Amino acid dipepetide frequency for Mycoplasma arthritidis (strain 158L3-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.655AlaAla: 3.655 ± 0.153
0.327AlaCys: 0.327 ± 0.037
2.707AlaAsp: 2.707 ± 0.201
3.477AlaGlu: 3.477 ± 0.144
2.724AlaPhe: 2.724 ± 0.133
2.5AlaGly: 2.5 ± 0.121
0.815AlaHis: 0.815 ± 0.06
6.954AlaIle: 6.954 ± 0.204
9.147AlaLys: 9.147 ± 0.562
6.792AlaLeu: 6.792 ± 0.27
1.105AlaMet: 1.105 ± 0.069
5.265AlaAsn: 5.265 ± 0.268
1.225AlaPro: 1.225 ± 0.083
2.156AlaGln: 2.156 ± 0.14
2.103AlaArg: 2.103 ± 0.115
4.152AlaSer: 4.152 ± 0.132
3.932AlaThr: 3.932 ± 0.134
2.525AlaVal: 2.525 ± 0.1
0.422AlaTrp: 0.422 ± 0.037
2.119AlaTyr: 2.119 ± 0.094
0.0AlaXaa: 0.0 ± 0.0
Cys
0.327CysAla: 0.327 ± 0.042
0.046CysCys: 0.046 ± 0.013
0.348CysAsp: 0.348 ± 0.037
0.377CysGlu: 0.377 ± 0.038
0.265CysPhe: 0.265 ± 0.032
0.36CysGly: 0.36 ± 0.042
0.137CysHis: 0.137 ± 0.026
0.36CysIle: 0.36 ± 0.04
0.352CysLys: 0.352 ± 0.047
0.555CysLeu: 0.555 ± 0.051
0.07CysMet: 0.07 ± 0.016
0.29CysAsn: 0.29 ± 0.035
0.182CysPro: 0.182 ± 0.025
0.236CysGln: 0.236 ± 0.032
0.157CysArg: 0.157 ± 0.027
0.323CysSer: 0.323 ± 0.037
0.199CysThr: 0.199 ± 0.029
0.24CysVal: 0.24 ± 0.034
0.041CysTrp: 0.041 ± 0.013
0.132CysTyr: 0.132 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
4.292AspAla: 4.292 ± 0.397
0.195AspCys: 0.195 ± 0.028
3.386AspAsp: 3.386 ± 0.137
4.739AspGlu: 4.739 ± 0.154
3.576AspPhe: 3.576 ± 0.121
2.38AspGly: 2.38 ± 0.106
0.869AspHis: 0.869 ± 0.076
4.528AspIle: 4.528 ± 0.133
5.807AspLys: 5.807 ± 0.216
6.101AspLeu: 6.101 ± 0.216
0.745AspMet: 0.745 ± 0.063
3.22AspAsn: 3.22 ± 0.109
1.945AspPro: 1.945 ± 0.157
1.875AspGln: 1.875 ± 0.101
1.498AspArg: 1.498 ± 0.066
3.68AspSer: 3.68 ± 0.147
2.21AspThr: 2.21 ± 0.117
2.881AspVal: 2.881 ± 0.103
0.501AspTrp: 0.501 ± 0.044
2.426AspTyr: 2.426 ± 0.112
0.0AspXaa: 0.0 ± 0.0
Glu
5.588GluAla: 5.588 ± 0.356
0.244GluCys: 0.244 ± 0.035
4.031GluAsp: 4.031 ± 0.19
5.48GluGlu: 5.48 ± 0.196
3.365GluPhe: 3.365 ± 0.121
2.682GluGly: 2.682 ± 0.138
0.898GluHis: 0.898 ± 0.071
7.442GluIle: 7.442 ± 0.205
8.551GluLys: 8.551 ± 0.301
8.075GluLeu: 8.075 ± 0.36
1.316GluMet: 1.316 ± 0.075
5.815GluAsn: 5.815 ± 0.166
1.37GluPro: 1.37 ± 0.113
2.748GluGln: 2.748 ± 0.166
2.041GluArg: 2.041 ± 0.097
3.676GluSer: 3.676 ± 0.151
3.841GluThr: 3.841 ± 0.215
4.027GluVal: 4.027 ± 0.144
0.517GluTrp: 0.517 ± 0.045
2.781GluTyr: 2.781 ± 0.106
0.0GluXaa: 0.0 ± 0.0
Phe
3.224PheAla: 3.224 ± 0.169
0.306PheCys: 0.306 ± 0.035
3.369PheAsp: 3.369 ± 0.148
3.572PheGlu: 3.572 ± 0.121
2.467PhePhe: 2.467 ± 0.129
2.521PheGly: 2.521 ± 0.118
0.621PheHis: 0.621 ± 0.059
4.156PheIle: 4.156 ± 0.189
4.536PheLys: 4.536 ± 0.173
4.536PheLeu: 4.536 ± 0.182
0.757PheMet: 0.757 ± 0.067
3.456PheAsn: 3.456 ± 0.147
1.138PhePro: 1.138 ± 0.087
1.304PheGln: 1.304 ± 0.074
1.486PheArg: 1.486 ± 0.083
3.804PheSer: 3.804 ± 0.162
2.214PheThr: 2.214 ± 0.12
2.74PheVal: 2.74 ± 0.128
0.584PheTrp: 0.584 ± 0.048
2.057PheTyr: 2.057 ± 0.099
0.0PheXaa: 0.0 ± 0.0
Gly
2.674GlyAla: 2.674 ± 0.133
0.174GlyCys: 0.174 ± 0.03
2.252GlyAsp: 2.252 ± 0.103
2.67GlyGlu: 2.67 ± 0.139
2.376GlyPhe: 2.376 ± 0.125
2.397GlyGly: 2.397 ± 0.146
0.886GlyHis: 0.886 ± 0.066
4.102GlyIle: 4.102 ± 0.167
4.387GlyLys: 4.387 ± 0.17
4.044GlyLeu: 4.044 ± 0.148
0.849GlyMet: 0.849 ± 0.068
2.293GlyAsn: 2.293 ± 0.097
1.002GlyPro: 1.002 ± 0.071
1.416GlyGln: 1.416 ± 0.081
1.523GlyArg: 1.523 ± 0.092
2.748GlySer: 2.748 ± 0.12
2.649GlyThr: 2.649 ± 0.134
2.537GlyVal: 2.537 ± 0.111
0.397GlyTrp: 0.397 ± 0.039
1.834GlyTyr: 1.834 ± 0.116
0.0GlyXaa: 0.0 ± 0.0
His
0.931HisAla: 0.931 ± 0.056
0.07HisCys: 0.07 ± 0.016
0.786HisAsp: 0.786 ± 0.058
0.985HisGlu: 0.985 ± 0.072
0.964HisPhe: 0.964 ± 0.073
0.861HisGly: 0.861 ± 0.07
0.298HisHis: 0.298 ± 0.036
1.151HisIle: 1.151 ± 0.068
1.18HisLys: 1.18 ± 0.078
1.424HisLeu: 1.424 ± 0.084
0.19HisMet: 0.19 ± 0.03
0.923HisAsn: 0.923 ± 0.069
0.555HisPro: 0.555 ± 0.062
0.476HisGln: 0.476 ± 0.042
0.505HisArg: 0.505 ± 0.049
0.948HisSer: 0.948 ± 0.07
0.571HisThr: 0.571 ± 0.057
0.658HisVal: 0.658 ± 0.072
0.128HisTrp: 0.128 ± 0.023
0.637HisTyr: 0.637 ± 0.05
0.0HisXaa: 0.0 ± 0.0
Ile
6.043IleAla: 6.043 ± 0.16
0.588IleCys: 0.588 ± 0.053
5.575IleAsp: 5.575 ± 0.16
6.221IleGlu: 6.221 ± 0.208
4.661IlePhe: 4.661 ± 0.228
3.738IleGly: 3.738 ± 0.16
1.055IleHis: 1.055 ± 0.077
7.285IleIle: 7.285 ± 0.264
9.822IleLys: 9.822 ± 0.275
7.62IleLeu: 7.62 ± 0.26
1.287IleMet: 1.287 ± 0.078
6.875IleAsn: 6.875 ± 0.178
2.417IlePro: 2.417 ± 0.126
2.475IleGln: 2.475 ± 0.111
2.641IleArg: 2.641 ± 0.11
6.85IleSer: 6.85 ± 0.188
4.876IleThr: 4.876 ± 0.156
4.851IleVal: 4.851 ± 0.2
0.625IleTrp: 0.625 ± 0.053
3.237IleTyr: 3.237 ± 0.148
0.0IleXaa: 0.0 ± 0.0
Lys
7.128LysAla: 7.128 ± 0.396
0.414LysCys: 0.414 ± 0.046
6.482LysAsp: 6.482 ± 0.28
9.942LysGlu: 9.942 ± 0.419
4.044LysPhe: 4.044 ± 0.166
3.469LysGly: 3.469 ± 0.136
1.581LysHis: 1.581 ± 0.088
10.608LysIle: 10.608 ± 0.266
12.637LysLys: 12.637 ± 0.399
10.923LysLeu: 10.923 ± 0.427
2.384LysMet: 2.384 ± 0.106
8.82LysAsn: 8.82 ± 0.237
2.798LysPro: 2.798 ± 0.192
4.226LysGln: 4.226 ± 0.234
3.262LysArg: 3.262 ± 0.114
6.142LysSer: 6.142 ± 0.173
6.362LysThr: 6.362 ± 0.203
5.07LysVal: 5.07 ± 0.16
0.96LysTrp: 0.96 ± 0.065
4.296LysTyr: 4.296 ± 0.16
0.0LysXaa: 0.0 ± 0.0
Leu
7.219LeuAla: 7.219 ± 0.195
0.555LeuCys: 0.555 ± 0.053
5.84LeuAsp: 5.84 ± 0.2
8.907LeuGlu: 8.907 ± 0.457
4.313LeuPhe: 4.313 ± 0.209
4.276LeuGly: 4.276 ± 0.163
1.176LeuHis: 1.176 ± 0.082
8.584LeuIle: 8.584 ± 0.242
11.589LeuLys: 11.589 ± 0.462
8.489LeuLeu: 8.489 ± 0.226
1.693LeuMet: 1.693 ± 0.084
7.148LeuAsn: 7.148 ± 0.22
2.893LeuPro: 2.893 ± 0.116
3.067LeuGln: 3.067 ± 0.144
2.819LeuArg: 2.819 ± 0.127
6.565LeuSer: 6.565 ± 0.194
4.942LeuThr: 4.942 ± 0.135
5.534LeuVal: 5.534 ± 0.151
0.662LeuTrp: 0.662 ± 0.057
2.608LeuTyr: 2.608 ± 0.124
0.0LeuXaa: 0.0 ± 0.0
Met
1.159MetAla: 1.159 ± 0.081
0.099MetCys: 0.099 ± 0.019
0.704MetAsp: 0.704 ± 0.058
0.811MetGlu: 0.811 ± 0.067
0.861MetPhe: 0.861 ± 0.076
0.766MetGly: 0.766 ± 0.056
0.277MetHis: 0.277 ± 0.033
1.403MetIle: 1.403 ± 0.091
1.879MetLys: 1.879 ± 0.09
1.697MetLeu: 1.697 ± 0.097
0.323MetMet: 0.323 ± 0.038
1.126MetAsn: 1.126 ± 0.082
0.741MetPro: 0.741 ± 0.058
0.621MetGln: 0.621 ± 0.042
0.575MetArg: 0.575 ± 0.041
1.167MetSer: 1.167 ± 0.071
0.944MetThr: 0.944 ± 0.064
0.853MetVal: 0.853 ± 0.06
0.153MetTrp: 0.153 ± 0.025
0.484MetTyr: 0.484 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
4.18AsnAla: 4.18 ± 0.194
0.269AsnCys: 0.269 ± 0.035
4.412AsnAsp: 4.412 ± 0.205
5.505AsnGlu: 5.505 ± 0.153
3.808AsnPhe: 3.808 ± 0.135
3.191AsnGly: 3.191 ± 0.13
0.993AsnHis: 0.993 ± 0.075
5.373AsnIle: 5.373 ± 0.166
8.485AsnLys: 8.485 ± 0.299
7.214AsnLeu: 7.214 ± 0.191
1.08AsnMet: 1.08 ± 0.079
5.455AsnAsn: 5.455 ± 0.219
2.272AsnPro: 2.272 ± 0.11
2.649AsnGln: 2.649 ± 0.137
1.887AsnArg: 1.887 ± 0.093
4.917AsnSer: 4.917 ± 0.167
2.86AsnThr: 2.86 ± 0.118
3.555AsnVal: 3.555 ± 0.123
0.617AsnTrp: 0.617 ± 0.055
3.187AsnTyr: 3.187 ± 0.139
0.0AsnXaa: 0.0 ± 0.0
Pro
1.445ProAla: 1.445 ± 0.141
0.137ProCys: 0.137 ± 0.024
1.329ProAsp: 1.329 ± 0.08
2.301ProGlu: 2.301 ± 0.146
1.387ProPhe: 1.387 ± 0.084
1.163ProGly: 1.163 ± 0.072
0.555ProHis: 0.555 ± 0.053
2.248ProIle: 2.248 ± 0.119
3.15ProLys: 3.15 ± 0.215
2.508ProLeu: 2.508 ± 0.108
0.389ProMet: 0.389 ± 0.041
2.012ProAsn: 2.012 ± 0.1
0.447ProPro: 0.447 ± 0.05
0.869ProGln: 0.869 ± 0.064
0.749ProArg: 0.749 ± 0.065
1.85ProSer: 1.85 ± 0.093
1.544ProThr: 1.544 ± 0.084
1.113ProVal: 1.113 ± 0.089
0.319ProTrp: 0.319 ± 0.039
1.031ProTyr: 1.031 ± 0.075
0.0ProXaa: 0.0 ± 0.0
Gln
2.446GlnAla: 2.446 ± 0.167
0.083GlnCys: 0.083 ± 0.018
2.086GlnAsp: 2.086 ± 0.147
2.852GlnGlu: 2.852 ± 0.172
1.167GlnPhe: 1.167 ± 0.077
1.192GlnGly: 1.192 ± 0.066
0.373GlnHis: 0.373 ± 0.042
3.175GlnIle: 3.175 ± 0.108
4.454GlnLys: 4.454 ± 0.245
2.781GlnLeu: 2.781 ± 0.111
0.629GlnMet: 0.629 ± 0.046
2.848GlnAsn: 2.848 ± 0.129
0.733GlnPro: 0.733 ± 0.066
1.25GlnGln: 1.25 ± 0.091
1.002GlnArg: 1.002 ± 0.059
2.099GlnSer: 2.099 ± 0.109
2.107GlnThr: 2.107 ± 0.119
1.548GlnVal: 1.548 ± 0.09
0.294GlnTrp: 0.294 ± 0.04
1.325GlnTyr: 1.325 ± 0.066
0.0GlnXaa: 0.0 ± 0.0
Arg
1.788ArgAla: 1.788 ± 0.081
0.166ArgCys: 0.166 ± 0.031
1.647ArgAsp: 1.647 ± 0.079
2.185ArgGlu: 2.185 ± 0.105
1.445ArgPhe: 1.445 ± 0.084
1.432ArgGly: 1.432 ± 0.104
0.517ArgHis: 0.517 ± 0.048
2.686ArgIle: 2.686 ± 0.123
3.001ArgLys: 3.001 ± 0.123
2.802ArgLeu: 2.802 ± 0.105
0.646ArgMet: 0.646 ± 0.056
1.983ArgAsn: 1.983 ± 0.077
0.869ArgPro: 0.869 ± 0.068
1.221ArgGln: 1.221 ± 0.078
1.097ArgArg: 1.097 ± 0.079
1.763ArgSer: 1.763 ± 0.095
1.403ArgThr: 1.403 ± 0.085
1.73ArgVal: 1.73 ± 0.106
0.277ArgTrp: 0.277 ± 0.038
1.279ArgTyr: 1.279 ± 0.08
0.0ArgXaa: 0.0 ± 0.0
Ser
3.551SerAla: 3.551 ± 0.132
0.464SerCys: 0.464 ± 0.045
3.613SerAsp: 3.613 ± 0.11
4.578SerGlu: 4.578 ± 0.152
3.634SerPhe: 3.634 ± 0.154
3.299SerGly: 3.299 ± 0.156
1.055SerHis: 1.055 ± 0.062
5.182SerIle: 5.182 ± 0.16
6.991SerLys: 6.991 ± 0.181
7.74SerLeu: 7.74 ± 0.2
0.902SerMet: 0.902 ± 0.066
4.156SerAsn: 4.156 ± 0.144
1.759SerPro: 1.759 ± 0.082
2.815SerGln: 2.815 ± 0.115
1.784SerArg: 1.784 ± 0.103
4.748SerSer: 4.748 ± 0.184
3.456SerThr: 3.456 ± 0.119
2.827SerVal: 2.827 ± 0.132
0.658SerTrp: 0.658 ± 0.062
2.732SerTyr: 2.732 ± 0.135
0.0SerXaa: 0.0 ± 0.0
Thr
2.397ThrAla: 2.397 ± 0.108
0.195ThrCys: 0.195 ± 0.026
2.243ThrAsp: 2.243 ± 0.118
2.761ThrGlu: 2.761 ± 0.168
2.575ThrPhe: 2.575 ± 0.15
2.152ThrGly: 2.152 ± 0.112
0.749ThrHis: 0.749 ± 0.059
5.584ThrIle: 5.584 ± 0.146
6.474ThrLys: 6.474 ± 0.248
5.82ThrLeu: 5.82 ± 0.207
0.687ThrMet: 0.687 ± 0.047
3.87ThrAsn: 3.87 ± 0.149
1.664ThrPro: 1.664 ± 0.138
1.606ThrGln: 1.606 ± 0.076
1.581ThrArg: 1.581 ± 0.085
3.779ThrSer: 3.779 ± 0.131
3.051ThrThr: 3.051 ± 0.112
2.161ThrVal: 2.161 ± 0.101
0.393ThrTrp: 0.393 ± 0.04
2.028ThrTyr: 2.028 ± 0.114
0.0ThrXaa: 0.0 ± 0.0
Val
3.655ValAla: 3.655 ± 0.137
0.36ValCys: 0.36 ± 0.041
3.125ValAsp: 3.125 ± 0.1
3.618ValGlu: 3.618 ± 0.131
2.537ValPhe: 2.537 ± 0.126
2.529ValGly: 2.529 ± 0.123
0.662ValHis: 0.662 ± 0.056
4.445ValIle: 4.445 ± 0.17
4.855ValLys: 4.855 ± 0.138
4.632ValLeu: 4.632 ± 0.175
0.84ValMet: 0.84 ± 0.058
3.315ValAsn: 3.315 ± 0.111
1.325ValPro: 1.325 ± 0.081
1.569ValGln: 1.569 ± 0.077
1.453ValArg: 1.453 ± 0.085
3.506ValSer: 3.506 ± 0.143
2.645ValThr: 2.645 ± 0.12
3.005ValVal: 3.005 ± 0.179
0.443ValTrp: 0.443 ± 0.051
1.792ValTyr: 1.792 ± 0.11
0.0ValXaa: 0.0 ± 0.0
Trp
0.459TrpAla: 0.459 ± 0.046
0.037TrpCys: 0.037 ± 0.012
0.443TrpAsp: 0.443 ± 0.042
0.608TrpGlu: 0.608 ± 0.053
0.464TrpPhe: 0.464 ± 0.056
0.348TrpGly: 0.348 ± 0.04
0.091TrpHis: 0.091 ± 0.02
0.811TrpIle: 0.811 ± 0.066
0.923TrpLys: 0.923 ± 0.056
0.762TrpLeu: 0.762 ± 0.06
0.228TrpMet: 0.228 ± 0.03
0.683TrpAsn: 0.683 ± 0.057
0.215TrpPro: 0.215 ± 0.03
0.252TrpGln: 0.252 ± 0.033
0.294TrpArg: 0.294 ± 0.036
0.522TrpSer: 0.522 ± 0.042
0.464TrpThr: 0.464 ± 0.049
0.509TrpVal: 0.509 ± 0.049
0.124TrpTrp: 0.124 ± 0.025
0.315TrpTyr: 0.315 ± 0.037
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.941TyrAla: 1.941 ± 0.1
0.269TyrCys: 0.269 ± 0.03
2.475TyrAsp: 2.475 ± 0.101
2.902TyrGlu: 2.902 ± 0.108
2.219TyrPhe: 2.219 ± 0.109
1.954TyrGly: 1.954 ± 0.114
0.633TyrHis: 0.633 ± 0.056
2.666TyrIle: 2.666 ± 0.127
3.332TyrLys: 3.332 ± 0.124
4.363TyrLeu: 4.363 ± 0.176
0.517TyrMet: 0.517 ± 0.048
2.359TyrAsn: 2.359 ± 0.111
0.993TyrPro: 0.993 ± 0.063
1.61TyrGln: 1.61 ± 0.077
1.482TyrArg: 1.482 ± 0.082
2.707TyrSer: 2.707 ± 0.124
1.498TyrThr: 1.498 ± 0.087
1.945TyrVal: 1.945 ± 0.103
0.435TyrTrp: 0.435 ± 0.043
1.734TyrTyr: 1.734 ± 0.11
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 631 proteins (241600 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski