Amino acid dipepetide frequency for Streptococcus satellite phage Javan228

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.936AlaAla: 0.936 ± 0.619
0.936AlaCys: 0.936 ± 0.668
3.745AlaAsp: 3.745 ± 1.112
2.809AlaGlu: 2.809 ± 1.721
0.936AlaPhe: 0.936 ± 0.702
3.745AlaGly: 3.745 ± 0.964
0.936AlaHis: 0.936 ± 0.642
4.682AlaIle: 4.682 ± 0.938
4.682AlaLys: 4.682 ± 1.101
5.15AlaLeu: 5.15 ± 1.449
1.404AlaMet: 1.404 ± 0.769
3.745AlaAsn: 3.745 ± 1.292
0.468AlaPro: 0.468 ± 0.502
0.936AlaGln: 0.936 ± 0.758
5.15AlaArg: 5.15 ± 1.104
4.213AlaSer: 4.213 ± 0.598
5.15AlaThr: 5.15 ± 1.409
2.809AlaVal: 2.809 ± 1.276
0.936AlaTrp: 0.936 ± 1.005
4.213AlaTyr: 4.213 ± 1.209
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.468CysAsp: 0.468 ± 0.521
0.0CysGlu: 0.0 ± 0.0
0.936CysPhe: 0.936 ± 0.697
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.936CysLeu: 0.936 ± 0.544
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.936CysGln: 0.936 ± 0.668
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.468CysTyr: 0.468 ± 0.479
0.0CysXaa: 0.0 ± 0.0
Asp
0.936AspAla: 0.936 ± 0.555
0.0AspCys: 0.0 ± 0.0
4.213AspAsp: 4.213 ± 1.934
5.15AspGlu: 5.15 ± 1.244
2.809AspPhe: 2.809 ± 1.405
1.404AspGly: 1.404 ± 0.618
0.468AspHis: 0.468 ± 0.479
6.086AspIle: 6.086 ± 1.432
4.682AspLys: 4.682 ± 1.443
6.086AspLeu: 6.086 ± 1.346
1.404AspMet: 1.404 ± 0.651
2.809AspAsn: 2.809 ± 1.209
0.936AspPro: 0.936 ± 0.698
0.936AspGln: 0.936 ± 0.635
4.682AspArg: 4.682 ± 1.379
1.873AspSer: 1.873 ± 0.979
3.277AspThr: 3.277 ± 1.385
3.745AspVal: 3.745 ± 1.014
0.0AspTrp: 0.0 ± 0.0
5.15AspTyr: 5.15 ± 1.078
0.0AspXaa: 0.0 ± 0.0
Glu
3.277GluAla: 3.277 ± 1.318
0.0GluCys: 0.0 ± 0.0
3.277GluAsp: 3.277 ± 1.257
7.491GluGlu: 7.491 ± 2.3
4.213GluPhe: 4.213 ± 1.078
1.873GluGly: 1.873 ± 0.826
0.468GluHis: 0.468 ± 0.538
7.491GluIle: 7.491 ± 2.161
6.554GluLys: 6.554 ± 1.205
11.704GluLeu: 11.704 ± 2.377
1.873GluMet: 1.873 ± 0.882
5.15GluAsn: 5.15 ± 1.499
0.936GluPro: 0.936 ± 0.555
5.618GluGln: 5.618 ± 1.468
4.213GluArg: 4.213 ± 1.261
2.809GluSer: 2.809 ± 1.289
3.277GluThr: 3.277 ± 1.087
4.213GluVal: 4.213 ± 1.033
2.341GluTrp: 2.341 ± 0.977
1.404GluTyr: 1.404 ± 0.714
0.0GluXaa: 0.0 ± 0.0
Phe
0.936PheAla: 0.936 ± 0.957
