Amino acid dipepetide frequency for Mycobacterium phage Vanisoa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.575AlaAla: 12.575 ± 1.193
0.359AlaCys: 0.359 ± 0.163
5.09AlaAsp: 5.09 ± 0.506
7.365AlaGlu: 7.365 ± 0.898
3.832AlaPhe: 3.832 ± 0.511
8.503AlaGly: 8.503 ± 0.757
2.096AlaHis: 2.096 ± 0.287
4.671AlaIle: 4.671 ± 0.489
5.329AlaLys: 5.329 ± 0.568
9.401AlaLeu: 9.401 ± 0.789
2.934AlaMet: 2.934 ± 0.357
3.593AlaAsn: 3.593 ± 0.489
5.329AlaPro: 5.329 ± 0.672
3.832AlaGln: 3.832 ± 0.491
6.287AlaArg: 6.287 ± 0.735
5.09AlaSer: 5.09 ± 0.447
5.569AlaThr: 5.569 ± 0.627
7.425AlaVal: 7.425 ± 0.628
1.737AlaTrp: 1.737 ± 0.33
2.515AlaTyr: 2.515 ± 0.338
0.0AlaXaa: 0.0 ± 0.0
Cys
0.778CysAla: 0.778 ± 0.236
0.06CysCys: 0.06 ± 0.059
0.599CysAsp: 0.599 ± 0.164
0.419CysGlu: 0.419 ± 0.174
0.24CysPhe: 0.24 ± 0.102
0.419CysGly: 0.419 ± 0.153
0.18CysHis: 0.18 ± 0.089
0.359CysIle: 0.359 ± 0.171
0.12CysLys: 0.12 ± 0.08
0.419CysLeu: 0.419 ± 0.166
0.18CysMet: 0.18 ± 0.102
0.479CysAsn: 0.479 ± 0.155
0.539CysPro: 0.539 ± 0.201
0.18CysGln: 0.18 ± 0.103
0.539CysArg: 0.539 ± 0.13
0.719CysSer: 0.719 ± 0.178
0.479CysThr: 0.479 ± 0.173
0.419CysVal: 0.419 ± 0.121
0.299CysTrp: 0.299 ± 0.143
0.359CysTyr: 0.359 ± 0.143
0.0CysXaa: 0.0 ± 0.0
Asp
6.467AspAla: 6.467 ± 0.603
0.659AspCys: 0.659 ± 0.219
3.174AspAsp: 3.174 ± 0.398
4.072AspGlu: 4.072 ± 0.499
2.814AspPhe: 2.814 ± 0.496
5.21AspGly: 5.21 ± 0.54
1.138AspHis: 1.138 ± 0.294
3.413AspIle: 3.413 ± 0.487
2.395AspLys: 2.395 ± 0.4
6.168AspLeu: 6.168 ± 0.642
1.018AspMet: 1.018 ± 0.258
1.737AspAsn: 1.737 ± 0.305
3.832AspPro: 3.832 ± 0.559
2.036AspGln: 2.036 ± 0.318
3.054AspArg: 3.054 ± 0.409
3.593AspSer: 3.593 ± 0.366
4.012AspThr: 4.012 ± 0.431
4.551AspVal: 4.551 ± 0.5
1.257AspTrp: 1.257 ± 0.292
2.395AspTyr: 2.395 ± 0.426
0.0AspXaa: 0.0 ± 0.0
Glu
6.407GluAla: 6.407 ± 0.592
0.24GluCys: 0.24 ± 0.114
4.491GluAsp: 4.491 ± 0.622
4.371GluGlu: 4.371 ± 0.549
2.036GluPhe: 2.036 ± 0.337
5.09GluGly: 5.09 ± 0.623
1.497GluHis: 1.497 ± 0.348
3.713GluIle: 3.713 ± 0.381
2.635GluLys: 2.635 ± 0.522
6.467GluLeu: 6.467 ± 0.573
1.976GluMet: 1.976 ± 0.305
2.335GluAsn: 2.335 ± 0.475
2.455GluPro: 2.455 ± 0.452
2.096GluGln: 2.096 ± 0.289
4.012GluArg: 4.012 ± 0.669
2.814GluSer: 2.814 ± 0.354
3.353GluThr: 3.353 ± 0.466
4.431GluVal: 4.431 ± 0.414
1.737GluTrp: 1.737 ± 0.387
2.036GluTyr: 2.036 ± 0.343
0.0GluXaa: 0.0 ± 0.0
Phe
3.234PheAla: 3.234 ± 0.616
0.299PheCys: 0.299 ± 0.147
2.754PheAsp: 2.754 ± 0.443
3.054PheGlu: 3.054 ± 0.44
0.838PhePhe: 0.838 ± 0.232
3.114PheGly: 3.114 ± 0.38
0.659PheHis: 0.659 ± 0.237
1.737PheIle: 1.737 ± 0.318
0.958PheLys: 0.958 ± 0.236
2.216PheLeu: 2.216 ± 0.377
0.898PheMet: 0.898 ± 0.24
1.976PheAsn: 1.976 ± 0.27
1.497PhePro: 1.497 ± 0.285
1.018PheGln: 1.018 ± 0.245
1.617PheArg: 1.617 ± 0.285
1.976PheSer: 1.976 ± 0.298
2.275PheThr: 2.275 ± 0.315
1.976PheVal: 1.976 ± 0.358
0.719PheTrp: 0.719 ± 0.209
1.018PheTyr: 1.018 ± 0.229
0.0PheXaa: 0.0 ± 0.0
Gly
7.246GlyAla: 7.246 ± 0.875
1.018GlyCys: 1.018 ± 0.23
5.629GlyAsp: 5.629 ± 0.652
4.251GlyGlu: 4.251 ± 0.495
3.174GlyPhe: 3.174 ± 0.438
9.701GlyGly: 9.701 ± 1.556
1.677GlyHis: 1.677 ± 0.287
3.892GlyIle: 3.892 ± 0.58
3.892GlyLys: 3.892 ± 0.472
6.467GlyLeu: 6.467 ± 0.644
2.635GlyMet: 2.635 ± 0.535
3.293GlyAsn: 3.293 ± 0.48
3.832GlyPro: 3.832 ± 0.434
2.874GlyGln: 2.874 ± 0.485
4.192GlyArg: 4.192 ± 0.354
5.449GlySer: 5.449 ± 0.958
4.85GlyThr: 4.85 ± 0.625
6.527GlyVal: 6.527 ± 0.54
1.677GlyTrp: 1.677 ± 0.266
2.335GlyTyr: 2.335 ± 0.461
0.0GlyXaa: 0.0 ± 0.0
His
1.557HisAla: 1.557 ± 0.303
0.24HisCys: 0.24 ± 0.117
1.198HisAsp: 1.198 ± 0.322
0.958HisGlu: 0.958 ± 0.213
0.359HisPhe: 0.359 ± 0.132
1.437HisGly: 1.437 ± 0.31
0.599HisHis: 0.599 ± 0.167
0.719HisIle: 0.719 ± 0.187
0.958HisLys: 0.958 ± 0.225
1.078HisLeu: 1.078 ± 0.343
0.479HisMet: 0.479 ± 0.194
0.539HisAsn: 0.539 ± 0.178
1.497HisPro: 1.497 ± 0.291
0.958HisGln: 0.958 ± 0.269
1.018HisArg: 1.018 ± 0.248
0.838HisSer: 0.838 ± 0.185
1.138HisThr: 1.138 ± 0.237
1.617HisVal: 1.617 ± 0.287
0.479HisTrp: 0.479 ± 0.174
0.719HisTyr: 0.719 ± 0.285
0.0HisXaa: 0.0 ± 0.0
Ile
4.491IleAla: 4.491 ± 0.502
0.479IleCys: 0.479 ± 0.152
3.832IleAsp: 3.832 ± 0.39
4.132IleGlu: 4.132 ± 0.53
1.377IlePhe: 1.377 ± 0.3
4.311IleGly: 4.311 ± 0.459
0.838IleHis: 0.838 ± 0.21
1.737IleIle: 1.737 ± 0.3
2.455IleLys: 2.455 ± 0.44
3.832IleLeu: 3.832 ± 0.458
0.719IleMet: 0.719 ± 0.174
2.335IleAsn: 2.335 ± 0.406
3.653IlePro: 3.653 ± 0.418
1.138IleGln: 1.138 ± 0.231
3.473IleArg: 3.473 ± 0.39
2.455IleSer: 2.455 ± 0.336
4.012IleThr: 4.012 ± 0.531
3.653IleVal: 3.653 ± 0.536
0.479IleTrp: 0.479 ± 0.161
1.317IleTyr: 1.317 ± 0.264
0.0IleXaa: 0.0 ± 0.0
Lys
5.03LysAla: 5.03 ± 0.529
0.18LysCys: 0.18 ± 0.1
1.916LysAsp: 1.916 ± 0.266
2.335LysGlu: 2.335 ± 0.367
1.138LysPhe: 1.138 ± 0.257
3.593LysGly: 3.593 ± 0.51
0.599LysHis: 0.599 ± 0.203
2.156LysIle: 2.156 ± 0.375
2.275LysLys: 2.275 ± 0.38
4.012LysLeu: 4.012 ± 0.535
1.078LysMet: 1.078 ± 0.273
1.018LysAsn: 1.018 ± 0.273
2.335LysPro: 2.335 ± 0.413
1.677LysGln: 1.677 ± 0.341
3.952LysArg: 3.952 ± 0.6
2.096LysSer: 2.096 ± 0.316
2.695LysThr: 2.695 ± 0.29
3.832LysVal: 3.832 ± 0.511
0.838LysTrp: 0.838 ± 0.249
1.377LysTyr: 1.377 ± 0.293
0.0LysXaa: 0.0 ± 0.0
Leu
10.12LeuAla: 10.12 ± 0.945
0.838LeuCys: 0.838 ± 0.229
4.671LeuAsp: 4.671 ± 0.548
4.91LeuGlu: 4.91 ± 0.506
2.335LeuPhe: 2.335 ± 0.349
6.347LeuGly: 6.347 ± 0.703
1.078LeuHis: 1.078 ± 0.304
3.952LeuIle: 3.952 ± 0.473
3.413LeuLys: 3.413 ± 0.365
5.509LeuLeu: 5.509 ± 0.592
2.515LeuMet: 2.515 ± 0.394
3.174LeuAsn: 3.174 ± 0.339
4.97LeuPro: 4.97 ± 0.571
2.754LeuGln: 2.754 ± 0.519
5.449LeuArg: 5.449 ± 0.507
5.449LeuSer: 5.449 ± 0.424
6.347LeuThr: 6.347 ± 0.534
4.251LeuVal: 4.251 ± 0.451
1.437LeuTrp: 1.437 ± 0.27
1.976LeuTyr: 1.976 ± 0.402
0.0LeuXaa: 0.0 ± 0.0
Met
2.994MetAla: 2.994 ± 0.433
0.299MetCys: 0.299 ± 0.142
1.138MetAsp: 1.138 ± 0.308
2.036MetGlu: 2.036 ± 0.356
0.479MetPhe: 0.479 ± 0.145
2.036MetGly: 2.036 ± 0.406
0.419MetHis: 0.419 ± 0.167
1.317MetIle: 1.317 ± 0.304
1.437MetLys: 1.437 ± 0.255
1.317MetLeu: 1.317 ± 0.294
0.599MetMet: 0.599 ± 0.295
1.018MetAsn: 1.018 ± 0.235
1.497MetPro: 1.497 ± 0.261
1.018MetGln: 1.018 ± 0.233
1.497MetArg: 1.497 ± 0.313
2.455MetSer: 2.455 ± 0.408
1.856MetThr: 1.856 ± 0.333
1.317MetVal: 1.317 ± 0.331
0.419MetTrp: 0.419 ± 0.147
0.479MetTyr: 0.479 ± 0.183
0.0MetXaa: 0.0 ± 0.0
Asn
4.012AsnAla: 4.012 ± 0.417
0.18AsnCys: 0.18 ± 0.093
1.497AsnAsp: 1.497 ± 0.279
2.096AsnGlu: 2.096 ± 0.395
1.497AsnPhe: 1.497 ± 0.324
3.234AsnGly: 3.234 ± 0.427
1.078AsnHis: 1.078 ± 0.265
1.737AsnIle: 1.737 ± 0.281
1.018AsnLys: 1.018 ± 0.272
3.054AsnLeu: 3.054 ± 0.381
0.958AsnMet: 0.958 ± 0.201
1.018AsnAsn: 1.018 ± 0.25
2.575AsnPro: 2.575 ± 0.34
0.838AsnGln: 0.838 ± 0.212
2.275AsnArg: 2.275 ± 0.426
2.216AsnSer: 2.216 ± 0.429
2.275AsnThr: 2.275 ± 0.36
2.754AsnVal: 2.754 ± 0.469
0.778AsnTrp: 0.778 ± 0.218
0.958AsnTyr: 0.958 ± 0.239
0.0AsnXaa: 0.0 ± 0.0
Pro
5.509ProAla: 5.509 ± 0.673
0.299ProCys: 0.299 ± 0.159
3.593ProAsp: 3.593 ± 0.447
4.012ProGlu: 4.012 ± 0.48
2.096ProPhe: 2.096 ± 0.308
4.671ProGly: 4.671 ± 0.533
0.958ProHis: 0.958 ± 0.266
3.174ProIle: 3.174 ± 0.383
2.156ProLys: 2.156 ± 0.409
3.054ProLeu: 3.054 ± 0.402
1.198ProMet: 1.198 ± 0.257
2.156ProAsn: 2.156 ± 0.387
1.976ProPro: 1.976 ± 0.323
1.377ProGln: 1.377 ± 0.257
2.934ProArg: 2.934 ± 0.482
2.754ProSer: 2.754 ± 0.34
4.371ProThr: 4.371 ± 0.511
3.892ProVal: 3.892 ± 0.478
0.659ProTrp: 0.659 ± 0.195
1.557ProTyr: 1.557 ± 0.278
0.0ProXaa: 0.0 ± 0.0
Gln
4.731GlnAla: 4.731 ± 0.554
0.12GlnCys: 0.12 ± 0.09
1.497GlnAsp: 1.497 ± 0.302
1.138GlnGlu: 1.138 ± 0.258
1.018GlnPhe: 1.018 ± 0.199
2.994GlnGly: 2.994 ± 0.448
0.659GlnHis: 0.659 ± 0.182
2.395GlnIle: 2.395 ± 0.314
1.617GlnLys: 1.617 ± 0.298
2.934GlnLeu: 2.934 ± 0.531
1.138GlnMet: 1.138 ± 0.325
0.719GlnAsn: 0.719 ± 0.204
1.138GlnPro: 1.138 ± 0.235
1.617GlnGln: 1.617 ± 0.409
2.635GlnArg: 2.635 ± 0.346
2.335GlnSer: 2.335 ± 0.353
2.395GlnThr: 2.395 ± 0.368
1.856GlnVal: 1.856 ± 0.334
0.838GlnTrp: 0.838 ± 0.218
1.138GlnTyr: 1.138 ± 0.277
0.0GlnXaa: 0.0 ± 0.0
Arg
4.79ArgAla: 4.79 ± 0.463
0.778ArgCys: 0.778 ± 0.228
4.491ArgAsp: 4.491 ± 0.472
4.431ArgGlu: 4.431 ± 0.55
2.754ArgPhe: 2.754 ± 0.438
4.132ArgGly: 4.132 ± 0.547
1.138ArgHis: 1.138 ± 0.263
3.772ArgIle: 3.772 ± 0.529
2.874ArgLys: 2.874 ± 0.486
5.509ArgLeu: 5.509 ± 0.559
1.976ArgMet: 1.976 ± 0.337
2.275ArgAsn: 2.275 ± 0.309
2.575ArgPro: 2.575 ± 0.338
2.635ArgGln: 2.635 ± 0.361
5.389ArgArg: 5.389 ± 0.709
2.934ArgSer: 2.934 ± 0.471
2.814ArgThr: 2.814 ± 0.306
4.072ArgVal: 4.072 ± 0.546
1.377ArgTrp: 1.377 ± 0.241
1.557ArgTyr: 1.557 ± 0.295
0.0ArgXaa: 0.0 ± 0.0
Ser
5.689SerAla: 5.689 ± 0.564
0.299SerCys: 0.299 ± 0.145
3.952SerAsp: 3.952 ± 0.461
3.713SerGlu: 3.713 ± 0.457
2.156SerPhe: 2.156 ± 0.305
5.689SerGly: 5.689 ± 0.721
0.719SerHis: 0.719 ± 0.171
2.036SerIle: 2.036 ± 0.347
2.635SerLys: 2.635 ± 0.382
4.431SerLeu: 4.431 ± 0.625
1.737SerMet: 1.737 ± 0.303
1.617SerAsn: 1.617 ± 0.352
2.635SerPro: 2.635 ± 0.378
2.275SerGln: 2.275 ± 0.287
3.892SerArg: 3.892 ± 0.45
3.174SerSer: 3.174 ± 0.496
2.635SerThr: 2.635 ± 0.49
4.132SerVal: 4.132 ± 0.463
1.377SerTrp: 1.377 ± 0.292
1.617SerTyr: 1.617 ± 0.345
0.0SerXaa: 0.0 ± 0.0
Thr
6.467ThrAla: 6.467 ± 0.535
0.299ThrCys: 0.299 ± 0.116
4.311ThrAsp: 4.311 ± 0.509
2.994ThrGlu: 2.994 ± 0.394
2.216ThrPhe: 2.216 ± 0.34
5.928ThrGly: 5.928 ± 0.749
1.198ThrHis: 1.198 ± 0.266
3.413ThrIle: 3.413 ± 0.417
3.413ThrLys: 3.413 ± 0.429
5.389ThrLeu: 5.389 ± 0.54
1.018ThrMet: 1.018 ± 0.23
1.796ThrAsn: 1.796 ± 0.436
4.371ThrPro: 4.371 ± 0.523
2.096ThrGln: 2.096 ± 0.335
2.754ThrArg: 2.754 ± 0.371
2.814ThrSer: 2.814 ± 0.494
3.952ThrThr: 3.952 ± 0.46
5.389ThrVal: 5.389 ± 0.609
1.198ThrTrp: 1.198 ± 0.299
1.976ThrTyr: 1.976 ± 0.304
0.0ThrXaa: 0.0 ± 0.0
Val
6.467ValAla: 6.467 ± 0.664
0.659ValCys: 0.659 ± 0.192
5.749ValAsp: 5.749 ± 0.708
4.551ValGlu: 4.551 ± 0.619
2.036ValPhe: 2.036 ± 0.399
5.15ValGly: 5.15 ± 0.578
1.257ValHis: 1.257 ± 0.302
3.832ValIle: 3.832 ± 0.477
3.234ValLys: 3.234 ± 0.41
5.689ValLeu: 5.689 ± 0.706
1.257ValMet: 1.257 ± 0.274
3.353ValAsn: 3.353 ± 0.495
3.653ValPro: 3.653 ± 0.526
2.275ValGln: 2.275 ± 0.327
4.311ValArg: 4.311 ± 0.379
4.431ValSer: 4.431 ± 0.487
4.79ValThr: 4.79 ± 0.426
4.611ValVal: 4.611 ± 0.501
1.437ValTrp: 1.437 ± 0.313
1.497ValTyr: 1.497 ± 0.293
0.0ValXaa: 0.0 ± 0.0
Trp
2.096TrpAla: 2.096 ± 0.392
0.299TrpCys: 0.299 ± 0.13
1.557TrpAsp: 1.557 ± 0.306
1.617TrpGlu: 1.617 ± 0.323
0.539TrpPhe: 0.539 ± 0.174
1.138TrpGly: 1.138 ± 0.275
0.299TrpHis: 0.299 ± 0.168
1.317TrpIle: 1.317 ± 0.266
0.659TrpLys: 0.659 ± 0.155
1.497TrpLeu: 1.497 ± 0.302
0.778TrpMet: 0.778 ± 0.227
0.599TrpAsn: 0.599 ± 0.205
0.778TrpPro: 0.778 ± 0.202
1.138TrpGln: 1.138 ± 0.25
0.838TrpArg: 0.838 ± 0.212
1.317TrpSer: 1.317 ± 0.246
1.198TrpThr: 1.198 ± 0.283
0.958TrpVal: 0.958 ± 0.216
0.479TrpTrp: 0.479 ± 0.183
0.419TrpTyr: 0.419 ± 0.141
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.874TyrAla: 2.874 ± 0.434
0.18TyrCys: 0.18 ± 0.117
1.856TyrAsp: 1.856 ± 0.354
1.737TyrGlu: 1.737 ± 0.301
0.898TyrPhe: 0.898 ± 0.23
1.916TyrGly: 1.916 ± 0.311
0.299TyrHis: 0.299 ± 0.144
1.377TyrIle: 1.377 ± 0.238
0.659TyrLys: 0.659 ± 0.218
3.054TyrLeu: 3.054 ± 0.426
0.479TyrMet: 0.479 ± 0.163
1.018TyrAsn: 1.018 ± 0.279
1.257TyrPro: 1.257 ± 0.217
1.078TyrGln: 1.078 ± 0.267
2.156TyrArg: 2.156 ± 0.402
1.557TyrSer: 1.557 ± 0.301
1.976TyrThr: 1.976 ± 0.328
2.575TyrVal: 2.575 ± 0.441
0.299TyrTrp: 0.299 ± 0.13
0.659TyrTyr: 0.659 ± 0.176
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 92 proteins (16701 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski