 ± 0.164	2.83AlaHis: 2.83 ± 0.065	3.342AlaIle: 3.342 ± 0.081	1.638AlaLys: 1.638 ± 0.06	14.982AlaLeu: 14.982 ± 0.198	2.463AlaMet: 2.463 ± 0.063	1.703AlaAsn: 1.703 ± 0.051	8.506AlaPro: 8.506 ± 0.14	3.744AlaGln: 3.744 ± 0.083	12.561AlaArg: 12.561 ± 0.176	7.548AlaSer: 7.548 ± 0.12	8.849AlaThr: 8.849 ± 0.133	14.175AlaVal: 14.175 ± 0.181	2.347AlaTrp: 2.347 ± 0.061	2.385AlaTyr: 2.385 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	0.92CysAla: 0.92 ± 0.037	0.137CysCys: 0.137 ± 0.012	0.363CysAsp: 0.363 ± 0.024	0.254CysGlu: 0.254 ± 0.018	0.164CysPhe: 0.164 ± 0.016	0.754CysGly: 0.754 ± 0.034	0.108CysHis: 0.108 ± 0.012	0.091CysIle: 0.091 ± 0.012	0.055CysLys: 0.055 ± 0.009	0.464CysLeu: 0.464 ± 0.026	0.097CysMet: 0.097 ± 0.01	0.055CysAsn: 0.055 ± 0.009	0.404CysPro: 0.404 ± 0.024	0.12CysGln: 0.12 ± 0.014	0.523CysArg: 0.523 ± 0.033	0.543CysSer: 0.543 ± 0.036	0.468CysThr: 0.468 ± 0.036	0.534CysVal: 0.534 ± 0.028	0.087CysTrp: 0.087 ± 0.01	0.089CysTyr: 0.089 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	10.401AspAla: 10.401 ± 0.131	0.24AspCys: 0.24 ± 0.018	5.406AspAsp: 5.406 ± 0.093	4.356AspGlu: 4.356 ± 0.08	1.242AspPhe: 1.242 ± 0.044	7.891AspGly: 7.891 ± 0.127	1.245AspHis: 1.245 ± 0.047	1.121AspIle: 1.121 ± 0.046	0.642AspLys: 0.642 ± 0.028	6.686AspLeu: 6.686 ± 0.108	0.659AspMet: 0.659 ± 0.033	0.631AspAsn: 0.631 ± 0.03	4.81AspPro: 4.81 ± 0.095	1.333AspGln: 1.333 ± 0.045	4.958AspArg: 4.958 ± 0.08	1.877AspSer: 1.877 ± 0.048	2.739AspThr: 2.739 ± 0.064	7.955AspVal: 7.955 ± 0.12	0.822AspTrp: 0.822 ± 0.032	0.942AspTyr: 0.942 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.791GluAla: 6.791 ± 0.11	0.233GluCys: 0.233 ± 0.02	3.312GluAsp: 3.312 ± 0.08	2.994GluGlu: 2.994 ± 0.081	1.103GluPhe: 1.103 ± 0.038	4.17GluGly: 4.17 ± 0.092	1.704GluHis: 1.704 ± 0.05	2.028GluIle: 2.028 ± 0.049	0.841GluLys: 0.841 ± 0.042	6.298GluLeu: 6.298 ± 0.101	0.73GluMet: 0.73 ± 0.031	0.934GluAsn: 0.934 ± 0.038	3.736GluPro: 3.736 ± 0.077	2.003GluGln: 2.003 ± 0.048	5.662GluArg: 5.662 ± 0.089	2.325GluSer: 2.325 ± 0.058	2.85GluThr: 2.85 ± 0.065	5.191GluVal: 5.191 ± 0.089	0.632GluTrp: 0.632 ± 0.03	0.883GluTyr: 0.883 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.48PheAla: 3.48 ± 0.065	0.168PheCys: 0.168 ± 0.017	1.884PheAsp: 1.884 ± 0.055	1.307PheGlu: 1.307 ± 0.043	0.745PhePhe: 0.745 ± 0.039	2.462PheGly: 2.462 ± 0.058	0.456PheHis: 0.456 ± 0.029	0.481PheIle: 0.481 ± 0.031	0.242PheLys: 0.242 ± 0.018	2.391PheLeu: 2.391 ± 0.057	0.291PheMet: 0.291 ± 0.021	0.369PheAsn: 0.369 ± 0.022	1.141PhePro: 1.141 ± 0.043	0.528PheGln: 0.528 ± 0.028	1.476PheArg: 1.476 ± 0.044	1.32PheSer: 1.32 ± 0.042	1.667PheThr: 1.667 ± 0.05	2.695PheVal: 2.695 ± 0.064	0.389PheTrp: 0.389 ± 0.025	0.467PheTyr: 0.467 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	13.236GlyAla: 13.236 ± 0.164	0.599GlyCys: 0.599 ± 0.029	5.8GlyAsp: 5.8 ± 0.1	5.197GlyGlu: 5.197 ± 0.096	2.591GlyPhe: 2.591 ± 0.058	8.815GlyGly: 8.815 ± 0.14	1.98GlyHis: 1.98 ± 0.061	2.871GlyIle: 2.871 ± 0.066	1.386GlyLys: 1.386 ± 0.045	8.979GlyLeu: 8.979 ± 0.144	1.794GlyMet: 1.794 ± 0.046	1.262GlyAsn: 1.262 ± 0.049	5.61GlyPro: 5.61 ± 0.089	2.394GlyGln: 2.394 ± 0.068	8.041GlyArg: 8.041 ± 0.127	5.584GlySer: 5.584 ± 0.089	7.155GlyThr: 7.155 ± 0.116	9.061GlyVal: 9.061 ± 0.12	1.712GlyTrp: 1.712 ± 0.049	2.013GlyTyr: 2.013 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.862HisAla: 2.862 ± 0.067	0.087HisCys: 0.087 ± 0.01	1.54HisAsp: 1.54 ± 0.047	1.189HisGlu: 1.189 ± 0.044	0.4HisPhe: 0.4 ± 0.023	2.271HisGly: 2.271 ± 0.064	0.53HisHis: 0.53 ± 0.03	0.309HisIle: 0.309 ± 0.021	0.173HisLys: 0.173 ± 0.016	2.189HisLeu: 2.189 ± 0.062	0.232HisMet: 0.232 ± 0.016	0.255HisAsn: 0.255 ± 0.018	1.475HisPro: 1.475 ± 0.052	0.434HisGln: 0.434 ± 0.025	1.836HisArg: 1.836 ± 0.051	0.655HisSer: 0.655 ± 0.028	0.86HisThr: 0.86 ± 0.039	2.182HisVal: 2.182 ± 0.065	0.255HisTrp: 0.255 ± 0.018	0.355HisTyr: 0.355 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	3.655IleAla: 3.655 ± 0.081	0.16IleCys: 0.16 ± 0.015	1.836IleAsp: 1.836 ± 0.051	1.592IleGlu: 1.592 ± 0.059	0.582IlePhe: 0.582 ± 0.037	2.585IleGly: 2.585 ± 0.072	0.366IleHis: 0.366 ± 0.021	0.664IleIle: 0.664 ± 0.033	0.403IleLys: 0.403 ± 0.025	1.962IleLeu: 1.962 ± 0.06	0.367IleMet: 0.367 ± 0.025	0.46IleAsn: 0.46 ± 0.031	1.341IlePro: 1.341 ± 0.046	0.524IleGln: 0.524 ± 0.03	1.44IleArg: 1.44 ± 0.046	1.152IleSer: 1.152 ± 0.04	1.72IleThr: 1.72 ± 0.057	2.566IleVal: 2.566 ± 0.072	0.284IleTrp: 0.284 ± 0.023	0.37IleTyr: 0.37 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	1.477LysAla: 1.477 ± 0.051	0.049LysCys: 0.049 ± 0.008	0.785LysAsp: 0.785 ± 0.038	0.653LysGlu: 0.653 ± 0.036	0.253LysPhe: 0.253 ± 0.02	1.024LysGly: 1.024 ± 0.039	0.309LysHis: 0.309 ± 0.021	0.558LysIle: 0.558 ± 0.032	0.365LysLys: 0.365 ± 0.03	1.029LysLeu: 1.029 ± 0.042	0.182LysMet: 0.182 ± 0.015	0.299LysAsn: 0.299 ± 0.022	0.717LysPro: 0.717 ± 0.034	0.385LysGln: 0.385 ± 0.025	0.89LysArg: 0.89 ± 0.041	0.657LysSer: 0.657 ± 0.034	0.694LysThr: 0.694 ± 0.031	1.222LysVal: 1.222 ± 0.046	0.115LysTrp: 0.115 ± 0.012	0.243LysTyr: 0.243 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	16.241LeuAla: 16.241 ± 0.209	0.556LeuCys: 0.556 ± 0.025	7.347LeuAsp: 7.347 ± 0.121	5.001LeuGlu: 5.001 ± 0.101	2.212LeuPhe: 2.212 ± 0.063	9.777LeuGly: 9.777 ± 0.139	1.891LeuHis: 1.891 ± 0.051	1.602LeuIle: 1.602 ± 0.052	0.991LeuLys: 0.991 ± 0.041	10.206LeuLeu: 10.206 ± 0.193	1.174LeuMet: 1.174 ± 0.042	1.165LeuAsn: 1.165 ± 0.047	5.553LeuPro: 5.553 ± 0.098	1.981LeuGln: 1.981 ± 0.059	8.012LeuArg: 8.012 ± 0.126	4.402LeuSer: 4.402 ± 0.081	5.954LeuThr: 5.954 ± 0.102	11.821LeuVal: 11.821 ± 0.163	1.176LeuTrp: 1.176 ± 0.046	1.46LeuTyr: 1.46 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	1.887MetAla: 1.887 ± 0.054	0.068MetCys: 0.068 ± 0.009	0.72MetAsp: 0.72 ± 0.031	0.586MetGlu: 0.586 ± 0.03	0.395MetPhe: 0.395 ± 0.022	1.012MetGly: 1.012 ± 0.038	0.315MetHis: 0.315 ± 0.019	0.509MetIle: 0.509 ± 0.027	0.253MetLys: 0.253 ± 0.018	1.563MetLeu: 1.563 ± 0.049	0.194MetMet: 0.194 ± 0.019	0.274MetAsn: 0.274 ± 0.021	1.027MetPro: 1.027 ± 0.036	0.336MetGln: 0.336 ± 0.02	1.253MetArg: 1.253 ± 0.041	1.167MetSer: 1.167 ± 0.042	1.544MetThr: 1.544 ± 0.043	1.229MetVal: 1.229 ± 0.045	0.162MetTrp: 0.162 ± 0.015	0.212MetTyr: 0.212 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	1.78AsnAla: 1.78 ± 0.061	0.079AsnCys: 0.079 ± 0.011	0.793AsnAsp: 0.793 ± 0.034	0.632AsnGlu: 0.632 ± 0.031	0.363AsnPhe: 0.363 ± 0.023	1.296AsnGly: 1.296 ± 0.047	0.281AsnHis: 0.281 ± 0.022	0.38AsnIle: 0.38 ± 0.026	0.203AsnLys: 0.203 ± 0.018	1.357AsnLeu: 1.357 ± 0.046	0.199AsnMet: 0.199 ± 0.016	0.258AsnAsn: 0.258 ± 0.018	1.107AsnPro: 1.107 ± 0.046	0.397AsnGln: 0.397 ± 0.025	0.896AsnArg: 0.896 ± 0.036	0.535AsnSer: 0.535 ± 0.028	0.788AsnThr: 0.788 ± 0.035	1.46AsnVal: 1.46 ± 0.043	0.197AsnTrp: 0.197 ± 0.018	0.319AsnTyr: 0.319 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	9.513ProAla: 9.513 ± 0.146	0.333ProCys: 0.333 ± 0.023	4.911ProAsp: 4.911 ± 0.091	3.8ProGlu: 3.8 ± 0.081	1.507ProPhe: 1.507 ± 0.042	7.142ProGly: 7.142 ± 0.123	1.083ProHis: 1.083 ± 0.038	1.043ProIle: 1.043 ± 0.039	0.561ProLys: 0.561 ± 0.026	4.783ProLeu: 4.783 ± 0.092	0.8ProMet: 0.8 ± 0.03	0.72ProAsn: 0.72 ± 0.031	3.494ProPro: 3.494 ± 0.107	1.501ProGln: 1.501 ± 0.053	4.853ProArg: 4.853 ± 0.106	3.723ProSer: 3.723 ± 0.084	3.854ProThr: 3.854 ± 0.08	6.286ProVal: 6.286 ± 0.115	0.952ProTrp: 0.952 ± 0.042	1.076ProTyr: 1.076 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.224GlnAla: 3.224 ± 0.076	0.109GlnCys: 0.109 ± 0.013	1.39GlnAsp: 1.39 ± 0.047	1.285GlnGlu: 1.285 ± 0.048	0.548GlnPhe: 0.548 ± 0.026	2.03GlnGly: 2.03 ± 0.059	0.567GlnHis: 0.567 ± 0.031	0.841GlnIle: 0.841 ± 0.036	0.326GlnLys: 0.326 ± 0.02	2.425GlnLeu: 2.425 ± 0.059	0.375GlnMet: 0.375 ± 0.022	0.399GlnAsn: 0.399 ± 0.027	1.495GlnPro: 1.495 ± 0.051	0.908GlnGln: 0.908 ± 0.04	2.119GlnArg: 2.119 ± 0.052	1.021GlnSer: 1.021 ± 0.041	1.182GlnThr: 1.182 ± 0.042	2.866GlnVal: 2.866 ± 0.065	0.365GlnTrp: 0.365 ± 0.024	0.472GlnTyr: 0.472 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	11.785ArgAla: 11.785 ± 0.161	0.662ArgCys: 0.662 ± 0.036	4.922ArgAsp: 4.922 ± 0.089	4.444ArgGlu: 4.444 ± 0.091	1.991ArgPhe: 1.991 ± 0.053	6.577ArgGly: 6.577 ± 0.113	1.826ArgHis: 1.826 ± 0.053	2.174ArgIle: 2.174 ± 0.058	0.941ArgLys: 0.941 ± 0.04	8.065ArgLeu: 8.065 ± 0.125	1.6ArgMet: 1.6 ± 0.049	0.948ArgAsn: 0.948 ± 0.04	5.528ArgPro: 5.528 ± 0.113	1.804ArgGln: 1.804 ± 0.05	9.814ArgArg: 9.814 ± 0.188	5.112ArgSer: 5.112 ± 0.11	5.989ArgThr: 5.989 ± 0.109	7.261ArgVal: 7.261 ± 0.122	1.536ArgTrp: 1.536 ± 0.054	1.554ArgTyr: 1.554 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	7.284SerAla: 7.284 ± 0.126	0.502SerCys: 0.502 ± 0.035	2.623SerAsp: 2.623 ± 0.062	2.159SerGlu: 2.159 ± 0.061	1.424SerPhe: 1.424 ± 0.046	5.728SerGly: 5.728 ± 0.109	0.8SerHis: 0.8 ± 0.03	1.375SerIle: 1.375 ± 0.049	0.598SerLys: 0.598 ± 0.031	4.47SerLeu: 4.47 ± 0.092	0.984SerMet: 0.984 ± 0.041	0.694SerAsn: 0.694 ± 0.027	3.483SerPro: 3.483 ± 0.087	1.125SerGln: 1.125 ± 0.043	4.422SerArg: 4.422 ± 0.103	3.86SerSer: 3.86 ± 0.127	4.111SerThr: 4.111 ± 0.092	4.533SerVal: 4.533 ± 0.089	1.014SerTrp: 1.014 ± 0.037	0.948SerTyr: 0.948 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	9.061ThrAla: 9.061 ± 0.133	0.448ThrCys: 0.448 ± 0.03	3.865ThrAsp: 3.865 ± 0.092	2.906ThrGlu: 2.906 ± 0.082	1.871ThrPhe: 1.871 ± 0.056	6.348ThrGly: 6.348 ± 0.115	1.075ThrHis: 1.075 ± 0.038	1.82ThrIle: 1.82 ± 0.05	0.81ThrLys: 0.81 ± 0.037	5.722ThrLeu: 5.722 ± 0.099	0.892ThrMet: 0.892 ± 0.03	1.027ThrAsn: 1.027 ± 0.046	4.454ThrPro: 4.454 ± 0.095	1.32ThrGln: 1.32 ± 0.046	4.371ThrArg: 4.371 ± 0.081	4.069ThrSer: 4.069 ± 0.1	5.191ThrThr: 5.191 ± 0.11	6.861ThrVal: 6.861 ± 0.111	1.162ThrTrp: 1.162 ± 0.04	1.285ThrTyr: 1.285 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	15.314ValAla: 15.314 ± 0.185	0.634ValCys: 0.634 ± 0.036	7.198ValAsp: 7.198 ± 0.117	6.293ValGlu: 6.293 ± 0.104	2.135ValPhe: 2.135 ± 0.062	8.93ValGly: 8.93 ± 0.127	2.054ValHis: 2.054 ± 0.061	2.108ValIle: 2.108 ± 0.063	1.109ValLys: 1.109 ± 0.047	11.537ValLeu: 11.537 ± 0.156	1.263ValMet: 1.263 ± 0.04	1.301ValAsn: 1.301 ± 0.043	6.402ValPro: 6.402 ± 0.107	2.16ValGln: 2.16 ± 0.047	8.519ValArg: 8.519 ± 0.134	4.646ValSer: 4.646 ± 0.092	6.812ValThr: 6.812 ± 0.105	13.822ValVal: 13.822 ± 0.182	1.245ValTrp: 1.245 ± 0.047	1.428ValTyr: 1.428 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.813TrpAla: 1.813 ± 0.054	0.139TrpCys: 0.139 ± 0.014	0.908TrpAsp: 0.908 ± 0.037	0.691TrpGlu: 0.691 ± 0.033	0.519TrpPhe: 0.519 ± 0.029	1.065TrpGly: 1.065 ± 0.036	0.36TrpHis: 0.36 ± 0.021	0.418TrpIle: 0.418 ± 0.027	0.209TrpLys: 0.209 ± 0.015	1.576TrpLeu: 1.576 ± 0.051	0.239TrpMet: 0.239 ± 0.019	0.303TrpAsn: 0.303 ± 0.022	0.728TrpPro: 0.728 ± 0.035	0.467TrpGln: 0.467 ± 0.028	1.371TrpArg: 1.371 ± 0.044	1.135TrpSer: 1.135 ± 0.04	1.137TrpThr: 1.137 ± 0.046	1.298TrpVal: 1.298 ± 0.04	0.415TrpTrp: 0.415 ± 0.024	0.351TrpTyr: 0.351 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.389TyrAla: 2.389 ± 0.065	0.097TyrCys: 0.097 ± 0.011	1.252TyrAsp: 1.252 ± 0.046	1.006TyrGlu: 1.006 ± 0.041	0.464TyrPhe: 0.464 ± 0.025	1.723TyrGly: 1.723 ± 0.05	0.311TyrHis: 0.311 ± 0.019	0.295TyrIle: 0.295 ± 0.02	0.16TyrLys: 0.16 ± 0.017	1.836TyrLeu: 1.836 ± 0.055	0.168TyrMet: 0.168 ± 0.016	0.268TyrAsn: 0.268 ± 0.021	0.923TyrPro: 0.923 ± 0.034	0.483TyrGln: 0.483 ± 0.025	1.514TyrArg: 1.514 ± 0.047	0.804TyrSer: 0.804 ± 0.037	0.99TyrThr: 0.99 ± 0.047	1.892TyrVal: 1.892 ± 0.061	0.274TyrTrp: 0.274 ± 0.023	0.374TyrTyr: 0.374 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2595 proteins (732398 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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