0.0PheCys: 0.0 ± 0.0
1.873PheAsp: 1.873 ± 0.79
4.213PheGlu: 4.213 ± 1.816
0.468PhePhe: 0.468 ± 0.502
0.936PheGly: 0.936 ± 0.431
0.468PheHis: 0.468 ± 0.502
4.682PheIle: 4.682 ± 2.028
7.491PheLys: 7.491 ± 2.199
5.15PheLeu: 5.15 ± 1.216
0.0PheMet: 0.0 ± 0.0
1.873PheAsn: 1.873 ± 0.826
0.936PhePro: 0.936 ± 0.585
0.468PheGln: 0.468 ± 0.479
1.873PheArg: 1.873 ± 0.851
3.745PheSer: 3.745 ± 1.003
2.341PheThr: 2.341 ± 0.734
2.341PheVal: 2.341 ± 1.03
0.468PheTrp: 0.468 ± 0.479
3.277PheTyr: 3.277 ± 1.381
0.0PheXaa: 0.0 ± 0.0
Gly
1.873GlyAla: 1.873 ± 0.689
0.0GlyCys: 0.0 ± 0.0
0.936GlyAsp: 0.936 ± 0.431
1.404GlyGlu: 1.404 ± 0.659
1.404GlyPhe: 1.404 ± 0.748
0.936GlyGly: 0.936 ± 0.63
1.404GlyHis: 1.404 ± 0.651
3.745GlyIle: 3.745 ± 1.492
4.213GlyLys: 4.213 ± 1.421
5.15GlyLeu: 5.15 ± 1.457
0.468GlyMet: 0.468 ± 0.509
2.809GlyAsn: 2.809 ± 0.799
0.0GlyPro: 0.0 ± 0.0
0.936GlyGln: 0.936 ± 0.551
1.404GlyArg: 1.404 ± 0.539
0.0GlySer: 0.0 ± 0.0
2.341GlyThr: 2.341 ± 1.007
5.618GlyVal: 5.618 ± 1.425
1.404GlyTrp: 1.404 ± 0.682
2.809GlyTyr: 2.809 ± 0.99
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.936HisGlu: 0.936 ± 0.616
0.0HisPhe: 0.0 ± 0.0
0.468HisGly: 0.468 ± 0.349
0.0HisHis: 0.0 ± 0.0
0.936HisIle: 0.936 ± 0.58
0.468HisLys: 0.468 ± 0.457
1.404HisLeu: 1.404 ± 0.651
0.0HisMet: 0.0 ± 0.0
2.341HisAsn: 2.341 ± 1.177
0.468HisPro: 0.468 ± 0.479
0.0HisGln: 0.0 ± 0.0
0.468HisArg: 0.468 ± 0.521
1.404HisSer: 1.404 ± 1.14
0.468HisThr: 0.468 ± 0.52
0.936HisVal: 0.936 ± 0.664
0.0HisTrp: 0.0 ± 0.0
1.404HisTyr: 1.404 ± 0.774
0.0HisXaa: 0.0 ± 0.0
Ile
5.618IleAla: 5.618 ± 2.593
1.404IleCys: 1.404 ± 0.788
2.809IleAsp: 2.809 ± 0.978
7.022IleGlu: 7.022 ± 1.896
4.213IlePhe: 4.213 ± 2.145
3.277IleGly: 3.277 ± 2.176
0.936IleHis: 0.936 ± 0.616
4.213IleIle: 4.213 ± 1.458
6.086IleLys: 6.086 ± 2.095
3.745IleLeu: 3.745 ± 1.721
3.277IleMet: 3.277 ± 1.254
6.086IleAsn: 6.086 ± 2.094
0.936IlePro: 0.936 ± 0.539
4.682IleGln: 4.682 ± 1.126
1.873IleArg: 1.873 ± 0.893
4.682IleSer: 4.682 ± 0.965
5.15IleThr: 5.15 ± 1.483
5.618IleVal: 5.618 ± 1.151
0.936IleTrp: 0.936 ± 0.568
1.404IleTyr: 1.404 ± 0.943
0.0IleXaa: 0.0 ± 0.0
Lys
7.959LysAla: 7.959 ± 2.033
0.0LysCys: 0.0 ± 0.0
3.745LysAsp: 3.745 ± 1.534
6.554LysGlu: 6.554 ± 1.723
2.809LysPhe: 2.809 ± 1.068
4.682LysGly: 4.682 ± 1.707
2.341LysHis: 2.341 ± 1.454
3.745LysIle: 3.745 ± 1.209
9.831LysLys: 9.831 ± 2.815
7.959LysLeu: 7.959 ± 1.224
2.341LysMet: 2.341 ± 0.861
7.491LysAsn: 7.491 ± 1.822
2.809LysPro: 2.809 ± 1.07
7.959LysGln: 7.959 ± 1.866
3.745LysArg: 3.745 ± 1.321
3.277LysSer: 3.277 ± 1.006
4.682LysThr: 4.682 ± 2.117
7.022LysVal: 7.022 ± 2.117
1.873LysTrp: 1.873 ± 0.908
3.745LysTyr: 3.745 ± 1.772
0.0LysXaa: 0.0 ± 0.0
Leu
7.022LeuAla: 7.022 ± 2.277
0.468LeuCys: 0.468 ± 0.479
7.959LeuAsp: 7.959 ± 1.356
10.768LeuGlu: 10.768 ± 1.8
5.15LeuPhe: 5.15 ± 1.698
3.745LeuGly: 3.745 ± 0.702
0.468LeuHis: 0.468 ± 0.406
5.15LeuIle: 5.15 ± 1.586
7.959LeuLys: 7.959 ± 0.769
7.491LeuLeu: 7.491 ± 1.693
2.341LeuMet: 2.341 ± 1.09
7.959LeuAsn: 7.959 ± 1.674
3.745LeuPro: 3.745 ± 1.279
1.404LeuGln: 1.404 ± 0.708
3.277LeuArg: 3.277 ± 0.712
6.554LeuSer: 6.554 ± 1.854
4.682LeuThr: 4.682 ± 1.433
4.682LeuVal: 4.682 ± 1.97
1.873LeuTrp: 1.873 ± 0.78
4.682LeuTyr: 4.682 ± 1.103
0.0LeuXaa: 0.0 ± 0.0
Met
1.404MetAla: 1.404 ± 0.793
0.0MetCys: 0.0 ± 0.0
2.809MetAsp: 2.809 ± 1.585
0.936MetGlu: 0.936 ± 0.585
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.936MetIle: 0.936 ± 0.758
1.873MetLys: 1.873 ± 1.273
4.682MetLeu: 4.682 ± 1.389
0.936MetMet: 0.936 ± 0.652
2.341MetAsn: 2.341 ± 0.736
0.0MetPro: 0.0 ± 0.0
0.468MetGln: 0.468 ± 0.406
0.468MetArg: 0.468 ± 0.349
0.936MetSer: 0.936 ± 0.567
3.745MetThr: 3.745 ± 1.641
1.404MetVal: 1.404 ± 0.965
0.0MetTrp: 0.0 ± 0.0
1.404MetTyr: 1.404 ± 0.682
0.0MetXaa: 0.0 ± 0.0
Asn
0.936AsnAla: 0.936 ± 0.714
0.0AsnCys: 0.0 ± 0.0
5.618AsnAsp: 5.618 ± 1.769
4.682AsnGlu: 4.682 ± 1.41
1.404AsnPhe: 1.404 ± 1.085
3.277AsnGly: 3.277 ± 1.101
1.404AsnHis: 1.404 ± 0.659
4.682AsnIle: 4.682 ± 1.356
5.618AsnLys: 5.618 ± 1.426
4.682AsnLeu: 4.682 ± 1.249
2.809AsnMet: 2.809 ± 1.21
3.277AsnAsn: 3.277 ± 1.106
4.682AsnPro: 4.682 ± 0.954
3.745AsnGln: 3.745 ± 1.351
3.277AsnArg: 3.277 ± 1.372
4.682AsnSer: 4.682 ± 1.709
4.213AsnThr: 4.213 ± 1.865
3.277AsnVal: 3.277 ± 0.802
0.936AsnTrp: 0.936 ± 0.703
3.745AsnTyr: 3.745 ± 0.791
0.0AsnXaa: 0.0 ± 0.0
Pro
0.468ProAla: 0.468 ± 0.406
0.0ProCys: 0.0 ± 0.0
1.404ProAsp: 1.404 ± 1.104
1.873ProGlu: 1.873 ± 0.969
1.873ProPhe: 1.873 ± 0.812
0.468ProGly: 0.468 ± 0.349
0.0ProHis: 0.0 ± 0.0
3.745ProIle: 3.745 ± 1.268
1.873ProLys: 1.873 ± 0.788
0.936ProLeu: 0.936 ± 0.702
0.0ProMet: 0.0 ± 0.0
0.468ProAsn: 0.468 ± 0.406
0.936ProPro: 0.936 ± 0.431
0.936ProGln: 0.936 ± 0.532
0.936ProArg: 0.936 ± 0.71
0.468ProSer: 0.468 ± 0.5
1.873ProThr: 1.873 ± 0.781
2.809ProVal: 2.809 ± 0.898
0.0ProTrp: 0.0 ± 0.0
0.468ProTyr: 0.468 ± 0.349
0.0ProXaa: 0.0 ± 0.0
Gln
5.15GlnAla: 5.15 ± 2.414
0.0GlnCys: 0.0 ± 0.0
2.341GlnAsp: 2.341 ± 0.847
4.213GlnGlu: 4.213 ± 0.837
2.341GlnPhe: 2.341 ± 0.871
0.936GlnGly: 0.936 ± 0.63
0.936GlnHis: 0.936 ± 0.607
3.277GlnIle: 3.277 ± 1.184
3.277GlnLys: 3.277 ± 0.889
6.554GlnLeu: 6.554 ± 1.228
0.0GlnMet: 0.0 ± 0.0
0.936GlnAsn: 0.936 ± 1.003
0.468GlnPro: 0.468 ± 0.502
2.809GlnGln: 2.809 ± 1.567
0.468GlnArg: 0.468 ± 0.349
3.277GlnSer: 3.277 ± 1.534
1.873GlnThr: 1.873 ± 0.813
2.809GlnVal: 2.809 ± 1.214
0.0GlnTrp: 0.0 ± 0.0
2.809GlnTyr: 2.809 ± 0.8
0.0GlnXaa: 0.0 ± 0.0
Arg
5.618ArgAla: 5.618 ± 1.907
0.0ArgCys: 0.0 ± 0.0
2.341ArgAsp: 2.341 ± 0.838
3.277ArgGlu: 3.277 ± 1.578
1.404ArgPhe: 1.404 ± 0.692
1.404ArgGly: 1.404 ± 0.756
0.0ArgHis: 0.0 ± 0.0
2.341ArgIle: 2.341 ± 1.059
3.745ArgLys: 3.745 ± 1.247
5.618ArgLeu: 5.618 ± 2.199
0.468ArgMet: 0.468 ± 0.503
1.873ArgAsn: 1.873 ± 0.874
0.936ArgPro: 0.936 ± 0.698
2.341ArgGln: 2.341 ± 0.984
2.341ArgArg: 2.341 ± 0.895
1.404ArgSer: 1.404 ± 0.7
3.745ArgThr: 3.745 ± 1.436
2.341ArgVal: 2.341 ± 0.904
0.0ArgTrp: 0.0 ± 0.0
2.341ArgTyr: 2.341 ± 0.836
0.0ArgXaa: 0.0 ± 0.0
Ser
1.404SerAla: 1.404 ± 0.807
0.0SerCys: 0.0 ± 0.0
4.682SerAsp: 4.682 ± 1.054
5.15SerGlu: 5.15 ± 1.535
3.277SerPhe: 3.277 ± 2.038
2.809SerGly: 2.809 ± 1.03
0.0SerHis: 0.0 ± 0.0
4.682SerIle: 4.682 ± 1.802
3.745SerLys: 3.745 ± 1.529
4.682SerLeu: 4.682 ± 1.141
0.468SerMet: 0.468 ± 0.529
2.809SerAsn: 2.809 ± 0.882
0.936SerPro: 0.936 ± 0.63
0.936SerGln: 0.936 ± 0.702
1.873SerArg: 1.873 ± 0.789
2.341SerSer: 2.341 ± 1.171
4.213SerThr: 4.213 ± 0.603
1.873SerVal: 1.873 ± 0.986
0.936SerTrp: 0.936 ± 0.58
3.745SerTyr: 3.745 ± 1.466
0.0SerXaa: 0.0 ± 0.0
Thr
4.682ThrAla: 4.682 ± 1.573
0.0ThrCys: 0.0 ± 0.0
4.213ThrAsp: 4.213 ± 1.312
3.277ThrGlu: 3.277 ± 0.792
3.277ThrPhe: 3.277 ± 1.013
5.15ThrGly: 5.15 ± 1.459
0.936ThrHis: 0.936 ± 0.616
6.554ThrIle: 6.554 ± 1.787
7.022ThrLys: 7.022 ± 1.947
2.809ThrLeu: 2.809 ± 1.247
2.341ThrMet: 2.341 ± 0.936
2.341ThrAsn: 2.341 ± 1.22
0.936ThrPro: 0.936 ± 0.575
3.277ThrGln: 3.277 ± 1.291
1.873ThrArg: 1.873 ± 1.038
1.404ThrSer: 1.404 ± 0.79
4.213ThrThr: 4.213 ± 1.203
6.086ThrVal: 6.086 ± 2.409
0.0ThrTrp: 0.0 ± 0.0
2.809ThrTyr: 2.809 ± 1.057
0.0ThrXaa: 0.0 ± 0.0
Val
4.682ValAla: 4.682 ± 1.855
0.0ValCys: 0.0 ± 0.0
0.936ValAsp: 0.936 ± 0.698
4.213ValGlu: 4.213 ± 1.939
4.213ValPhe: 4.213 ± 1.28
1.404ValGly: 1.404 ± 0.807
0.468ValHis: 0.468 ± 0.406
4.682ValIle: 4.682 ± 1.369
6.554ValLys: 6.554 ± 1.94
6.086ValLeu: 6.086 ± 1.658
2.809ValMet: 2.809 ± 1.147
7.959ValAsn: 7.959 ± 1.952
1.404ValPro: 1.404 ± 0.598
1.404ValGln: 1.404 ± 0.728
2.341ValArg: 2.341 ± 1.141
4.213ValSer: 4.213 ± 1.072
3.277ValThr: 3.277 ± 1.48
6.086ValVal: 6.086 ± 1.575
0.0ValTrp: 0.0 ± 0.0
2.809ValTyr: 2.809 ± 1.412
0.0ValXaa: 0.0 ± 0.0
Trp
2.809TrpAla: 2.809 ± 0.899
0.0TrpCys: 0.0 ± 0.0
0.468TrpAsp: 0.468 ± 0.406
0.468TrpGlu: 0.468 ± 0.538
0.936TrpPhe: 0.936 ± 0.734
0.936TrpGly: 0.936 ± 0.698
0.0TrpHis: 0.0 ± 0.0
0.468TrpIle: 0.468 ± 0.502
0.936TrpLys: 0.936 ± 0.544
0.468TrpLeu: 0.468 ± 0.538
0.0TrpMet: 0.0 ± 0.0
0.468TrpAsn: 0.468 ± 0.502
0.0TrpPro: 0.0 ± 0.0
0.936TrpGln: 0.936 ± 0.58
0.468TrpArg: 0.468 ± 0.521
0.468TrpSer: 0.468 ± 0.406
0.468TrpThr: 0.468 ± 0.479
0.936TrpVal: 0.936 ± 0.539
0.468TrpTrp: 0.468 ± 0.406
0.468TrpTyr: 0.468 ± 0.349
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.873TyrAla: 1.873 ± 1.061
0.936TyrCys: 0.936 ± 0.544
2.809TyrAsp: 2.809 ± 1.1
3.745TyrGlu: 3.745 ± 1.132
1.873TyrPhe: 1.873 ± 1.282
1.404TyrGly: 1.404 ± 0.517
0.468TyrHis: 0.468 ± 0.502
1.873TyrIle: 1.873 ± 0.872
8.427TyrLys: 8.427 ± 1.501
6.086TyrLeu: 6.086 ± 1.619
0.936TyrMet: 0.936 ± 0.627
4.213TyrAsn: 4.213 ± 1.318
0.0TyrPro: 0.0 ± 0.0
3.745TyrGln: 3.745 ± 1.088
2.809TyrArg: 2.809 ± 1.93
2.809TyrSer: 2.809 ± 1.582
4.213TyrThr: 4.213 ± 1.349
0.936TyrVal: 0.936 ± 0.698
0.0TyrTrp: 0.0 ± 0.0
2.341TyrTyr: 2.341 ± 1.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (2137 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski