Amino acid dipepetide frequency for Clostridium sp. 7_2_43FAA

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.578AlaAla: 3.578 ± 0.078
0.615AlaCys: 0.615 ± 0.028
2.477AlaAsp: 2.477 ± 0.055
3.241AlaGlu: 3.241 ± 0.062
2.471AlaPhe: 2.471 ± 0.055
3.617AlaGly: 3.617 ± 0.074
0.731AlaHis: 0.731 ± 0.031
6.079AlaIle: 6.079 ± 0.093
4.625AlaLys: 4.625 ± 0.084
5.707AlaLeu: 5.707 ± 0.088
1.56AlaMet: 1.56 ± 0.042
2.798AlaAsn: 2.798 ± 0.059
1.414AlaPro: 1.414 ± 0.042
1.289AlaGln: 1.289 ± 0.041
1.835AlaArg: 1.835 ± 0.043
3.296AlaSer: 3.296 ± 0.062
2.884AlaThr: 2.884 ± 0.062
3.64AlaVal: 3.64 ± 0.065
0.364AlaTrp: 0.364 ± 0.018
2.06AlaTyr: 2.06 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.482CysAla: 0.482 ± 0.022
0.189CysCys: 0.189 ± 0.015
0.669CysAsp: 0.669 ± 0.024
0.685CysGlu: 0.685 ± 0.027
0.42CysPhe: 0.42 ± 0.021
0.943CysGly: 0.943 ± 0.029
0.171CysHis: 0.171 ± 0.016
1.092CysIle: 1.092 ± 0.034
0.949CysLys: 0.949 ± 0.036
0.764CysLeu: 0.764 ± 0.029
0.209CysMet: 0.209 ± 0.015
0.735CysAsn: 0.735 ± 0.027
0.422CysPro: 0.422 ± 0.023
0.169CysGln: 0.169 ± 0.012
0.341CysArg: 0.341 ± 0.018
0.639CysSer: 0.639 ± 0.025
0.557CysThr: 0.557 ± 0.026
0.579CysVal: 0.579 ± 0.025
0.055CysTrp: 0.055 ± 0.007
0.418CysTyr: 0.418 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
2.608AspAla: 2.608 ± 0.053
0.495AspCys: 0.495 ± 0.023
2.876AspAsp: 2.876 ± 0.067
4.856AspGlu: 4.856 ± 0.064
2.81AspPhe: 2.81 ± 0.053
3.502AspGly: 3.502 ± 0.071
0.575AspHis: 0.575 ± 0.023
6.521AspIle: 6.521 ± 0.088
5.493AspLys: 5.493 ± 0.091
5.325AspLeu: 5.325 ± 0.068
1.459AspMet: 1.459 ± 0.038
3.551AspAsn: 3.551 ± 0.063
1.329AspPro: 1.329 ± 0.035
0.763AspGln: 0.763 ± 0.026
1.768AspArg: 1.768 ± 0.051
3.314AspSer: 3.314 ± 0.064
2.521AspThr: 2.521 ± 0.057
3.549AspVal: 3.549 ± 0.06
0.354AspTrp: 0.354 ± 0.019
2.773AspTyr: 2.773 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
4.428GluAla: 4.428 ± 0.078
0.641GluCys: 0.641 ± 0.028
4.744GluAsp: 4.744 ± 0.081
7.644GluGlu: 7.644 ± 0.118
3.196GluPhe: 3.196 ± 0.064
4.347GluGly: 4.347 ± 0.07
0.796GluHis: 0.796 ± 0.031
7.744GluIle: 7.744 ± 0.101
7.545GluLys: 7.545 ± 0.094
6.923GluLeu: 6.923 ± 0.079
1.943GluMet: 1.943 ± 0.044
5.811GluAsn: 5.811 ± 0.086
1.337GluPro: 1.337 ± 0.032
1.496GluGln: 1.496 ± 0.04
2.531GluArg: 2.531 ± 0.056
3.791GluSer: 3.791 ± 0.071
2.804GluThr: 2.804 ± 0.052
5.607GluVal: 5.607 ± 0.088
0.477GluTrp: 0.477 ± 0.024
3.217GluTyr: 3.217 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
2.137PheAla: 2.137 ± 0.05
0.431PheCys: 0.431 ± 0.02
2.559PheAsp: 2.559 ± 0.054
2.843PheGlu: 2.843 ± 0.056
1.883PhePhe: 1.883 ± 0.055
2.852PheGly: 2.852 ± 0.06
0.475PheHis: 0.475 ± 0.023
5.139PheIle: 5.139 ± 0.087
3.994PheLys: 3.994 ± 0.064
3.793PheLeu: 3.793 ± 0.074
1.138PheMet: 1.138 ± 0.033
3.325PheAsn: 3.325 ± 0.056
1.104PhePro: 1.104 ± 0.035
0.802PheGln: 0.802 ± 0.027
1.243PheArg: 1.243 ± 0.038
3.158PheSer: 3.158 ± 0.062
2.369PheThr: 2.369 ± 0.052
2.507PheVal: 2.507 ± 0.048
0.315PheTrp: 0.315 ± 0.019
1.813PheTyr: 1.813 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
4.135GlyAla: 4.135 ± 0.082
0.819GlyCys: 0.819 ± 0.033
3.316GlyAsp: 3.316 ± 0.057
4.536GlyGlu: 4.536 ± 0.076
3.128GlyPhe: 3.128 ± 0.058
4.261GlyGly: 4.261 ± 0.084
0.942GlyHis: 0.942 ± 0.029
6.783GlyIle: 6.783 ± 0.103
5.278GlyLys: 5.278 ± 0.064
5.649GlyLeu: 5.649 ± 0.085
1.689GlyMet: 1.689 ± 0.04
3.408GlyAsn: 3.408 ± 0.069
1.191GlyPro: 1.191 ± 0.038
1.329GlyGln: 1.329 ± 0.037
2.169GlyArg: 2.169 ± 0.051
3.7GlySer: 3.7 ± 0.066
3.269GlyThr: 3.269 ± 0.066
4.887GlyVal: 4.887 ± 0.081
0.477GlyTrp: 0.477 ± 0.026
3.027GlyTyr: 3.027 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
0.587HisAla: 0.587 ± 0.024
0.186HisCys: 0.186 ± 0.014
0.637HisAsp: 0.637 ± 0.025
0.81HisGlu: 0.81 ± 0.027
0.532HisPhe: 0.532 ± 0.025
0.924HisGly: 0.924 ± 0.03
0.263HisHis: 0.263 ± 0.016
1.233HisIle: 1.233 ± 0.03
0.982HisLys: 0.982 ± 0.035
1.106HisLeu: 1.106 ± 0.03
0.305HisMet: 0.305 ± 0.018
0.767HisAsn: 0.767 ± 0.03
0.559HisPro: 0.559 ± 0.025
0.256HisGln: 0.256 ± 0.016
0.439HisArg: 0.439 ± 0.023
0.789HisSer: 0.789 ± 0.028
0.565HisThr: 0.565 ± 0.025
0.63HisVal: 0.63 ± 0.025
0.103HisTrp: 0.103 ± 0.01
0.487HisTyr: 0.487 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.782IleAla: 5.782 ± 0.083
1.176IleCys: 1.176 ± 0.037
6.347IleAsp: 6.347 ± 0.09
7.7IleGlu: 7.7 ± 0.102
4.508IlePhe: 4.508 ± 0.1
6.352IleGly: 6.352 ± 0.095
1.193IleHis: 1.193 ± 0.033
10.299IleIle: 10.299 ± 0.15
9.333IleLys: 9.333 ± 0.101
9.568IleLeu: 9.568 ± 0.132
2.406IleMet: 2.406 ± 0.048
7.49IleAsn: 7.49 ± 0.1
3.331IlePro: 3.331 ± 0.054
2.056IleGln: 2.056 ± 0.048
3.171IleArg: 3.171 ± 0.065
7.366IleSer: 7.366 ± 0.092
4.973IleThr: 4.973 ± 0.067
6.228IleVal: 6.228 ± 0.084
0.556IleTrp: 0.556 ± 0.028
3.969IleTyr: 3.969 ± 0.072
0.0IleXaa: 0.0 ± 0.0
Lys
4.628LysAla: 4.628 ± 0.069
0.834LysCys: 0.834 ± 0.032
6.01LysAsp: 6.01 ± 0.076
9.456LysGlu: 9.456 ± 0.12
3.39LysPhe: 3.39 ± 0.068
5.073LysGly: 5.073 ± 0.076
0.958LysHis: 0.958 ± 0.032
8.354LysIle: 8.354 ± 0.085
7.881LysLys: 7.881 ± 0.102
7.597LysLeu: 7.597 ± 0.099
2.25LysMet: 2.25 ± 0.05
6.503LysAsn: 6.503 ± 0.083
1.875LysPro: 1.875 ± 0.042
1.793LysGln: 1.793 ± 0.041
3.055LysArg: 3.055 ± 0.063
5.479LysSer: 5.479 ± 0.078
3.622LysThr: 3.622 ± 0.062
6.191LysVal: 6.191 ± 0.088
0.581LysTrp: 0.581 ± 0.023
4.279LysTyr: 4.279 ± 0.071
0.0LysXaa: 0.0 ± 0.0
Leu
5.222LeuAla: 5.222 ± 0.085
0.971LeuCys: 0.971 ± 0.034
5.333LeuAsp: 5.333 ± 0.075
6.736LeuGlu: 6.736 ± 0.09
3.729LeuPhe: 3.729 ± 0.065
6.076LeuGly: 6.076 ± 0.086
1.022LeuHis: 1.022 ± 0.035
8.917LeuIle: 8.917 ± 0.12
8.345LeuLys: 8.345 ± 0.09
7.923LeuLeu: 7.923 ± 0.117
2.232LeuMet: 2.232 ± 0.047
6.446LeuAsn: 6.446 ± 0.074
2.718LeuPro: 2.718 ± 0.053
1.935LeuGln: 1.935 ± 0.047
3.026LeuArg: 3.026 ± 0.056
6.809LeuSer: 6.809 ± 0.085
4.436LeuThr: 4.436 ± 0.063
5.543LeuVal: 5.543 ± 0.076
0.604LeuTrp: 0.604 ± 0.026
3.252LeuTyr: 3.252 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
1.641MetAla: 1.641 ± 0.04
0.215MetCys: 0.215 ± 0.015
1.437MetAsp: 1.437 ± 0.04
1.76MetGlu: 1.76 ± 0.038
1.015MetPhe: 1.015 ± 0.032
1.699MetGly: 1.699 ± 0.043
0.336MetHis: 0.336 ± 0.018
2.349MetIle: 2.349 ± 0.052
2.496MetLys: 2.496 ± 0.047
2.111MetLeu: 2.111 ± 0.05
0.685MetMet: 0.685 ± 0.028
1.653MetAsn: 1.653 ± 0.043
0.873MetPro: 0.873 ± 0.031
0.644MetGln: 0.644 ± 0.026
0.805MetArg: 0.805 ± 0.026
1.568MetSer: 1.568 ± 0.04
1.15MetThr: 1.15 ± 0.032
1.554MetVal: 1.554 ± 0.039
0.162MetTrp: 0.162 ± 0.013
0.835MetTyr: 0.835 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
2.741AsnAla: 2.741 ± 0.053
0.658AsnCys: 0.658 ± 0.027
3.541AsnAsp: 3.541 ± 0.066
5.251AsnGlu: 5.251 ± 0.082
2.765AsnPhe: 2.765 ± 0.058
4.147AsnGly: 4.147 ± 0.077
0.745AsnHis: 0.745 ± 0.026
7.808AsnIle: 7.808 ± 0.095
6.866AsnLys: 6.866 ± 0.089
6.174AsnLeu: 6.174 ± 0.09
1.727AsnMet: 1.727 ± 0.049
5.343AsnAsn: 5.343 ± 0.104
2.135AsnPro: 2.135 ± 0.052
1.339AsnGln: 1.339 ± 0.036
2.049AsnArg: 2.049 ± 0.047
4.393AsnSer: 4.393 ± 0.076
2.952AsnThr: 2.952 ± 0.061
3.628AsnVal: 3.628 ± 0.055
0.472AsnTrp: 0.472 ± 0.026
3.052AsnTyr: 3.052 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
1.356ProAla: 1.356 ± 0.036
0.254ProCys: 0.254 ± 0.014
1.307ProAsp: 1.307 ± 0.04
2.071ProGlu: 2.071 ± 0.049
1.362ProPhe: 1.362 ± 0.041
1.645ProGly: 1.645 ± 0.046
0.385ProHis: 0.385 ± 0.019
2.728ProIle: 2.728 ± 0.046
2.098ProLys: 2.098 ± 0.04
2.478ProLeu: 2.478 ± 0.052
0.705ProMet: 0.705 ± 0.025
1.628ProAsn: 1.628 ± 0.048
0.548ProPro: 0.548 ± 0.024
0.725ProGln: 0.725 ± 0.028
0.766ProArg: 0.766 ± 0.026
1.774ProSer: 1.774 ± 0.042
1.464ProThr: 1.464 ± 0.039
1.912ProVal: 1.912 ± 0.047
0.239ProTrp: 0.239 ± 0.018
1.228ProTyr: 1.228 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
1.234GlnAla: 1.234 ± 0.035
0.222GlnCys: 0.222 ± 0.017
1.054GlnAsp: 1.054 ± 0.04
1.638GlnGlu: 1.638 ± 0.041
0.816GlnPhe: 0.816 ± 0.033
1.514GlnGly: 1.514 ± 0.039
0.238GlnHis: 0.238 ± 0.015
1.954GlnIle: 1.954 ± 0.046
1.734GlnLys: 1.734 ± 0.043
1.807GlnLeu: 1.807 ± 0.047
0.561GlnMet: 0.561 ± 0.031
1.314GlnAsn: 1.314 ± 0.036
0.484GlnPro: 0.484 ± 0.021
0.497GlnGln: 0.497 ± 0.027
0.827GlnArg: 0.827 ± 0.03
1.212GlnSer: 1.212 ± 0.038
0.882GlnThr: 0.882 ± 0.032
1.367GlnVal: 1.367 ± 0.037
0.185GlnTrp: 0.185 ± 0.014
0.945GlnTyr: 0.945 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
1.822ArgAla: 1.822 ± 0.042
0.354ArgCys: 0.354 ± 0.018
1.887ArgAsp: 1.887 ± 0.047
2.971ArgGlu: 2.971 ± 0.057
1.444ArgPhe: 1.444 ± 0.041
2.054ArgGly: 2.054 ± 0.05
0.411ArgHis: 0.411 ± 0.019
3.145ArgIle: 3.145 ± 0.054
2.95ArgLys: 2.95 ± 0.057
2.838ArgLeu: 2.838 ± 0.063
0.883ArgMet: 0.883 ± 0.031
2.091ArgAsn: 2.091 ± 0.043
0.752ArgPro: 0.752 ± 0.025
0.686ArgGln: 0.686 ± 0.024
1.396ArgArg: 1.396 ± 0.043
1.708ArgSer: 1.708 ± 0.042
1.351ArgThr: 1.351 ± 0.044
2.193ArgVal: 2.193 ± 0.05
0.231ArgTrp: 0.231 ± 0.014
1.481ArgTyr: 1.481 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
3.137SerAla: 3.137 ± 0.054
0.592SerCys: 0.592 ± 0.024
3.172SerAsp: 3.172 ± 0.054
4.141SerGlu: 4.141 ± 0.071
3.184SerPhe: 3.184 ± 0.06
4.235SerGly: 4.235 ± 0.074
0.832SerHis: 0.832 ± 0.031
7.257SerIle: 7.257 ± 0.09
5.991SerLys: 5.991 ± 0.083
6.299SerLeu: 6.299 ± 0.082
1.562SerMet: 1.562 ± 0.039
4.505SerAsn: 4.505 ± 0.075
1.61SerPro: 1.61 ± 0.044
1.437SerGln: 1.437 ± 0.039
2.041SerArg: 2.041 ± 0.046
4.333SerSer: 4.333 ± 0.069
3.132SerThr: 3.132 ± 0.054
3.673SerVal: 3.673 ± 0.059
0.414SerTrp: 0.414 ± 0.02
2.75SerTyr: 2.75 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
2.663ThrAla: 2.663 ± 0.064
0.507ThrCys: 0.507 ± 0.022
2.279ThrAsp: 2.279 ± 0.051
2.874ThrGlu: 2.874 ± 0.058
2.178ThrPhe: 2.178 ± 0.051
3.393ThrGly: 3.393 ± 0.067
0.676ThrHis: 0.676 ± 0.024
4.855ThrIle: 4.855 ± 0.074
3.529ThrLys: 3.529 ± 0.062
4.811ThrLeu: 4.811 ± 0.076
1.062ThrMet: 1.062 ± 0.034
2.905ThrAsn: 2.905 ± 0.065
1.75ThrPro: 1.75 ± 0.037
1.011ThrGln: 1.011 ± 0.035
1.514ThrArg: 1.514 ± 0.039
3.23ThrSer: 3.23 ± 0.057
2.582ThrThr: 2.582 ± 0.071
3.141ThrVal: 3.141 ± 0.059
0.356ThrTrp: 0.356 ± 0.02
1.812ThrTyr: 1.812 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
3.844ValAla: 3.844 ± 0.061
0.743ValCys: 0.743 ± 0.024
3.92ValAsp: 3.92 ± 0.066
4.447ValGlu: 4.447 ± 0.071
2.777ValPhe: 2.777 ± 0.055
4.256ValGly: 4.256 ± 0.08
0.749ValHis: 0.749 ± 0.03
6.508ValIle: 6.508 ± 0.095
5.354ValLys: 5.354 ± 0.082
5.949ValLeu: 5.949 ± 0.072
1.489ValMet: 1.489 ± 0.041
3.966ValAsn: 3.966 ± 0.063
1.847ValPro: 1.847 ± 0.044
1.282ValGln: 1.282 ± 0.038
2.006ValArg: 2.006 ± 0.048
4.322ValSer: 4.322 ± 0.07
3.243ValThr: 3.243 ± 0.063
4.613ValVal: 4.613 ± 0.074
0.401ValTrp: 0.401 ± 0.022
2.378ValTyr: 2.378 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.364TrpAla: 0.364 ± 0.021
0.09TrpCys: 0.09 ± 0.01
0.387TrpAsp: 0.387 ± 0.022
0.445TrpGlu: 0.445 ± 0.022
0.313TrpPhe: 0.313 ± 0.019
0.515TrpGly: 0.515 ± 0.025
0.12TrpHis: 0.12 ± 0.01
0.689TrpIle: 0.689 ± 0.029
0.463TrpLys: 0.463 ± 0.02
0.557TrpLeu: 0.557 ± 0.027
0.184TrpMet: 0.184 ± 0.013
0.478TrpAsn: 0.478 ± 0.023
0.169TrpPro: 0.169 ± 0.013
0.183TrpGln: 0.183 ± 0.014
0.258TrpArg: 0.258 ± 0.015
0.458TrpSer: 0.458 ± 0.022
0.33TrpThr: 0.33 ± 0.021
0.389TrpVal: 0.389 ± 0.023
0.088TrpTrp: 0.088 ± 0.01
0.265TrpTyr: 0.265 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.891TyrAla: 1.891 ± 0.05
0.5TyrCys: 0.5 ± 0.022
2.489TyrAsp: 2.489 ± 0.054
2.916TyrGlu: 2.916 ± 0.045
1.96TyrPhe: 1.96 ± 0.045
2.587TyrGly: 2.587 ± 0.061
0.539TyrHis: 0.539 ± 0.024
4.35TyrIle: 4.35 ± 0.071
3.906TyrLys: 3.906 ± 0.066
3.897TyrLeu: 3.897 ± 0.062
0.94TyrMet: 0.94 ± 0.029
3.069TyrAsn: 3.069 ± 0.061
1.225TyrPro: 1.225 ± 0.034
0.791TyrGln: 0.791 ± 0.029
1.412TyrArg: 1.412 ± 0.034
2.958TyrSer: 2.958 ± 0.052
2.041TyrThr: 2.041 ± 0.054
2.262TyrVal: 2.262 ± 0.044
0.309TyrTrp: 0.309 ± 0.02
1.951TyrTyr: 1.951 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3389 proteins (1046289 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski