Amino acid dipepetide frequency for Chloracidobacterium thermophilum (strain B)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.269AlaAla: 15.269 ± 0.182	1.217AlaCys: 1.217 ± 0.036	5.449AlaAsp: 5.449 ± 0.08	7.382AlaGlu: 7.382 ± 0.115	4.039AlaPhe: 4.039 ± 0.065	8.675AlaGly: 8.675 ± 0.104	2.273AlaHis: 2.273 ± 0.053	4.918AlaIle: 4.918 ± 0.082	2.911AlaLys: 2.911 ± 0.052	13.009AlaLeu: 13.009 ± 0.152	2.326AlaMet: 2.326 ± 0.054	2.658AlaAsn: 2.658 ± 0.054	5.471AlaPro: 5.471 ± 0.105	4.759AlaGln: 4.759 ± 0.072	9.173AlaArg: 9.173 ± 0.095	5.155AlaSer: 5.155 ± 0.082	6.537AlaThr: 6.537 ± 0.085	8.294AlaVal: 8.294 ± 0.094	1.425AlaTrp: 1.425 ± 0.046	2.755AlaTyr: 2.755 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.057CysAla: 1.057 ± 0.037	0.139CysCys: 0.139 ± 0.012	0.54CysAsp: 0.54 ± 0.023	0.527CysGlu: 0.527 ± 0.021	0.472CysPhe: 0.472 ± 0.02	0.949CysGly: 0.949 ± 0.03	0.316CysHis: 0.316 ± 0.026	0.392CysIle: 0.392 ± 0.02	0.176CysLys: 0.176 ± 0.014	1.157CysLeu: 1.157 ± 0.028	0.112CysMet: 0.112 ± 0.009	0.25CysAsn: 0.25 ± 0.018	0.643CysPro: 0.643 ± 0.028	0.396CysGln: 0.396 ± 0.02	0.858CysArg: 0.858 ± 0.032	0.442CysSer: 0.442 ± 0.019	0.53CysThr: 0.53 ± 0.023	0.705CysVal: 0.705 ± 0.028	0.141CysTrp: 0.141 ± 0.011	0.293CysTyr: 0.293 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.661AspAla: 5.661 ± 0.073	0.475AspCys: 0.475 ± 0.019	2.735AspAsp: 2.735 ± 0.054	3.415AspGlu: 3.415 ± 0.06	2.49AspPhe: 2.49 ± 0.049	4.263AspGly: 4.263 ± 0.08	0.815AspHis: 0.815 ± 0.035	2.783AspIle: 2.783 ± 0.049	1.21AspLys: 1.21 ± 0.035	5.139AspLeu: 5.139 ± 0.071	0.782AspMet: 0.782 ± 0.027	1.158AspAsn: 1.158 ± 0.034	2.905AspPro: 2.905 ± 0.058	1.261AspGln: 1.261 ± 0.034	3.507AspArg: 3.507 ± 0.059	1.693AspSer: 1.693 ± 0.043	2.628AspThr: 2.628 ± 0.052	3.916AspVal: 3.916 ± 0.066	0.963AspTrp: 0.963 ± 0.03	1.599AspTyr: 1.599 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.86GluAla: 7.86 ± 0.119	0.449GluCys: 0.449 ± 0.021	2.599GluAsp: 2.599 ± 0.053	3.228GluGlu: 3.228 ± 0.065	1.793GluPhe: 1.793 ± 0.044	3.773GluGly: 3.773 ± 0.06	1.242GluHis: 1.242 ± 0.034	2.854GluIle: 2.854 ± 0.06	2.26GluLys: 2.26 ± 0.061	6.111GluLeu: 6.111 ± 0.09	1.332GluMet: 1.332 ± 0.034	1.534GluAsn: 1.534 ± 0.04	2.909GluPro: 2.909 ± 0.05	2.913GluGln: 2.913 ± 0.063	5.832GluArg: 5.832 ± 0.093	2.52GluSer: 2.52 ± 0.05	4.063GluThr: 4.063 ± 0.061	4.786GluVal: 4.786 ± 0.071	0.703GluTrp: 0.703 ± 0.025	1.459GluTyr: 1.459 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.938PheAla: 3.938 ± 0.061	0.466PheCys: 0.466 ± 0.02	2.504PheAsp: 2.504 ± 0.049	2.259PheGlu: 2.259 ± 0.041	1.862PhePhe: 1.862 ± 0.049	3.544PheGly: 3.544 ± 0.071	0.835PheHis: 0.835 ± 0.025	1.888PheIle: 1.888 ± 0.039	0.959PheLys: 0.959 ± 0.03	3.922PheLeu: 3.922 ± 0.07	0.511PheMet: 0.511 ± 0.021	1.251PheAsn: 1.251 ± 0.046	2.011PhePro: 2.011 ± 0.044	1.355PheGln: 1.355 ± 0.04	2.748PheArg: 2.748 ± 0.053	2.071PheSer: 2.071 ± 0.052	2.326PheThr: 2.326 ± 0.054	2.913PheVal: 2.913 ± 0.058	0.523PheTrp: 0.523 ± 0.026	1.115PheTyr: 1.115 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	6.767GlyAla: 6.767 ± 0.108	0.9GlyCys: 0.9 ± 0.033	3.681GlyAsp: 3.681 ± 0.064	4.448GlyGlu: 4.448 ± 0.061	3.284GlyPhe: 3.284 ± 0.053	6.271GlyGly: 6.271 ± 0.116	1.448GlyHis: 1.448 ± 0.04	4.198GlyIle: 4.198 ± 0.071	3.017GlyLys: 3.017 ± 0.06	8.246GlyLeu: 8.246 ± 0.112	1.674GlyMet: 1.674 ± 0.041	2.299GlyAsn: 2.299 ± 0.053	2.621GlyPro: 2.621 ± 0.072	3.427GlyGln: 3.427 ± 0.061	6.251GlyArg: 6.251 ± 0.081	3.764GlySer: 3.764 ± 0.072	4.734GlyThr: 4.734 ± 0.1	5.931GlyVal: 5.931 ± 0.081	1.413GlyTrp: 1.413 ± 0.042	2.342GlyTyr: 2.342 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.997HisAla: 1.997 ± 0.05	0.262HisCys: 0.262 ± 0.019	0.963HisAsp: 0.963 ± 0.036	1.028HisGlu: 1.028 ± 0.035	0.915HisPhe: 0.915 ± 0.026	1.629HisGly: 1.629 ± 0.039	0.695HisHis: 0.695 ± 0.027	1.051HisIle: 1.051 ± 0.032	0.448HisLys: 0.448 ± 0.02	2.494HisLeu: 2.494 ± 0.056	0.281HisMet: 0.281 ± 0.017	0.488HisAsn: 0.488 ± 0.021	1.8HisPro: 1.8 ± 0.056	0.767HisGln: 0.767 ± 0.028	1.792HisArg: 1.792 ± 0.04	0.777HisSer: 0.777 ± 0.029	1.074HisThr: 1.074 ± 0.032	1.44HisVal: 1.44 ± 0.037	0.333HisTrp: 0.333 ± 0.017	0.676HisTyr: 0.676 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.289IleAla: 5.289 ± 0.074	0.443IleCys: 0.443 ± 0.02	1.879IleAsp: 1.879 ± 0.048	3.407IleGlu: 3.407 ± 0.062	1.562IlePhe: 1.562 ± 0.042	4.043IleGly: 4.043 ± 0.073	1.032IleHis: 1.032 ± 0.035	2.09IleIle: 2.09 ± 0.051	1.201IleLys: 1.201 ± 0.038	4.302IleLeu: 4.302 ± 0.08	0.569IleMet: 0.569 ± 0.02	1.41IleAsn: 1.41 ± 0.037	2.627IlePro: 2.627 ± 0.042	1.489IleGln: 1.489 ± 0.046	3.623IleArg: 3.623 ± 0.058	2.185IleSer: 2.185 ± 0.044	2.764IleThr: 2.764 ± 0.057	3.901IleVal: 3.901 ± 0.062	0.46IleTrp: 0.46 ± 0.023	1.129IleTyr: 1.129 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.149LysAla: 3.149 ± 0.069	0.222LysCys: 0.222 ± 0.017	1.208LysAsp: 1.208 ± 0.038	1.421LysGlu: 1.421 ± 0.045	0.946LysPhe: 0.946 ± 0.027	1.808LysGly: 1.808 ± 0.045	0.624LysHis: 0.624 ± 0.026	1.285LysIle: 1.285 ± 0.042	1.235LysLys: 1.235 ± 0.048	3.235LysLeu: 3.235 ± 0.056	0.556LysMet: 0.556 ± 0.024	0.806LysAsn: 0.806 ± 0.03	2.072LysPro: 2.072 ± 0.053	1.144LysGln: 1.144 ± 0.037	2.298LysArg: 2.298 ± 0.053	1.509LysSer: 1.509 ± 0.041	1.837LysThr: 1.837 ± 0.044	2.08LysVal: 2.08 ± 0.049	0.283LysTrp: 0.283 ± 0.016	0.769LysTyr: 0.769 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	13.698LeuAla: 13.698 ± 0.144	1.199LeuCys: 1.199 ± 0.039	5.985LeuAsp: 5.985 ± 0.074	6.519LeuGlu: 6.519 ± 0.105	3.574LeuPhe: 3.574 ± 0.067	7.937LeuGly: 7.937 ± 0.115	2.203LeuHis: 2.203 ± 0.055	4.195LeuIle: 4.195 ± 0.075	3.063LeuLys: 3.063 ± 0.061	10.972LeuLeu: 10.972 ± 0.137	1.847LeuMet: 1.847 ± 0.045	2.713LeuAsn: 2.713 ± 0.052	7.221LeuPro: 7.221 ± 0.094	3.54LeuGln: 3.54 ± 0.058	8.698LeuArg: 8.698 ± 0.104	5.607LeuSer: 5.607 ± 0.087	7.134LeuThr: 7.134 ± 0.093	8.022LeuVal: 8.022 ± 0.104	1.46LeuTrp: 1.46 ± 0.047	2.581LeuTyr: 2.581 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.119MetAla: 2.119 ± 0.042	0.165MetCys: 0.165 ± 0.012	0.737MetAsp: 0.737 ± 0.029	0.955MetGlu: 0.955 ± 0.029	0.608MetPhe: 0.608 ± 0.024	1.207MetGly: 1.207 ± 0.035	0.334MetHis: 0.334 ± 0.018	0.66MetIle: 0.66 ± 0.024	0.672MetLys: 0.672 ± 0.025	2.064MetLeu: 2.064 ± 0.049	0.41MetMet: 0.41 ± 0.022	0.533MetAsn: 0.533 ± 0.021	1.172MetPro: 1.172 ± 0.033	0.741MetGln: 0.741 ± 0.029	1.405MetArg: 1.405 ± 0.038	1.105MetSer: 1.105 ± 0.029	1.517MetThr: 1.517 ± 0.033	1.313MetVal: 1.313 ± 0.033	0.212MetTrp: 0.212 ± 0.013	0.343MetTyr: 0.343 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.612AsnAla: 2.612 ± 0.055	0.268AsnCys: 0.268 ± 0.015	1.272AsnAsp: 1.272 ± 0.039	1.315AsnGlu: 1.315 ± 0.035	1.185AsnPhe: 1.185 ± 0.045	2.214AsnGly: 2.214 ± 0.066	0.595AsnHis: 0.595 ± 0.024	1.477AsnIle: 1.477 ± 0.045	0.6AsnLys: 0.6 ± 0.025	3.265AsnLeu: 3.265 ± 0.068	0.362AsnMet: 0.362 ± 0.017	0.875AsnAsn: 0.875 ± 0.046	2.118AsnPro: 2.118 ± 0.054	1.032AsnGln: 1.032 ± 0.037	2.174AsnArg: 2.174 ± 0.049	1.093AsnSer: 1.093 ± 0.039	1.275AsnThr: 1.275 ± 0.043	1.996AsnVal: 1.996 ± 0.046	0.386AsnTrp: 0.386 ± 0.019	0.822AsnTyr: 0.822 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	6.869ProAla: 6.869 ± 0.098	0.444ProCys: 0.444 ± 0.019	3.912ProAsp: 3.912 ± 0.067	4.348ProGlu: 4.348 ± 0.07	2.117ProPhe: 2.117 ± 0.05	4.568ProGly: 4.568 ± 0.086	1.169ProHis: 1.169 ± 0.039	2.07ProIle: 2.07 ± 0.047	1.633ProLys: 1.633 ± 0.042	5.573ProLeu: 5.573 ± 0.074	1.085ProMet: 1.085 ± 0.034	1.768ProAsn: 1.768 ± 0.058	4.697ProPro: 4.697 ± 0.131	1.915ProGln: 1.915 ± 0.044	3.481ProArg: 3.481 ± 0.058	3.099ProSer: 3.099 ± 0.073	3.859ProThr: 3.859 ± 0.068	4.796ProVal: 4.796 ± 0.079	0.694ProTrp: 0.694 ± 0.028	1.373ProTyr: 1.373 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.852GlnAla: 4.852 ± 0.08	0.332GlnCys: 0.332 ± 0.018	1.472GlnAsp: 1.472 ± 0.036	1.993GlnGlu: 1.993 ± 0.042	1.32GlnPhe: 1.32 ± 0.038	2.663GlnGly: 2.663 ± 0.054	0.826GlnHis: 0.826 ± 0.032	1.56GlnIle: 1.56 ± 0.04	1.076GlnLys: 1.076 ± 0.039	3.834GlnLeu: 3.834 ± 0.066	0.837GlnMet: 0.837 ± 0.029	0.932GlnAsn: 0.932 ± 0.036	2.762GlnPro: 2.762 ± 0.05	1.789GlnGln: 1.789 ± 0.048	3.568GlnArg: 3.568 ± 0.067	1.983GlnSer: 1.983 ± 0.043	2.395GlnThr: 2.395 ± 0.052	3.155GlnVal: 3.155 ± 0.058	0.522GlnTrp: 0.522 ± 0.025	0.849GlnTyr: 0.849 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	7.916ArgAla: 7.916 ± 0.101	0.726ArgCys: 0.726 ± 0.025	3.772ArgAsp: 3.772 ± 0.063	5.211ArgGlu: 5.211 ± 0.072	3.411ArgPhe: 3.411 ± 0.056	4.573ArgGly: 4.573 ± 0.073	2.058ArgHis: 2.058 ± 0.045	3.813ArgIle: 3.813 ± 0.062	2.166ArgLys: 2.166 ± 0.051	10.047ArgLeu: 10.047 ± 0.114	1.55ArgMet: 1.55 ± 0.04	1.966ArgAsn: 1.966 ± 0.049	4.397ArgPro: 4.397 ± 0.073	4.44ArgGln: 4.44 ± 0.079	7.331ArgArg: 7.331 ± 0.107	3.167ArgSer: 3.167 ± 0.057	4.34ArgThr: 4.34 ± 0.066	5.083ArgVal: 5.083 ± 0.072	1.286ArgTrp: 1.286 ± 0.039	2.381ArgTyr: 2.381 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	4.859SerAla: 4.859 ± 0.072	0.445SerCys: 0.445 ± 0.024	2.531SerAsp: 2.531 ± 0.047	2.625SerGlu: 2.625 ± 0.052	2.032SerPhe: 2.032 ± 0.047	4.355SerGly: 4.355 ± 0.087	0.968SerHis: 0.968 ± 0.03	2.077SerIle: 2.077 ± 0.053	1.223SerLys: 1.223 ± 0.039	5.366SerLeu: 5.366 ± 0.078	0.817SerMet: 0.817 ± 0.032	1.31SerAsn: 1.31 ± 0.043	3.489SerPro: 3.489 ± 0.08	1.684SerGln: 1.684 ± 0.04	3.48SerArg: 3.48 ± 0.058	2.588SerSer: 2.588 ± 0.058	2.486SerThr: 2.486 ± 0.056	3.539SerVal: 3.539 ± 0.062	0.576SerTrp: 0.576 ± 0.02	1.142SerTyr: 1.142 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.833ThrAla: 6.833 ± 0.097	0.576ThrCys: 0.576 ± 0.023	3.0ThrAsp: 3.0 ± 0.055	3.099ThrGlu: 3.099 ± 0.055	2.542ThrPhe: 2.542 ± 0.055	5.417ThrGly: 5.417 ± 0.083	1.21ThrHis: 1.21 ± 0.036	2.636ThrIle: 2.636 ± 0.055	1.413ThrLys: 1.413 ± 0.041	6.954ThrLeu: 6.954 ± 0.092	1.006ThrMet: 1.006 ± 0.033	1.659ThrAsn: 1.659 ± 0.054	4.727ThrPro: 4.727 ± 0.074	1.811ThrGln: 1.811 ± 0.037	3.703ThrArg: 3.703 ± 0.061	3.042ThrSer: 3.042 ± 0.063	3.974ThrThr: 3.974 ± 0.062	4.852ThrVal: 4.852 ± 0.076	0.82ThrTrp: 0.82 ± 0.029	1.577ThrTyr: 1.577 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.912ValAla: 8.912 ± 0.096	0.876ValCys: 0.876 ± 0.029	3.041ValAsp: 3.041 ± 0.057	4.762ValGlu: 4.762 ± 0.068	2.989ValPhe: 2.989 ± 0.061	5.761ValGly: 5.761 ± 0.085	1.349ValHis: 1.349 ± 0.037	3.99ValIle: 3.99 ± 0.071	2.137ValLys: 2.137 ± 0.051	7.479ValLeu: 7.479 ± 0.093	1.554ValMet: 1.554 ± 0.038	2.287ValAsn: 2.287 ± 0.059	4.001ValPro: 4.001 ± 0.071	2.424ValGln: 2.424 ± 0.046	5.885ValArg: 5.885 ± 0.088	4.065ValSer: 4.065 ± 0.062	5.223ValThr: 5.223 ± 0.082	6.785ValVal: 6.785 ± 0.09	1.113ValTrp: 1.113 ± 0.04	1.753ValTyr: 1.753 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.128TrpAla: 1.128 ± 0.04	0.185TrpCys: 0.185 ± 0.013	0.516TrpAsp: 0.516 ± 0.023	0.748TrpGlu: 0.748 ± 0.026	0.655TrpPhe: 0.655 ± 0.027	0.769TrpGly: 0.769 ± 0.031	0.333TrpHis: 0.333 ± 0.019	0.492TrpIle: 0.492 ± 0.024	0.491TrpLys: 0.491 ± 0.022	2.256TrpLeu: 2.256 ± 0.06	0.342TrpMet: 0.342 ± 0.017	0.421TrpAsn: 0.421 ± 0.021	0.477TrpPro: 0.477 ± 0.026	0.858TrpGln: 0.858 ± 0.027	1.353TrpArg: 1.353 ± 0.041	0.709TrpSer: 0.709 ± 0.024	0.727TrpThr: 0.727 ± 0.032	0.914TrpVal: 0.914 ± 0.034	0.347TrpTrp: 0.347 ± 0.02	0.329TrpTyr: 0.329 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.912TyrAla: 2.912 ± 0.062	0.306TyrCys: 0.306 ± 0.016	1.601TyrAsp: 1.601 ± 0.038	1.53TyrGlu: 1.53 ± 0.037	1.204TyrPhe: 1.204 ± 0.034	2.3TyrGly: 2.3 ± 0.053	0.583TyrHis: 0.583 ± 0.024	0.975TyrIle: 0.975 ± 0.034	0.597TyrLys: 0.597 ± 0.023	2.745TyrLeu: 2.745 ± 0.051	0.321TyrMet: 0.321 ± 0.018	0.619TyrAsn: 0.619 ± 0.029	1.35TyrPro: 1.35 ± 0.035	0.973TyrGln: 0.973 ± 0.033	2.474TyrArg: 2.474 ± 0.056	1.02TyrSer: 1.02 ± 0.029	1.425TyrThr: 1.425 ± 0.034	1.964TyrVal: 1.964 ± 0.048	0.389TyrTrp: 0.389 ± 0.017	0.704TyrTyr: 0.704 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3053 proteins (1097942 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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