Amino acid dipepetide frequency for Gordonia phage Mollymur

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.907AlaAla: 15.907 ± 1.358
0.776AlaCys: 0.776 ± 0.242
7.932AlaAsp: 7.932 ± 0.565
7.501AlaGlu: 7.501 ± 0.702
2.5AlaPhe: 2.5 ± 0.358
9.44AlaGly: 9.44 ± 0.636
1.595AlaHis: 1.595 ± 0.249
5.087AlaIle: 5.087 ± 0.454
4.569AlaLys: 4.569 ± 0.458
10.992AlaLeu: 10.992 ± 0.958
4.009AlaMet: 4.009 ± 0.369
3.405AlaAsn: 3.405 ± 0.442
4.181AlaPro: 4.181 ± 0.48
5.044AlaGln: 5.044 ± 0.83
7.458AlaArg: 7.458 ± 0.639
5.819AlaSer: 5.819 ± 0.519
7.156AlaThr: 7.156 ± 0.612
7.328AlaVal: 7.328 ± 0.563
2.026AlaTrp: 2.026 ± 0.267
2.543AlaTyr: 2.543 ± 0.377
0.0AlaXaa: 0.0 ± 0.0
Cys
0.776CysAla: 0.776 ± 0.237
0.043CysCys: 0.043 ± 0.048
0.604CysAsp: 0.604 ± 0.195
0.216CysGlu: 0.216 ± 0.106
0.129CysPhe: 0.129 ± 0.064
0.948CysGly: 0.948 ± 0.242
0.302CysHis: 0.302 ± 0.11
0.302CysIle: 0.302 ± 0.135
0.172CysLys: 0.172 ± 0.097
0.302CysLeu: 0.302 ± 0.126
0.172CysMet: 0.172 ± 0.097
0.388CysAsn: 0.388 ± 0.142
0.474CysPro: 0.474 ± 0.148
0.259CysGln: 0.259 ± 0.111
0.819CysArg: 0.819 ± 0.257
0.388CysSer: 0.388 ± 0.11
0.517CysThr: 0.517 ± 0.16
0.474CysVal: 0.474 ± 0.137
0.086CysTrp: 0.086 ± 0.059
0.129CysTyr: 0.129 ± 0.064
0.0CysXaa: 0.0 ± 0.0
Asp
6.94AspAla: 6.94 ± 0.653
0.517AspCys: 0.517 ± 0.131
3.966AspAsp: 3.966 ± 0.375
4.44AspGlu: 4.44 ± 0.631
2.328AspPhe: 2.328 ± 0.363
5.69AspGly: 5.69 ± 0.457
1.379AspHis: 1.379 ± 0.27
3.19AspIle: 3.19 ± 0.478
1.897AspLys: 1.897 ± 0.325
5.345AspLeu: 5.345 ± 0.41
1.638AspMet: 1.638 ± 0.228
2.026AspAsn: 2.026 ± 0.285
4.612AspPro: 4.612 ± 0.464
2.285AspGln: 2.285 ± 0.268
5.432AspArg: 5.432 ± 0.596
3.19AspSer: 3.19 ± 0.404
3.621AspThr: 3.621 ± 0.463
4.914AspVal: 4.914 ± 0.436
1.595AspTrp: 1.595 ± 0.378
1.854AspTyr: 1.854 ± 0.342
0.0AspXaa: 0.0 ± 0.0
Glu
6.983GluAla: 6.983 ± 0.747
0.431GluCys: 0.431 ± 0.149
4.052GluAsp: 4.052 ± 0.451
3.923GluGlu: 3.923 ± 0.449
2.112GluPhe: 2.112 ± 0.312
5.044GluGly: 5.044 ± 0.461
1.207GluHis: 1.207 ± 0.267
4.009GluIle: 4.009 ± 0.5
2.759GluLys: 2.759 ± 0.379
6.639GluLeu: 6.639 ± 0.552
1.336GluMet: 1.336 ± 0.269
2.026GluAsn: 2.026 ± 0.254
3.362GluPro: 3.362 ± 0.618
2.802GluGln: 2.802 ± 0.351
5.087GluArg: 5.087 ± 0.556
3.104GluSer: 3.104 ± 0.418
3.449GluThr: 3.449 ± 0.435
4.354GluVal: 4.354 ± 0.54
1.466GluTrp: 1.466 ± 0.282
1.854GluTyr: 1.854 ± 0.287
0.0GluXaa: 0.0 ± 0.0
Phe
3.621PheAla: 3.621 ± 0.322
0.388PheCys: 0.388 ± 0.112
2.414PheAsp: 2.414 ± 0.394
2.285PheGlu: 2.285 ± 0.387
0.819PhePhe: 0.819 ± 0.186
2.586PheGly: 2.586 ± 0.426
0.604PheHis: 0.604 ± 0.201
1.164PheIle: 1.164 ± 0.201
0.991PheLys: 0.991 ± 0.202
1.552PheLeu: 1.552 ± 0.325
0.56PheMet: 0.56 ± 0.15
1.078PheAsn: 1.078 ± 0.186
1.164PhePro: 1.164 ± 0.199
0.862PheGln: 0.862 ± 0.187
2.155PheArg: 2.155 ± 0.332
1.681PheSer: 1.681 ± 0.275
2.328PheThr: 2.328 ± 0.337
1.724PheVal: 1.724 ± 0.244
0.604PheTrp: 0.604 ± 0.153
0.733PheTyr: 0.733 ± 0.178
0.0PheXaa: 0.0 ± 0.0
Gly
7.544GlyAla: 7.544 ± 0.831
0.474GlyCys: 0.474 ± 0.182
5.518GlyAsp: 5.518 ± 0.584
6.294GlyGlu: 6.294 ± 0.572
2.888GlyPhe: 2.888 ± 0.355
8.492GlyGly: 8.492 ± 1.137
2.069GlyHis: 2.069 ± 0.285
3.535GlyIle: 3.535 ± 0.59
3.19GlyLys: 3.19 ± 0.389
6.035GlyLeu: 6.035 ± 0.494
2.242GlyMet: 2.242 ± 0.395
2.586GlyAsn: 2.586 ± 0.33
4.138GlyPro: 4.138 ± 0.454
3.535GlyGln: 3.535 ± 0.389
5.432GlyArg: 5.432 ± 0.565
4.656GlySer: 4.656 ± 0.46
5.13GlyThr: 5.13 ± 0.63
6.294GlyVal: 6.294 ± 0.635
1.379GlyTrp: 1.379 ± 0.232
2.414GlyTyr: 2.414 ± 0.309
0.0GlyXaa: 0.0 ± 0.0
His
1.379HisAla: 1.379 ± 0.247
0.388HisCys: 0.388 ± 0.145
1.121HisAsp: 1.121 ± 0.285
1.164HisGlu: 1.164 ± 0.27
0.733HisPhe: 0.733 ± 0.185
1.293HisGly: 1.293 ± 0.19
0.474HisHis: 0.474 ± 0.144
1.035HisIle: 1.035 ± 0.252
0.431HisLys: 0.431 ± 0.146
2.414HisLeu: 2.414 ± 0.359
0.56HisMet: 0.56 ± 0.189
0.474HisAsn: 0.474 ± 0.139
1.379HisPro: 1.379 ± 0.299
0.733HisGln: 0.733 ± 0.181
1.035HisArg: 1.035 ± 0.242
1.078HisSer: 1.078 ± 0.206
0.991HisThr: 0.991 ± 0.205
1.423HisVal: 1.423 ± 0.268
0.345HisTrp: 0.345 ± 0.126
0.733HisTyr: 0.733 ± 0.201
0.0HisXaa: 0.0 ± 0.0
Ile
5.906IleAla: 5.906 ± 0.442
0.388IleCys: 0.388 ± 0.132
3.75IleAsp: 3.75 ± 0.332
4.569IleGlu: 4.569 ± 0.481
1.681IlePhe: 1.681 ± 0.28
3.449IleGly: 3.449 ± 0.407
1.035IleHis: 1.035 ± 0.268
2.242IleIle: 2.242 ± 0.327
1.595IleLys: 1.595 ± 0.244
2.974IleLeu: 2.974 ± 0.339
0.733IleMet: 0.733 ± 0.178
1.767IleAsn: 1.767 ± 0.311
2.543IlePro: 2.543 ± 0.329
1.854IleGln: 1.854 ± 0.284
3.578IleArg: 3.578 ± 0.402
2.716IleSer: 2.716 ± 0.337
2.888IleThr: 2.888 ± 0.433
3.75IleVal: 3.75 ± 0.535
0.991IleTrp: 0.991 ± 0.24
1.681IleTyr: 1.681 ± 0.298
0.0IleXaa: 0.0 ± 0.0
Lys
4.656LysAla: 4.656 ± 0.525
0.216LysCys: 0.216 ± 0.102
2.198LysAsp: 2.198 ± 0.373
1.466LysGlu: 1.466 ± 0.346
1.121LysPhe: 1.121 ± 0.205
2.414LysGly: 2.414 ± 0.267
0.733LysHis: 0.733 ± 0.157
2.155LysIle: 2.155 ± 0.291
1.854LysLys: 1.854 ± 0.377
3.147LysLeu: 3.147 ± 0.329
0.733LysMet: 0.733 ± 0.185
1.035LysAsn: 1.035 ± 0.193
2.242LysPro: 2.242 ± 0.345
1.207LysGln: 1.207 ± 0.257
3.19LysArg: 3.19 ± 0.359
2.759LysSer: 2.759 ± 0.368
2.069LysThr: 2.069 ± 0.264
2.5LysVal: 2.5 ± 0.373
0.862LysTrp: 0.862 ± 0.166
1.121LysTyr: 1.121 ± 0.218
0.0LysXaa: 0.0 ± 0.0
Leu
9.311LeuAla: 9.311 ± 0.746
0.862LeuCys: 0.862 ± 0.221
6.164LeuAsp: 6.164 ± 0.459
4.483LeuGlu: 4.483 ± 0.424
2.414LeuPhe: 2.414 ± 0.356
6.337LeuGly: 6.337 ± 0.515
1.94LeuHis: 1.94 ± 0.35
3.966LeuIle: 3.966 ± 0.493
2.974LeuLys: 2.974 ± 0.509
5.906LeuLeu: 5.906 ± 0.517
1.293LeuMet: 1.293 ± 0.225
2.63LeuAsn: 2.63 ± 0.345
4.44LeuPro: 4.44 ± 0.506
2.888LeuGln: 2.888 ± 0.406
5.863LeuArg: 5.863 ± 0.55
4.871LeuSer: 4.871 ± 0.412
5.0LeuThr: 5.0 ± 0.41
4.268LeuVal: 4.268 ± 0.394
1.466LeuTrp: 1.466 ± 0.329
2.026LeuTyr: 2.026 ± 0.309
0.0LeuXaa: 0.0 ± 0.0
Met
3.19MetAla: 3.19 ± 0.312
0.172MetCys: 0.172 ± 0.084
1.035MetAsp: 1.035 ± 0.154
0.948MetGlu: 0.948 ± 0.194
0.776MetPhe: 0.776 ± 0.179
1.724MetGly: 1.724 ± 0.255
0.776MetHis: 0.776 ± 0.183
0.819MetIle: 0.819 ± 0.246
1.035MetLys: 1.035 ± 0.246
1.379MetLeu: 1.379 ± 0.273
0.474MetMet: 0.474 ± 0.143
0.604MetAsn: 0.604 ± 0.149
1.552MetPro: 1.552 ± 0.251
0.776MetGln: 0.776 ± 0.22
1.379MetArg: 1.379 ± 0.198
2.285MetSer: 2.285 ± 0.313
2.328MetThr: 2.328 ± 0.306
1.423MetVal: 1.423 ± 0.26
0.345MetTrp: 0.345 ± 0.107
0.56MetTyr: 0.56 ± 0.164
0.0MetXaa: 0.0 ± 0.0
Asn
4.009AsnAla: 4.009 ± 0.424
0.086AsnCys: 0.086 ± 0.07
1.811AsnAsp: 1.811 ± 0.26
1.897AsnGlu: 1.897 ± 0.288
0.345AsnPhe: 0.345 ± 0.112
3.104AsnGly: 3.104 ± 0.542
0.474AsnHis: 0.474 ± 0.146
1.466AsnIle: 1.466 ± 0.225
0.905AsnLys: 0.905 ± 0.165
2.759AsnLeu: 2.759 ± 0.398
0.474AsnMet: 0.474 ± 0.146
0.905AsnAsn: 0.905 ± 0.189
2.155AsnPro: 2.155 ± 0.361
0.991AsnGln: 0.991 ± 0.189
2.759AsnArg: 2.759 ± 0.329
1.897AsnSer: 1.897 ± 0.375
1.897AsnThr: 1.897 ± 0.272
1.94AsnVal: 1.94 ± 0.249
0.345AsnTrp: 0.345 ± 0.133
0.991AsnTyr: 0.991 ± 0.164
0.0AsnXaa: 0.0 ± 0.0
Pro
5.863ProAla: 5.863 ± 0.651
0.388ProCys: 0.388 ± 0.14
4.095ProAsp: 4.095 ± 0.438
4.181ProGlu: 4.181 ± 0.361
1.336ProPhe: 1.336 ± 0.251
5.345ProGly: 5.345 ± 0.496
0.819ProHis: 0.819 ± 0.188
2.371ProIle: 2.371 ± 0.331
1.897ProLys: 1.897 ± 0.268
2.888ProLeu: 2.888 ± 0.284
1.207ProMet: 1.207 ± 0.216
1.724ProAsn: 1.724 ± 0.27
2.63ProPro: 2.63 ± 0.41
1.423ProGln: 1.423 ± 0.244
2.586ProArg: 2.586 ± 0.347
3.578ProSer: 3.578 ± 0.438
3.147ProThr: 3.147 ± 0.449
3.664ProVal: 3.664 ± 0.523
0.991ProTrp: 0.991 ± 0.208
1.293ProTyr: 1.293 ± 0.246
0.0ProXaa: 0.0 ± 0.0
Gln
4.138GlnAla: 4.138 ± 0.715
0.302GlnCys: 0.302 ± 0.126
1.724GlnAsp: 1.724 ± 0.31
1.983GlnGlu: 1.983 ± 0.283
1.466GlnPhe: 1.466 ± 0.315
2.457GlnGly: 2.457 ± 0.454
0.647GlnHis: 0.647 ± 0.185
1.94GlnIle: 1.94 ± 0.246
1.681GlnLys: 1.681 ± 0.527
3.405GlnLeu: 3.405 ± 0.412
0.905GlnMet: 0.905 ± 0.173
0.948GlnAsn: 0.948 ± 0.204
1.595GlnPro: 1.595 ± 0.238
1.983GlnGln: 1.983 ± 0.503
2.802GlnArg: 2.802 ± 0.453
1.638GlnSer: 1.638 ± 0.305
1.638GlnThr: 1.638 ± 0.238
2.974GlnVal: 2.974 ± 0.381
0.733GlnTrp: 0.733 ± 0.191
0.862GlnTyr: 0.862 ± 0.237
0.0GlnXaa: 0.0 ± 0.0
Arg
7.975ArgAla: 7.975 ± 0.728
0.56ArgCys: 0.56 ± 0.165
4.569ArgAsp: 4.569 ± 0.394
4.914ArgGlu: 4.914 ± 0.501
2.716ArgPhe: 2.716 ± 0.333
4.785ArgGly: 4.785 ± 0.486
1.336ArgHis: 1.336 ± 0.288
3.449ArgIle: 3.449 ± 0.329
3.837ArgLys: 3.837 ± 0.439
5.863ArgLeu: 5.863 ± 0.529
2.371ArgMet: 2.371 ± 0.299
2.63ArgAsn: 2.63 ± 0.287
3.147ArgPro: 3.147 ± 0.463
2.716ArgGln: 2.716 ± 0.445
5.776ArgArg: 5.776 ± 0.644
3.233ArgSer: 3.233 ± 0.358
4.009ArgThr: 4.009 ± 0.437
5.561ArgVal: 5.561 ± 0.514
1.164ArgTrp: 1.164 ± 0.226
2.285ArgTyr: 2.285 ± 0.292
0.0ArgXaa: 0.0 ± 0.0
Ser
6.509SerAla: 6.509 ± 0.517
0.302SerCys: 0.302 ± 0.122
3.405SerAsp: 3.405 ± 0.371
3.233SerGlu: 3.233 ± 0.406
1.336SerPhe: 1.336 ± 0.198
5.69SerGly: 5.69 ± 0.535
0.733SerHis: 0.733 ± 0.136
3.276SerIle: 3.276 ± 0.43
2.242SerLys: 2.242 ± 0.28
4.095SerLeu: 4.095 ± 0.403
1.293SerMet: 1.293 ± 0.22
1.767SerAsn: 1.767 ± 0.282
2.586SerPro: 2.586 ± 0.348
1.509SerGln: 1.509 ± 0.29
4.656SerArg: 4.656 ± 0.458
3.492SerSer: 3.492 ± 0.43
3.233SerThr: 3.233 ± 0.31
3.578SerVal: 3.578 ± 0.368
1.164SerTrp: 1.164 ± 0.249
1.379SerTyr: 1.379 ± 0.255
0.0SerXaa: 0.0 ± 0.0
Thr
7.285ThrAla: 7.285 ± 0.731
0.345ThrCys: 0.345 ± 0.16
3.837ThrAsp: 3.837 ± 0.413
3.75ThrGlu: 3.75 ± 0.431
1.897ThrPhe: 1.897 ± 0.326
5.216ThrGly: 5.216 ± 0.564
0.948ThrHis: 0.948 ± 0.204
3.966ThrIle: 3.966 ± 0.383
2.414ThrLys: 2.414 ± 0.32
4.095ThrLeu: 4.095 ± 0.523
1.035ThrMet: 1.035 ± 0.225
1.811ThrAsn: 1.811 ± 0.263
3.88ThrPro: 3.88 ± 0.365
1.897ThrGln: 1.897 ± 0.383
3.621ThrArg: 3.621 ± 0.454
3.319ThrSer: 3.319 ± 0.381
3.793ThrThr: 3.793 ± 0.415
4.225ThrVal: 4.225 ± 0.382
1.379ThrTrp: 1.379 ± 0.202
1.336ThrTyr: 1.336 ± 0.224
0.0ThrXaa: 0.0 ± 0.0
Val
8.751ValAla: 8.751 ± 0.623
0.345ValCys: 0.345 ± 0.126
5.647ValAsp: 5.647 ± 0.488
5.216ValGlu: 5.216 ± 0.546
1.681ValPhe: 1.681 ± 0.28
6.337ValGly: 6.337 ± 0.652
1.25ValHis: 1.25 ± 0.251
4.009ValIle: 4.009 ± 0.443
2.155ValLys: 2.155 ± 0.297
5.432ValLeu: 5.432 ± 0.427
1.25ValMet: 1.25 ± 0.168
1.724ValAsn: 1.724 ± 0.39
3.492ValPro: 3.492 ± 0.455
1.681ValGln: 1.681 ± 0.226
5.087ValArg: 5.087 ± 0.611
3.319ValSer: 3.319 ± 0.309
4.095ValThr: 4.095 ± 0.391
5.432ValVal: 5.432 ± 0.565
1.121ValTrp: 1.121 ± 0.237
1.423ValTyr: 1.423 ± 0.267
0.0ValXaa: 0.0 ± 0.0
Trp
1.466TrpAla: 1.466 ± 0.2
0.216TrpCys: 0.216 ± 0.116
1.379TrpAsp: 1.379 ± 0.253
1.164TrpGlu: 1.164 ± 0.302
0.56TrpPhe: 0.56 ± 0.156
1.293TrpGly: 1.293 ± 0.301
0.431TrpHis: 0.431 ± 0.124
1.164TrpIle: 1.164 ± 0.204
0.431TrpLys: 0.431 ± 0.138
1.724TrpLeu: 1.724 ± 0.254
0.604TrpMet: 0.604 ± 0.163
0.69TrpAsn: 0.69 ± 0.172
0.733TrpPro: 0.733 ± 0.178
0.69TrpGln: 0.69 ± 0.175
1.811TrpArg: 1.811 ± 0.377
1.078TrpSer: 1.078 ± 0.23
1.293TrpThr: 1.293 ± 0.222
1.293TrpVal: 1.293 ± 0.219
0.517TrpTrp: 0.517 ± 0.139
0.388TrpTyr: 0.388 ± 0.133
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.061TyrAla: 3.061 ± 0.391
0.302TyrCys: 0.302 ± 0.1
1.638TyrAsp: 1.638 ± 0.279
2.371TyrGlu: 2.371 ± 0.318
0.474TyrPhe: 0.474 ± 0.149
2.198TyrGly: 2.198 ± 0.344
0.431TyrHis: 0.431 ± 0.157
0.948TyrIle: 0.948 ± 0.207
0.69TyrLys: 0.69 ± 0.164
2.155TyrLeu: 2.155 ± 0.299
0.647TyrMet: 0.647 ± 0.127
0.991TyrAsn: 0.991 ± 0.226
1.121TyrPro: 1.121 ± 0.239
0.69TyrGln: 0.69 ± 0.148
2.371TyrArg: 2.371 ± 0.314
1.379TyrSer: 1.379 ± 0.28
1.466TyrThr: 1.466 ± 0.217
2.328TyrVal: 2.328 ± 0.264
0.345TyrTrp: 0.345 ± 0.115
0.733TyrTyr: 0.733 ± 0.224
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 113 proteins (23199 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski