Amino acid dipepetide frequency for Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus awamori var. kawachi)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.935AlaAla: 8.935 ± 0.057	1.095AlaCys: 1.095 ± 0.017	4.237AlaAsp: 4.237 ± 0.029	5.077AlaGlu: 5.077 ± 0.038	3.14AlaPhe: 3.14 ± 0.024	5.743AlaGly: 5.743 ± 0.038	1.796AlaHis: 1.796 ± 0.018	4.303AlaIle: 4.303 ± 0.031	3.737AlaLys: 3.737 ± 0.034	7.8AlaLeu: 7.8 ± 0.042	2.014AlaMet: 2.014 ± 0.021	2.88AlaAsn: 2.88 ± 0.026	4.634AlaPro: 4.634 ± 0.037	3.357AlaGln: 3.357 ± 0.03	4.874AlaArg: 4.874 ± 0.035	7.175AlaSer: 7.175 ± 0.043	5.299AlaThr: 5.299 ± 0.032	5.483AlaVal: 5.483 ± 0.041	1.184AlaTrp: 1.184 ± 0.014	2.273AlaTyr: 2.273 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	0.963CysAla: 0.963 ± 0.013	0.228CysCys: 0.228 ± 0.007	0.683CysAsp: 0.683 ± 0.012	0.604CysGlu: 0.604 ± 0.011	0.543CysPhe: 0.543 ± 0.009	0.919CysGly: 0.919 ± 0.016	0.345CysHis: 0.345 ± 0.008	0.719CysIle: 0.719 ± 0.013	0.457CysLys: 0.457 ± 0.009	1.355CysLeu: 1.355 ± 0.017	0.276CysMet: 0.276 ± 0.007	0.42CysAsn: 0.42 ± 0.01	0.654CysPro: 0.654 ± 0.012	0.458CysGln: 0.458 ± 0.01	0.766CysArg: 0.766 ± 0.013	0.934CysSer: 0.934 ± 0.014	0.714CysThr: 0.714 ± 0.013	0.845CysVal: 0.845 ± 0.014	0.21CysTrp: 0.21 ± 0.006	0.367CysTyr: 0.367 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.625AspAla: 4.625 ± 0.031	0.625AspCys: 0.625 ± 0.012	4.059AspAsp: 4.059 ± 0.042	4.33AspGlu: 4.33 ± 0.038	2.128AspPhe: 2.128 ± 0.021	3.959AspGly: 3.959 ± 0.027	1.292AspHis: 1.292 ± 0.016	3.184AspIle: 3.184 ± 0.027	2.214AspLys: 2.214 ± 0.023	5.212AspLeu: 5.212 ± 0.037	1.282AspMet: 1.282 ± 0.016	1.921AspAsn: 1.921 ± 0.02	3.38AspPro: 3.38 ± 0.03	1.916AspGln: 1.916 ± 0.017	3.127AspArg: 3.127 ± 0.03	4.08AspSer: 4.08 ± 0.036	3.066AspThr: 3.066 ± 0.028	3.702AspVal: 3.702 ± 0.028	0.907AspTrp: 0.907 ± 0.014	1.726AspTyr: 1.726 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.339GluAla: 5.339 ± 0.033	0.651GluCys: 0.651 ± 0.011	4.124GluAsp: 4.124 ± 0.037	5.631GluGlu: 5.631 ± 0.057	1.933GluPhe: 1.933 ± 0.017	3.84GluGly: 3.84 ± 0.03	1.413GluHis: 1.413 ± 0.017	2.992GluIle: 2.992 ± 0.025	3.513GluLys: 3.513 ± 0.033	5.188GluLeu: 5.188 ± 0.039	1.473GluMet: 1.473 ± 0.016	2.216GluAsn: 2.216 ± 0.02	2.853GluPro: 2.853 ± 0.046	2.57GluGln: 2.57 ± 0.024	3.928GluArg: 3.928 ± 0.039	4.345GluSer: 4.345 ± 0.037	3.548GluThr: 3.548 ± 0.03	3.695GluVal: 3.695 ± 0.031	0.919GluTrp: 0.919 ± 0.011	1.769GluTyr: 1.769 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	2.992PheAla: 2.992 ± 0.026	0.575PheCys: 0.575 ± 0.011	2.266PheAsp: 2.266 ± 0.02	2.087PheGlu: 2.087 ± 0.019	1.628PhePhe: 1.628 ± 0.021	2.827PheGly: 2.827 ± 0.029	0.945PheHis: 0.945 ± 0.014	1.851PheIle: 1.851 ± 0.02	1.353PheLys: 1.353 ± 0.014	3.592PheLeu: 3.592 ± 0.03	0.782PheMet: 0.782 ± 0.012	1.389PheAsn: 1.389 ± 0.014	1.987PhePro: 1.987 ± 0.019	1.417PheGln: 1.417 ± 0.016	2.037PheArg: 2.037 ± 0.022	2.963PheSer: 2.963 ± 0.026	2.19PheThr: 2.19 ± 0.022	2.39PheVal: 2.39 ± 0.021	0.653PheTrp: 0.653 ± 0.012	1.166PheTyr: 1.166 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.215GlyAla: 5.215 ± 0.035	0.896GlyCys: 0.896 ± 0.014	3.612GlyAsp: 3.612 ± 0.029	3.664GlyGlu: 3.664 ± 0.029	2.785GlyPhe: 2.785 ± 0.025	5.494GlyGly: 5.494 ± 0.046	1.678GlyHis: 1.678 ± 0.021	3.533GlyIle: 3.533 ± 0.032	3.22GlyLys: 3.22 ± 0.025	6.201GlyLeu: 6.201 ± 0.035	1.596GlyMet: 1.596 ± 0.019	2.456GlyAsn: 2.456 ± 0.024	3.315GlyPro: 3.315 ± 0.027	2.564GlyGln: 2.564 ± 0.025	4.02GlyArg: 4.02 ± 0.031	5.696GlySer: 5.696 ± 0.043	3.971GlyThr: 3.971 ± 0.033	4.556GlyVal: 4.556 ± 0.035	1.2GlyTrp: 1.2 ± 0.016	2.237GlyTyr: 2.237 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.89HisAla: 1.89 ± 0.018	0.342HisCys: 0.342 ± 0.009	1.35HisAsp: 1.35 ± 0.018	1.355HisGlu: 1.355 ± 0.017	0.922HisPhe: 0.922 ± 0.013	1.694HisGly: 1.694 ± 0.019	0.91HisHis: 0.91 ± 0.017	1.245HisIle: 1.245 ± 0.013	0.825HisLys: 0.825 ± 0.011	2.369HisLeu: 2.369 ± 0.024	0.516HisMet: 0.516 ± 0.011	0.869HisAsn: 0.869 ± 0.015	1.757HisPro: 1.757 ± 0.021	0.988HisGln: 0.988 ± 0.013	1.581HisArg: 1.581 ± 0.02	1.812HisSer: 1.812 ± 0.02	1.348HisThr: 1.348 ± 0.016	1.444HisVal: 1.444 ± 0.015	0.363HisTrp: 0.363 ± 0.008	0.744HisTyr: 0.744 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.179IleAla: 4.179 ± 0.033	0.79IleCys: 0.79 ± 0.012	2.876IleAsp: 2.876 ± 0.026	2.799IleGlu: 2.799 ± 0.024	2.03IlePhe: 2.03 ± 0.021	3.207IleGly: 3.207 ± 0.03	1.263IleHis: 1.263 ± 0.015	2.602IleIle: 2.602 ± 0.028	1.989IleLys: 1.989 ± 0.022	4.767IleLeu: 4.767 ± 0.037	1.03IleMet: 1.03 ± 0.012	1.783IleAsn: 1.783 ± 0.019	3.177IlePro: 3.177 ± 0.026	1.954IleGln: 1.954 ± 0.02	2.85IleArg: 2.85 ± 0.023	3.865IleSer: 3.865 ± 0.029	2.922IleThr: 2.922 ± 0.026	3.229IleVal: 3.229 ± 0.029	0.733IleTrp: 0.733 ± 0.013	1.519IleTyr: 1.519 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.867LysAla: 3.867 ± 0.031	0.465LysCys: 0.465 ± 0.01	2.579LysAsp: 2.579 ± 0.024	3.232LysGlu: 3.232 ± 0.033	1.307LysPhe: 1.307 ± 0.015	2.784LysGly: 2.784 ± 0.025	1.06LysHis: 1.06 ± 0.014	2.105LysIle: 2.105 ± 0.021	2.873LysLys: 2.873 ± 0.04	3.864LysLeu: 3.864 ± 0.034	0.923LysMet: 0.923 ± 0.014	1.583LysAsn: 1.583 ± 0.019	2.553LysPro: 2.553 ± 0.022	1.78LysGln: 1.78 ± 0.017	3.163LysArg: 3.163 ± 0.029	3.22LysSer: 3.22 ± 0.027	2.555LysThr: 2.555 ± 0.027	2.696LysVal: 2.696 ± 0.02	0.632LysTrp: 0.632 ± 0.01	1.344LysTyr: 1.344 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.898LeuAla: 7.898 ± 0.044	1.251LeuCys: 1.251 ± 0.018	5.282LeuAsp: 5.282 ± 0.036	5.58LeuGlu: 5.58 ± 0.045	3.436LeuPhe: 3.436 ± 0.028	6.077LeuGly: 6.077 ± 0.037	2.33LeuHis: 2.33 ± 0.023	4.079LeuIle: 4.079 ± 0.033	3.943LeuLys: 3.943 ± 0.03	8.795LeuLeu: 8.795 ± 0.054	1.867LeuMet: 1.867 ± 0.018	3.21LeuAsn: 3.21 ± 0.025	5.579LeuPro: 5.579 ± 0.031	3.994LeuGln: 3.994 ± 0.032	5.899LeuArg: 5.899 ± 0.04	7.539LeuSer: 7.539 ± 0.043	5.036LeuThr: 5.036 ± 0.038	5.576LeuVal: 5.576 ± 0.036	1.261LeuTrp: 1.261 ± 0.017	2.57LeuTyr: 2.57 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.159MetAla: 2.159 ± 0.018	0.246MetCys: 0.246 ± 0.006	1.253MetAsp: 1.253 ± 0.014	1.332MetGlu: 1.332 ± 0.015	0.761MetPhe: 0.761 ± 0.012	1.486MetGly: 1.486 ± 0.018	0.496MetHis: 0.496 ± 0.01	1.015MetIle: 1.015 ± 0.013	0.969MetLys: 0.969 ± 0.013	1.886MetLeu: 1.886 ± 0.019	0.577MetMet: 0.577 ± 0.01	0.81MetAsn: 0.81 ± 0.013	1.235MetPro: 1.235 ± 0.017	0.891MetGln: 0.891 ± 0.014	1.275MetArg: 1.275 ± 0.017	1.906MetSer: 1.906 ± 0.018	1.315MetThr: 1.315 ± 0.016	1.379MetVal: 1.379 ± 0.014	0.271MetTrp: 0.271 ± 0.008	0.545MetTyr: 0.545 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.061AsnAla: 3.061 ± 0.024	0.457AsnCys: 0.457 ± 0.009	1.92AsnAsp: 1.92 ± 0.018	1.99AsnGlu: 1.99 ± 0.019	1.333AsnPhe: 1.333 ± 0.016	2.883AsnGly: 2.883 ± 0.03	0.852AsnHis: 0.852 ± 0.013	2.05AsnIle: 2.05 ± 0.02	1.434AsnLys: 1.434 ± 0.017	3.219AsnLeu: 3.219 ± 0.026	0.834AsnMet: 0.834 ± 0.012	1.514AsnAsn: 1.514 ± 0.019	2.448AsnPro: 2.448 ± 0.025	1.314AsnGln: 1.314 ± 0.016	1.927AsnArg: 1.927 ± 0.019	2.642AsnSer: 2.642 ± 0.025	2.214AsnThr: 2.214 ± 0.024	2.344AsnVal: 2.344 ± 0.019	0.561AsnTrp: 0.561 ± 0.012	1.116AsnTyr: 1.116 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.203ProAla: 5.203 ± 0.042	0.539ProCys: 0.539 ± 0.011	3.285ProAsp: 3.285 ± 0.026	3.966ProGlu: 3.966 ± 0.041	2.093ProPhe: 2.093 ± 0.019	3.864ProGly: 3.864 ± 0.031	1.378ProHis: 1.378 ± 0.018	2.542ProIle: 2.542 ± 0.021	2.442ProLys: 2.442 ± 0.026	4.774ProLeu: 4.774 ± 0.033	1.067ProMet: 1.067 ± 0.014	2.18ProAsn: 2.18 ± 0.021	4.781ProPro: 4.781 ± 0.061	2.465ProGln: 2.465 ± 0.029	3.321ProArg: 3.321 ± 0.034	6.102ProSer: 6.102 ± 0.05	4.033ProThr: 4.033 ± 0.027	3.719ProVal: 3.719 ± 0.033	0.799ProTrp: 0.799 ± 0.014	1.6ProTyr: 1.6 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.431GlnAla: 3.431 ± 0.03	0.468GlnCys: 0.468 ± 0.009	2.047GlnAsp: 2.047 ± 0.021	2.499GlnGlu: 2.499 ± 0.024	1.308GlnPhe: 1.308 ± 0.017	2.384GlnGly: 2.384 ± 0.025	1.069GlnHis: 1.069 ± 0.014	1.915GlnIle: 1.915 ± 0.019	1.93GlnLys: 1.93 ± 0.022	3.617GlnLeu: 3.617 ± 0.028	0.891GlnMet: 0.891 ± 0.012	1.52GlnAsn: 1.52 ± 0.019	2.603GlnPro: 2.603 ± 0.03	2.451GlnGln: 2.451 ± 0.043	2.627GlnArg: 2.627 ± 0.023	3.194GlnSer: 3.194 ± 0.028	2.367GlnThr: 2.367 ± 0.021	2.262GlnVal: 2.262 ± 0.021	0.601GlnTrp: 0.601 ± 0.012	1.226GlnTyr: 1.226 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.641ArgAla: 4.641 ± 0.034	0.72ArgCys: 0.72 ± 0.013	3.373ArgAsp: 3.373 ± 0.031	3.858ArgGlu: 3.858 ± 0.033	2.201ArgPhe: 2.201 ± 0.019	3.666ArgGly: 3.666 ± 0.031	1.55ArgHis: 1.55 ± 0.018	2.883ArgIle: 2.883 ± 0.024	3.26ArgLys: 3.26 ± 0.028	5.668ArgLeu: 5.668 ± 0.034	1.312ArgMet: 1.312 ± 0.016	2.181ArgAsn: 2.181 ± 0.022	3.439ArgPro: 3.439 ± 0.03	2.636ArgGln: 2.636 ± 0.024	4.982ArgArg: 4.982 ± 0.043	4.753ArgSer: 4.753 ± 0.041	3.283ArgThr: 3.283 ± 0.027	3.526ArgVal: 3.526 ± 0.023	0.945ArgTrp: 0.945 ± 0.014	1.763ArgTyr: 1.763 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.694SerAla: 6.694 ± 0.042	0.876SerCys: 0.876 ± 0.014	4.304SerAsp: 4.304 ± 0.035	4.225SerGlu: 4.225 ± 0.032	3.03SerPhe: 3.03 ± 0.024	5.544SerGly: 5.544 ± 0.04	1.97SerHis: 1.97 ± 0.021	4.013SerIle: 4.013 ± 0.03	3.376SerLys: 3.376 ± 0.032	7.428SerLeu: 7.428 ± 0.04	1.719SerMet: 1.719 ± 0.02	2.934SerAsn: 2.934 ± 0.025	5.413SerPro: 5.413 ± 0.049	3.339SerGln: 3.339 ± 0.028	4.942SerArg: 4.942 ± 0.043	8.913SerSer: 8.913 ± 0.075	5.739SerThr: 5.739 ± 0.042	4.751SerVal: 4.751 ± 0.031	1.162SerTrp: 1.162 ± 0.015	2.156SerTyr: 2.156 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.248ThrAla: 5.248 ± 0.039	0.744ThrCys: 0.744 ± 0.012	2.995ThrAsp: 2.995 ± 0.022	3.27ThrGlu: 3.27 ± 0.027	2.234ThrPhe: 2.234 ± 0.022	4.278ThrGly: 4.278 ± 0.033	1.341ThrHis: 1.341 ± 0.015	3.167ThrIle: 3.167 ± 0.023	2.433ThrLys: 2.433 ± 0.024	5.433ThrLeu: 5.433 ± 0.036	1.212ThrMet: 1.212 ± 0.017	2.146ThrAsn: 2.146 ± 0.021	4.347ThrPro: 4.347 ± 0.035	2.121ThrGln: 2.121 ± 0.023	3.039ThrArg: 3.039 ± 0.026	5.376ThrSer: 5.376 ± 0.042	4.699ThrThr: 4.699 ± 0.044	3.906ThrVal: 3.906 ± 0.029	0.892ThrTrp: 0.892 ± 0.011	1.747ThrTyr: 1.747 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.26ValAla: 5.26 ± 0.033	0.861ValCys: 0.861 ± 0.013	3.873ValAsp: 3.873 ± 0.028	3.946ValGlu: 3.946 ± 0.031	2.491ValPhe: 2.491 ± 0.024	4.107ValGly: 4.107 ± 0.034	1.454ValHis: 1.454 ± 0.017	3.09ValIle: 3.09 ± 0.024	2.747ValLys: 2.747 ± 0.025	5.755ValLeu: 5.755 ± 0.042	1.391ValMet: 1.391 ± 0.016	2.271ValAsn: 2.271 ± 0.019	3.721ValPro: 3.721 ± 0.026	2.471ValGln: 2.471 ± 0.024	3.575ValArg: 3.575 ± 0.026	4.806ValSer: 4.806 ± 0.033	3.629ValThr: 3.629 ± 0.026	4.445ValVal: 4.445 ± 0.032	0.891ValTrp: 0.891 ± 0.013	1.867ValTyr: 1.867 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.149TrpAla: 1.149 ± 0.016	0.196TrpCys: 0.196 ± 0.006	0.915TrpAsp: 0.915 ± 0.014	0.892TrpGlu: 0.892 ± 0.013	0.556TrpPhe: 0.556 ± 0.01	0.966TrpGly: 0.966 ± 0.015	0.366TrpHis: 0.366 ± 0.007	0.784TrpIle: 0.784 ± 0.013	0.814TrpLys: 0.814 ± 0.013	1.4TrpLeu: 1.4 ± 0.017	0.373TrpMet: 0.373 ± 0.009	0.641TrpAsn: 0.641 ± 0.011	0.634TrpPro: 0.634 ± 0.012	0.569TrpGln: 0.569 ± 0.011	0.978TrpArg: 0.978 ± 0.014	1.083TrpSer: 1.083 ± 0.015	0.955TrpThr: 0.955 ± 0.013	0.947TrpVal: 0.947 ± 0.014	0.285TrpTrp: 0.285 ± 0.007	0.454TrpTyr: 0.454 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.288TyrAla: 2.288 ± 0.021	0.435TyrCys: 0.435 ± 0.009	1.698TyrAsp: 1.698 ± 0.017	1.602TyrGlu: 1.602 ± 0.017	1.229TyrPhe: 1.229 ± 0.017	2.187TyrGly: 2.187 ± 0.024	0.818TyrHis: 0.818 ± 0.012	1.493TyrIle: 1.493 ± 0.017	1.055TyrLys: 1.055 ± 0.015	2.88TyrLeu: 2.88 ± 0.027	0.672TyrMet: 0.672 ± 0.011	1.188TyrAsn: 1.188 ± 0.016	1.642TyrPro: 1.642 ± 0.021	1.154TyrGln: 1.154 ± 0.015	1.728TyrArg: 1.728 ± 0.019	2.125TyrSer: 2.125 ± 0.022	1.745TyrThr: 1.745 ± 0.018	1.761TyrVal: 1.761 ± 0.019	0.49TyrTrp: 0.49 ± 0.009	1.073TyrTyr: 1.073 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11491 proteins (5648345 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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