Amino acid dipepetide frequency for Limnothrix rosea IAM M-220

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.196AlaAla: 8.196 ± 0.109
0.821AlaCys: 0.821 ± 0.027
4.417AlaAsp: 4.417 ± 0.068
5.926AlaGlu: 5.926 ± 0.081
2.947AlaPhe: 2.947 ± 0.051
5.835AlaGly: 5.835 ± 0.114
1.407AlaHis: 1.407 ± 0.039
7.798AlaIle: 7.798 ± 0.097
4.307AlaLys: 4.307 ± 0.074
8.917AlaLeu: 8.917 ± 0.106
1.965AlaMet: 1.965 ± 0.041
3.244AlaAsn: 3.244 ± 0.077
3.31AlaPro: 3.31 ± 0.063
4.149AlaGln: 4.149 ± 0.07
3.349AlaArg: 3.349 ± 0.054
4.487AlaSer: 4.487 ± 0.069
4.956AlaThr: 4.956 ± 0.071
5.529AlaVal: 5.529 ± 0.073
1.12AlaTrp: 1.12 ± 0.036
2.138AlaTyr: 2.138 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.671CysAla: 0.671 ± 0.025
0.156CysCys: 0.156 ± 0.013
0.652CysAsp: 0.652 ± 0.023
0.572CysGlu: 0.572 ± 0.022
0.457CysPhe: 0.457 ± 0.023
0.855CysGly: 0.855 ± 0.028
0.295CysHis: 0.295 ± 0.018
0.505CysIle: 0.505 ± 0.02
0.304CysLys: 0.304 ± 0.016
1.202CysLeu: 1.202 ± 0.036
0.148CysMet: 0.148 ± 0.01
0.341CysAsn: 0.341 ± 0.015
0.515CysPro: 0.515 ± 0.026
0.522CysGln: 0.522 ± 0.022
0.573CysArg: 0.573 ± 0.025
0.606CysSer: 0.606 ± 0.028
0.455CysThr: 0.455 ± 0.024
0.552CysVal: 0.552 ± 0.021
0.118CysTrp: 0.118 ± 0.011
0.347CysTyr: 0.347 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.961AspAla: 3.961 ± 0.076
0.571AspCys: 0.571 ± 0.026
2.95AspAsp: 2.95 ± 0.104
3.56AspGlu: 3.56 ± 0.076
2.87AspPhe: 2.87 ± 0.064
3.649AspGly: 3.649 ± 0.097
1.014AspHis: 1.014 ± 0.038
3.844AspIle: 3.844 ± 0.067
2.163AspLys: 2.163 ± 0.045
6.492AspLeu: 6.492 ± 0.09
0.915AspMet: 0.915 ± 0.031
2.138AspAsn: 2.138 ± 0.056
2.7AspPro: 2.7 ± 0.054
2.53AspGln: 2.53 ± 0.053
3.825AspArg: 3.825 ± 0.058
2.877AspSer: 2.877 ± 0.07
2.559AspThr: 2.559 ± 0.064
3.463AspVal: 3.463 ± 0.059
0.924AspTrp: 0.924 ± 0.03
2.085AspTyr: 2.085 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
6.11GluAla: 6.11 ± 0.085
0.429GluCys: 0.429 ± 0.024
3.164GluAsp: 3.164 ± 0.071
4.363GluGlu: 4.363 ± 0.086
2.682GluPhe: 2.682 ± 0.055
3.522GluGly: 3.522 ± 0.081
1.102GluHis: 1.102 ± 0.033
5.006GluIle: 5.006 ± 0.07
4.002GluLys: 4.002 ± 0.058
7.125GluLeu: 7.125 ± 0.088
1.571GluMet: 1.571 ± 0.045
2.825GluAsn: 2.825 ± 0.056
2.687GluPro: 2.687 ± 0.058
3.693GluGln: 3.693 ± 0.071
3.227GluArg: 3.227 ± 0.062
3.545GluSer: 3.545 ± 0.064
4.154GluThr: 4.154 ± 0.066
4.077GluVal: 4.077 ± 0.07
0.746GluTrp: 0.746 ± 0.028
1.765GluTyr: 1.765 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.406PheAla: 3.406 ± 0.06
0.562PheCys: 0.562 ± 0.022
2.612PheAsp: 2.612 ± 0.05
2.549PheGlu: 2.549 ± 0.047
2.01PhePhe: 2.01 ± 0.051
3.254PheGly: 3.254 ± 0.058
0.744PheHis: 0.744 ± 0.028
2.363PheIle: 2.363 ± 0.051
1.637PheLys: 1.637 ± 0.046
4.307PheLeu: 4.307 ± 0.076
0.747PheMet: 0.747 ± 0.026
1.678PheAsn: 1.678 ± 0.05
1.904PhePro: 1.904 ± 0.043
1.888PheGln: 1.888 ± 0.041
1.963PheArg: 1.963 ± 0.042
3.078PheSer: 3.078 ± 0.053
2.341PheThr: 2.341 ± 0.048
2.81PheVal: 2.81 ± 0.053
0.718PheTrp: 0.718 ± 0.029
1.373PheTyr: 1.373 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
5.139GlyAla: 5.139 ± 0.105
0.834GlyCys: 0.834 ± 0.027
4.689GlyAsp: 4.689 ± 0.164
4.435GlyGlu: 4.435 ± 0.067
3.306GlyPhe: 3.306 ± 0.064
5.256GlyGly: 5.256 ± 0.392
1.254GlyHis: 1.254 ± 0.035
4.957GlyIle: 4.957 ± 0.071
3.895GlyLys: 3.895 ± 0.06
7.086GlyLeu: 7.086 ± 0.096
1.554GlyMet: 1.554 ± 0.043
2.901GlyAsn: 2.901 ± 0.155
0.947GlyPro: 0.947 ± 0.033
2.966GlyGln: 2.966 ± 0.06
3.14GlyArg: 3.14 ± 0.059
4.172GlySer: 4.172 ± 0.122
3.833GlyThr: 3.833 ± 0.072
4.738GlyVal: 4.738 ± 0.092
1.049GlyTrp: 1.049 ± 0.035
2.299GlyTyr: 2.299 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.127HisAla: 1.127 ± 0.033
0.303HisCys: 0.303 ± 0.017
0.904HisAsp: 0.904 ± 0.033
0.987HisGlu: 0.987 ± 0.028
0.891HisPhe: 0.891 ± 0.027
1.233HisGly: 1.233 ± 0.034
0.713HisHis: 0.713 ± 0.032
1.095HisIle: 1.095 ± 0.031
0.719HisLys: 0.719 ± 0.023
2.24HisLeu: 2.24 ± 0.049
0.292HisMet: 0.292 ± 0.018
0.762HisAsn: 0.762 ± 0.027
1.273HisPro: 1.273 ± 0.037
1.127HisGln: 1.127 ± 0.032
1.104HisArg: 1.104 ± 0.035
1.122HisSer: 1.122 ± 0.042
0.865HisThr: 0.865 ± 0.031
0.884HisVal: 0.884 ± 0.03
0.368HisTrp: 0.368 ± 0.02
0.714HisTyr: 0.714 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
8.063IleAla: 8.063 ± 0.095
0.731IleCys: 0.731 ± 0.027
3.755IleAsp: 3.755 ± 0.062
4.365IleGlu: 4.365 ± 0.069
2.875IlePhe: 2.875 ± 0.066
4.389IleGly: 4.389 ± 0.077
1.204IleHis: 1.204 ± 0.038
3.627IleIle: 3.627 ± 0.065
2.707IleLys: 2.707 ± 0.059
6.576IleLeu: 6.576 ± 0.093
0.952IleMet: 0.952 ± 0.03
2.638IleAsn: 2.638 ± 0.052
3.445IlePro: 3.445 ± 0.063
2.893IleGln: 2.893 ± 0.056
3.159IleArg: 3.159 ± 0.062
4.106IleSer: 4.106 ± 0.067
3.713IleThr: 3.713 ± 0.072
4.146IleVal: 4.146 ± 0.067
0.827IleTrp: 0.827 ± 0.029
1.911IleTyr: 1.911 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
3.98LysAla: 3.98 ± 0.067
0.296LysCys: 0.296 ± 0.017
2.355LysAsp: 2.355 ± 0.046
2.937LysGlu: 2.937 ± 0.059
1.8LysPhe: 1.8 ± 0.039
2.709LysGly: 2.709 ± 0.057
0.846LysHis: 0.846 ± 0.028
3.552LysIle: 3.552 ± 0.059
2.976LysLys: 2.976 ± 0.061
5.014LysLeu: 5.014 ± 0.08
1.015LysMet: 1.015 ± 0.032
2.213LysAsn: 2.213 ± 0.048
2.247LysPro: 2.247 ± 0.046
2.486LysGln: 2.486 ± 0.045
2.46LysArg: 2.46 ± 0.054
2.743LysSer: 2.743 ± 0.053
3.056LysThr: 3.056 ± 0.058
3.097LysVal: 3.097 ± 0.05
0.498LysTrp: 0.498 ± 0.021
1.43LysTyr: 1.43 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
9.333LeuAla: 9.333 ± 0.101
1.025LeuCys: 1.025 ± 0.034
6.148LeuAsp: 6.148 ± 0.097
7.752LeuGlu: 7.752 ± 0.098
4.039LeuPhe: 4.039 ± 0.073
8.039LeuGly: 8.039 ± 0.1
1.816LeuHis: 1.816 ± 0.04
6.285LeuIle: 6.285 ± 0.098
5.685LeuLys: 5.685 ± 0.074
10.624LeuLeu: 10.624 ± 0.157
2.309LeuMet: 2.309 ± 0.054
4.409LeuAsn: 4.409 ± 0.069
5.547LeuPro: 5.547 ± 0.074
5.266LeuGln: 5.266 ± 0.08
5.377LeuArg: 5.377 ± 0.081
7.116LeuSer: 7.116 ± 0.095
6.377LeuThr: 6.377 ± 0.088
6.88LeuVal: 6.88 ± 0.084
1.516LeuTrp: 1.516 ± 0.044
2.692LeuTyr: 2.692 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.138MetAla: 2.138 ± 0.046
0.138MetCys: 0.138 ± 0.011
0.966MetAsp: 0.966 ± 0.029
1.048MetGlu: 1.048 ± 0.031
0.651MetPhe: 0.651 ± 0.025
1.649MetGly: 1.649 ± 0.042
0.288MetHis: 0.288 ± 0.016
1.173MetIle: 1.173 ± 0.038
0.905MetLys: 0.905 ± 0.032
1.941MetLeu: 1.941 ± 0.047
0.545MetMet: 0.545 ± 0.024
0.79MetAsn: 0.79 ± 0.031
1.121MetPro: 1.121 ± 0.032
0.898MetGln: 0.898 ± 0.031
0.995MetArg: 0.995 ± 0.033
1.506MetSer: 1.506 ± 0.035
1.474MetThr: 1.474 ± 0.037
1.504MetVal: 1.504 ± 0.035
0.179MetTrp: 0.179 ± 0.013
0.365MetTyr: 0.365 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.953AsnAla: 2.953 ± 0.055
0.413AsnCys: 0.413 ± 0.019
1.948AsnAsp: 1.948 ± 0.086
1.924AsnGlu: 1.924 ± 0.051
1.93AsnPhe: 1.93 ± 0.049
2.621AsnGly: 2.621 ± 0.084
0.851AsnHis: 0.851 ± 0.028
2.856AsnIle: 2.856 ± 0.065
1.522AsnLys: 1.522 ± 0.039
5.139AsnLeu: 5.139 ± 0.103
0.659AsnMet: 0.659 ± 0.021
1.761AsnAsn: 1.761 ± 0.045
2.68AsnPro: 2.68 ± 0.056
2.183AsnGln: 2.183 ± 0.051
2.165AsnArg: 2.165 ± 0.044
2.363AsnSer: 2.363 ± 0.058
2.055AsnThr: 2.055 ± 0.052
2.311AsnVal: 2.311 ± 0.044
0.635AsnTrp: 0.635 ± 0.027
1.296AsnTyr: 1.296 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
3.515ProAla: 3.515 ± 0.074
0.354ProCys: 0.354 ± 0.02
3.142ProAsp: 3.142 ± 0.057
4.356ProGlu: 4.356 ± 0.083
1.873ProPhe: 1.873 ± 0.039
2.235ProGly: 2.235 ± 0.051
0.929ProHis: 0.929 ± 0.029
2.916ProIle: 2.916 ± 0.052
2.207ProLys: 2.207 ± 0.051
4.584ProLeu: 4.584 ± 0.082
0.932ProMet: 0.932 ± 0.029
1.932ProAsn: 1.932 ± 0.047
2.062ProPro: 2.062 ± 0.063
2.466ProGln: 2.466 ± 0.054
1.797ProArg: 1.797 ± 0.042
2.732ProSer: 2.732 ± 0.056
2.907ProThr: 2.907 ± 0.057
3.11ProVal: 3.11 ± 0.062
0.695ProTrp: 0.695 ± 0.028
1.295ProTyr: 1.295 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
4.676GlnAla: 4.676 ± 0.083
0.37GlnCys: 0.37 ± 0.019
2.366GlnAsp: 2.366 ± 0.046
3.173GlnGlu: 3.173 ± 0.055
1.756GlnPhe: 1.756 ± 0.04
3.402GlnGly: 3.402 ± 0.058
0.833GlnHis: 0.833 ± 0.028
3.299GlnIle: 3.299 ± 0.062
2.804GlnLys: 2.804 ± 0.06
5.443GlnLeu: 5.443 ± 0.071
1.034GlnMet: 1.034 ± 0.029
2.141GlnAsn: 2.141 ± 0.048
2.425GlnPro: 2.425 ± 0.047
3.386GlnGln: 3.386 ± 0.079
2.833GlnArg: 2.833 ± 0.059
2.954GlnSer: 2.954 ± 0.065
3.133GlnThr: 3.133 ± 0.058
3.208GlnVal: 3.208 ± 0.062
0.821GlnTrp: 0.821 ± 0.028
1.266GlnTyr: 1.266 ± 0.038
0.001GlnXaa: 0.001 ± 0.001
Arg
3.271ArgAla: 3.271 ± 0.062
0.484ArgCys: 0.484 ± 0.021
2.734ArgAsp: 2.734 ± 0.053
3.179ArgGlu: 3.179 ± 0.064
2.176ArgPhe: 2.176 ± 0.05
2.959ArgGly: 2.959 ± 0.055
1.176ArgHis: 1.176 ± 0.033
2.932ArgIle: 2.932 ± 0.044
2.351ArgLys: 2.351 ± 0.05
6.03ArgLeu: 6.03 ± 0.09
1.004ArgMet: 1.004 ± 0.032
2.048ArgAsn: 2.048 ± 0.044
2.205ArgPro: 2.205 ± 0.047
3.211ArgGln: 3.211 ± 0.063
3.277ArgArg: 3.277 ± 0.063
3.197ArgSer: 3.197 ± 0.059
2.39ArgThr: 2.39 ± 0.055
3.068ArgVal: 3.068 ± 0.053
0.808ArgTrp: 0.808 ± 0.028
1.792ArgTyr: 1.792 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
4.312SerAla: 4.312 ± 0.065
0.599SerCys: 0.599 ± 0.02
3.24SerAsp: 3.24 ± 0.07
3.853SerGlu: 3.853 ± 0.064
2.693SerPhe: 2.693 ± 0.047
4.584SerGly: 4.584 ± 0.135
1.275SerHis: 1.275 ± 0.036
3.58SerIle: 3.58 ± 0.07
2.425SerLys: 2.425 ± 0.048
7.184SerLeu: 7.184 ± 0.088
1.271SerMet: 1.271 ± 0.037
2.264SerAsn: 2.264 ± 0.057
3.338SerPro: 3.338 ± 0.05
3.109SerGln: 3.109 ± 0.057
3.052SerArg: 3.052 ± 0.051
3.929SerSer: 3.929 ± 0.074
3.312SerThr: 3.312 ± 0.063
3.722SerVal: 3.722 ± 0.065
0.854SerTrp: 0.854 ± 0.032
1.77SerTyr: 1.77 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
5.121ThrAla: 5.121 ± 0.095
0.51ThrCys: 0.51 ± 0.026
3.0ThrAsp: 3.0 ± 0.063
3.824ThrGlu: 3.824 ± 0.062
2.348ThrPhe: 2.348 ± 0.05
4.065ThrGly: 4.065 ± 0.079
0.995ThrHis: 0.995 ± 0.03
3.723ThrIle: 3.723 ± 0.069
2.55ThrLys: 2.55 ± 0.045
6.42ThrLeu: 6.42 ± 0.07
1.025ThrMet: 1.025 ± 0.037
2.148ThrAsn: 2.148 ± 0.047
3.23ThrPro: 3.23 ± 0.067
2.58ThrGln: 2.58 ± 0.048
2.209ThrArg: 2.209 ± 0.046
3.28ThrSer: 3.28 ± 0.066
3.465ThrThr: 3.465 ± 0.073
4.151ThrVal: 4.151 ± 0.065
0.705ThrTrp: 0.705 ± 0.024
1.599ThrTyr: 1.599 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
5.859ValAla: 5.859 ± 0.085
0.701ValCys: 0.701 ± 0.027
3.678ValAsp: 3.678 ± 0.063
4.298ValGlu: 4.298 ± 0.071
2.588ValPhe: 2.588 ± 0.046
4.83ValGly: 4.83 ± 0.086
1.021ValHis: 1.021 ± 0.034
4.278ValIle: 4.278 ± 0.065
2.995ValLys: 2.995 ± 0.052
6.428ValLeu: 6.428 ± 0.092
1.616ValMet: 1.616 ± 0.042
2.657ValAsn: 2.657 ± 0.047
2.713ValPro: 2.713 ± 0.055
2.663ValGln: 2.663 ± 0.046
2.93ValArg: 2.93 ± 0.049
3.91ValSer: 3.91 ± 0.071
4.064ValThr: 4.064 ± 0.073
4.641ValVal: 4.641 ± 0.082
0.836ValTrp: 0.836 ± 0.027
1.693ValTyr: 1.693 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.943TrpAla: 0.943 ± 0.03
0.143TrpCys: 0.143 ± 0.011
0.679TrpAsp: 0.679 ± 0.023
0.904TrpGlu: 0.904 ± 0.03
0.631TrpPhe: 0.631 ± 0.025
1.035TrpGly: 1.035 ± 0.035
0.344TrpHis: 0.344 ± 0.019
0.786TrpIle: 0.786 ± 0.027
0.444TrpLys: 0.444 ± 0.018
1.985TrpLeu: 1.985 ± 0.054
0.292TrpMet: 0.292 ± 0.017
0.414TrpAsn: 0.414 ± 0.02
0.21TrpPro: 0.21 ± 0.015
1.439TrpGln: 1.439 ± 0.044
0.899TrpArg: 0.899 ± 0.031
0.908TrpSer: 0.908 ± 0.036
0.599TrpThr: 0.599 ± 0.025
0.887TrpVal: 0.887 ± 0.031
0.238TrpTrp: 0.238 ± 0.016
0.409TrpTyr: 0.409 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.044TyrAla: 2.044 ± 0.046
0.409TyrCys: 0.409 ± 0.018
1.691TyrAsp: 1.691 ± 0.043
1.788TyrGlu: 1.788 ± 0.039
1.42TyrPhe: 1.42 ± 0.038
2.331TyrGly: 2.331 ± 0.066
0.618TyrHis: 0.618 ± 0.022
1.507TyrIle: 1.507 ± 0.046
1.114TyrLys: 1.114 ± 0.031
3.497TyrLeu: 3.497 ± 0.061
0.427TyrMet: 0.427 ± 0.019
0.958TyrAsn: 0.958 ± 0.028
1.48TyrPro: 1.48 ± 0.04
1.867TyrGln: 1.867 ± 0.05
1.955TyrArg: 1.955 ± 0.049
1.733TyrSer: 1.733 ± 0.04
1.241TyrThr: 1.241 ± 0.03
1.621TyrVal: 1.621 ± 0.036
0.536TyrTrp: 0.536 ± 0.022
0.966TyrTyr: 0.966 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.001XaaAsn: 0.001 ± 0.001
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3542 proteins (1119968 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski