Amino acid dipepetide frequency for Leucobacter chromiiresistens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.295AlaAla: 22.295 ± 0.273	0.773AlaCys: 0.773 ± 0.031	8.357AlaAsp: 8.357 ± 0.142	10.057AlaGlu: 10.057 ± 0.161	4.222AlaPhe: 4.222 ± 0.082	12.957AlaGly: 12.957 ± 0.16	2.736AlaHis: 2.736 ± 0.074	6.386AlaIle: 6.386 ± 0.112	2.632AlaLys: 2.632 ± 0.081	14.865AlaLeu: 14.865 ± 0.173	2.722AlaMet: 2.722 ± 0.061	2.435AlaAsn: 2.435 ± 0.077	7.282AlaPro: 7.282 ± 0.134	4.25AlaGln: 4.25 ± 0.091	9.868AlaArg: 9.868 ± 0.174	7.532AlaSer: 7.532 ± 0.114	6.614AlaThr: 6.614 ± 0.105	11.547AlaVal: 11.547 ± 0.146	1.705AlaTrp: 1.705 ± 0.049	2.494AlaTyr: 2.494 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.696CysAla: 0.696 ± 0.032	0.056CysCys: 0.056 ± 0.008	0.352CysAsp: 0.352 ± 0.021	0.28CysGlu: 0.28 ± 0.02	0.209CysPhe: 0.209 ± 0.017	0.587CysGly: 0.587 ± 0.027	0.099CysHis: 0.099 ± 0.011	0.239CysIle: 0.239 ± 0.017	0.053CysLys: 0.053 ± 0.008	0.367CysLeu: 0.367 ± 0.02	0.069CysMet: 0.069 ± 0.01	0.09CysAsn: 0.09 ± 0.01	0.262CysPro: 0.262 ± 0.019	0.106CysGln: 0.106 ± 0.012	0.295CysArg: 0.295 ± 0.019	0.378CysSer: 0.378 ± 0.024	0.371CysThr: 0.371 ± 0.022	0.426CysVal: 0.426 ± 0.022	0.057CysTrp: 0.057 ± 0.009	0.108CysTyr: 0.108 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	9.775AspAla: 9.775 ± 0.137	0.206AspCys: 0.206 ± 0.018	3.798AspAsp: 3.798 ± 0.097	4.187AspGlu: 4.187 ± 0.075	1.79AspPhe: 1.79 ± 0.057	5.684AspGly: 5.684 ± 0.092	1.171AspHis: 1.171 ± 0.042	2.176AspIle: 2.176 ± 0.058	0.682AspLys: 0.682 ± 0.035	5.801AspLeu: 5.801 ± 0.079	0.708AspMet: 0.708 ± 0.031	0.755AspAsn: 0.755 ± 0.043	4.199AspPro: 4.199 ± 0.079	1.46AspGln: 1.46 ± 0.044	4.93AspArg: 4.93 ± 0.09	2.338AspSer: 2.338 ± 0.061	2.716AspThr: 2.716 ± 0.063	4.756AspVal: 4.756 ± 0.081	0.797AspTrp: 0.797 ± 0.031	1.147AspTyr: 1.147 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.3GluAla: 8.3 ± 0.14	0.27GluCys: 0.27 ± 0.019	2.536GluAsp: 2.536 ± 0.069	3.326GluGlu: 3.326 ± 0.076	1.96GluPhe: 1.96 ± 0.054	4.056GluGly: 4.056 ± 0.079	1.734GluHis: 1.734 ± 0.046	3.031GluIle: 3.031 ± 0.074	1.165GluLys: 1.165 ± 0.05	7.101GluLeu: 7.101 ± 0.114	1.183GluMet: 1.183 ± 0.038	1.269GluAsn: 1.269 ± 0.044	3.25GluPro: 3.25 ± 0.074	2.77GluGln: 2.77 ± 0.062	6.447GluArg: 6.447 ± 0.114	3.226GluSer: 3.226 ± 0.06	3.446GluThr: 3.446 ± 0.074	4.871GluVal: 4.871 ± 0.089	0.877GluTrp: 0.877 ± 0.035	1.244GluTyr: 1.244 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	4.84PheAla: 4.84 ± 0.084	0.2PheCys: 0.2 ± 0.017	2.279PheAsp: 2.279 ± 0.055	1.878PheGlu: 1.878 ± 0.052	1.152PhePhe: 1.152 ± 0.051	3.614PheGly: 3.614 ± 0.083	0.535PheHis: 0.535 ± 0.028	1.311PheIle: 1.311 ± 0.048	0.402PheLys: 0.402 ± 0.024	2.6PheLeu: 2.6 ± 0.063	0.542PheMet: 0.542 ± 0.026	0.623PheAsn: 0.623 ± 0.027	1.434PhePro: 1.434 ± 0.046	0.757PheGln: 0.757 ± 0.037	1.801PheArg: 1.801 ± 0.052	2.052PheSer: 2.052 ± 0.049	2.178PheThr: 2.178 ± 0.06	2.782PheVal: 2.782 ± 0.062	0.449PheTrp: 0.449 ± 0.026	0.604PheTyr: 0.604 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	12.763GlyAla: 12.763 ± 0.153	0.537GlyCys: 0.537 ± 0.03	5.203GlyAsp: 5.203 ± 0.091	5.46GlyGlu: 5.46 ± 0.093	3.399GlyPhe: 3.399 ± 0.077	8.239GlyGly: 8.239 ± 0.132	1.616GlyHis: 1.616 ± 0.048	4.823GlyIle: 4.823 ± 0.096	1.96GlyLys: 1.96 ± 0.058	8.651GlyLeu: 8.651 ± 0.12	1.83GlyMet: 1.83 ± 0.051	1.614GlyAsn: 1.614 ± 0.051	3.791GlyPro: 3.791 ± 0.077	2.288GlyGln: 2.288 ± 0.061	6.542GlyArg: 6.542 ± 0.109	5.957GlySer: 5.957 ± 0.104	5.044GlyThr: 5.044 ± 0.098	8.258GlyVal: 8.258 ± 0.109	1.456GlyTrp: 1.456 ± 0.05	2.118GlyTyr: 2.118 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.627HisAla: 2.627 ± 0.07	0.112HisCys: 0.112 ± 0.013	1.311HisAsp: 1.311 ± 0.041	1.265HisGlu: 1.265 ± 0.044	0.586HisPhe: 0.586 ± 0.028	1.956HisGly: 1.956 ± 0.058	0.478HisHis: 0.478 ± 0.028	0.693HisIle: 0.693 ± 0.033	0.233HisLys: 0.233 ± 0.018	2.186HisLeu: 2.186 ± 0.06	0.289HisMet: 0.289 ± 0.018	0.292HisAsn: 0.292 ± 0.017	1.523HisPro: 1.523 ± 0.05	0.481HisGln: 0.481 ± 0.023	1.728HisArg: 1.728 ± 0.054	0.949HisSer: 0.949 ± 0.035	0.966HisThr: 0.966 ± 0.037	1.512HisVal: 1.512 ± 0.047	0.301HisTrp: 0.301 ± 0.021	0.398HisTyr: 0.398 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.766IleAla: 7.766 ± 0.102	0.272IleCys: 0.272 ± 0.019	3.521IleAsp: 3.521 ± 0.067	3.108IleGlu: 3.108 ± 0.063	1.202IlePhe: 1.202 ± 0.045	4.863IleGly: 4.863 ± 0.093	0.57IleHis: 0.57 ± 0.028	1.893IleIle: 1.893 ± 0.06	0.694IleLys: 0.694 ± 0.033	3.582IleLeu: 3.582 ± 0.092	0.697IleMet: 0.697 ± 0.027	0.863IleAsn: 0.863 ± 0.033	2.389IlePro: 2.389 ± 0.06	0.844IleGln: 0.844 ± 0.034	2.578IleArg: 2.578 ± 0.058	2.552IleSer: 2.552 ± 0.064	2.865IleThr: 2.865 ± 0.069	4.657IleVal: 4.657 ± 0.092	0.497IleTrp: 0.497 ± 0.024	0.718IleTyr: 0.718 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	1.75LysAla: 1.75 ± 0.054	0.065LysCys: 0.065 ± 0.01	0.83LysAsp: 0.83 ± 0.038	0.75LysGlu: 0.75 ± 0.039	0.507LysPhe: 0.507 ± 0.028	1.212LysGly: 1.212 ± 0.046	0.472LysHis: 0.472 ± 0.025	0.918LysIle: 0.918 ± 0.04	0.641LysLys: 0.641 ± 0.04	1.831LysLeu: 1.831 ± 0.056	0.351LysMet: 0.351 ± 0.023	0.5LysAsn: 0.5 ± 0.03	1.1LysPro: 1.1 ± 0.05	0.726LysGln: 0.726 ± 0.031	1.611LysArg: 1.611 ± 0.046	1.088LysSer: 1.088 ± 0.039	1.136LysThr: 1.136 ± 0.042	1.369LysVal: 1.369 ± 0.052	0.221LysTrp: 0.221 ± 0.018	0.417LysTyr: 0.417 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.961LeuAla: 14.961 ± 0.184	0.509LeuCys: 0.509 ± 0.023	6.694LeuAsp: 6.694 ± 0.106	5.491LeuGlu: 5.491 ± 0.101	2.819LeuPhe: 2.819 ± 0.086	9.637LeuGly: 9.637 ± 0.127	1.86LeuHis: 1.86 ± 0.061	4.59LeuIle: 4.59 ± 0.105	1.507LeuLys: 1.507 ± 0.054	10.201LeuLeu: 10.201 ± 0.16	1.631LeuMet: 1.631 ± 0.046	1.689LeuAsn: 1.689 ± 0.054	5.414LeuPro: 5.414 ± 0.096	2.759LeuGln: 2.759 ± 0.059	7.552LeuArg: 7.552 ± 0.112	5.614LeuSer: 5.614 ± 0.1	5.661LeuThr: 5.661 ± 0.083	9.014LeuVal: 9.014 ± 0.136	1.125LeuTrp: 1.125 ± 0.042	1.502LeuTyr: 1.502 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.829MetAla: 1.829 ± 0.053	0.104MetCys: 0.104 ± 0.009	0.724MetAsp: 0.724 ± 0.029	0.735MetGlu: 0.735 ± 0.032	0.453MetPhe: 0.453 ± 0.025	1.349MetGly: 1.349 ± 0.04	0.426MetHis: 0.426 ± 0.027	0.905MetIle: 0.905 ± 0.038	0.394MetLys: 0.394 ± 0.023	2.138MetLeu: 2.138 ± 0.054	0.305MetMet: 0.305 ± 0.021	0.516MetAsn: 0.516 ± 0.028	1.11MetPro: 1.11 ± 0.038	0.615MetGln: 0.615 ± 0.025	1.499MetArg: 1.499 ± 0.051	1.437MetSer: 1.437 ± 0.041	1.49MetThr: 1.49 ± 0.041	1.274MetVal: 1.274 ± 0.041	0.172MetTrp: 0.172 ± 0.016	0.308MetTyr: 0.308 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.486AsnAla: 2.486 ± 0.071	0.085AsnCys: 0.085 ± 0.01	1.007AsnAsp: 1.007 ± 0.039	1.053AsnGlu: 1.053 ± 0.044	0.628AsnPhe: 0.628 ± 0.027	1.943AsnGly: 1.943 ± 0.059	0.312AsnHis: 0.312 ± 0.021	0.792AsnIle: 0.792 ± 0.039	0.31AsnLys: 0.31 ± 0.023	1.784AsnLeu: 1.784 ± 0.045	0.286AsnMet: 0.286 ± 0.021	0.435AsnAsn: 0.435 ± 0.029	1.45AsnPro: 1.45 ± 0.043	0.554AsnGln: 0.554 ± 0.028	1.287AsnArg: 1.287 ± 0.039	0.847AsnSer: 0.847 ± 0.036	1.165AsnThr: 1.165 ± 0.086	1.573AsnVal: 1.573 ± 0.057	0.31AsnTrp: 0.31 ± 0.019	0.45AsnTyr: 0.45 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.949ProAla: 6.949 ± 0.12	0.188ProCys: 0.188 ± 0.016	3.599ProAsp: 3.599 ± 0.069	4.779ProGlu: 4.779 ± 0.08	1.666ProPhe: 1.666 ± 0.05	5.18ProGly: 5.18 ± 0.088	1.195ProHis: 1.195 ± 0.043	2.258ProIle: 2.258 ± 0.053	1.025ProLys: 1.025 ± 0.038	4.813ProLeu: 4.813 ± 0.083	0.894ProMet: 0.894 ± 0.04	1.068ProAsn: 1.068 ± 0.036	2.026ProPro: 2.026 ± 0.07	1.712ProGln: 1.712 ± 0.059	3.452ProArg: 3.452 ± 0.076	2.878ProSer: 2.878 ± 0.056	2.72ProThr: 2.72 ± 0.059	4.774ProVal: 4.774 ± 0.083	0.727ProTrp: 0.727 ± 0.031	0.996ProTyr: 0.996 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.596GlnAla: 3.596 ± 0.071	0.134GlnCys: 0.134 ± 0.014	1.067GlnAsp: 1.067 ± 0.035	1.506GlnGlu: 1.506 ± 0.048	0.886GlnPhe: 0.886 ± 0.039	2.113GlnGly: 2.113 ± 0.054	0.791GlnHis: 0.791 ± 0.034	1.504GlnIle: 1.504 ± 0.047	0.589GlnLys: 0.589 ± 0.031	3.314GlnLeu: 3.314 ± 0.062	0.558GlnMet: 0.558 ± 0.03	0.68GlnAsn: 0.68 ± 0.037	1.609GlnPro: 1.609 ± 0.052	1.504GlnGln: 1.504 ± 0.058	2.806GlnArg: 2.806 ± 0.076	1.564GlnSer: 1.564 ± 0.052	1.517GlnThr: 1.517 ± 0.038	2.215GlnVal: 2.215 ± 0.062	0.398GlnTrp: 0.398 ± 0.024	0.675GlnTyr: 0.675 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	10.216ArgAla: 10.216 ± 0.169	0.331ArgCys: 0.331 ± 0.022	4.482ArgAsp: 4.482 ± 0.083	5.077ArgGlu: 5.077 ± 0.088	2.608ArgPhe: 2.608 ± 0.069	6.013ArgGly: 6.013 ± 0.109	1.408ArgHis: 1.408 ± 0.05	3.952ArgIle: 3.952 ± 0.082	1.344ArgLys: 1.344 ± 0.048	7.426ArgLeu: 7.426 ± 0.107	1.666ArgMet: 1.666 ± 0.047	1.241ArgAsn: 1.241 ± 0.045	3.548ArgPro: 3.548 ± 0.076	1.902ArgGln: 1.902 ± 0.054	6.503ArgArg: 6.503 ± 0.122	4.522ArgSer: 4.522 ± 0.072	4.175ArgThr: 4.175 ± 0.081	6.453ArgVal: 6.453 ± 0.089	1.064ArgTrp: 1.064 ± 0.038	1.562ArgTyr: 1.562 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	7.852SerAla: 7.852 ± 0.14	0.282SerCys: 0.282 ± 0.02	3.148SerAsp: 3.148 ± 0.065	3.315SerGlu: 3.315 ± 0.064	1.957SerPhe: 1.957 ± 0.052	6.555SerGly: 6.555 ± 0.115	0.993SerHis: 0.993 ± 0.035	2.555SerIle: 2.555 ± 0.055	1.024SerLys: 1.024 ± 0.043	5.136SerLeu: 5.136 ± 0.079	1.095SerMet: 1.095 ± 0.037	1.096SerAsn: 1.096 ± 0.036	2.894SerPro: 2.894 ± 0.065	1.49SerGln: 1.49 ± 0.046	3.878SerArg: 3.878 ± 0.079	3.206SerSer: 3.206 ± 0.08	3.251SerThr: 3.251 ± 0.074	4.625SerVal: 4.625 ± 0.081	0.874SerTrp: 0.874 ± 0.041	1.076SerTyr: 1.076 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	7.481ThrAla: 7.481 ± 0.122	0.254ThrCys: 0.254 ± 0.018	3.014ThrAsp: 3.014 ± 0.076	3.17ThrGlu: 3.17 ± 0.069	1.731ThrPhe: 1.731 ± 0.055	5.824ThrGly: 5.824 ± 0.103	1.132ThrHis: 1.132 ± 0.041	2.595ThrIle: 2.595 ± 0.07	0.945ThrLys: 0.945 ± 0.036	5.445ThrLeu: 5.445 ± 0.095	0.926ThrMet: 0.926 ± 0.034	1.058ThrAsn: 1.058 ± 0.052	3.619ThrPro: 3.619 ± 0.076	1.328ThrGln: 1.328 ± 0.046	3.728ThrArg: 3.728 ± 0.064	3.146ThrSer: 3.146 ± 0.072	3.253ThrThr: 3.253 ± 0.078	5.324ThrVal: 5.324 ± 0.097	0.749ThrTrp: 0.749 ± 0.035	1.017ThrTyr: 1.017 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	11.453ValAla: 11.453 ± 0.13	0.511ValCys: 0.511 ± 0.027	5.289ValAsp: 5.289 ± 0.097	4.887ValGlu: 4.887 ± 0.074	3.01ValPhe: 3.01 ± 0.077	6.901ValGly: 6.901 ± 0.099	1.768ValHis: 1.768 ± 0.05	4.203ValIle: 4.203 ± 0.079	1.359ValLys: 1.359 ± 0.047	9.491ValLeu: 9.491 ± 0.141	1.492ValMet: 1.492 ± 0.05	1.731ValAsn: 1.731 ± 0.048	4.388ValPro: 4.388 ± 0.078	2.495ValGln: 2.495 ± 0.058	6.171ValArg: 6.171 ± 0.119	5.079ValSer: 5.079 ± 0.088	5.29ValThr: 5.29 ± 0.112	8.12ValVal: 8.12 ± 0.116	1.097ValTrp: 1.097 ± 0.036	1.527ValTyr: 1.527 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.52TrpAla: 1.52 ± 0.045	0.094TrpCys: 0.094 ± 0.011	0.65TrpAsp: 0.65 ± 0.027	0.67TrpGlu: 0.67 ± 0.031	0.546TrpPhe: 0.546 ± 0.029	1.021TrpGly: 1.021 ± 0.041	0.286TrpHis: 0.286 ± 0.021	0.697TrpIle: 0.697 ± 0.035	0.286TrpLys: 0.286 ± 0.019	1.422TrpLeu: 1.422 ± 0.049	0.268TrpMet: 0.268 ± 0.02	0.425TrpAsn: 0.425 ± 0.024	0.601TrpPro: 0.601 ± 0.034	0.445TrpGln: 0.445 ± 0.025	1.138TrpArg: 1.138 ± 0.039	0.9TrpSer: 0.9 ± 0.039	0.758TrpThr: 0.758 ± 0.035	1.16TrpVal: 1.16 ± 0.043	0.273TrpTrp: 0.273 ± 0.019	0.266TrpTyr: 0.266 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.576TyrAla: 2.576 ± 0.064	0.118TyrCys: 0.118 ± 0.012	1.217TyrAsp: 1.217 ± 0.044	1.067TyrGlu: 1.067 ± 0.033	0.703TyrPhe: 0.703 ± 0.027	1.843TyrGly: 1.843 ± 0.051	0.304TyrHis: 0.304 ± 0.019	0.608TyrIle: 0.608 ± 0.029	0.252TyrLys: 0.252 ± 0.017	2.079TyrLeu: 2.079 ± 0.053	0.271TyrMet: 0.271 ± 0.02	0.376TyrAsn: 0.376 ± 0.024	1.008TyrPro: 1.008 ± 0.038	0.542TyrGln: 0.542 ± 0.027	1.678TyrArg: 1.678 ± 0.045	1.038TyrSer: 1.038 ± 0.034	1.122TyrThr: 1.122 ± 0.038	1.55TyrVal: 1.55 ± 0.049	0.275TyrTrp: 0.275 ± 0.018	0.399TyrTyr: 0.399 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2423 proteins (786420 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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