Amino acid dipepetide frequency for Synechococcus phage ACG-2014h

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.643AlaAla: 6.643 ± 0.483
0.534AlaCys: 0.534 ± 0.102
4.223AlaAsp: 4.223 ± 0.276
3.972AlaGlu: 3.972 ± 0.295
2.72AlaPhe: 2.72 ± 0.23
6.509AlaGly: 6.509 ± 0.546
0.901AlaHis: 0.901 ± 0.15
4.389AlaIle: 4.389 ± 0.307
3.772AlaLys: 3.772 ± 0.424
4.773AlaLeu: 4.773 ± 0.358
1.335AlaMet: 1.335 ± 0.181
4.239AlaAsn: 4.239 ± 0.392
2.954AlaPro: 2.954 ± 0.284
2.236AlaGln: 2.236 ± 0.204
2.504AlaArg: 2.504 ± 0.238
5.558AlaSer: 5.558 ± 0.42
5.958AlaThr: 5.958 ± 0.437
4.74AlaVal: 4.74 ± 0.321
0.517AlaTrp: 0.517 ± 0.104
2.57AlaTyr: 2.57 ± 0.246
0.0AlaXaa: 0.0 ± 0.0
Cys
0.584CysAla: 0.584 ± 0.092
0.134CysCys: 0.134 ± 0.046
0.718CysAsp: 0.718 ± 0.127
0.517CysGlu: 0.517 ± 0.112
0.384CysPhe: 0.384 ± 0.095
0.634CysGly: 0.634 ± 0.128
0.15CysHis: 0.15 ± 0.053
0.467CysIle: 0.467 ± 0.094
0.467CysLys: 0.467 ± 0.103
0.501CysLeu: 0.501 ± 0.099
0.15CysMet: 0.15 ± 0.053
0.384CysAsn: 0.384 ± 0.08
0.384CysPro: 0.384 ± 0.088
0.417CysGln: 0.417 ± 0.086
0.367CysArg: 0.367 ± 0.088
0.401CysSer: 0.401 ± 0.087
0.601CysThr: 0.601 ± 0.104
0.451CysVal: 0.451 ± 0.104
0.033CysTrp: 0.033 ± 0.026
0.334CysTyr: 0.334 ± 0.079
0.0CysXaa: 0.0 ± 0.0
Asp
4.807AspAla: 4.807 ± 0.318
0.618AspCys: 0.618 ± 0.13
4.64AspAsp: 4.64 ± 0.319
3.772AspGlu: 3.772 ± 0.38
3.171AspPhe: 3.171 ± 0.243
5.675AspGly: 5.675 ± 0.346
0.951AspHis: 0.951 ± 0.134
4.523AspIle: 4.523 ± 0.242
3.321AspLys: 3.321 ± 0.332
4.59AspLeu: 4.59 ± 0.296
1.402AspMet: 1.402 ± 0.217
3.922AspAsn: 3.922 ± 0.349
3.255AspPro: 3.255 ± 0.311
1.853AspGln: 1.853 ± 0.214
2.303AspArg: 2.303 ± 0.221
4.323AspSer: 4.323 ± 0.344
4.723AspThr: 4.723 ± 0.343
4.406AspVal: 4.406 ± 0.226
1.001AspTrp: 1.001 ± 0.182
2.687AspTyr: 2.687 ± 0.328
0.0AspXaa: 0.0 ± 0.0
Glu
3.338GluAla: 3.338 ± 0.264
0.601GluCys: 0.601 ± 0.102
3.755GluAsp: 3.755 ± 0.297
4.356GluGlu: 4.356 ± 0.547
3.121GluPhe: 3.121 ± 0.251
3.922GluGly: 3.922 ± 0.299
0.935GluHis: 0.935 ± 0.138
3.922GluIle: 3.922 ± 0.352
3.638GluLys: 3.638 ± 0.386
4.69GluLeu: 4.69 ± 0.371
1.402GluMet: 1.402 ± 0.208
3.054GluAsn: 3.054 ± 0.228
1.819GluPro: 1.819 ± 0.211
2.003GluGln: 2.003 ± 0.233
2.704GluArg: 2.704 ± 0.227
3.355GluSer: 3.355 ± 0.307
3.739GluThr: 3.739 ± 0.273
4.606GluVal: 4.606 ± 0.291
1.152GluTrp: 1.152 ± 0.174
2.904GluTyr: 2.904 ± 0.251
0.0GluXaa: 0.0 ± 0.0
Phe
2.971PheAla: 2.971 ± 0.25
0.534PheCys: 0.534 ± 0.121
3.739PheAsp: 3.739 ± 0.235
2.42PheGlu: 2.42 ± 0.197
1.519PhePhe: 1.519 ± 0.153
3.071PheGly: 3.071 ± 0.271
0.551PheHis: 0.551 ± 0.096
2.37PheIle: 2.37 ± 0.219
2.27PheLys: 2.27 ± 0.221
2.954PheLeu: 2.954 ± 0.217
0.851PheMet: 0.851 ± 0.147
2.988PheAsn: 2.988 ± 0.252
1.602PhePro: 1.602 ± 0.175
1.819PheGln: 1.819 ± 0.181
1.853PheArg: 1.853 ± 0.191
3.004PheSer: 3.004 ± 0.23
3.388PheThr: 3.388 ± 0.275
3.071PheVal: 3.071 ± 0.244
0.417PheTrp: 0.417 ± 0.089
1.719PheTyr: 1.719 ± 0.155
0.0PheXaa: 0.0 ± 0.0
Gly
5.825GlyAla: 5.825 ± 0.481
0.367GlyCys: 0.367 ± 0.08
5.224GlyAsp: 5.224 ± 0.421
4.373GlyGlu: 4.373 ± 0.308
3.121GlyPhe: 3.121 ± 0.252
7.978GlyGly: 7.978 ± 0.748
0.885GlyHis: 0.885 ± 0.123
4.456GlyIle: 4.456 ± 0.304
3.922GlyLys: 3.922 ± 0.296
4.523GlyLeu: 4.523 ± 0.269
1.302GlyMet: 1.302 ± 0.171
5.408GlyAsn: 5.408 ± 0.597
1.903GlyPro: 1.903 ± 0.187
2.787GlyGln: 2.787 ± 0.246
2.537GlyArg: 2.537 ± 0.252
7.511GlySer: 7.511 ± 0.684
7.761GlyThr: 7.761 ± 0.719
5.124GlyVal: 5.124 ± 0.258
1.168GlyTrp: 1.168 ± 0.193
3.004GlyTyr: 3.004 ± 0.237
0.0GlyXaa: 0.0 ± 0.0
His
0.684HisAla: 0.684 ± 0.153
0.167HisCys: 0.167 ± 0.058
0.784HisAsp: 0.784 ± 0.143
1.018HisGlu: 1.018 ± 0.153
0.684HisPhe: 0.684 ± 0.106
1.102HisGly: 1.102 ± 0.177
0.25HisHis: 0.25 ± 0.071
0.835HisIle: 0.835 ± 0.133
0.751HisLys: 0.751 ± 0.118
0.935HisLeu: 0.935 ± 0.151
0.384HisMet: 0.384 ± 0.09
0.684HisAsn: 0.684 ± 0.121
0.784HisPro: 0.784 ± 0.147
0.501HisGln: 0.501 ± 0.096
0.618HisArg: 0.618 ± 0.129
0.885HisSer: 0.885 ± 0.138
1.068HisThr: 1.068 ± 0.168
0.801HisVal: 0.801 ± 0.139
0.1HisTrp: 0.1 ± 0.04
0.784HisTyr: 0.784 ± 0.113
0.0HisXaa: 0.0 ± 0.0
Ile
4.59IleAla: 4.59 ± 0.252
0.567IleCys: 0.567 ± 0.101
4.873IleAsp: 4.873 ± 0.32
4.106IleGlu: 4.106 ± 0.245
2.32IlePhe: 2.32 ± 0.167
4.64IleGly: 4.64 ± 0.43
0.901IleHis: 0.901 ± 0.152
3.905IleIle: 3.905 ± 0.266
3.956IleLys: 3.956 ± 0.381
3.872IleLeu: 3.872 ± 0.251
0.918IleMet: 0.918 ± 0.127
4.189IleAsn: 4.189 ± 0.407
2.537IlePro: 2.537 ± 0.195
2.353IleGln: 2.353 ± 0.188
2.37IleArg: 2.37 ± 0.189
4.44IleSer: 4.44 ± 0.253
5.942IleThr: 5.942 ± 0.483
4.206IleVal: 4.206 ± 0.336
0.668IleTrp: 0.668 ± 0.108
1.986IleTyr: 1.986 ± 0.171
0.0IleXaa: 0.0 ± 0.0
Lys
3.188LysAla: 3.188 ± 0.303
0.467LysCys: 0.467 ± 0.078
3.321LysAsp: 3.321 ± 0.342
3.622LysGlu: 3.622 ± 0.405
2.554LysPhe: 2.554 ± 0.251
2.887LysGly: 2.887 ± 0.288
0.835LysHis: 0.835 ± 0.15
4.423LysIle: 4.423 ± 0.345
4.556LysLys: 4.556 ± 0.554
4.606LysLeu: 4.606 ± 0.394
1.419LysMet: 1.419 ± 0.251
2.954LysAsn: 2.954 ± 0.265
1.702LysPro: 1.702 ± 0.205
2.036LysGln: 2.036 ± 0.243
2.487LysArg: 2.487 ± 0.298
3.104LysSer: 3.104 ± 0.311
3.438LysThr: 3.438 ± 0.266
3.688LysVal: 3.688 ± 0.297
0.584LysTrp: 0.584 ± 0.104
2.871LysTyr: 2.871 ± 0.298
0.0LysXaa: 0.0 ± 0.0
Leu
4.807LeuAla: 4.807 ± 0.261
0.517LeuCys: 0.517 ± 0.112
4.957LeuAsp: 4.957 ± 0.31
4.907LeuGlu: 4.907 ± 0.363
2.737LeuPhe: 2.737 ± 0.275
4.957LeuGly: 4.957 ± 0.347
1.152LeuHis: 1.152 ± 0.198
3.989LeuIle: 3.989 ± 0.321
4.139LeuLys: 4.139 ± 0.338
5.374LeuLeu: 5.374 ± 0.432
1.519LeuMet: 1.519 ± 0.193
4.657LeuAsn: 4.657 ± 0.267
3.255LeuPro: 3.255 ± 0.237
2.787LeuGln: 2.787 ± 0.212
3.271LeuArg: 3.271 ± 0.208
5.257LeuSer: 5.257 ± 0.266
5.558LeuThr: 5.558 ± 0.466
4.523LeuVal: 4.523 ± 0.24
0.634LeuTrp: 0.634 ± 0.09
3.004LeuTyr: 3.004 ± 0.251
0.0LeuXaa: 0.0 ± 0.0
Met
1.402MetAla: 1.402 ± 0.22
0.217MetCys: 0.217 ± 0.071
1.135MetAsp: 1.135 ± 0.2
0.918MetGlu: 0.918 ± 0.167
0.985MetPhe: 0.985 ± 0.177
1.051MetGly: 1.051 ± 0.16
0.367MetHis: 0.367 ± 0.103
1.001MetIle: 1.001 ± 0.15
1.535MetLys: 1.535 ± 0.223
1.886MetLeu: 1.886 ± 0.258
0.551MetMet: 0.551 ± 0.129
1.252MetAsn: 1.252 ± 0.209
0.918MetPro: 0.918 ± 0.12
0.768MetGln: 0.768 ± 0.136
0.918MetArg: 0.918 ± 0.134
1.519MetSer: 1.519 ± 0.218
1.702MetThr: 1.702 ± 0.207
1.001MetVal: 1.001 ± 0.133
0.3MetTrp: 0.3 ± 0.083
0.584MetTyr: 0.584 ± 0.126
0.0MetXaa: 0.0 ± 0.0
Asn
4.156AsnAla: 4.156 ± 0.433
0.551AsnCys: 0.551 ± 0.093
3.755AsnAsp: 3.755 ± 0.26
3.138AsnGlu: 3.138 ± 0.246
3.004AsnPhe: 3.004 ± 0.258
5.207AsnGly: 5.207 ± 0.51
1.018AsnHis: 1.018 ± 0.159
4.406AsnIle: 4.406 ± 0.348
2.871AsnLys: 2.871 ± 0.236
4.289AsnLeu: 4.289 ± 0.272
1.085AsnMet: 1.085 ± 0.179
4.173AsnAsn: 4.173 ± 0.432
3.038AsnPro: 3.038 ± 0.216
2.136AsnGln: 2.136 ± 0.188
2.637AsnArg: 2.637 ± 0.205
4.406AsnSer: 4.406 ± 0.471
4.256AsnThr: 4.256 ± 0.463
4.139AsnVal: 4.139 ± 0.379
0.851AsnTrp: 0.851 ± 0.137
2.771AsnTyr: 2.771 ± 0.191
0.0AsnXaa: 0.0 ± 0.0
Pro
2.587ProAla: 2.587 ± 0.238
0.134ProCys: 0.134 ± 0.055
2.587ProAsp: 2.587 ± 0.226
2.587ProGlu: 2.587 ± 0.244
1.769ProPhe: 1.769 ± 0.182
3.438ProGly: 3.438 ± 0.263
0.517ProHis: 0.517 ± 0.113
2.036ProIle: 2.036 ± 0.19
1.836ProLys: 1.836 ± 0.23
2.37ProLeu: 2.37 ± 0.23
0.684ProMet: 0.684 ± 0.136
2.42ProAsn: 2.42 ± 0.171
1.819ProPro: 1.819 ± 0.193
1.369ProGln: 1.369 ± 0.144
1.285ProArg: 1.285 ± 0.143
3.321ProSer: 3.321 ± 0.266
3.705ProThr: 3.705 ± 0.24
2.57ProVal: 2.57 ± 0.2
0.601ProTrp: 0.601 ± 0.122
1.602ProTyr: 1.602 ± 0.208
0.0ProXaa: 0.0 ± 0.0
Gln
2.22GlnAla: 2.22 ± 0.215
0.25GlnCys: 0.25 ± 0.075
1.786GlnAsp: 1.786 ± 0.192
2.236GlnGlu: 2.236 ± 0.224
1.586GlnPhe: 1.586 ± 0.165
2.37GlnGly: 2.37 ± 0.207
0.501GlnHis: 0.501 ± 0.124
2.37GlnIle: 2.37 ± 0.203
2.186GlnLys: 2.186 ± 0.243
3.355GlnLeu: 3.355 ± 0.202
0.985GlnMet: 0.985 ± 0.162
1.936GlnAsn: 1.936 ± 0.178
1.202GlnPro: 1.202 ± 0.132
1.535GlnGln: 1.535 ± 0.154
1.619GlnArg: 1.619 ± 0.15
2.437GlnSer: 2.437 ± 0.211
2.37GlnThr: 2.37 ± 0.264
2.32GlnVal: 2.32 ± 0.205
0.434GlnTrp: 0.434 ± 0.105
1.903GlnTyr: 1.903 ± 0.164
0.0GlnXaa: 0.0 ± 0.0
Arg
2.604ArgAla: 2.604 ± 0.219
0.3ArgCys: 0.3 ± 0.082
2.37ArgAsp: 2.37 ± 0.21
2.303ArgGlu: 2.303 ± 0.225
1.953ArgPhe: 1.953 ± 0.184
3.004ArgGly: 3.004 ± 0.242
0.551ArgHis: 0.551 ± 0.1
2.403ArgIle: 2.403 ± 0.192
2.437ArgLys: 2.437 ± 0.272
3.572ArgLeu: 3.572 ± 0.249
1.001ArgMet: 1.001 ± 0.134
2.186ArgAsn: 2.186 ± 0.199
1.319ArgPro: 1.319 ± 0.147
1.535ArgGln: 1.535 ± 0.174
2.287ArgArg: 2.287 ± 0.245
2.537ArgSer: 2.537 ± 0.187
2.337ArgThr: 2.337 ± 0.186
3.038ArgVal: 3.038 ± 0.242
0.501ArgTrp: 0.501 ± 0.09
2.17ArgTyr: 2.17 ± 0.207
0.0ArgXaa: 0.0 ± 0.0
Ser
5.725SerAla: 5.725 ± 0.473
0.35SerCys: 0.35 ± 0.097
4.573SerAsp: 4.573 ± 0.296
3.688SerGlu: 3.688 ± 0.255
2.837SerPhe: 2.837 ± 0.29
7.995SerGly: 7.995 ± 0.72
0.768SerHis: 0.768 ± 0.12
4.606SerIle: 4.606 ± 0.297
3.688SerLys: 3.688 ± 0.322
4.707SerLeu: 4.707 ± 0.265
1.218SerMet: 1.218 ± 0.181
5.307SerAsn: 5.307 ± 0.471
2.654SerPro: 2.654 ± 0.214
2.303SerGln: 2.303 ± 0.161
2.47SerArg: 2.47 ± 0.183
5.842SerSer: 5.842 ± 0.496
5.825SerThr: 5.825 ± 0.529
4.907SerVal: 4.907 ± 0.369
0.501SerTrp: 0.501 ± 0.103
2.754SerTyr: 2.754 ± 0.205
0.0SerXaa: 0.0 ± 0.0
Thr
5.858ThrAla: 5.858 ± 0.351
0.718ThrCys: 0.718 ± 0.13
4.89ThrAsp: 4.89 ± 0.359
3.905ThrGlu: 3.905 ± 0.259
3.538ThrPhe: 3.538 ± 0.291
7.027ThrGly: 7.027 ± 0.682
0.835ThrHis: 0.835 ± 0.114
5.808ThrIle: 5.808 ± 0.597
3.004ThrLys: 3.004 ± 0.319
6.359ThrLeu: 6.359 ± 0.431
0.985ThrMet: 0.985 ± 0.136
4.223ThrAsn: 4.223 ± 0.405
3.488ThrPro: 3.488 ± 0.255
3.038ThrGln: 3.038 ± 0.287
2.871ThrArg: 2.871 ± 0.271
5.992ThrSer: 5.992 ± 0.618
5.958ThrThr: 5.958 ± 0.674
6.292ThrVal: 6.292 ± 0.654
0.868ThrTrp: 0.868 ± 0.14
3.221ThrTyr: 3.221 ± 0.282
0.0ThrXaa: 0.0 ± 0.0
Val
5.441ValAla: 5.441 ± 0.357
0.451ValCys: 0.451 ± 0.116
4.74ValAsp: 4.74 ± 0.279
4.273ValGlu: 4.273 ± 0.282
2.737ValPhe: 2.737 ± 0.184
4.423ValGly: 4.423 ± 0.319
0.935ValHis: 0.935 ± 0.151
4.072ValIle: 4.072 ± 0.351
3.622ValLys: 3.622 ± 0.237
4.64ValLeu: 4.64 ± 0.27
1.535ValMet: 1.535 ± 0.203
4.039ValAsn: 4.039 ± 0.327
2.687ValPro: 2.687 ± 0.229
2.07ValGln: 2.07 ± 0.211
3.054ValArg: 3.054 ± 0.267
5.207ValSer: 5.207 ± 0.503
6.492ValThr: 6.492 ± 0.695
4.156ValVal: 4.156 ± 0.417
0.484ValTrp: 0.484 ± 0.086
2.52ValTyr: 2.52 ± 0.178
0.0ValXaa: 0.0 ± 0.0
Trp
0.801TrpAla: 0.801 ± 0.112
0.05TrpCys: 0.05 ± 0.025
0.868TrpAsp: 0.868 ± 0.115
0.584TrpGlu: 0.584 ± 0.113
0.35TrpPhe: 0.35 ± 0.086
0.768TrpGly: 0.768 ± 0.167
0.284TrpHis: 0.284 ± 0.103
0.634TrpIle: 0.634 ± 0.119
0.551TrpLys: 0.551 ± 0.1
0.701TrpLeu: 0.701 ± 0.119
0.434TrpMet: 0.434 ± 0.113
0.968TrpAsn: 0.968 ± 0.136
0.25TrpPro: 0.25 ± 0.069
0.501TrpGln: 0.501 ± 0.098
0.501TrpArg: 0.501 ± 0.086
0.851TrpSer: 0.851 ± 0.126
1.001TrpThr: 1.001 ± 0.131
0.818TrpVal: 0.818 ± 0.117
0.15TrpTrp: 0.15 ± 0.05
0.484TrpTyr: 0.484 ± 0.086
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.821TyrAla: 2.821 ± 0.198
0.551TyrCys: 0.551 ± 0.104
3.004TyrAsp: 3.004 ± 0.228
2.337TyrGlu: 2.337 ± 0.272
2.019TyrPhe: 2.019 ± 0.208
2.52TyrGly: 2.52 ± 0.203
0.534TyrHis: 0.534 ± 0.097
2.72TyrIle: 2.72 ± 0.248
2.22TyrLys: 2.22 ± 0.196
3.305TyrLeu: 3.305 ± 0.284
0.835TyrMet: 0.835 ± 0.162
2.904TyrAsn: 2.904 ± 0.234
1.669TyrPro: 1.669 ± 0.136
1.552TyrGln: 1.552 ± 0.165
1.752TyrArg: 1.752 ± 0.2
2.771TyrSer: 2.771 ± 0.298
3.054TyrThr: 3.054 ± 0.259
2.72TyrVal: 2.72 ± 0.197
0.584TyrTrp: 0.584 ± 0.101
1.986TyrTyr: 1.986 ± 0.218
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 221 proteins (59917 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski