Amino acid dipepetide frequency for Streptococcus satellite phage Javan413

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
1.061AlaCys: 1.061 ± 0.767
3.183AlaAsp: 3.183 ± 1.042
4.244AlaGlu: 4.244 ± 1.522
1.592AlaPhe: 1.592 ± 0.812
2.122AlaGly: 2.122 ± 0.889
0.0AlaHis: 0.0 ± 0.0
4.775AlaIle: 4.775 ± 1.218
2.122AlaLys: 2.122 ± 0.831
4.775AlaLeu: 4.775 ± 1.192
2.122AlaMet: 2.122 ± 0.876
4.244AlaAsn: 4.244 ± 1.565
0.531AlaPro: 0.531 ± 0.513
1.592AlaGln: 1.592 ± 0.89
2.122AlaArg: 2.122 ± 0.884
1.061AlaSer: 1.061 ± 0.48
4.244AlaThr: 4.244 ± 1.0
2.122AlaVal: 2.122 ± 1.218
0.0AlaTrp: 0.0 ± 0.0
3.183AlaTyr: 3.183 ± 1.371
0.0AlaXaa: 0.0 ± 0.0
Cys
0.531CysAla: 0.531 ± 0.516
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
1.061CysGlu: 1.061 ± 0.691
0.0CysPhe: 0.0 ± 0.0
1.061CysGly: 1.061 ± 0.715
0.531CysHis: 0.531 ± 0.36
0.531CysIle: 0.531 ± 0.639
0.0CysLys: 0.0 ± 0.0
0.531CysLeu: 0.531 ± 0.516
0.531CysMet: 0.531 ± 0.596
0.0CysAsn: 0.0 ± 0.0
0.531CysPro: 0.531 ± 0.438
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.531CysVal: 0.531 ± 0.438
0.0CysTrp: 0.0 ± 0.0
0.531CysTyr: 0.531 ± 0.593
0.0CysXaa: 0.0 ± 0.0
Asp
0.0AspAla: 0.0 ± 0.0
1.061AspCys: 1.061 ± 0.48
7.958AspAsp: 7.958 ± 3.311
3.183AspGlu: 3.183 ± 1.197
1.592AspPhe: 1.592 ± 0.89
1.592AspGly: 1.592 ± 0.81
1.061AspHis: 1.061 ± 0.671
9.549AspIle: 9.549 ± 1.386
5.836AspLys: 5.836 ± 1.573
7.958AspLeu: 7.958 ± 1.795
2.653AspMet: 2.653 ± 1.125
5.836AspAsn: 5.836 ± 2.454
0.531AspPro: 0.531 ± 0.438
1.061AspGln: 1.061 ± 0.882
2.653AspArg: 2.653 ± 1.003
2.653AspSer: 2.653 ± 1.229
4.775AspThr: 4.775 ± 2.079
2.122AspVal: 2.122 ± 0.762
0.531AspTrp: 0.531 ± 0.438
5.305AspTyr: 5.305 ± 1.83
0.0AspXaa: 0.0 ± 0.0
Glu
6.897GluAla: 6.897 ± 1.724
1.061GluCys: 1.061 ± 0.766
5.836GluAsp: 5.836 ± 2.274
4.244GluGlu: 4.244 ± 1.766
4.775GluPhe: 4.775 ± 1.47
1.592GluGly: 1.592 ± 0.784
2.653GluHis: 2.653 ± 1.706
7.958GluIle: 7.958 ± 3.311
11.671GluLys: 11.671 ± 3.656
10.08GluLeu: 10.08 ± 1.87
1.592GluMet: 1.592 ± 0.788
5.305GluAsn: 5.305 ± 1.455
2.122GluPro: 2.122 ± 1.104
2.122GluGln: 2.122 ± 1.091
4.244GluArg: 4.244 ± 1.327
5.305GluSer: 5.305 ± 2.514
4.244GluThr: 4.244 ± 1.224
3.183GluVal: 3.183 ± 1.905
1.592GluTrp: 1.592 ± 0.752
2.653GluTyr: 2.653 ± 1.257
0.0GluXaa: 0.0 ± 0.0
Phe
0.531PheAla: 0.531 ± 0.36
0.0PheCys: 0.0 ± 0.0
3.183PheAsp: 3.183 ± 1.552
5.305PheGlu: 5.305 ± 2.026
1.061PhePhe: 1.061 ± 0.716
3.183PheGly: 3.183 ± 1.784
1.061PheHis: 1.061 ± 0.72
1.592PheIle: 1.592 ± 0.846
2.653PheLys: 2.653 ± 1.116
2.122PheLeu: 2.122 ± 1.283
1.061PheMet: 1.061 ± 0.482
1.592PheAsn: 1.592 ± 0.631
0.0PhePro: 0.0 ± 0.0
1.061PheGln: 1.061 ± 0.634
2.653PheArg: 2.653 ± 1.086
1.061PheSer: 1.061 ± 0.775
3.714PheThr: 3.714 ± 1.6
2.122PheVal: 2.122 ± 0.744
0.531PheTrp: 0.531 ± 0.438
1.061PheTyr: 1.061 ± 0.629
0.0PheXaa: 0.0 ± 0.0
Gly
2.653GlyAla: 2.653 ± 1.362
0.0GlyCys: 0.0 ± 0.0
1.592GlyAsp: 1.592 ± 0.955
2.122GlyGlu: 2.122 ± 0.885
1.592GlyPhe: 1.592 ± 0.804
3.183GlyGly: 3.183 ± 1.209
0.531GlyHis: 0.531 ± 0.36
4.775GlyIle: 4.775 ± 0.901
3.714GlyLys: 3.714 ± 1.8
4.775GlyLeu: 4.775 ± 1.36
0.531GlyMet: 0.531 ± 0.42
4.244GlyAsn: 4.244 ± 1.733
0.0GlyPro: 0.0 ± 0.0
0.531GlyGln: 0.531 ± 0.438
2.122GlyArg: 2.122 ± 1.218
2.122GlySer: 2.122 ± 1.141
2.122GlyThr: 2.122 ± 0.887
3.183GlyVal: 3.183 ± 1.222
0.0GlyTrp: 0.0 ± 0.0
4.775GlyTyr: 4.775 ± 1.399
0.0GlyXaa: 0.0 ± 0.0
His
1.592HisAla: 1.592 ± 0.812
0.0HisCys: 0.0 ± 0.0
1.061HisAsp: 1.061 ± 0.882
2.653HisGlu: 2.653 ± 0.752
0.531HisPhe: 0.531 ± 0.602
0.531HisGly: 0.531 ± 0.441
0.0HisHis: 0.0 ± 0.0
0.531HisIle: 0.531 ± 0.438
0.0HisLys: 0.0 ± 0.0
1.592HisLeu: 1.592 ± 0.833
0.0HisMet: 0.0 ± 0.0
0.531HisAsn: 0.531 ± 0.555
0.0HisPro: 0.0 ± 0.0
0.531HisGln: 0.531 ± 0.555
0.0HisArg: 0.0 ± 0.0
0.531HisSer: 0.531 ± 0.36
1.061HisThr: 1.061 ± 0.545
0.0HisVal: 0.0 ± 0.0
0.531HisTrp: 0.531 ± 0.555
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.305IleAla: 5.305 ± 1.018
1.061IleCys: 1.061 ± 1.279
8.488IleAsp: 8.488 ± 1.432
6.897IleGlu: 6.897 ± 2.548
1.592IlePhe: 1.592 ± 1.083
3.183IleGly: 3.183 ± 1.697
0.531IleHis: 0.531 ± 0.441
4.775IleIle: 4.775 ± 1.712
6.897IleLys: 6.897 ± 1.722
4.244IleLeu: 4.244 ± 1.229
3.714IleMet: 3.714 ± 1.443
6.897IleAsn: 6.897 ± 2.127
3.183IlePro: 3.183 ± 1.517
3.714IleGln: 3.714 ± 1.056
3.183IleArg: 3.183 ± 1.4
6.897IleSer: 6.897 ± 1.266
4.775IleThr: 4.775 ± 1.501
2.653IleVal: 2.653 ± 1.066
0.531IleTrp: 0.531 ± 0.571
4.244IleTyr: 4.244 ± 1.392
0.0IleXaa: 0.0 ± 0.0
Lys
4.775LysAla: 4.775 ± 1.91
0.531LysCys: 0.531 ± 0.438
5.305LysAsp: 5.305 ± 1.804
16.976LysGlu: 16.976 ± 3.416
2.122LysPhe: 2.122 ± 1.039
2.653LysGly: 2.653 ± 0.946
0.531LysHis: 0.531 ± 0.441
5.305LysIle: 5.305 ± 1.621
12.732LysLys: 12.732 ± 2.255
9.019LysLeu: 9.019 ± 1.842
2.122LysMet: 2.122 ± 0.814
4.775LysAsn: 4.775 ± 2.15
3.714LysPro: 3.714 ± 1.098
4.775LysGln: 4.775 ± 1.042
5.305LysArg: 5.305 ± 2.332
3.714LysSer: 3.714 ± 1.67
5.305LysThr: 5.305 ± 1.065
4.244LysVal: 4.244 ± 1.273
0.0LysTrp: 0.0 ± 0.0
1.061LysTyr: 1.061 ± 0.691
0.0LysXaa: 0.0 ± 0.0
Leu
4.775LeuAla: 4.775 ± 1.405
0.0LeuCys: 0.0 ± 0.0
5.836LeuAsp: 5.836 ± 2.133
9.019LeuGlu: 9.019 ± 1.155
1.061LeuPhe: 1.061 ± 0.611
6.897LeuGly: 6.897 ± 1.598
0.0LeuHis: 0.0 ± 0.0
10.61LeuIle: 10.61 ± 1.527
7.427LeuLys: 7.427 ± 1.609
8.488LeuLeu: 8.488 ± 2.598
1.592LeuMet: 1.592 ± 0.784
7.958LeuAsn: 7.958 ± 2.128
3.714LeuPro: 3.714 ± 1.128
3.183LeuGln: 3.183 ± 1.22
4.244LeuArg: 4.244 ± 1.281
7.958LeuSer: 7.958 ± 1.608
7.427LeuThr: 7.427 ± 1.91
3.714LeuVal: 3.714 ± 1.082
1.061LeuTrp: 1.061 ± 0.609
3.714LeuTyr: 3.714 ± 0.883
0.0LeuXaa: 0.0 ± 0.0
Met
1.061MetAla: 1.061 ± 0.612
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
1.592MetGlu: 1.592 ± 0.857
0.0MetPhe: 0.0 ± 0.0
1.592MetGly: 1.592 ± 1.128
0.0MetHis: 0.0 ± 0.0
1.061MetIle: 1.061 ± 0.658
4.775MetLys: 4.775 ± 1.462
2.653MetLeu: 2.653 ± 1.25
0.0MetMet: 0.0 ± 0.0
1.061MetAsn: 1.061 ± 0.896
0.531MetPro: 0.531 ± 0.639
1.061MetGln: 1.061 ± 0.876
0.531MetArg: 0.531 ± 0.441
0.531MetSer: 0.531 ± 0.438
3.183MetThr: 3.183 ± 0.954
2.122MetVal: 2.122 ± 1.015
0.0MetTrp: 0.0 ± 0.0
0.531MetTyr: 0.531 ± 0.36
0.0MetXaa: 0.0 ± 0.0
Asn
3.183AsnAla: 3.183 ± 1.107
0.531AsnCys: 0.531 ± 0.596
5.305AsnAsp: 5.305 ± 1.528
4.775AsnGlu: 4.775 ± 2.365
3.183AsnPhe: 3.183 ± 0.916
4.244AsnGly: 4.244 ± 1.522
0.531AsnHis: 0.531 ± 0.441
3.714AsnIle: 3.714 ± 0.961
4.775AsnLys: 4.775 ± 1.725
5.836AsnLeu: 5.836 ± 1.095
1.061AsnMet: 1.061 ± 0.769
4.244AsnAsn: 4.244 ± 1.134
1.592AsnPro: 1.592 ± 0.718
1.592AsnGln: 1.592 ± 0.719
2.122AsnArg: 2.122 ± 1.252
6.366AsnSer: 6.366 ± 0.864
3.714AsnThr: 3.714 ± 0.802
1.592AsnVal: 1.592 ± 0.861
1.592AsnTrp: 1.592 ± 0.987
5.305AsnTyr: 5.305 ± 1.829
0.0AsnXaa: 0.0 ± 0.0
Pro
1.061ProAla: 1.061 ± 0.667
0.0ProCys: 0.0 ± 0.0
2.653ProAsp: 2.653 ± 1.014
2.122ProGlu: 2.122 ± 0.886
1.061ProPhe: 1.061 ± 0.48
0.531ProGly: 0.531 ± 0.36
0.0ProHis: 0.0 ± 0.0
1.061ProIle: 1.061 ± 0.749
3.183ProLys: 3.183 ± 1.088
2.122ProLeu: 2.122 ± 1.104
0.0ProMet: 0.0 ± 0.0
0.531ProAsn: 0.531 ± 0.441
1.061ProPro: 1.061 ± 0.751
1.592ProGln: 1.592 ± 0.716
1.592ProArg: 1.592 ± 1.146
0.0ProSer: 0.0 ± 0.0
2.653ProThr: 2.653 ± 1.1
0.0ProVal: 0.0 ± 0.0
0.0ProTrp: 0.0 ± 0.0
1.592ProTyr: 1.592 ± 0.68
0.0ProXaa: 0.0 ± 0.0
Gln
4.244GlnAla: 4.244 ± 0.872
0.0GlnCys: 0.0 ± 0.0
0.531GlnAsp: 0.531 ± 0.513
3.183GlnGlu: 3.183 ± 0.917
1.592GlnPhe: 1.592 ± 1.014
2.122GlnGly: 2.122 ± 1.087
1.061GlnHis: 1.061 ± 0.546
2.653GlnIle: 2.653 ± 0.91
4.244GlnLys: 4.244 ± 1.138
3.183GlnLeu: 3.183 ± 0.912
0.0GlnMet: 0.0 ± 0.0
1.592GlnAsn: 1.592 ± 0.843
1.061GlnPro: 1.061 ± 0.668
2.653GlnGln: 2.653 ± 1.301
1.061GlnArg: 1.061 ± 0.611
4.244GlnSer: 4.244 ± 1.089
3.183GlnThr: 3.183 ± 1.143
1.592GlnVal: 1.592 ± 1.079
0.531GlnTrp: 0.531 ± 0.593
1.592GlnTyr: 1.592 ± 0.727
0.0GlnXaa: 0.0 ± 0.0
Arg
1.061ArgAla: 1.061 ± 0.853
0.531ArgCys: 0.531 ± 0.36
1.592ArgAsp: 1.592 ± 0.86
3.714ArgGlu: 3.714 ± 1.2
1.061ArgPhe: 1.061 ± 0.609
1.592ArgGly: 1.592 ± 0.935
0.531ArgHis: 0.531 ± 0.36
3.714ArgIle: 3.714 ± 1.102
3.183ArgLys: 3.183 ± 1.417
9.019ArgLeu: 9.019 ± 1.81
2.122ArgMet: 2.122 ± 1.278
0.531ArgAsn: 0.531 ± 0.555
0.0ArgPro: 0.0 ± 0.0
4.775ArgGln: 4.775 ± 1.206
2.122ArgArg: 2.122 ± 1.0
2.122ArgSer: 2.122 ± 1.075
3.183ArgThr: 3.183 ± 1.481
2.653ArgVal: 2.653 ± 1.01
1.061ArgTrp: 1.061 ± 0.751
2.653ArgTyr: 2.653 ± 1.063
0.0ArgXaa: 0.0 ± 0.0
Ser
1.592SerAla: 1.592 ± 0.955
0.531SerCys: 0.531 ± 0.438
6.897SerAsp: 6.897 ± 1.684
2.122SerGlu: 2.122 ± 0.823
3.183SerPhe: 3.183 ± 1.246
2.653SerGly: 2.653 ± 1.68
1.061SerHis: 1.061 ± 0.682
4.775SerIle: 4.775 ± 1.377
7.427SerLys: 7.427 ± 1.392
5.836SerLeu: 5.836 ± 1.665
1.061SerMet: 1.061 ± 0.612
4.244SerAsn: 4.244 ± 1.32
1.061SerPro: 1.061 ± 0.546
3.183SerGln: 3.183 ± 1.186
4.244SerArg: 4.244 ± 1.364
1.592SerSer: 1.592 ± 0.78
1.061SerThr: 1.061 ± 0.545
3.183SerVal: 3.183 ± 1.097
0.531SerTrp: 0.531 ± 0.516
3.714SerTyr: 3.714 ± 1.244
0.0SerXaa: 0.0 ± 0.0
Thr
1.061ThrAla: 1.061 ± 0.546
0.0ThrCys: 0.0 ± 0.0
4.244ThrAsp: 4.244 ± 1.439
5.836ThrGlu: 5.836 ± 1.82
3.714ThrPhe: 3.714 ± 1.371
4.244ThrGly: 4.244 ± 1.328
0.531ThrHis: 0.531 ± 0.36
7.958ThrIle: 7.958 ± 2.219
6.366ThrLys: 6.366 ± 1.94
6.366ThrLeu: 6.366 ± 1.789
0.0ThrMet: 0.0 ± 0.0
3.183ThrAsn: 3.183 ± 0.917
2.122ThrPro: 2.122 ± 0.995
1.592ThrGln: 1.592 ± 0.852
2.653ThrArg: 2.653 ± 1.5
2.122ThrSer: 2.122 ± 1.007
3.183ThrThr: 3.183 ± 1.2
5.305ThrVal: 5.305 ± 1.222
0.531ThrTrp: 0.531 ± 0.571
2.653ThrTyr: 2.653 ± 1.106
0.0ThrXaa: 0.0 ± 0.0
Val
3.714ValAla: 3.714 ± 1.145
0.0ValCys: 0.0 ± 0.0
2.653ValAsp: 2.653 ± 0.86
2.653ValGlu: 2.653 ± 1.116
2.122ValPhe: 2.122 ± 1.186
0.531ValGly: 0.531 ± 0.36
0.531ValHis: 0.531 ± 0.438
2.653ValIle: 2.653 ± 0.846
4.775ValLys: 4.775 ± 1.672
3.714ValLeu: 3.714 ± 1.472
0.0ValMet: 0.0 ± 0.0
4.244ValAsn: 4.244 ± 1.528
0.531ValPro: 0.531 ± 0.36
2.122ValGln: 2.122 ± 0.66
2.653ValArg: 2.653 ± 1.189
5.836ValSer: 5.836 ± 1.836
2.122ValThr: 2.122 ± 1.173
0.0ValVal: 0.0 ± 0.0
0.0ValTrp: 0.0 ± 0.0
1.592ValTyr: 1.592 ± 0.698
0.0ValXaa: 0.0 ± 0.0
Trp
1.061TrpAla: 1.061 ± 0.612
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
2.122TrpGlu: 2.122 ± 1.096
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.531TrpIle: 0.531 ± 0.593
0.0TrpLys: 0.0 ± 0.0
2.122TrpLeu: 2.122 ± 0.786
0.0TrpMet: 0.0 ± 0.0
0.531TrpAsn: 0.531 ± 0.555
0.0TrpPro: 0.0 ± 0.0
0.531TrpGln: 0.531 ± 0.516
0.531TrpArg: 0.531 ± 0.571
0.531TrpSer: 0.531 ± 0.36
0.0TrpThr: 0.0 ± 0.0
0.531TrpVal: 0.531 ± 0.555
0.531TrpTrp: 0.531 ± 0.555
0.531TrpTyr: 0.531 ± 0.516
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.531TyrAla: 0.531 ± 0.438
0.0TyrCys: 0.0 ± 0.0
1.592TyrAsp: 1.592 ± 0.714
5.305TyrGlu: 5.305 ± 1.778
3.714TyrPhe: 3.714 ± 1.845
1.061TyrGly: 1.061 ± 0.682
0.531TyrHis: 0.531 ± 0.441
4.244TyrIle: 4.244 ± 1.579
3.183TyrLys: 3.183 ± 1.384
4.244TyrLeu: 4.244 ± 1.109
1.592TyrMet: 1.592 ± 0.755
3.714TyrAsn: 3.714 ± 1.787
0.531TyrPro: 0.531 ± 0.516
2.653TyrGln: 2.653 ± 0.915
3.183TyrArg: 3.183 ± 1.519
5.305TyrSer: 5.305 ± 1.314
3.714TyrThr: 3.714 ± 1.61
1.592TyrVal: 1.592 ± 0.924
0.0TyrTrp: 0.0 ± 0.0
3.183TyrTyr: 3.183 ± 1.245
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (1886 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski