Amino acid dipepetide frequency for Ezakiella coagulans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.8AlaAla: 3.8 ± 0.12	0.563AlaCys: 0.563 ± 0.037	3.337AlaAsp: 3.337 ± 0.102	3.868AlaGlu: 3.868 ± 0.088	2.622AlaPhe: 2.622 ± 0.08	3.889AlaGly: 3.889 ± 0.094	0.863AlaHis: 0.863 ± 0.042	5.693AlaIle: 5.693 ± 0.137	4.965AlaLys: 4.965 ± 0.115	5.892AlaLeu: 5.892 ± 0.134	1.698AlaMet: 1.698 ± 0.062	2.701AlaAsn: 2.701 ± 0.081	1.756AlaPro: 1.756 ± 0.066	1.261AlaGln: 1.261 ± 0.055	2.382AlaArg: 2.382 ± 0.071	3.123AlaSer: 3.123 ± 0.081	3.125AlaThr: 3.125 ± 0.104	4.057AlaVal: 4.057 ± 0.1	0.334AlaTrp: 0.334 ± 0.024	2.084AlaTyr: 2.084 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.501CysAla: 0.501 ± 0.036	0.143CysCys: 0.143 ± 0.026	0.612CysAsp: 0.612 ± 0.038	0.565CysGlu: 0.565 ± 0.038	0.293CysPhe: 0.293 ± 0.022	0.865CysGly: 0.865 ± 0.047	0.214CysHis: 0.214 ± 0.023	0.621CysIle: 0.621 ± 0.037	0.552CysLys: 0.552 ± 0.036	0.632CysLeu: 0.632 ± 0.036	0.212CysMet: 0.212 ± 0.022	0.37CysAsn: 0.37 ± 0.027	0.392CysPro: 0.392 ± 0.033	0.156CysGln: 0.156 ± 0.019	0.251CysArg: 0.251 ± 0.023	0.416CysSer: 0.416 ± 0.026	0.4CysThr: 0.4 ± 0.026	0.51CysVal: 0.51 ± 0.037	0.06CysTrp: 0.06 ± 0.01	0.347CysTyr: 0.347 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	3.532AspAla: 3.532 ± 0.085	0.456AspCys: 0.456 ± 0.034	4.009AspAsp: 4.009 ± 0.11	6.502AspGlu: 6.502 ± 0.133	3.632AspPhe: 3.632 ± 0.083	4.455AspGly: 4.455 ± 0.135	0.741AspHis: 0.741 ± 0.045	5.605AspIle: 5.605 ± 0.113	6.059AspLys: 6.059 ± 0.138	5.59AspLeu: 5.59 ± 0.112	1.808AspMet: 1.808 ± 0.058	2.793AspAsn: 2.793 ± 0.084	1.76AspPro: 1.76 ± 0.072	0.919AspGln: 0.919 ± 0.045	2.35AspArg: 2.35 ± 0.072	3.371AspSer: 3.371 ± 0.084	2.896AspThr: 2.896 ± 0.101	4.35AspVal: 4.35 ± 0.094	0.42AspTrp: 0.42 ± 0.032	3.013AspTyr: 3.013 ± 0.079	0.0AspXaa: 0.0 ± 0.0
Glu	4.436GluAla: 4.436 ± 0.101	0.454GluCys: 0.454 ± 0.03	4.812GluAsp: 4.812 ± 0.111	6.913GluGlu: 6.913 ± 0.143	3.617GluPhe: 3.617 ± 0.085	4.2GluGly: 4.2 ± 0.083	0.979GluHis: 0.979 ± 0.044	7.528GluIle: 7.528 ± 0.136	8.413GluLys: 8.413 ± 0.17	7.049GluLeu: 7.049 ± 0.127	2.21GluMet: 2.21 ± 0.074	5.569GluAsn: 5.569 ± 0.114	1.896GluPro: 1.896 ± 0.069	1.534GluGln: 1.534 ± 0.057	3.157GluArg: 3.157 ± 0.084	3.868GluSer: 3.868 ± 0.088	3.622GluThr: 3.622 ± 0.084	5.044GluVal: 5.044 ± 0.108	0.42GluTrp: 0.42 ± 0.024	3.076GluTyr: 3.076 ± 0.084	0.0GluXaa: 0.0 ± 0.0
Phe	2.711PheAla: 2.711 ± 0.08	0.409PheCys: 0.409 ± 0.03	3.3PheAsp: 3.3 ± 0.078	3.354PheGlu: 3.354 ± 0.085	2.337PhePhe: 2.337 ± 0.087	3.106PheGly: 3.106 ± 0.071	0.606PheHis: 0.606 ± 0.034	4.191PheIle: 4.191 ± 0.121	4.114PheLys: 4.114 ± 0.096	4.453PheLeu: 4.453 ± 0.131	1.409PheMet: 1.409 ± 0.047	2.487PheAsn: 2.487 ± 0.083	1.246PhePro: 1.246 ± 0.05	0.966PheGln: 0.966 ± 0.041	1.76PheArg: 1.76 ± 0.062	3.365PheSer: 3.365 ± 0.087	2.504PheThr: 2.504 ± 0.07	3.305PheVal: 3.305 ± 0.089	0.326PheTrp: 0.326 ± 0.024	2.067PheTyr: 2.067 ± 0.065	0.0PheXaa: 0.0 ± 0.0
Gly	4.076GlyAla: 4.076 ± 0.1	0.698GlyCys: 0.698 ± 0.04	3.864GlyAsp: 3.864 ± 0.094	5.125GlyGlu: 5.125 ± 0.102	3.133GlyPhe: 3.133 ± 0.091	4.35GlyGly: 4.35 ± 0.116	1.024GlyHis: 1.024 ± 0.047	5.658GlyIle: 5.658 ± 0.112	5.759GlyLys: 5.759 ± 0.135	5.493GlyLeu: 5.493 ± 0.102	1.812GlyMet: 1.812 ± 0.064	2.921GlyAsn: 2.921 ± 0.086	1.326GlyPro: 1.326 ± 0.057	1.334GlyGln: 1.334 ± 0.051	2.69GlyArg: 2.69 ± 0.068	3.38GlySer: 3.38 ± 0.08	3.435GlyThr: 3.435 ± 0.091	4.705GlyVal: 4.705 ± 0.118	0.452GlyTrp: 0.452 ± 0.036	2.981GlyTyr: 2.981 ± 0.102	0.0GlyXaa: 0.0 ± 0.0
His	0.793HisAla: 0.793 ± 0.041	0.126HisCys: 0.126 ± 0.017	0.859HisAsp: 0.859 ± 0.044	1.06HisGlu: 1.06 ± 0.046	0.675HisPhe: 0.675 ± 0.038	1.009HisGly: 1.009 ± 0.046	0.291HisHis: 0.291 ± 0.027	1.189HisIle: 1.189 ± 0.049	0.921HisLys: 0.921 ± 0.042	1.21HisLeu: 1.21 ± 0.051	0.375HisMet: 0.375 ± 0.031	0.717HisAsn: 0.717 ± 0.033	0.555HisPro: 0.555 ± 0.034	0.298HisGln: 0.298 ± 0.023	0.606HisArg: 0.606 ± 0.033	0.803HisSer: 0.803 ± 0.041	0.658HisThr: 0.658 ± 0.041	0.795HisVal: 0.795 ± 0.04	0.088HisTrp: 0.088 ± 0.014	0.552HisTyr: 0.552 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.573IleAla: 5.573 ± 0.118	0.795IleCys: 0.795 ± 0.044	5.765IleAsp: 5.765 ± 0.099	6.687IleGlu: 6.687 ± 0.128	4.277IlePhe: 4.277 ± 0.133	5.425IleGly: 5.425 ± 0.124	1.065IleHis: 1.065 ± 0.042	7.267IleIle: 7.267 ± 0.168	7.867IleLys: 7.867 ± 0.121	8.229IleLeu: 8.229 ± 0.2	2.251IleMet: 2.251 ± 0.068	4.821IleAsn: 4.821 ± 0.112	2.887IlePro: 2.887 ± 0.077	1.594IleGln: 1.594 ± 0.056	3.298IleArg: 3.298 ± 0.09	6.166IleSer: 6.166 ± 0.131	4.311IleThr: 4.311 ± 0.09	5.774IleVal: 5.774 ± 0.128	0.446IleTrp: 0.446 ± 0.029	3.497IleTyr: 3.497 ± 0.098	0.0IleXaa: 0.0 ± 0.0
Lys	4.986LysAla: 4.986 ± 0.124	0.613LysCys: 0.613 ± 0.041	6.689LysAsp: 6.689 ± 0.154	8.301LysGlu: 8.301 ± 0.146	3.626LysPhe: 3.626 ± 0.091	4.596LysGly: 4.596 ± 0.098	1.133LysHis: 1.133 ± 0.046	7.646LysIle: 7.646 ± 0.132	9.074LysLys: 9.074 ± 0.18	7.108LysLeu: 7.108 ± 0.13	2.671LysMet: 2.671 ± 0.074	6.712LysAsn: 6.712 ± 0.126	2.431LysPro: 2.431 ± 0.097	1.703LysGln: 1.703 ± 0.074	3.748LysArg: 3.748 ± 0.1	5.125LysSer: 5.125 ± 0.115	5.01LysThr: 5.01 ± 0.114	5.236LysVal: 5.236 ± 0.142	0.529LysTrp: 0.529 ± 0.039	3.99LysTyr: 3.99 ± 0.088	0.0LysXaa: 0.0 ± 0.0
Leu	4.994LeuAla: 4.994 ± 0.109	0.703LeuCys: 0.703 ± 0.033	5.549LeuAsp: 5.549 ± 0.101	6.303LeuGlu: 6.303 ± 0.135	4.217LeuPhe: 4.217 ± 0.127	5.493LeuGly: 5.493 ± 0.124	1.011LeuHis: 1.011 ± 0.044	7.381LeuIle: 7.381 ± 0.15	8.7LeuLys: 8.7 ± 0.15	7.353LeuLeu: 7.353 ± 0.179	2.523LeuMet: 2.523 ± 0.076	5.444LeuAsn: 5.444 ± 0.111	2.923LeuPro: 2.923 ± 0.073	1.942LeuGln: 1.942 ± 0.052	3.527LeuArg: 3.527 ± 0.088	6.751LeuSer: 6.751 ± 0.139	4.444LeuThr: 4.444 ± 0.087	5.438LeuVal: 5.438 ± 0.109	0.418LeuTrp: 0.418 ± 0.03	3.273LeuTyr: 3.273 ± 0.082	0.0LeuXaa: 0.0 ± 0.0
Met	1.713MetAla: 1.713 ± 0.058	0.229MetCys: 0.229 ± 0.022	1.82MetAsp: 1.82 ± 0.053	1.977MetGlu: 1.977 ± 0.065	1.064MetPhe: 1.064 ± 0.045	1.895MetGly: 1.895 ± 0.066	0.33MetHis: 0.33 ± 0.026	2.364MetIle: 2.364 ± 0.076	2.667MetLys: 2.667 ± 0.081	2.215MetLeu: 2.215 ± 0.066	0.741MetMet: 0.741 ± 0.038	1.707MetAsn: 1.707 ± 0.055	0.93MetPro: 0.93 ± 0.045	0.587MetGln: 0.587 ± 0.035	1.253MetArg: 1.253 ± 0.059	1.775MetSer: 1.775 ± 0.062	1.527MetThr: 1.527 ± 0.058	1.722MetVal: 1.722 ± 0.064	0.173MetTrp: 0.173 ± 0.019	0.835MetTyr: 0.835 ± 0.04	0.0MetXaa: 0.0 ± 0.0
Asn	3.12AsnAla: 3.12 ± 0.089	0.415AsnCys: 0.415 ± 0.029	3.131AsnAsp: 3.131 ± 0.082	4.388AsnGlu: 4.388 ± 0.095	2.829AsnPhe: 2.829 ± 0.081	3.617AsnGly: 3.617 ± 0.11	0.745AsnHis: 0.745 ± 0.038	5.391AsnIle: 5.391 ± 0.111	5.078AsnLys: 5.078 ± 0.118	5.275AsnLeu: 5.275 ± 0.099	1.559AsnMet: 1.559 ± 0.06	3.06AsnAsn: 3.06 ± 0.093	2.309AsnPro: 2.309 ± 0.091	1.291AsnGln: 1.291 ± 0.055	2.18AsnArg: 2.18 ± 0.08	3.258AsnSer: 3.258 ± 0.083	2.591AsnThr: 2.591 ± 0.074	3.523AsnVal: 3.523 ± 0.091	0.398AsnTrp: 0.398 ± 0.03	2.292AsnTyr: 2.292 ± 0.076	0.0AsnXaa: 0.0 ± 0.0
Pro	1.576ProAla: 1.576 ± 0.073	0.246ProCys: 0.246 ± 0.026	1.975ProAsp: 1.975 ± 0.067	2.673ProGlu: 2.673 ± 0.079	1.529ProPhe: 1.529 ± 0.057	2.071ProGly: 2.071 ± 0.074	0.531ProHis: 0.531 ± 0.03	2.6ProIle: 2.6 ± 0.066	2.437ProLys: 2.437 ± 0.069	2.386ProLeu: 2.386 ± 0.075	0.724ProMet: 0.724 ± 0.038	1.647ProAsn: 1.647 ± 0.069	0.627ProPro: 0.627 ± 0.037	0.786ProGln: 0.786 ± 0.046	0.96ProArg: 0.96 ± 0.043	1.739ProSer: 1.739 ± 0.058	1.799ProThr: 1.799 ± 0.067	2.195ProVal: 2.195 ± 0.073	0.203ProTrp: 0.203 ± 0.02	1.255ProTyr: 1.255 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	1.268GlnAla: 1.268 ± 0.054	0.135GlnCys: 0.135 ± 0.013	1.135GlnAsp: 1.135 ± 0.052	1.473GlnGlu: 1.473 ± 0.054	0.953GlnPhe: 0.953 ± 0.038	1.322GlnGly: 1.322 ± 0.052	0.191GlnHis: 0.191 ± 0.019	1.865GlnIle: 1.865 ± 0.059	2.197GlnLys: 2.197 ± 0.068	1.467GlnLeu: 1.467 ± 0.055	0.681GlnMet: 0.681 ± 0.035	1.551GlnAsn: 1.551 ± 0.058	0.476GlnPro: 0.476 ± 0.036	0.475GlnGln: 0.475 ± 0.032	1.02GlnArg: 1.02 ± 0.045	1.214GlnSer: 1.214 ± 0.049	1.071GlnThr: 1.071 ± 0.048	1.343GlnVal: 1.343 ± 0.053	0.133GlnTrp: 0.133 ± 0.018	0.78GlnTyr: 0.78 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	2.405ArgAla: 2.405 ± 0.074	0.28ArgCys: 0.28 ± 0.025	2.536ArgAsp: 2.536 ± 0.076	3.542ArgGlu: 3.542 ± 0.104	1.701ArgPhe: 1.701 ± 0.061	2.307ArgGly: 2.307 ± 0.071	0.565ArgHis: 0.565 ± 0.032	3.42ArgIle: 3.42 ± 0.09	3.266ArgLys: 3.266 ± 0.086	3.393ArgLeu: 3.393 ± 0.086	1.268ArgMet: 1.268 ± 0.051	2.217ArgAsn: 2.217 ± 0.07	1.199ArgPro: 1.199 ± 0.055	1.0ArgGln: 1.0 ± 0.046	1.874ArgArg: 1.874 ± 0.061	1.938ArgSer: 1.938 ± 0.056	1.857ArgThr: 1.857 ± 0.057	2.615ArgVal: 2.615 ± 0.075	0.223ArgTrp: 0.223 ± 0.022	1.557ArgTyr: 1.557 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	3.213SerAla: 3.213 ± 0.084	0.473SerCys: 0.473 ± 0.03	3.806SerAsp: 3.806 ± 0.095	4.294SerGlu: 4.294 ± 0.102	3.369SerPhe: 3.369 ± 0.092	4.461SerGly: 4.461 ± 0.089	0.917SerHis: 0.917 ± 0.043	5.641SerIle: 5.641 ± 0.135	5.065SerLys: 5.065 ± 0.095	5.382SerLeu: 5.382 ± 0.119	1.568SerMet: 1.568 ± 0.06	3.178SerAsn: 3.178 ± 0.09	1.593SerPro: 1.593 ± 0.059	1.341SerGln: 1.341 ± 0.056	2.144SerArg: 2.144 ± 0.072	3.493SerSer: 3.493 ± 0.096	2.872SerThr: 2.872 ± 0.085	3.922SerVal: 3.922 ± 0.083	0.401SerTrp: 0.401 ± 0.023	2.701SerTyr: 2.701 ± 0.082	0.0SerXaa: 0.0 ± 0.0
Thr	3.15ThrAla: 3.15 ± 0.099	0.416ThrCys: 0.416 ± 0.032	3.21ThrAsp: 3.21 ± 0.082	3.572ThrGlu: 3.572 ± 0.095	2.455ThrPhe: 2.455 ± 0.075	3.733ThrGly: 3.733 ± 0.077	0.852ThrHis: 0.852 ± 0.042	4.607ThrIle: 4.607 ± 0.095	3.939ThrLys: 3.939 ± 0.114	4.812ThrLeu: 4.812 ± 0.097	1.186ThrMet: 1.186 ± 0.047	2.534ThrAsn: 2.534 ± 0.076	2.011ThrPro: 2.011 ± 0.074	1.047ThrGln: 1.047 ± 0.044	1.703ThrArg: 1.703 ± 0.062	2.844ThrSer: 2.844 ± 0.074	2.919ThrThr: 2.919 ± 0.096	3.795ThrVal: 3.795 ± 0.126	0.291ThrTrp: 0.291 ± 0.02	1.842ThrTyr: 1.842 ± 0.073	0.0ThrXaa: 0.0 ± 0.0
Val	3.699ValAla: 3.699 ± 0.091	0.576ValCys: 0.576 ± 0.034	4.534ValAsp: 4.534 ± 0.102	4.626ValGlu: 4.626 ± 0.101	3.275ValPhe: 3.275 ± 0.085	4.435ValGly: 4.435 ± 0.103	0.895ValHis: 0.895 ± 0.043	5.399ValIle: 5.399 ± 0.126	5.751ValLys: 5.751 ± 0.124	6.25ValLeu: 6.25 ± 0.128	1.638ValMet: 1.638 ± 0.058	3.21ValAsn: 3.21 ± 0.091	2.247ValPro: 2.247 ± 0.079	1.441ValGln: 1.441 ± 0.05	2.469ValArg: 2.469 ± 0.083	4.431ValSer: 4.431 ± 0.098	3.478ValThr: 3.478 ± 0.118	4.896ValVal: 4.896 ± 0.121	0.398ValTrp: 0.398 ± 0.029	2.557ValTyr: 2.557 ± 0.071	0.0ValXaa: 0.0 ± 0.0
Trp	0.353TrpAla: 0.353 ± 0.028	0.041TrpCys: 0.041 ± 0.009	0.411TrpAsp: 0.411 ± 0.029	0.381TrpGlu: 0.381 ± 0.025	0.296TrpPhe: 0.296 ± 0.025	0.401TrpGly: 0.401 ± 0.027	0.092TrpHis: 0.092 ± 0.013	0.561TrpIle: 0.561 ± 0.036	0.486TrpLys: 0.486 ± 0.038	0.523TrpLeu: 0.523 ± 0.039	0.221TrpMet: 0.221 ± 0.021	0.409TrpAsn: 0.409 ± 0.029	0.129TrpPro: 0.129 ± 0.017	0.197TrpGln: 0.197 ± 0.019	0.242TrpArg: 0.242 ± 0.024	0.36TrpSer: 0.36 ± 0.029	0.323TrpThr: 0.323 ± 0.03	0.319TrpVal: 0.319 ± 0.025	0.079TrpTrp: 0.079 ± 0.013	0.233TrpTyr: 0.233 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.116TyrAla: 2.116 ± 0.064	0.34TyrCys: 0.34 ± 0.027	2.909TyrAsp: 2.909 ± 0.082	3.198TyrGlu: 3.198 ± 0.081	2.116TyrPhe: 2.116 ± 0.069	2.585TyrGly: 2.585 ± 0.075	0.536TyrHis: 0.536 ± 0.035	3.371TyrIle: 3.371 ± 0.081	3.619TyrLys: 3.619 ± 0.079	3.673TyrLeu: 3.673 ± 0.087	0.966TyrMet: 0.966 ± 0.037	2.399TyrAsn: 2.399 ± 0.073	1.264TyrPro: 1.264 ± 0.044	0.88TyrGln: 0.88 ± 0.045	1.548TyrArg: 1.548 ± 0.058	2.414TyrSer: 2.414 ± 0.08	2.075TyrThr: 2.075 ± 0.074	2.658TyrVal: 2.658 ± 0.097	0.264TyrTrp: 0.264 ± 0.024	1.913TyrTyr: 1.913 ± 0.086	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1626 proteins (533091 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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