Amino acid dipepetide frequency for Apis mellifera associated microvirus 40

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.593AlaAla: 12.593 ± 4.653
0.0AlaCys: 0.0 ± 0.0
4.444AlaAsp: 4.444 ± 1.631
5.926AlaGlu: 5.926 ± 2.15
1.481AlaPhe: 1.481 ± 1.059
5.926AlaGly: 5.926 ± 2.47
2.222AlaHis: 2.222 ± 1.158
4.444AlaIle: 4.444 ± 1.971
2.963AlaLys: 2.963 ± 0.973
9.63AlaLeu: 9.63 ± 2.577
0.0AlaMet: 0.0 ± 0.0
2.963AlaAsn: 2.963 ± 1.523
6.667AlaPro: 6.667 ± 3.423
6.667AlaGln: 6.667 ± 2.947
10.37AlaArg: 10.37 ± 3.039
6.667AlaSer: 6.667 ± 2.121
7.407AlaThr: 7.407 ± 2.848
6.667AlaVal: 6.667 ± 2.278
2.963AlaTrp: 2.963 ± 0.691
2.222AlaTyr: 2.222 ± 1.158
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.741CysAsp: 0.741 ± 0.529
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
2.222CysGly: 2.222 ± 2.5
0.741CysHis: 0.741 ± 0.833
0.0CysIle: 0.0 ± 0.0
1.481CysLys: 1.481 ± 1.443
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.741CysArg: 0.741 ± 0.833
0.741CysSer: 0.741 ± 0.529
0.0CysThr: 0.0 ± 0.0
1.481CysVal: 1.481 ± 1.443
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.704AspAla: 3.704 ± 1.284
0.0AspCys: 0.0 ± 0.0
2.963AspAsp: 2.963 ± 2.296
3.704AspGlu: 3.704 ± 2.28
4.444AspPhe: 4.444 ± 2.143
4.444AspGly: 4.444 ± 2.466
0.0AspHis: 0.0 ± 0.0
1.481AspIle: 1.481 ± 0.819
1.481AspLys: 1.481 ± 1.213
4.444AspLeu: 4.444 ± 2.077
2.963AspMet: 2.963 ± 1.512
1.481AspAsn: 1.481 ± 0.79
2.222AspPro: 2.222 ± 0.955
0.741AspGln: 0.741 ± 0.529
2.222AspArg: 2.222 ± 1.158
0.741AspSer: 0.741 ± 0.529
2.963AspThr: 2.963 ± 0.973
1.481AspVal: 1.481 ± 0.723
0.741AspTrp: 0.741 ± 0.529
3.704AspTyr: 3.704 ± 1.789
0.0AspXaa: 0.0 ± 0.0
Glu
6.667GluAla: 6.667 ± 1.905
0.0GluCys: 0.0 ± 0.0
5.926GluAsp: 5.926 ± 1.13
4.444GluGlu: 4.444 ± 2.559
2.963GluPhe: 2.963 ± 1.629
2.963GluGly: 2.963 ± 2.333
1.481GluHis: 1.481 ± 0.79
4.444GluIle: 4.444 ± 2.119
1.481GluLys: 1.481 ± 0.723
4.444GluLeu: 4.444 ± 0.817
0.741GluMet: 0.741 ± 0.833
1.481GluAsn: 1.481 ± 0.932
1.481GluPro: 1.481 ± 1.118
2.963GluGln: 2.963 ± 1.46
3.704GluArg: 3.704 ± 1.429
2.222GluSer: 2.222 ± 1.039
2.222GluThr: 2.222 ± 0.872
5.185GluVal: 5.185 ± 1.039
2.222GluTrp: 2.222 ± 1.158
4.444GluTyr: 4.444 ± 1.248
0.0GluXaa: 0.0 ± 0.0
Phe
1.481PheAla: 1.481 ± 0.666
0.0PheCys: 0.0 ± 0.0
2.222PheAsp: 2.222 ± 1.768
2.222PheGlu: 2.222 ± 1.512
2.222PhePhe: 2.222 ± 0.955
2.963PheGly: 2.963 ± 1.446
0.0PheHis: 0.0 ± 0.0
2.222PheIle: 2.222 ± 1.588
0.0PheLys: 0.0 ± 0.0
1.481PheLeu: 1.481 ± 0.819
0.741PheMet: 0.741 ± 0.493
0.741PheAsn: 0.741 ± 0.812
1.481PhePro: 1.481 ± 0.723
1.481PheGln: 1.481 ± 0.79
2.963PheArg: 2.963 ± 0.691
5.185PheSer: 5.185 ± 3.524
0.741PheThr: 0.741 ± 0.529
2.963PheVal: 2.963 ± 1.446
0.741PheTrp: 0.741 ± 0.529
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
11.852GlyAla: 11.852 ± 2.763
1.481GlyCys: 1.481 ± 1.667
5.926GlyAsp: 5.926 ± 1.197
3.704GlyGlu: 3.704 ± 1.381
2.222GlyPhe: 2.222 ± 1.468
7.407GlyGly: 7.407 ± 1.765
1.481GlyHis: 1.481 ± 0.666
5.185GlyIle: 5.185 ± 1.123
1.481GlyLys: 1.481 ± 0.723
8.889GlyLeu: 8.889 ± 3.355
0.0GlyMet: 0.0 ± 0.0
2.963GlyAsn: 2.963 ± 1.319
4.444GlyPro: 4.444 ± 1.853
3.704GlyGln: 3.704 ± 1.125
7.407GlyArg: 7.407 ± 4.039
5.926GlySer: 5.926 ± 1.178
5.185GlyThr: 5.185 ± 2.842
5.926GlyVal: 5.926 ± 1.346
0.0GlyTrp: 0.0 ± 0.0
4.444GlyTyr: 4.444 ± 1.148
0.0GlyXaa: 0.0 ± 0.0
His
1.481HisAla: 1.481 ± 1.239
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.741HisGlu: 0.741 ± 0.833
0.0HisPhe: 0.0 ± 0.0
2.963HisGly: 2.963 ± 0.913
0.741HisHis: 0.741 ± 0.529
0.741HisIle: 0.741 ± 0.529
0.0HisLys: 0.0 ± 0.0
1.481HisLeu: 1.481 ± 1.213
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
4.444HisPro: 4.444 ± 1.209
0.0HisGln: 0.0 ± 0.0
3.704HisArg: 3.704 ± 0.883
0.741HisSer: 0.741 ± 0.529
0.0HisThr: 0.0 ± 0.0
2.963HisVal: 2.963 ± 1.446
1.481HisTrp: 1.481 ± 1.059
2.222HisTyr: 2.222 ± 0.955
0.0HisXaa: 0.0 ± 0.0
Ile
5.926IleAla: 5.926 ± 1.076
0.0IleCys: 0.0 ± 0.0
2.222IleAsp: 2.222 ± 0.792
0.741IleGlu: 0.741 ± 0.812
0.741IlePhe: 0.741 ± 0.529
8.148IleGly: 8.148 ± 1.766
0.741IleHis: 0.741 ± 0.529
0.741IleIle: 0.741 ± 0.529
1.481IleLys: 1.481 ± 1.059
0.741IleLeu: 0.741 ± 0.529
0.0IleMet: 0.0 ± 0.0
0.741IleAsn: 0.741 ± 0.529
0.741IlePro: 0.741 ± 0.833
2.222IleGln: 2.222 ± 0.955
2.963IleArg: 2.963 ± 1.864
1.481IleSer: 1.481 ± 0.666
2.963IleThr: 2.963 ± 0.691
1.481IleVal: 1.481 ± 0.666
2.222IleTrp: 2.222 ± 0.542
0.741IleTyr: 0.741 ± 0.529
0.0IleXaa: 0.0 ± 0.0
Lys
1.481LysAla: 1.481 ± 0.932
0.0LysCys: 0.0 ± 0.0
2.222LysAsp: 2.222 ± 1.158
2.963LysGlu: 2.963 ± 1.319
0.741LysPhe: 0.741 ± 0.529
2.963LysGly: 2.963 ± 1.708
0.0LysHis: 0.0 ± 0.0
1.481LysIle: 1.481 ± 0.723
2.963LysLys: 2.963 ± 2.673
2.963LysLeu: 2.963 ± 1.238
1.481LysMet: 1.481 ± 1.257
0.0LysAsn: 0.0 ± 0.0
3.704LysPro: 3.704 ± 2.28
2.222LysGln: 2.222 ± 1.468
2.222LysArg: 2.222 ± 0.955
1.481LysSer: 1.481 ± 1.059
3.704LysThr: 3.704 ± 1.174
2.963LysVal: 2.963 ± 1.655
0.0LysTrp: 0.0 ± 0.0
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
5.185LeuAla: 5.185 ± 1.794
0.0LeuCys: 0.0 ± 0.0
2.222LeuAsp: 2.222 ± 1.64
7.407LeuGlu: 7.407 ± 3.452
3.704LeuPhe: 3.704 ± 2.385
8.148LeuGly: 8.148 ± 1.978
2.963LeuHis: 2.963 ± 1.042
0.0LeuIle: 0.0 ± 0.0
1.481LeuLys: 1.481 ± 1.443
8.889LeuLeu: 8.889 ± 2.003
1.481LeuMet: 1.481 ± 0.748
5.926LeuAsn: 5.926 ± 2.545
4.444LeuPro: 4.444 ± 1.557
7.407LeuGln: 7.407 ± 2.211
8.148LeuArg: 8.148 ± 5.268
6.667LeuSer: 6.667 ± 1.639
4.444LeuThr: 4.444 ± 1.248
2.963LeuVal: 2.963 ± 1.364
1.481LeuTrp: 1.481 ± 0.723
0.741LeuTyr: 0.741 ± 0.607
0.0LeuXaa: 0.0 ± 0.0
Met
1.481MetAla: 1.481 ± 0.79
0.741MetCys: 0.741 ± 0.833
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
4.444MetGly: 4.444 ± 1.407
0.741MetHis: 0.741 ± 0.529
0.741MetIle: 0.741 ± 0.607
0.741MetLys: 0.741 ± 0.529
1.481MetLeu: 1.481 ± 0.666
0.0MetMet: 0.0 ± 0.0
1.481MetAsn: 1.481 ± 0.932
1.481MetPro: 1.481 ± 0.819
2.222MetGln: 2.222 ± 0.542
2.222MetArg: 2.222 ± 1.67
1.481MetSer: 1.481 ± 0.819
0.741MetThr: 0.741 ± 0.607
0.741MetVal: 0.741 ± 0.529
0.0MetTrp: 0.0 ± 0.0
0.741MetTyr: 0.741 ± 0.529
0.0MetXaa: 0.0 ± 0.0
Asn
4.444AsnAla: 4.444 ± 0.618
0.0AsnCys: 0.0 ± 0.0
1.481AsnAsp: 1.481 ± 0.723
0.741AsnGlu: 0.741 ± 0.529
0.741AsnPhe: 0.741 ± 0.529
3.704AsnGly: 3.704 ± 1.351
1.481AsnHis: 1.481 ± 0.79
0.741AsnIle: 0.741 ± 0.529
2.222AsnLys: 2.222 ± 1.512
3.704AsnLeu: 3.704 ± 0.849
1.481AsnMet: 1.481 ± 0.79
0.741AsnAsn: 0.741 ± 0.812
2.222AsnPro: 2.222 ± 0.792
1.481AsnGln: 1.481 ± 0.79
5.185AsnArg: 5.185 ± 2.601
0.0AsnSer: 0.0 ± 0.0
1.481AsnThr: 1.481 ± 0.723
0.741AsnVal: 0.741 ± 1.278
0.0AsnTrp: 0.0 ± 0.0
0.741AsnTyr: 0.741 ± 0.607
0.0AsnXaa: 0.0 ± 0.0
Pro
5.185ProAla: 5.185 ± 1.26
0.741ProCys: 0.741 ± 0.833
3.704ProAsp: 3.704 ± 1.351
4.444ProGlu: 4.444 ± 0.96
2.963ProPhe: 2.963 ± 1.472
5.185ProGly: 5.185 ± 2.31
1.481ProHis: 1.481 ± 0.723
1.481ProIle: 1.481 ± 0.79
2.222ProLys: 2.222 ± 0.872
6.667ProLeu: 6.667 ± 1.644
1.481ProMet: 1.481 ± 1.248
2.963ProAsn: 2.963 ± 2.415
3.704ProPro: 3.704 ± 1.686
2.963ProGln: 2.963 ± 1.869
2.963ProArg: 2.963 ± 1.682
6.667ProSer: 6.667 ± 4.084
3.704ProThr: 3.704 ± 2.008
5.185ProVal: 5.185 ± 1.841
1.481ProTrp: 1.481 ± 0.79
0.741ProTyr: 0.741 ± 0.833
0.0ProXaa: 0.0 ± 0.0
Gln
5.185GlnAla: 5.185 ± 1.811
0.741GlnCys: 0.741 ± 0.833
2.222GlnAsp: 2.222 ± 1.039
2.963GlnGlu: 2.963 ± 0.61
1.481GlnPhe: 1.481 ± 0.723
3.704GlnGly: 3.704 ± 1.227
2.222GlnHis: 2.222 ± 1.039
2.963GlnIle: 2.963 ± 1.864
2.222GlnLys: 2.222 ± 0.542
2.963GlnLeu: 2.963 ± 1.629
2.222GlnMet: 2.222 ± 1.82
0.0GlnAsn: 0.0 ± 0.0
3.704GlnPro: 3.704 ± 2.226
2.222GlnGln: 2.222 ± 0.955
5.185GlnArg: 5.185 ± 1.067
2.222GlnSer: 2.222 ± 1.82
1.481GlnThr: 1.481 ± 1.059
2.222GlnVal: 2.222 ± 1.039
0.0GlnTrp: 0.0 ± 0.0
0.741GlnTyr: 0.741 ± 0.833
0.0GlnXaa: 0.0 ± 0.0
Arg
7.407ArgAla: 7.407 ± 1.623
0.741ArgCys: 0.741 ± 1.278
1.481ArgAsp: 1.481 ± 0.723
5.926ArgGlu: 5.926 ± 1.884
3.704ArgPhe: 3.704 ± 2.08
3.704ArgGly: 3.704 ± 2.042
2.222ArgHis: 2.222 ± 0.542
2.963ArgIle: 2.963 ± 1.508
2.963ArgLys: 2.963 ± 1.813
8.889ArgLeu: 8.889 ± 3.021
2.222ArgMet: 2.222 ± 1.176
3.704ArgAsn: 3.704 ± 2.042
8.889ArgPro: 8.889 ± 2.468
4.444ArgGln: 4.444 ± 2.352
10.37ArgArg: 10.37 ± 1.342
6.667ArgSer: 6.667 ± 1.763
1.481ArgThr: 1.481 ± 1.443
3.704ArgVal: 3.704 ± 2.332
1.481ArgTrp: 1.481 ± 0.932
5.185ArgTyr: 5.185 ± 2.295
0.0ArgXaa: 0.0 ± 0.0
Ser
8.148SerAla: 8.148 ± 2.684
1.481SerCys: 1.481 ± 0.723
3.704SerAsp: 3.704 ± 0.883
2.963SerGlu: 2.963 ± 1.331
0.741SerPhe: 0.741 ± 0.529
9.63SerGly: 9.63 ± 2.895
0.741SerHis: 0.741 ± 0.529
1.481SerIle: 1.481 ± 1.059
4.444SerLys: 4.444 ± 2.793
2.222SerLeu: 2.222 ± 0.955
1.481SerMet: 1.481 ± 1.239
1.481SerAsn: 1.481 ± 0.79
5.185SerPro: 5.185 ± 2.181
2.222SerGln: 2.222 ± 0.792
3.704SerArg: 3.704 ± 1.291
4.444SerSer: 4.444 ± 2.077
7.407SerThr: 7.407 ± 2.198
4.444SerVal: 4.444 ± 1.468
0.741SerTrp: 0.741 ± 0.607
0.741SerTyr: 0.741 ± 0.529
0.0SerXaa: 0.0 ± 0.0
Thr
6.667ThrAla: 6.667 ± 2.374
0.741ThrCys: 0.741 ± 0.529
0.741ThrAsp: 0.741 ± 0.529
5.926ThrGlu: 5.926 ± 1.178
1.481ThrPhe: 1.481 ± 0.79
4.444ThrGly: 4.444 ± 0.989
0.741ThrHis: 0.741 ± 0.833
2.963ThrIle: 2.963 ± 1.508
2.222ThrLys: 2.222 ± 1.039
5.185ThrLeu: 5.185 ± 2.867
2.222ThrMet: 2.222 ± 1.039
2.222ThrAsn: 2.222 ± 0.955
4.444ThrPro: 4.444 ± 2.248
0.0ThrGln: 0.0 ± 0.0
2.222ThrArg: 2.222 ± 1.176
5.185ThrSer: 5.185 ± 2.001
5.926ThrThr: 5.926 ± 2.02
0.741ThrVal: 0.741 ± 0.529
0.0ThrTrp: 0.0 ± 0.0
0.741ThrTyr: 0.741 ± 0.833
0.0ThrXaa: 0.0 ± 0.0
Val
9.63ValAla: 9.63 ± 2.435
1.481ValCys: 1.481 ± 1.443
1.481ValAsp: 1.481 ± 1.059
1.481ValGlu: 1.481 ± 0.819
0.741ValPhe: 0.741 ± 0.529
2.963ValGly: 2.963 ± 1.472
2.222ValHis: 2.222 ± 1.468
2.222ValIle: 2.222 ± 1.039
2.222ValLys: 2.222 ± 1.468
5.185ValLeu: 5.185 ± 1.16
2.222ValMet: 2.222 ± 0.955
1.481ValAsn: 1.481 ± 1.059
6.667ValPro: 6.667 ± 1.591
2.222ValGln: 2.222 ± 1.357
7.407ValArg: 7.407 ± 2.473
3.704ValSer: 3.704 ± 1.969
1.481ValThr: 1.481 ± 0.932
1.481ValVal: 1.481 ± 1.443
0.741ValTrp: 0.741 ± 0.529
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
0.741TrpAla: 0.741 ± 0.812
0.0TrpCys: 0.0 ± 0.0
0.741TrpAsp: 0.741 ± 0.529
2.963TrpGlu: 2.963 ± 1.508
0.741TrpPhe: 0.741 ± 0.529
0.741TrpGly: 0.741 ± 0.833
0.741TrpHis: 0.741 ± 0.529
0.0TrpIle: 0.0 ± 0.0
0.741TrpLys: 0.741 ± 0.607
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
1.481TrpAsn: 1.481 ± 1.059
0.741TrpPro: 0.741 ± 0.607
0.0TrpGln: 0.0 ± 0.0
0.741TrpArg: 0.741 ± 0.607
2.963TrpSer: 2.963 ± 0.895
0.741TrpThr: 0.741 ± 0.833
0.741TrpVal: 0.741 ± 0.529
0.0TrpTrp: 0.0 ± 0.0
1.481TrpTyr: 1.481 ± 0.79
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.963TyrAla: 2.963 ± 2.118
0.0TyrCys: 0.0 ± 0.0
1.481TyrAsp: 1.481 ± 0.666
2.222TyrGlu: 2.222 ± 1.176
0.741TyrPhe: 0.741 ± 0.529
2.963TyrGly: 2.963 ± 1.238
0.741TyrHis: 0.741 ± 0.833
0.741TyrIle: 0.741 ± 0.529
0.741TyrLys: 0.741 ± 0.529
4.444TyrLeu: 4.444 ± 1.59
0.0TyrMet: 0.0 ± 0.0
1.481TyrAsn: 1.481 ± 1.213
0.0TyrPro: 0.0 ± 0.0
1.481TyrGln: 1.481 ± 1.059
3.704TyrArg: 3.704 ± 1.105
2.222TyrSer: 2.222 ± 1.347
0.741TyrThr: 0.741 ± 0.529
2.963TyrVal: 2.963 ± 2.275
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1351 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski