Amino acid dipepetide frequency for Gemmata obscuriglobus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.57AlaAla: 18.57 ± 0.152	1.273AlaCys: 1.273 ± 0.027	7.74AlaAsp: 7.74 ± 0.071	7.688AlaGlu: 7.688 ± 0.068	4.237AlaPhe: 4.237 ± 0.042	11.325AlaGly: 11.325 ± 0.098	2.259AlaHis: 2.259 ± 0.032	3.753AlaIle: 3.753 ± 0.038	4.893AlaLys: 4.893 ± 0.062	12.921AlaLeu: 12.921 ± 0.109	1.919AlaMet: 1.919 ± 0.03	2.911AlaAsn: 2.911 ± 0.043	7.509AlaPro: 7.509 ± 0.071	3.357AlaGln: 3.357 ± 0.045	8.995AlaArg: 8.995 ± 0.083	5.106AlaSer: 5.106 ± 0.06	6.427AlaThr: 6.427 ± 0.07	11.186AlaVal: 11.186 ± 0.086	1.643AlaTrp: 1.643 ± 0.029	2.242AlaTyr: 2.242 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.14CysAla: 1.14 ± 0.025	0.174CysCys: 0.174 ± 0.01	0.641CysAsp: 0.641 ± 0.019	0.572CysGlu: 0.572 ± 0.017	0.356CysPhe: 0.356 ± 0.012	1.147CysGly: 1.147 ± 0.025	0.369CysHis: 0.369 ± 0.016	0.249CysIle: 0.249 ± 0.01	0.314CysLys: 0.314 ± 0.013	0.932CysLeu: 0.932 ± 0.02	0.148CysMet: 0.148 ± 0.008	0.23CysAsn: 0.23 ± 0.009	0.72CysPro: 0.72 ± 0.021	0.302CysGln: 0.302 ± 0.011	0.901CysArg: 0.901 ± 0.023	0.512CysSer: 0.512 ± 0.017	0.499CysThr: 0.499 ± 0.015	0.941CysVal: 0.941 ± 0.022	0.208CysTrp: 0.208 ± 0.01	0.244CysTyr: 0.244 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.305AspAla: 7.305 ± 0.076	0.449AspCys: 0.449 ± 0.015	3.104AspAsp: 3.104 ± 0.041	3.571AspGlu: 3.571 ± 0.048	1.854AspPhe: 1.854 ± 0.025	5.912AspGly: 5.912 ± 0.077	1.175AspHis: 1.175 ± 0.025	1.808AspIle: 1.808 ± 0.031	2.089AspLys: 2.089 ± 0.036	5.646AspLeu: 5.646 ± 0.055	0.759AspMet: 0.759 ± 0.02	1.122AspAsn: 1.122 ± 0.025	4.262AspPro: 4.262 ± 0.046	1.556AspGln: 1.556 ± 0.029	4.631AspArg: 4.631 ± 0.047	2.063AspSer: 2.063 ± 0.034	2.815AspThr: 2.815 ± 0.038	4.17AspVal: 4.17 ± 0.05	0.947AspTrp: 0.947 ± 0.021	1.276AspTyr: 1.276 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.414GluAla: 6.414 ± 0.069	0.522GluCys: 0.522 ± 0.017	2.24GluAsp: 2.24 ± 0.035	2.894GluGlu: 2.894 ± 0.047	2.179GluPhe: 2.179 ± 0.037	3.566GluGly: 3.566 ± 0.038	1.272GluHis: 1.272 ± 0.022	2.067GluIle: 2.067 ± 0.035	2.664GluLys: 2.664 ± 0.046	6.817GluLeu: 6.817 ± 0.061	1.136GluMet: 1.136 ± 0.024	1.162GluAsn: 1.162 ± 0.023	3.599GluPro: 3.599 ± 0.044	2.33GluGln: 2.33 ± 0.034	4.87GluArg: 4.87 ± 0.056	2.516GluSer: 2.516 ± 0.034	2.697GluThr: 2.697 ± 0.032	4.536GluVal: 4.536 ± 0.053	0.943GluTrp: 0.943 ± 0.021	1.394GluTyr: 1.394 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.514PheAla: 4.514 ± 0.044	0.395PheCys: 0.395 ± 0.013	2.535PheAsp: 2.535 ± 0.031	2.013PheGlu: 2.013 ± 0.035	1.19PhePhe: 1.19 ± 0.025	3.51PheGly: 3.51 ± 0.041	0.741PheHis: 0.741 ± 0.019	0.932PheIle: 0.932 ± 0.022	1.139PheLys: 1.139 ± 0.024	3.23PheLeu: 3.23 ± 0.046	0.471PheMet: 0.471 ± 0.015	0.982PheAsn: 0.982 ± 0.021	1.79PhePro: 1.79 ± 0.029	1.002PheGln: 1.002 ± 0.017	2.634PheArg: 2.634 ± 0.039	1.735PheSer: 1.735 ± 0.032	2.232PheThr: 2.232 ± 0.034	3.07PheVal: 3.07 ± 0.037	0.534PheTrp: 0.534 ± 0.017	0.763PheTyr: 0.763 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	10.392GlyAla: 10.392 ± 0.1	1.117GlyCys: 1.117 ± 0.024	4.557GlyAsp: 4.557 ± 0.055	4.506GlyGlu: 4.506 ± 0.047	3.228GlyPhe: 3.228 ± 0.04	8.474GlyGly: 8.474 ± 0.117	1.85GlyHis: 1.85 ± 0.028	2.742GlyIle: 2.742 ± 0.041	3.979GlyLys: 3.979 ± 0.057	8.024GlyLeu: 8.024 ± 0.067	1.617GlyMet: 1.617 ± 0.027	2.21GlyAsn: 2.21 ± 0.043	4.604GlyPro: 4.604 ± 0.053	2.532GlyGln: 2.532 ± 0.04	6.686GlyArg: 6.686 ± 0.057	4.492GlySer: 4.492 ± 0.051	5.961GlyThr: 5.961 ± 0.084	6.737GlyVal: 6.737 ± 0.057	1.613GlyTrp: 1.613 ± 0.029	2.267GlyTyr: 2.267 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.319HisAla: 2.319 ± 0.034	0.271HisCys: 0.271 ± 0.011	1.132HisAsp: 1.132 ± 0.022	1.131HisGlu: 1.131 ± 0.022	0.788HisPhe: 0.788 ± 0.02	1.772HisGly: 1.772 ± 0.032	0.555HisHis: 0.555 ± 0.016	0.673HisIle: 0.673 ± 0.016	0.609HisLys: 0.609 ± 0.019	2.194HisLeu: 2.194 ± 0.034	0.288HisMet: 0.288 ± 0.013	0.547HisAsn: 0.547 ± 0.016	1.63HisPro: 1.63 ± 0.028	0.55HisGln: 0.55 ± 0.015	1.587HisArg: 1.587 ± 0.034	0.861HisSer: 0.861 ± 0.018	1.172HisThr: 1.172 ± 0.023	1.563HisVal: 1.563 ± 0.025	0.362HisTrp: 0.362 ± 0.012	0.493HisTyr: 0.493 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.156IleAla: 4.156 ± 0.045	0.361IleCys: 0.361 ± 0.013	2.378IleAsp: 2.378 ± 0.033	2.38IleGlu: 2.38 ± 0.038	0.866IlePhe: 0.866 ± 0.021	3.299IleGly: 3.299 ± 0.04	0.638IleHis: 0.638 ± 0.018	0.997IleIle: 0.997 ± 0.025	1.185IleLys: 1.185 ± 0.027	2.575IleLeu: 2.575 ± 0.038	0.409IleMet: 0.409 ± 0.015	0.909IleAsn: 0.909 ± 0.022	1.831IlePro: 1.831 ± 0.033	0.908IleGln: 0.908 ± 0.024	2.428IleArg: 2.428 ± 0.039	1.489IleSer: 1.489 ± 0.028	2.058IleThr: 2.058 ± 0.036	2.624IleVal: 2.624 ± 0.035	0.365IleTrp: 0.365 ± 0.012	0.7IleTyr: 0.7 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.446LysAla: 4.446 ± 0.062	0.335LysCys: 0.335 ± 0.013	2.202LysAsp: 2.202 ± 0.043	2.321LysGlu: 2.321 ± 0.048	1.202LysPhe: 1.202 ± 0.025	3.043LysGly: 3.043 ± 0.047	0.784LysHis: 0.784 ± 0.019	1.254LysIle: 1.254 ± 0.028	2.317LysLys: 2.317 ± 0.05	4.294LysLeu: 4.294 ± 0.057	0.973LysMet: 0.973 ± 0.02	1.015LysAsn: 1.015 ± 0.023	2.932LysPro: 2.932 ± 0.044	1.354LysGln: 1.354 ± 0.028	2.594LysArg: 2.594 ± 0.039	1.857LysSer: 1.857 ± 0.029	2.157LysThr: 2.157 ± 0.037	3.28LysVal: 3.28 ± 0.042	0.601LysTrp: 0.601 ± 0.017	0.928LysTyr: 0.928 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.712LeuAla: 13.712 ± 0.114	1.078LeuCys: 1.078 ± 0.021	5.698LeuAsp: 5.698 ± 0.057	4.858LeuGlu: 4.858 ± 0.062	3.446LeuPhe: 3.446 ± 0.046	8.022LeuGly: 8.022 ± 0.062	1.857LeuHis: 1.857 ± 0.029	3.548LeuIle: 3.548 ± 0.042	4.196LeuLys: 4.196 ± 0.06	10.006LeuLeu: 10.006 ± 0.086	1.551LeuMet: 1.551 ± 0.03	2.604LeuAsn: 2.604 ± 0.036	6.102LeuPro: 6.102 ± 0.055	2.387LeuGln: 2.387 ± 0.036	7.293LeuArg: 7.293 ± 0.067	5.062LeuSer: 5.062 ± 0.048	6.535LeuThr: 6.535 ± 0.062	8.131LeuVal: 8.131 ± 0.067	1.242LeuTrp: 1.242 ± 0.023	1.971LeuTyr: 1.971 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	1.857MetAla: 1.857 ± 0.031	0.188MetCys: 0.188 ± 0.009	0.719MetAsp: 0.719 ± 0.018	0.699MetGlu: 0.699 ± 0.019	0.558MetPhe: 0.558 ± 0.016	1.206MetGly: 1.206 ± 0.025	0.324MetHis: 0.324 ± 0.012	0.638MetIle: 0.638 ± 0.017	0.75MetLys: 0.75 ± 0.018	1.586MetLeu: 1.586 ± 0.03	0.344MetMet: 0.344 ± 0.015	0.569MetAsn: 0.569 ± 0.017	1.221MetPro: 1.221 ± 0.022	0.45MetGln: 0.45 ± 0.014	1.366MetArg: 1.366 ± 0.022	1.243MetSer: 1.243 ± 0.022	1.143MetThr: 1.143 ± 0.025	1.117MetVal: 1.117 ± 0.026	0.213MetTrp: 0.213 ± 0.01	0.356MetTyr: 0.356 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.767AsnAla: 2.767 ± 0.036	0.282AsnCys: 0.282 ± 0.011	1.399AsnAsp: 1.399 ± 0.029	1.289AsnGlu: 1.289 ± 0.026	0.832AsnPhe: 0.832 ± 0.017	2.583AsnGly: 2.583 ± 0.046	0.528AsnHis: 0.528 ± 0.015	0.816AsnIle: 0.816 ± 0.017	0.896AsnLys: 0.896 ± 0.022	2.431AsnLeu: 2.431 ± 0.032	0.407AsnMet: 0.407 ± 0.014	0.834AsnAsn: 0.834 ± 0.028	2.106AsnPro: 2.106 ± 0.035	0.794AsnGln: 0.794 ± 0.023	1.949AsnArg: 1.949 ± 0.028	1.132AsnSer: 1.132 ± 0.024	1.391AsnThr: 1.391 ± 0.028	2.007AsnVal: 2.007 ± 0.034	0.458AsnTrp: 0.458 ± 0.015	0.66AsnTyr: 0.66 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	8.729ProAla: 8.729 ± 0.083	0.427ProCys: 0.427 ± 0.013	4.611ProAsp: 4.611 ± 0.049	4.166ProGlu: 4.166 ± 0.047	2.117ProPhe: 2.117 ± 0.028	5.788ProGly: 5.788 ± 0.062	1.332ProHis: 1.332 ± 0.026	1.758ProIle: 1.758 ± 0.027	2.755ProLys: 2.755 ± 0.052	5.28ProLeu: 5.28 ± 0.046	0.907ProMet: 0.907 ± 0.023	1.912ProAsn: 1.912 ± 0.033	4.95ProPro: 4.95 ± 0.074	1.716ProGln: 1.716 ± 0.028	3.775ProArg: 3.775 ± 0.042	2.913ProSer: 2.913 ± 0.042	3.593ProThr: 3.593 ± 0.046	5.407ProVal: 5.407 ± 0.06	0.792ProTrp: 0.792 ± 0.02	1.151ProTyr: 1.151 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.203GlnAla: 3.203 ± 0.043	0.287GlnCys: 0.287 ± 0.012	1.176GlnAsp: 1.176 ± 0.023	1.397GlnGlu: 1.397 ± 0.026	1.286GlnPhe: 1.286 ± 0.023	1.879GlnGly: 1.879 ± 0.033	0.634GlnHis: 0.634 ± 0.018	1.272GlnIle: 1.272 ± 0.025	1.39GlnLys: 1.39 ± 0.027	3.256GlnLeu: 3.256 ± 0.039	0.647GlnMet: 0.647 ± 0.018	0.819GlnAsn: 0.819 ± 0.019	1.985GlnPro: 1.985 ± 0.032	1.156GlnGln: 1.156 ± 0.029	2.071GlnArg: 2.071 ± 0.035	1.397GlnSer: 1.397 ± 0.029	1.628GlnThr: 1.628 ± 0.031	2.459GlnVal: 2.459 ± 0.035	0.466GlnTrp: 0.466 ± 0.015	0.653GlnTyr: 0.653 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.032ArgAla: 9.032 ± 0.094	0.85ArgCys: 0.85 ± 0.024	4.305ArgAsp: 4.305 ± 0.043	4.417ArgGlu: 4.417 ± 0.049	2.977ArgPhe: 2.977 ± 0.039	5.544ArgGly: 5.544 ± 0.049	1.671ArgHis: 1.671 ± 0.033	2.489ArgIle: 2.489 ± 0.036	2.657ArgLys: 2.657 ± 0.039	7.756ArgLeu: 7.756 ± 0.077	1.428ArgMet: 1.428 ± 0.026	1.778ArgAsn: 1.778 ± 0.033	4.533ArgPro: 4.533 ± 0.05	2.271ArgGln: 2.271 ± 0.033	6.0ArgArg: 6.0 ± 0.066	3.487ArgSer: 3.487 ± 0.039	4.325ArgThr: 4.325 ± 0.046	6.306ArgVal: 6.306 ± 0.055	1.28ArgTrp: 1.28 ± 0.027	1.896ArgTyr: 1.896 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	5.832SerAla: 5.832 ± 0.059	0.477SerCys: 0.477 ± 0.015	2.783SerAsp: 2.783 ± 0.033	2.517SerGlu: 2.517 ± 0.034	1.698SerPhe: 1.698 ± 0.027	5.314SerGly: 5.314 ± 0.064	0.946SerHis: 0.946 ± 0.022	1.46SerIle: 1.46 ± 0.025	1.587SerLys: 1.587 ± 0.031	4.145SerLeu: 4.145 ± 0.043	0.773SerMet: 0.773 ± 0.019	1.299SerAsn: 1.299 ± 0.027	3.136SerPro: 3.136 ± 0.042	1.227SerGln: 1.227 ± 0.027	3.281SerArg: 3.281 ± 0.043	2.408SerSer: 2.408 ± 0.039	2.531SerThr: 2.531 ± 0.039	3.856SerVal: 3.856 ± 0.045	0.692SerTrp: 0.692 ± 0.019	1.109SerTyr: 1.109 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	7.422ThrAla: 7.422 ± 0.073	0.545ThrCys: 0.545 ± 0.017	3.56ThrAsp: 3.56 ± 0.051	2.936ThrGlu: 2.936 ± 0.033	2.306ThrPhe: 2.306 ± 0.034	5.944ThrGly: 5.944 ± 0.088	1.19ThrHis: 1.19 ± 0.023	2.0ThrIle: 2.0 ± 0.036	2.007ThrLys: 2.007 ± 0.036	5.53ThrLeu: 5.53 ± 0.064	0.777ThrMet: 0.777 ± 0.018	1.515ThrAsn: 1.515 ± 0.031	3.92ThrPro: 3.92 ± 0.043	1.468ThrGln: 1.468 ± 0.026	3.826ThrArg: 3.826 ± 0.037	2.511ThrSer: 2.511 ± 0.039	3.2ThrThr: 3.2 ± 0.058	5.39ThrVal: 5.39 ± 0.073	0.798ThrTrp: 0.798 ± 0.02	1.253ThrTyr: 1.253 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	10.047ValAla: 10.047 ± 0.076	1.087ValCys: 1.087 ± 0.028	3.466ValAsp: 3.466 ± 0.043	4.445ValGlu: 4.445 ± 0.053	2.834ValPhe: 2.834 ± 0.037	6.235ValGly: 6.235 ± 0.056	1.481ValHis: 1.481 ± 0.024	3.043ValIle: 3.043 ± 0.041	3.078ValLys: 3.078 ± 0.045	8.598ValLeu: 8.598 ± 0.069	1.362ValMet: 1.362 ± 0.028	2.077ValAsn: 2.077 ± 0.039	5.28ValPro: 5.28 ± 0.056	2.361ValGln: 2.361 ± 0.034	6.949ValArg: 6.949 ± 0.064	4.366ValSer: 4.366 ± 0.052	5.631ValThr: 5.631 ± 0.073	7.319ValVal: 7.319 ± 0.076	1.387ValTrp: 1.387 ± 0.029	1.933ValTyr: 1.933 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.675TrpAla: 1.675 ± 0.029	0.204TrpCys: 0.204 ± 0.009	0.938TrpAsp: 0.938 ± 0.03	0.755TrpGlu: 0.755 ± 0.018	0.575TrpPhe: 0.575 ± 0.015	1.066TrpGly: 1.066 ± 0.024	0.38TrpHis: 0.38 ± 0.015	0.429TrpIle: 0.429 ± 0.014	0.609TrpLys: 0.609 ± 0.017	1.798TrpLeu: 1.798 ± 0.034	0.307TrpMet: 0.307 ± 0.013	0.451TrpAsn: 0.451 ± 0.014	0.743TrpPro: 0.743 ± 0.019	0.538TrpGln: 0.538 ± 0.014	1.188TrpArg: 1.188 ± 0.022	0.826TrpSer: 0.826 ± 0.018	0.763TrpThr: 0.763 ± 0.023	1.284TrpVal: 1.284 ± 0.024	0.309TrpTrp: 0.309 ± 0.013	0.362TrpTyr: 0.362 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.418TyrAla: 2.418 ± 0.034	0.275TyrCys: 0.275 ± 0.011	1.331TyrAsp: 1.331 ± 0.035	1.266TyrGlu: 1.266 ± 0.024	0.882TyrPhe: 0.882 ± 0.02	1.958TyrGly: 1.958 ± 0.031	0.511TyrHis: 0.511 ± 0.016	0.624TyrIle: 0.624 ± 0.018	0.776TyrLys: 0.776 ± 0.022	2.279TyrLeu: 2.279 ± 0.034	0.322TyrMet: 0.322 ± 0.011	0.616TyrAsn: 0.616 ± 0.019	1.23TyrPro: 1.23 ± 0.027	0.802TyrGln: 0.802 ± 0.02	1.983TyrArg: 1.983 ± 0.031	1.094TyrSer: 1.094 ± 0.022	1.341TyrThr: 1.341 ± 0.034	1.596TyrVal: 1.596 ± 0.031	0.347TyrTrp: 0.347 ± 0.012	0.619TyrTyr: 0.619 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6809 proteins (2352850 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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