Amino acid dipepetide frequency for Corynebacterium canis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.705AlaAla: 16.705 ± 0.198	1.187AlaCys: 1.187 ± 0.036	6.519AlaAsp: 6.519 ± 0.101	8.37AlaGlu: 8.37 ± 0.12	3.59AlaPhe: 3.59 ± 0.064	9.799AlaGly: 9.799 ± 0.134	2.534AlaHis: 2.534 ± 0.063	5.751AlaIle: 5.751 ± 0.092	3.705AlaLys: 3.705 ± 0.081	11.917AlaLeu: 11.917 ± 0.142	2.716AlaMet: 2.716 ± 0.053	2.734AlaAsn: 2.734 ± 0.054	5.195AlaPro: 5.195 ± 0.107	4.251AlaGln: 4.251 ± 0.077	7.258AlaArg: 7.258 ± 0.128	5.794AlaSer: 5.794 ± 0.089	6.851AlaThr: 6.851 ± 0.098	9.411AlaVal: 9.411 ± 0.128	1.633AlaTrp: 1.633 ± 0.046	2.357AlaTyr: 2.357 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.073CysAla: 1.073 ± 0.042	0.126CysCys: 0.126 ± 0.013	0.57CysAsp: 0.57 ± 0.023	0.529CysGlu: 0.529 ± 0.027	0.323CysPhe: 0.323 ± 0.021	0.962CysGly: 0.962 ± 0.036	0.2CysHis: 0.2 ± 0.015	0.398CysIle: 0.398 ± 0.02	0.198CysLys: 0.198 ± 0.015	0.755CysLeu: 0.755 ± 0.028	0.178CysMet: 0.178 ± 0.015	0.244CysAsn: 0.244 ± 0.018	0.471CysPro: 0.471 ± 0.022	0.25CysGln: 0.25 ± 0.017	0.504CysArg: 0.504 ± 0.024	0.594CysSer: 0.594 ± 0.028	0.628CysThr: 0.628 ± 0.028	0.767CysVal: 0.767 ± 0.036	0.124CysTrp: 0.124 ± 0.014	0.185CysTyr: 0.185 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.121AspAla: 7.121 ± 0.083	0.483AspCys: 0.483 ± 0.025	3.007AspAsp: 3.007 ± 0.072	3.624AspGlu: 3.624 ± 0.075	1.872AspPhe: 1.872 ± 0.058	4.598AspGly: 4.598 ± 0.08	1.172AspHis: 1.172 ± 0.038	3.047AspIle: 3.047 ± 0.057	1.5AspLys: 1.5 ± 0.046	5.282AspLeu: 5.282 ± 0.088	1.135AspMet: 1.135 ± 0.041	1.462AspAsn: 1.462 ± 0.043	3.603AspPro: 3.603 ± 0.064	1.739AspGln: 1.739 ± 0.042	3.411AspArg: 3.411 ± 0.071	2.911AspSer: 2.911 ± 0.065	3.059AspThr: 3.059 ± 0.06	4.655AspVal: 4.655 ± 0.08	0.75AspTrp: 0.75 ± 0.032	1.481AspTyr: 1.481 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.37GluAla: 6.37 ± 0.101	0.489GluCys: 0.489 ± 0.024	3.059GluAsp: 3.059 ± 0.07	3.866GluGlu: 3.866 ± 0.079	2.378GluPhe: 2.378 ± 0.054	3.914GluGly: 3.914 ± 0.066	1.812GluHis: 1.812 ± 0.052	3.413GluIle: 3.413 ± 0.072	1.978GluLys: 1.978 ± 0.058	7.206GluLeu: 7.206 ± 0.108	1.171GluMet: 1.171 ± 0.036	1.649GluAsn: 1.649 ± 0.048	2.86GluPro: 2.86 ± 0.067	2.804GluGln: 2.804 ± 0.069	4.413GluArg: 4.413 ± 0.085	2.995GluSer: 2.995 ± 0.059	3.269GluThr: 3.269 ± 0.061	5.001GluVal: 5.001 ± 0.09	0.763GluTrp: 0.763 ± 0.031	1.574GluTyr: 1.574 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	4.116PheAla: 4.116 ± 0.08	0.317PheCys: 0.317 ± 0.018	2.384PheAsp: 2.384 ± 0.053	1.929PheGlu: 1.929 ± 0.051	1.301PhePhe: 1.301 ± 0.048	3.469PheGly: 3.469 ± 0.067	0.786PheHis: 0.786 ± 0.035	1.673PheIle: 1.673 ± 0.052	0.743PheLys: 0.743 ± 0.036	3.191PheLeu: 3.191 ± 0.067	0.626PheMet: 0.626 ± 0.032	0.904PheAsn: 0.904 ± 0.037	1.558PhePro: 1.558 ± 0.043	1.11PheGln: 1.11 ± 0.043	1.855PheArg: 1.855 ± 0.051	2.043PheSer: 2.043 ± 0.047	2.219PheThr: 2.219 ± 0.057	2.668PheVal: 2.668 ± 0.056	0.477PheTrp: 0.477 ± 0.026	0.792PheTyr: 0.792 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	8.489GlyAla: 8.489 ± 0.116	0.834GlyCys: 0.834 ± 0.033	4.22GlyAsp: 4.22 ± 0.071	4.955GlyGlu: 4.955 ± 0.084	3.276GlyPhe: 3.276 ± 0.058	6.672GlyGly: 6.672 ± 0.128	1.78GlyHis: 1.78 ± 0.045	4.612GlyIle: 4.612 ± 0.078	3.046GlyLys: 3.046 ± 0.062	7.898GlyLeu: 7.898 ± 0.121	2.122GlyMet: 2.122 ± 0.054	2.211GlyAsn: 2.211 ± 0.055	3.322GlyPro: 3.322 ± 0.068	2.507GlyGln: 2.507 ± 0.056	4.808GlyArg: 4.808 ± 0.087	4.604GlySer: 4.604 ± 0.087	5.312GlyThr: 5.312 ± 0.082	7.414GlyVal: 7.414 ± 0.109	1.413GlyTrp: 1.413 ± 0.043	2.227GlyTyr: 2.227 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.457HisAla: 2.457 ± 0.058	0.227HisCys: 0.227 ± 0.019	1.235HisAsp: 1.235 ± 0.041	1.218HisGlu: 1.218 ± 0.041	0.722HisPhe: 0.722 ± 0.029	2.003HisGly: 2.003 ± 0.05	0.687HisHis: 0.687 ± 0.031	1.099HisIle: 1.099 ± 0.036	0.567HisLys: 0.567 ± 0.027	2.09HisLeu: 2.09 ± 0.05	0.467HisMet: 0.467 ± 0.025	0.725HisAsn: 0.725 ± 0.029	1.539HisPro: 1.539 ± 0.044	0.783HisGln: 0.783 ± 0.029	1.689HisArg: 1.689 ± 0.052	1.347HisSer: 1.347 ± 0.048	1.34HisThr: 1.34 ± 0.044	1.64HisVal: 1.64 ± 0.042	0.328HisTrp: 0.328 ± 0.02	0.584HisTyr: 0.584 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.806IleAla: 6.806 ± 0.107	0.5IleCys: 0.5 ± 0.026	3.659IleAsp: 3.659 ± 0.066	3.145IleGlu: 3.145 ± 0.068	1.499IlePhe: 1.499 ± 0.044	4.672IleGly: 4.672 ± 0.088	1.069IleHis: 1.069 ± 0.035	2.542IleIle: 2.542 ± 0.062	1.301IleLys: 1.301 ± 0.043	4.254IleLeu: 4.254 ± 0.068	1.006IleMet: 1.006 ± 0.039	1.471IleAsn: 1.471 ± 0.045	2.858IlePro: 2.858 ± 0.06	1.373IleGln: 1.373 ± 0.037	2.943IleArg: 2.943 ± 0.059	2.947IleSer: 2.947 ± 0.059	3.525IleThr: 3.525 ± 0.066	4.563IleVal: 4.563 ± 0.076	0.532IleTrp: 0.532 ± 0.029	0.962IleTyr: 0.962 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.193LysAla: 3.193 ± 0.075	0.174LysCys: 0.174 ± 0.016	1.719LysAsp: 1.719 ± 0.049	1.856LysGlu: 1.856 ± 0.059	0.941LysPhe: 0.941 ± 0.037	1.881LysGly: 1.881 ± 0.054	0.775LysHis: 0.775 ± 0.032	1.507LysIle: 1.507 ± 0.044	1.404LysLys: 1.404 ± 0.054	3.1LysLeu: 3.1 ± 0.057	0.651LysMet: 0.651 ± 0.028	0.924LysAsn: 0.924 ± 0.037	1.696LysPro: 1.696 ± 0.053	1.158LysGln: 1.158 ± 0.038	2.018LysArg: 2.018 ± 0.058	1.535LysSer: 1.535 ± 0.047	1.814LysThr: 1.814 ± 0.044	2.614LysVal: 2.614 ± 0.073	0.33LysTrp: 0.33 ± 0.022	0.765LysTyr: 0.765 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	12.669LeuAla: 12.669 ± 0.135	0.919LeuCys: 0.919 ± 0.036	5.815LeuAsp: 5.815 ± 0.096	5.208LeuGlu: 5.208 ± 0.09	3.128LeuPhe: 3.128 ± 0.064	8.575LeuGly: 8.575 ± 0.108	2.136LeuHis: 2.136 ± 0.046	5.135LeuIle: 5.135 ± 0.074	2.682LeuLys: 2.682 ± 0.065	9.684LeuLeu: 9.684 ± 0.15	1.969LeuMet: 1.969 ± 0.052	2.534LeuAsn: 2.534 ± 0.063	5.495LeuPro: 5.495 ± 0.096	3.106LeuGln: 3.106 ± 0.057	7.022LeuArg: 7.022 ± 0.103	5.671LeuSer: 5.671 ± 0.096	5.876LeuThr: 5.876 ± 0.087	8.425LeuVal: 8.425 ± 0.127	1.216LeuTrp: 1.216 ± 0.045	1.879LeuTyr: 1.879 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.364MetAla: 2.364 ± 0.053	0.228MetCys: 0.228 ± 0.014	1.05MetAsp: 1.05 ± 0.037	1.08MetGlu: 1.08 ± 0.036	0.77MetPhe: 0.77 ± 0.034	1.562MetGly: 1.562 ± 0.046	0.465MetHis: 0.465 ± 0.021	1.088MetIle: 1.088 ± 0.038	0.713MetLys: 0.713 ± 0.03	2.35MetLeu: 2.35 ± 0.052	0.47MetMet: 0.47 ± 0.025	0.672MetAsn: 0.672 ± 0.026	1.205MetPro: 1.205 ± 0.036	0.696MetGln: 0.696 ± 0.029	1.514MetArg: 1.514 ± 0.048	1.547MetSer: 1.547 ± 0.046	1.468MetThr: 1.468 ± 0.041	1.828MetVal: 1.828 ± 0.048	0.281MetTrp: 0.281 ± 0.019	0.361MetTyr: 0.361 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.029AsnAla: 3.029 ± 0.058	0.232AsnCys: 0.232 ± 0.017	1.289AsnAsp: 1.289 ± 0.036	1.472AsnGlu: 1.472 ± 0.045	0.899AsnPhe: 0.899 ± 0.036	2.126AsnGly: 2.126 ± 0.061	0.635AsnHis: 0.635 ± 0.027	1.496AsnIle: 1.496 ± 0.046	0.809AsnLys: 0.809 ± 0.033	2.701AsnLeu: 2.701 ± 0.057	0.579AsnMet: 0.579 ± 0.024	0.84AsnAsn: 0.84 ± 0.039	1.996AsnPro: 1.996 ± 0.05	0.957AsnGln: 0.957 ± 0.037	1.524AsnArg: 1.524 ± 0.052	1.51AsnSer: 1.51 ± 0.048	1.712AsnThr: 1.712 ± 0.051	2.308AsnVal: 2.308 ± 0.058	0.427AsnTrp: 0.427 ± 0.021	0.727AsnTyr: 0.727 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	6.017ProAla: 6.017 ± 0.104	0.328ProCys: 0.328 ± 0.02	3.176ProAsp: 3.176 ± 0.058	4.333ProGlu: 4.333 ± 0.078	1.587ProPhe: 1.587 ± 0.047	4.378ProGly: 4.378 ± 0.085	1.229ProHis: 1.229 ± 0.037	2.289ProIle: 2.289 ± 0.046	1.772ProLys: 1.772 ± 0.058	4.622ProLeu: 4.622 ± 0.072	1.094ProMet: 1.094 ± 0.034	1.62ProAsn: 1.62 ± 0.049	2.395ProPro: 2.395 ± 0.076	2.012ProGln: 2.012 ± 0.057	2.872ProArg: 2.872 ± 0.06	2.762ProSer: 2.762 ± 0.062	3.297ProThr: 3.297 ± 0.074	4.443ProVal: 4.443 ± 0.076	0.756ProTrp: 0.756 ± 0.035	1.088ProTyr: 1.088 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.913GlnAla: 3.913 ± 0.083	0.248GlnCys: 0.248 ± 0.018	1.501GlnAsp: 1.501 ± 0.046	1.941GlnGlu: 1.941 ± 0.053	0.992GlnPhe: 0.992 ± 0.032	2.341GlnGly: 2.341 ± 0.049	0.877GlnHis: 0.877 ± 0.036	1.681GlnIle: 1.681 ± 0.038	0.893GlnLys: 0.893 ± 0.033	4.012GlnLeu: 4.012 ± 0.074	0.761GlnMet: 0.761 ± 0.029	0.8GlnAsn: 0.8 ± 0.03	1.988GlnPro: 1.988 ± 0.057	1.745GlnGln: 1.745 ± 0.055	3.107GlnArg: 3.107 ± 0.068	1.539GlnSer: 1.539 ± 0.04	1.587GlnThr: 1.587 ± 0.044	2.9GlnVal: 2.9 ± 0.055	0.588GlnTrp: 0.588 ± 0.028	0.702GlnTyr: 0.702 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	7.044ArgAla: 7.044 ± 0.109	0.484ArgCys: 0.484 ± 0.026	3.63ArgAsp: 3.63 ± 0.065	3.94ArgGlu: 3.94 ± 0.077	2.301ArgPhe: 2.301 ± 0.055	4.767ArgGly: 4.767 ± 0.085	1.477ArgHis: 1.477 ± 0.039	3.663ArgIle: 3.663 ± 0.065	2.14ArgLys: 2.14 ± 0.057	6.037ArgLeu: 6.037 ± 0.103	1.693ArgMet: 1.693 ± 0.043	2.012ArgAsn: 2.012 ± 0.047	3.073ArgPro: 3.073 ± 0.064	2.319ArgGln: 2.319 ± 0.056	5.293ArgArg: 5.293 ± 0.116	3.443ArgSer: 3.443 ± 0.066	3.74ArgThr: 3.74 ± 0.062	4.976ArgVal: 4.976 ± 0.089	0.998ArgTrp: 0.998 ± 0.041	1.65ArgTyr: 1.65 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.178SerAla: 6.178 ± 0.091	0.428SerCys: 0.428 ± 0.024	2.834SerAsp: 2.834 ± 0.058	3.172SerGlu: 3.172 ± 0.059	2.022SerPhe: 2.022 ± 0.043	5.316SerGly: 5.316 ± 0.086	1.113SerHis: 1.113 ± 0.036	2.761SerIle: 2.761 ± 0.07	1.661SerLys: 1.661 ± 0.049	5.323SerLeu: 5.323 ± 0.085	1.384SerMet: 1.384 ± 0.042	1.578SerAsn: 1.578 ± 0.044	2.765SerPro: 2.765 ± 0.055	1.721SerGln: 1.721 ± 0.04	3.327SerArg: 3.327 ± 0.067	3.103SerSer: 3.103 ± 0.067	3.357SerThr: 3.357 ± 0.075	4.548SerVal: 4.548 ± 0.084	0.867SerTrp: 0.867 ± 0.03	1.347SerTyr: 1.347 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.659ThrAla: 6.659 ± 0.077	0.619ThrCys: 0.619 ± 0.031	3.115ThrAsp: 3.115 ± 0.064	3.324ThrGlu: 3.324 ± 0.063	2.012ThrPhe: 2.012 ± 0.049	5.256ThrGly: 5.256 ± 0.081	1.375ThrHis: 1.375 ± 0.043	3.169ThrIle: 3.169 ± 0.08	1.813ThrLys: 1.813 ± 0.052	6.083ThrLeu: 6.083 ± 0.089	1.31ThrMet: 1.31 ± 0.043	1.667ThrAsn: 1.667 ± 0.049	3.858ThrPro: 3.858 ± 0.074	1.861ThrGln: 1.861 ± 0.047	3.355ThrArg: 3.355 ± 0.065	3.334ThrSer: 3.334 ± 0.066	3.889ThrThr: 3.889 ± 0.081	5.471ThrVal: 5.471 ± 0.081	0.935ThrTrp: 0.935 ± 0.038	1.348ThrTyr: 1.348 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	10.169ValAla: 10.169 ± 0.123	0.845ValCys: 0.845 ± 0.028	5.113ValAsp: 5.113 ± 0.088	4.925ValGlu: 4.925 ± 0.089	3.138ValPhe: 3.138 ± 0.068	6.459ValGly: 6.459 ± 0.095	1.793ValHis: 1.793 ± 0.049	4.635ValIle: 4.635 ± 0.08	2.16ValLys: 2.16 ± 0.056	8.496ValLeu: 8.496 ± 0.117	1.682ValMet: 1.682 ± 0.043	2.127ValAsn: 2.127 ± 0.056	4.329ValPro: 4.329 ± 0.101	2.302ValGln: 2.302 ± 0.053	5.157ValArg: 5.157 ± 0.084	4.982ValSer: 4.982 ± 0.08	5.501ValThr: 5.501 ± 0.092	7.841ValVal: 7.841 ± 0.108	1.08ValTrp: 1.08 ± 0.043	1.684ValTyr: 1.684 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.465TrpAla: 1.465 ± 0.049	0.154TrpCys: 0.154 ± 0.015	0.727TrpAsp: 0.727 ± 0.028	0.863TrpGlu: 0.863 ± 0.032	0.56TrpPhe: 0.56 ± 0.03	0.958TrpGly: 0.958 ± 0.042	0.308TrpHis: 0.308 ± 0.02	0.725TrpIle: 0.725 ± 0.034	0.417TrpLys: 0.417 ± 0.019	1.764TrpLeu: 1.764 ± 0.053	0.342TrpMet: 0.342 ± 0.02	0.442TrpAsn: 0.442 ± 0.024	0.66TrpPro: 0.66 ± 0.028	0.532TrpGln: 0.532 ± 0.026	0.991TrpArg: 0.991 ± 0.035	0.757TrpSer: 0.757 ± 0.03	0.668TrpThr: 0.668 ± 0.032	1.192TrpVal: 1.192 ± 0.044	0.349TrpTrp: 0.349 ± 0.021	0.308TrpTyr: 0.308 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.44TyrAla: 2.44 ± 0.057	0.258TyrCys: 0.258 ± 0.019	1.289TyrAsp: 1.289 ± 0.046	1.231TyrGlu: 1.231 ± 0.038	0.85TyrPhe: 0.85 ± 0.035	2.015TyrGly: 2.015 ± 0.048	0.525TyrHis: 0.525 ± 0.025	0.942TyrIle: 0.942 ± 0.033	0.554TyrLys: 0.554 ± 0.026	2.38TyrLeu: 2.38 ± 0.058	0.355TyrMet: 0.355 ± 0.02	0.653TyrAsn: 0.653 ± 0.028	1.204TyrPro: 1.204 ± 0.035	0.888TyrGln: 0.888 ± 0.035	1.62TyrArg: 1.62 ± 0.044	1.385TyrSer: 1.385 ± 0.04	1.341TyrThr: 1.341 ± 0.039	1.752TyrVal: 1.752 ± 0.047	0.339TyrTrp: 0.339 ± 0.019	0.567TyrTyr: 0.567 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2534 proteins (838831 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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