Amino acid dipepetide frequency for Shahe picorna-like virus 12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.602AlaAla: 4.602 ± 0.141
0.0AlaCys: 0.0 ± 0.0
2.761AlaAsp: 2.761 ± 0.203
0.46AlaGlu: 0.46 ± 0.273
2.761AlaPhe: 2.761 ± 1.235
4.602AlaGly: 4.602 ± 0.86
0.46AlaHis: 0.46 ± 0.273
3.682AlaIle: 3.682 ± 0.031
2.761AlaLys: 2.761 ± 1.64
4.142AlaLeu: 4.142 ± 0.415
1.841AlaMet: 1.841 ± 0.937
4.142AlaAsn: 4.142 ± 1.133
3.221AlaPro: 3.221 ± 0.961
1.381AlaGln: 1.381 ± 0.617
0.92AlaArg: 0.92 ± 0.891
4.602AlaSer: 4.602 ± 1.579
4.142AlaThr: 4.142 ± 0.304
5.062AlaVal: 5.062 ± 0.587
0.46AlaTrp: 0.46 ± 0.273
2.301AlaTyr: 2.301 ± 0.648
0.0AlaXaa: 0.0 ± 0.0
Cys
0.92CysAla: 0.92 ± 0.172
0.0CysCys: 0.0 ± 0.0
0.92CysAsp: 0.92 ± 0.547
0.46CysGlu: 0.46 ± 0.273
0.92CysPhe: 0.92 ± 0.547
0.92CysGly: 0.92 ± 0.547
0.46CysHis: 0.46 ± 0.445
0.46CysIle: 0.46 ± 0.273
1.381CysLys: 1.381 ± 0.101
0.92CysLeu: 0.92 ± 0.172
0.92CysMet: 0.92 ± 0.547
0.0CysAsn: 0.0 ± 0.0
0.46CysPro: 0.46 ± 0.273
0.46CysGln: 0.46 ± 0.273
0.92CysArg: 0.92 ± 0.172
1.841CysSer: 1.841 ± 1.093
0.46CysThr: 0.46 ± 0.273
1.381CysVal: 1.381 ± 0.617
0.0CysTrp: 0.0 ± 0.0
0.92CysTyr: 0.92 ± 0.172
0.0CysXaa: 0.0 ± 0.0
Asp
4.142AspAla: 4.142 ± 1.133
1.381AspCys: 1.381 ± 0.82
3.221AspAsp: 3.221 ± 0.476
3.682AspGlu: 3.682 ± 0.688
3.682AspPhe: 3.682 ± 0.749
3.682AspGly: 3.682 ± 0.031
0.0AspHis: 0.0 ± 0.0
5.522AspIle: 5.522 ± 0.405
2.301AspLys: 2.301 ± 0.648
3.682AspLeu: 3.682 ± 1.468
3.221AspMet: 3.221 ± 0.961
4.142AspAsn: 4.142 ± 0.304
0.92AspPro: 0.92 ± 0.172
1.381AspGln: 1.381 ± 0.101
2.761AspArg: 2.761 ± 0.921
5.983AspSer: 5.983 ± 2.196
3.682AspThr: 3.682 ± 0.749
4.602AspVal: 4.602 ± 1.296
1.841AspTrp: 1.841 ± 0.375
2.761AspTyr: 2.761 ± 0.203
0.0AspXaa: 0.0 ± 0.0
Glu
1.381GluAla: 1.381 ± 0.82
0.92GluCys: 0.92 ± 0.172
2.301GluAsp: 2.301 ± 1.367
1.381GluGlu: 1.381 ± 0.101
1.841GluPhe: 1.841 ± 0.344
1.381GluGly: 1.381 ± 0.101
0.92GluHis: 0.92 ± 0.547
2.761GluIle: 2.761 ± 0.921
2.301GluLys: 2.301 ± 1.367
4.142GluLeu: 4.142 ± 0.415
2.761GluMet: 2.761 ± 0.203
1.381GluAsn: 1.381 ± 0.101
1.841GluPro: 1.841 ± 1.093
1.841GluGln: 1.841 ± 1.093
1.381GluArg: 1.381 ± 0.82
1.381GluSer: 1.381 ± 0.101
3.682GluThr: 3.682 ± 1.468
2.761GluVal: 2.761 ± 0.203
1.381GluTrp: 1.381 ± 0.82
0.92GluTyr: 0.92 ± 0.547
0.0GluXaa: 0.0 ± 0.0
Phe
1.381PheAla: 1.381 ± 0.617
0.92PheCys: 0.92 ± 0.891
2.301PheAsp: 2.301 ± 1.367
0.92PheGlu: 0.92 ± 0.547
2.301PhePhe: 2.301 ± 0.648
1.841PheGly: 1.841 ± 0.375
1.841PheHis: 1.841 ± 0.375
4.602PheIle: 4.602 ± 0.577
1.841PheLys: 1.841 ± 1.093
3.682PheLeu: 3.682 ± 0.031
1.841PheMet: 1.841 ± 1.063
2.761PheAsn: 2.761 ± 1.235
1.841PhePro: 1.841 ± 0.375
1.381PheGln: 1.381 ± 0.101
3.682PheArg: 3.682 ± 0.688
8.744PheSer: 8.744 ± 3.038
2.761PheThr: 2.761 ± 1.64
3.221PheVal: 3.221 ± 0.961
0.0PheTrp: 0.0 ± 0.0
2.761PheTyr: 2.761 ± 1.235
0.0PheXaa: 0.0 ± 0.0
Gly
2.761GlyAla: 2.761 ± 1.235
1.841GlyCys: 1.841 ± 1.093
3.221GlyAsp: 3.221 ± 0.476
0.92GlyGlu: 0.92 ± 0.172
1.841GlyPhe: 1.841 ± 0.344
2.761GlyGly: 2.761 ± 1.235
1.381GlyHis: 1.381 ± 0.101
5.522GlyIle: 5.522 ± 1.124
3.682GlyLys: 3.682 ± 0.749
5.522GlyLeu: 5.522 ± 0.313
2.301GlyMet: 2.301 ± 0.218
3.682GlyAsn: 3.682 ± 0.031
1.381GlyPro: 1.381 ± 0.617
0.46GlyGln: 0.46 ± 0.273
0.46GlyArg: 0.46 ± 0.273
6.443GlySer: 6.443 ± 1.923
4.142GlyThr: 4.142 ± 1.852
5.522GlyVal: 5.522 ± 0.313
0.46GlyTrp: 0.46 ± 0.273
0.92GlyTyr: 0.92 ± 0.547
0.0GlyXaa: 0.0 ± 0.0
His
1.841HisAla: 1.841 ± 0.344
0.0HisCys: 0.0 ± 0.0
0.46HisAsp: 0.46 ± 0.445
0.46HisGlu: 0.46 ± 0.273
1.841HisPhe: 1.841 ± 0.344
0.92HisGly: 0.92 ± 0.172
0.92HisHis: 0.92 ± 0.547
0.92HisIle: 0.92 ± 0.172
1.381HisLys: 1.381 ± 0.101
0.46HisLeu: 0.46 ± 0.445
0.92HisMet: 0.92 ± 0.172
0.92HisAsn: 0.92 ± 0.172
1.381HisPro: 1.381 ± 0.101
2.301HisGln: 2.301 ± 0.071
0.0HisArg: 0.0 ± 0.0
1.381HisSer: 1.381 ± 0.101
2.761HisThr: 2.761 ± 1.235
2.761HisVal: 2.761 ± 0.921
0.46HisTrp: 0.46 ± 0.445
0.46HisTyr: 0.46 ± 0.445
0.0HisXaa: 0.0 ± 0.0
Ile
3.221IleAla: 3.221 ± 0.243
0.46IleCys: 0.46 ± 0.273
4.602IleAsp: 4.602 ± 0.141
1.841IleGlu: 1.841 ± 1.093
2.301IlePhe: 2.301 ± 0.071
4.142IleGly: 4.142 ± 0.304
1.381IleHis: 1.381 ± 0.617
4.142IleIle: 4.142 ± 0.304
4.142IleLys: 4.142 ± 1.742
6.903IleLeu: 6.903 ± 1.944
3.682IleMet: 3.682 ± 1.468
4.602IleAsn: 4.602 ± 0.141
4.602IlePro: 4.602 ± 3.016
3.682IleGln: 3.682 ± 2.125
2.761IleArg: 2.761 ± 0.203
4.142IleSer: 4.142 ± 0.415
4.602IleThr: 4.602 ± 0.141
3.682IleVal: 3.682 ± 1.407
0.0IleTrp: 0.0 ± 0.0
1.381IleTyr: 1.381 ± 0.101
0.0IleXaa: 0.0 ± 0.0
Lys
2.761LysAla: 2.761 ± 1.64
1.381LysCys: 1.381 ± 0.82
6.903LysAsp: 6.903 ± 4.1
6.443LysGlu: 6.443 ± 3.108
2.761LysPhe: 2.761 ± 1.64
3.682LysGly: 3.682 ± 0.749
1.381LysHis: 1.381 ± 0.101
3.221LysIle: 3.221 ± 0.243
2.761LysLys: 2.761 ± 1.64
6.443LysLeu: 6.443 ± 0.234
0.46LysMet: 0.46 ± 0.273
3.221LysAsn: 3.221 ± 1.195
0.92LysPro: 0.92 ± 0.891
2.301LysGln: 2.301 ± 0.648
2.761LysArg: 2.761 ± 1.64
4.602LysSer: 4.602 ± 0.577
1.381LysThr: 1.381 ± 0.82
6.903LysVal: 6.903 ± 2.663
0.46LysTrp: 0.46 ± 0.273
1.381LysTyr: 1.381 ± 0.101
0.0LysXaa: 0.0 ± 0.0
Leu
5.522LeuAla: 5.522 ± 1.032
1.841LeuCys: 1.841 ± 1.093
7.823LeuAsp: 7.823 ± 0.335
2.301LeuGlu: 2.301 ± 0.071
4.142LeuPhe: 4.142 ± 0.304
3.221LeuGly: 3.221 ± 0.961
3.221LeuHis: 3.221 ± 1.68
5.062LeuIle: 5.062 ± 1.57
9.664LeuLys: 9.664 ± 2.147
12.425LeuLeu: 12.425 ± 4.506
2.301LeuMet: 2.301 ± 0.648
5.983LeuAsn: 5.983 ± 1.477
3.221LeuPro: 3.221 ± 1.68
2.761LeuGln: 2.761 ± 0.516
3.221LeuArg: 3.221 ± 0.476
7.363LeuSer: 7.363 ± 0.78
3.682LeuThr: 3.682 ± 0.031
5.062LeuVal: 5.062 ± 0.851
0.46LeuTrp: 0.46 ± 0.273
1.841LeuTyr: 1.841 ± 0.375
0.0LeuXaa: 0.0 ± 0.0
Met
1.381MetAla: 1.381 ± 0.101
1.381MetCys: 1.381 ± 0.82
4.142MetAsp: 4.142 ± 0.304
1.381MetGlu: 1.381 ± 0.101
0.92MetPhe: 0.92 ± 0.172
0.92MetGly: 0.92 ± 0.891
0.46MetHis: 0.46 ± 0.273
2.761MetIle: 2.761 ± 0.516
1.841MetLys: 1.841 ± 0.344
3.221MetLeu: 3.221 ± 0.961
0.0MetMet: 0.0 ± 0.0
1.381MetAsn: 1.381 ± 0.101
0.92MetPro: 0.92 ± 0.547
1.381MetGln: 1.381 ± 0.101
0.92MetArg: 0.92 ± 0.547
4.142MetSer: 4.142 ± 1.133
1.381MetThr: 1.381 ± 0.617
1.841MetVal: 1.841 ± 1.093
0.46MetTrp: 0.46 ± 0.273
0.92MetTyr: 0.92 ± 0.547
0.0MetXaa: 0.0 ± 0.0
Asn
4.142AsnAla: 4.142 ± 0.304
0.46AsnCys: 0.46 ± 0.273
2.301AsnAsp: 2.301 ± 0.071
2.301AsnGlu: 2.301 ± 1.367
5.062AsnPhe: 5.062 ± 0.132
1.381AsnGly: 1.381 ± 0.82
0.0AsnHis: 0.0 ± 0.0
2.761AsnIle: 2.761 ± 0.516
4.142AsnLys: 4.142 ± 1.023
4.142AsnLeu: 4.142 ± 0.415
1.381AsnMet: 1.381 ± 0.82
2.761AsnAsn: 2.761 ± 1.64
4.602AsnPro: 4.602 ± 1.579
1.381AsnGln: 1.381 ± 0.101
0.92AsnArg: 0.92 ± 0.172
4.142AsnSer: 4.142 ± 1.133
4.142AsnThr: 4.142 ± 1.133
4.142AsnVal: 4.142 ± 2.571
0.46AsnTrp: 0.46 ± 0.445
1.841AsnTyr: 1.841 ± 1.063
0.0AsnXaa: 0.0 ± 0.0
Pro
2.761ProAla: 2.761 ± 1.235
0.46ProCys: 0.46 ± 0.273
0.46ProAsp: 0.46 ± 0.273
1.381ProGlu: 1.381 ± 0.101
3.682ProPhe: 3.682 ± 1.407
1.381ProGly: 1.381 ± 0.617
0.46ProHis: 0.46 ± 0.445
3.682ProIle: 3.682 ± 2.125
0.92ProLys: 0.92 ± 0.547
6.443ProLeu: 6.443 ± 2.641
0.0ProMet: 0.0 ± 0.0
1.381ProAsn: 1.381 ± 1.336
2.301ProPro: 2.301 ± 0.789
1.841ProGln: 1.841 ± 0.344
0.92ProArg: 0.92 ± 0.172
4.602ProSer: 4.602 ± 2.297
1.381ProThr: 1.381 ± 0.617
5.062ProVal: 5.062 ± 0.132
0.92ProTrp: 0.92 ± 0.172
4.142ProTyr: 4.142 ± 0.415
0.0ProXaa: 0.0 ± 0.0
Gln
0.92GlnAla: 0.92 ± 0.891
0.46GlnCys: 0.46 ± 0.445
3.221GlnAsp: 3.221 ± 0.476
2.761GlnGlu: 2.761 ± 0.203
1.841GlnPhe: 1.841 ± 0.344
2.761GlnGly: 2.761 ± 0.203
1.841GlnHis: 1.841 ± 0.375
1.381GlnIle: 1.381 ± 0.617
1.841GlnLys: 1.841 ± 0.375
5.062GlnLeu: 5.062 ± 0.132
0.0GlnMet: 0.0 ± 0.0
0.0GlnAsn: 0.0 ± 0.0
1.381GlnPro: 1.381 ± 0.101
0.0GlnGln: 0.0 ± 0.0
0.46GlnArg: 0.46 ± 0.445
4.602GlnSer: 4.602 ± 0.86
1.841GlnThr: 1.841 ± 0.344
3.221GlnVal: 3.221 ± 0.243
0.46GlnTrp: 0.46 ± 0.445
1.381GlnTyr: 1.381 ± 0.82
0.0GlnXaa: 0.0 ± 0.0
Arg
2.301ArgAla: 2.301 ± 0.071
1.381ArgCys: 1.381 ± 0.101
2.301ArgAsp: 2.301 ± 0.789
2.301ArgGlu: 2.301 ± 0.648
1.841ArgPhe: 1.841 ± 0.375
1.841ArgGly: 1.841 ± 1.063
0.46ArgHis: 0.46 ± 0.445
3.221ArgIle: 3.221 ± 0.243
2.761ArgLys: 2.761 ± 1.64
0.92ArgLeu: 0.92 ± 0.172
1.381ArgMet: 1.381 ± 0.101
0.46ArgAsn: 0.46 ± 0.445
1.381ArgPro: 1.381 ± 1.336
2.301ArgGln: 2.301 ± 0.789
2.761ArgArg: 2.761 ± 0.516
2.761ArgSer: 2.761 ± 0.921
1.841ArgThr: 1.841 ± 0.375
2.761ArgVal: 2.761 ± 0.203
0.0ArgTrp: 0.0 ± 0.0
0.0ArgTyr: 0.0 ± 0.0
0.0ArgXaa: 0.0 ± 0.0
Ser
4.142SerAla: 4.142 ± 2.571
0.92SerCys: 0.92 ± 0.891
6.903SerAsp: 6.903 ± 3.805
4.142SerGlu: 4.142 ± 1.742
5.062SerPhe: 5.062 ± 0.851
5.062SerGly: 5.062 ± 0.587
3.682SerHis: 3.682 ± 0.031
6.443SerIle: 6.443 ± 1.204
5.062SerLys: 5.062 ± 0.851
6.443SerLeu: 6.443 ± 1.671
4.142SerMet: 4.142 ± 1.133
5.522SerAsn: 5.522 ± 0.405
3.682SerPro: 3.682 ± 1.407
1.841SerGln: 1.841 ± 0.344
1.841SerArg: 1.841 ± 0.344
6.903SerSer: 6.903 ± 0.507
6.443SerThr: 6.443 ± 0.234
5.983SerVal: 5.983 ± 1.477
0.92SerTrp: 0.92 ± 0.547
3.221SerTyr: 3.221 ± 0.476
0.0SerXaa: 0.0 ± 0.0
Thr
3.221ThrAla: 3.221 ± 1.195
0.46ThrCys: 0.46 ± 0.445
2.301ThrAsp: 2.301 ± 1.508
0.92ThrGlu: 0.92 ± 0.172
1.841ThrPhe: 1.841 ± 0.375
4.602ThrGly: 4.602 ± 0.141
1.381ThrHis: 1.381 ± 0.101
3.682ThrIle: 3.682 ± 0.749
2.761ThrLys: 2.761 ± 0.921
5.522ThrLeu: 5.522 ± 0.405
2.761ThrMet: 2.761 ± 0.203
4.142ThrAsn: 4.142 ± 1.852
5.062ThrPro: 5.062 ± 2.024
4.602ThrGln: 4.602 ± 0.141
1.841ThrArg: 1.841 ± 1.063
4.602ThrSer: 4.602 ± 0.86
8.744ThrThr: 8.744 ± 4.868
5.062ThrVal: 5.062 ± 1.305
0.46ThrTrp: 0.46 ± 0.273
3.221ThrTyr: 3.221 ± 0.476
0.0ThrXaa: 0.0 ± 0.0
Val
5.522ValAla: 5.522 ± 0.405
0.46ValCys: 0.46 ± 0.273
3.221ValAsp: 3.221 ± 0.243
1.841ValGlu: 1.841 ± 0.375
3.682ValPhe: 3.682 ± 1.468
4.142ValGly: 4.142 ± 1.133
1.841ValHis: 1.841 ± 1.781
4.142ValIle: 4.142 ± 1.133
6.903ValLys: 6.903 ± 3.382
6.903ValLeu: 6.903 ± 0.507
0.46ValMet: 0.46 ± 0.273
4.142ValAsn: 4.142 ± 1.023
3.221ValPro: 3.221 ± 0.961
2.761ValGln: 2.761 ± 0.921
3.221ValArg: 3.221 ± 0.961
5.522ValSer: 5.522 ± 0.313
5.062ValThr: 5.062 ± 3.461
7.823ValVal: 7.823 ± 1.103
0.46ValTrp: 0.46 ± 0.273
6.903ValTyr: 6.903 ± 0.931
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.46TrpAsp: 0.46 ± 0.273
0.92TrpGlu: 0.92 ± 0.547
0.0TrpPhe: 0.0 ± 0.0
0.92TrpGly: 0.92 ± 0.547
0.46TrpHis: 0.46 ± 0.273
0.92TrpIle: 0.92 ± 0.547
0.92TrpLys: 0.92 ± 0.172
0.92TrpLeu: 0.92 ± 0.547
0.0TrpMet: 0.0 ± 0.0
0.46TrpAsn: 0.46 ± 0.273
0.46TrpPro: 0.46 ± 0.273
0.46TrpGln: 0.46 ± 0.273
0.46TrpArg: 0.46 ± 0.445
0.92TrpSer: 0.92 ± 0.891
0.46TrpThr: 0.46 ± 0.445
0.46TrpVal: 0.46 ± 0.273
0.46TrpTrp: 0.46 ± 0.273
0.46TrpTyr: 0.46 ± 0.273
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.841TyrAla: 1.841 ± 0.344
0.0TyrCys: 0.0 ± 0.0
2.761TyrAsp: 2.761 ± 0.203
1.841TyrGlu: 1.841 ± 1.093
2.301TyrPhe: 2.301 ± 0.648
5.062TyrGly: 5.062 ± 0.851
0.0TyrHis: 0.0 ± 0.0
1.381TyrIle: 1.381 ± 0.617
2.761TyrLys: 2.761 ± 1.64
3.221TyrLeu: 3.221 ± 0.476
0.92TyrMet: 0.92 ± 0.172
1.381TyrAsn: 1.381 ± 0.101
1.381TyrPro: 1.381 ± 0.617
0.92TyrGln: 0.92 ± 0.891
2.761TyrArg: 2.761 ± 0.516
3.682TyrSer: 3.682 ± 0.031
4.602TyrThr: 4.602 ± 0.86
0.92TyrVal: 0.92 ± 0.172
0.0TyrTrp: 0.0 ± 0.0
1.381TyrTyr: 1.381 ± 0.617
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2174 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski