Amino acid dipepetide frequency for Lapidilactobacillus dextrinicus DSM 20335

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.604AlaAla: 7.604 ± 0.135
0.34AlaCys: 0.34 ± 0.026
5.47AlaAsp: 5.47 ± 0.112
4.803AlaGlu: 4.803 ± 0.108
3.039AlaPhe: 3.039 ± 0.071
5.718AlaGly: 5.718 ± 0.113
1.554AlaHis: 1.554 ± 0.056
6.175AlaIle: 6.175 ± 0.119
5.631AlaLys: 5.631 ± 0.111
7.931AlaLeu: 7.931 ± 0.144
2.031AlaMet: 2.031 ± 0.064
4.008AlaAsn: 4.008 ± 0.109
2.382AlaPro: 2.382 ± 0.068
4.38AlaGln: 4.38 ± 0.11
2.918AlaArg: 2.918 ± 0.09
4.221AlaSer: 4.221 ± 0.091
5.554AlaThr: 5.554 ± 0.12
5.697AlaVal: 5.697 ± 0.107
0.667AlaTrp: 0.667 ± 0.035
2.427AlaTyr: 2.427 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.329CysAla: 0.329 ± 0.023
0.061CysCys: 0.061 ± 0.011
0.232CysAsp: 0.232 ± 0.023
0.223CysGlu: 0.223 ± 0.021
0.24CysPhe: 0.24 ± 0.021
0.5CysGly: 0.5 ± 0.033
0.144CysHis: 0.144 ± 0.017
0.259CysIle: 0.259 ± 0.021
0.115CysLys: 0.115 ± 0.014
0.478CysLeu: 0.478 ± 0.029
0.088CysMet: 0.088 ± 0.013
0.161CysAsn: 0.161 ± 0.018
0.215CysPro: 0.215 ± 0.026
0.334CysGln: 0.334 ± 0.027
0.163CysArg: 0.163 ± 0.018
0.261CysSer: 0.261 ± 0.025
0.188CysThr: 0.188 ± 0.018
0.252CysVal: 0.252 ± 0.025
0.054CysTrp: 0.054 ± 0.011
0.209CysTyr: 0.209 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
4.087AspAla: 4.087 ± 0.093
0.219AspCys: 0.219 ± 0.022
3.479AspAsp: 3.479 ± 0.099
3.998AspGlu: 3.998 ± 0.101
2.943AspPhe: 2.943 ± 0.088
3.533AspGly: 3.533 ± 0.088
1.61AspHis: 1.61 ± 0.052
3.624AspIle: 3.624 ± 0.076
3.022AspLys: 3.022 ± 0.083
6.229AspLeu: 6.229 ± 0.118
1.274AspMet: 1.274 ± 0.047
2.473AspAsn: 2.473 ± 0.07
2.413AspPro: 2.413 ± 0.072
3.6AspGln: 3.6 ± 0.103
2.229AspArg: 2.229 ± 0.069
2.807AspSer: 2.807 ± 0.069
2.77AspThr: 2.77 ± 0.081
3.919AspVal: 3.919 ± 0.086
0.751AspTrp: 0.751 ± 0.041
2.795AspTyr: 2.795 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
4.646GluAla: 4.646 ± 0.104
0.175GluCys: 0.175 ± 0.019
2.717GluAsp: 2.717 ± 0.08
3.014GluGlu: 3.014 ± 0.092
2.209GluPhe: 2.209 ± 0.073
2.475GluGly: 2.475 ± 0.073
1.262GluHis: 1.262 ± 0.054
4.413GluIle: 4.413 ± 0.097
3.827GluLys: 3.827 ± 0.092
6.45GluLeu: 6.45 ± 0.129
1.691GluMet: 1.691 ± 0.059
2.788GluAsn: 2.788 ± 0.081
1.827GluPro: 1.827 ± 0.067
3.512GluGln: 3.512 ± 0.097
2.553GluArg: 2.553 ± 0.072
2.48GluSer: 2.48 ± 0.077
3.51GluThr: 3.51 ± 0.085
4.023GluVal: 4.023 ± 0.106
0.446GluTrp: 0.446 ± 0.031
1.627GluTyr: 1.627 ± 0.061
0.0GluXaa: 0.0 ± 0.0
Phe
3.579PheAla: 3.579 ± 0.085
0.269PheCys: 0.269 ± 0.026
2.676PheAsp: 2.676 ± 0.069
2.127PheGlu: 2.127 ± 0.067
1.944PhePhe: 1.944 ± 0.073
3.112PheGly: 3.112 ± 0.081
0.751PheHis: 0.751 ± 0.039
2.892PheIle: 2.892 ± 0.08
2.519PheLys: 2.519 ± 0.078
3.912PheLeu: 3.912 ± 0.106
1.105PheMet: 1.105 ± 0.049
2.183PheAsn: 2.183 ± 0.06
1.47PhePro: 1.47 ± 0.049
1.502PheGln: 1.502 ± 0.057
1.312PheArg: 1.312 ± 0.049
2.867PheSer: 2.867 ± 0.074
2.646PheThr: 2.646 ± 0.081
3.109PheVal: 3.109 ± 0.078
0.496PheTrp: 0.496 ± 0.03
1.562PheTyr: 1.562 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
4.913GlyAla: 4.913 ± 0.108
0.377GlyCys: 0.377 ± 0.028
3.241GlyAsp: 3.241 ± 0.085
3.439GlyGlu: 3.439 ± 0.086
2.961GlyPhe: 2.961 ± 0.072
4.219GlyGly: 4.219 ± 0.127
1.441GlyHis: 1.441 ± 0.056
5.172GlyIle: 5.172 ± 0.113
3.931GlyLys: 3.931 ± 0.09
6.571GlyLeu: 6.571 ± 0.123
1.756GlyMet: 1.756 ± 0.067
2.598GlyAsn: 2.598 ± 0.072
1.564GlyPro: 1.564 ± 0.055
3.362GlyGln: 3.362 ± 0.086
2.655GlyArg: 2.655 ± 0.083
3.783GlySer: 3.783 ± 0.094
4.023GlyThr: 4.023 ± 0.1
4.845GlyVal: 4.845 ± 0.101
0.678GlyTrp: 0.678 ± 0.047
2.705GlyTyr: 2.705 ± 0.09
0.0GlyXaa: 0.0 ± 0.0
His
1.387HisAla: 1.387 ± 0.049
0.123HisCys: 0.123 ± 0.015
1.462HisAsp: 1.462 ± 0.059
1.301HisGlu: 1.301 ± 0.052
1.17HisPhe: 1.17 ± 0.053
1.531HisGly: 1.531 ± 0.061
0.801HisHis: 0.801 ± 0.048
1.262HisIle: 1.262 ± 0.05
0.813HisLys: 0.813 ± 0.036
2.263HisLeu: 2.263 ± 0.072
0.4HisMet: 0.4 ± 0.03
0.909HisAsn: 0.909 ± 0.036
0.984HisPro: 0.984 ± 0.051
1.485HisGln: 1.485 ± 0.059
0.924HisArg: 0.924 ± 0.049
1.045HisSer: 1.045 ± 0.048
0.955HisThr: 0.955 ± 0.045
1.339HisVal: 1.339 ± 0.06
0.271HisTrp: 0.271 ± 0.022
1.076HisTyr: 1.076 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
6.48IleAla: 6.48 ± 0.118
0.5IleCys: 0.5 ± 0.028
4.536IleAsp: 4.536 ± 0.092
3.839IleGlu: 3.839 ± 0.084
3.136IlePhe: 3.136 ± 0.087
5.186IleGly: 5.186 ± 0.112
1.23IleHis: 1.23 ± 0.05
5.439IleIle: 5.439 ± 0.137
4.338IleLys: 4.338 ± 0.1
6.819IleLeu: 6.819 ± 0.135
1.758IleMet: 1.758 ± 0.061
3.745IleAsn: 3.745 ± 0.089
2.794IlePro: 2.794 ± 0.083
2.757IleGln: 2.757 ± 0.075
2.628IleArg: 2.628 ± 0.07
4.513IleSer: 4.513 ± 0.099
4.417IleThr: 4.417 ± 0.097
5.355IleVal: 5.355 ± 0.109
0.678IleTrp: 0.678 ± 0.034
2.396IleTyr: 2.396 ± 0.08
0.0IleXaa: 0.0 ± 0.0
Lys
4.623LysAla: 4.623 ± 0.111
0.163LysCys: 0.163 ± 0.018
3.207LysAsp: 3.207 ± 0.083
3.266LysGlu: 3.266 ± 0.099
2.013LysPhe: 2.013 ± 0.066
3.028LysGly: 3.028 ± 0.081
1.16LysHis: 1.16 ± 0.042
4.636LysIle: 4.636 ± 0.095
4.49LysLys: 4.49 ± 0.128
5.704LysLeu: 5.704 ± 0.119
2.121LysMet: 2.121 ± 0.065
3.155LysAsn: 3.155 ± 0.073
2.121LysPro: 2.121 ± 0.063
3.351LysGln: 3.351 ± 0.087
2.759LysArg: 2.759 ± 0.077
3.232LysSer: 3.232 ± 0.095
4.115LysThr: 4.115 ± 0.093
4.14LysVal: 4.14 ± 0.097
0.513LysTrp: 0.513 ± 0.033
2.208LysTyr: 2.208 ± 0.082
0.0LysXaa: 0.0 ± 0.0
Leu
9.72LeuAla: 9.72 ± 0.142
0.451LeuCys: 0.451 ± 0.031
5.506LeuAsp: 5.506 ± 0.118
4.567LeuGlu: 4.567 ± 0.096
3.848LeuPhe: 3.848 ± 0.106
6.601LeuGly: 6.601 ± 0.133
1.733LeuHis: 1.733 ± 0.059
7.677LeuIle: 7.677 ± 0.157
6.16LeuLys: 6.16 ± 0.12
10.071LeuLeu: 10.071 ± 0.193
2.478LeuMet: 2.478 ± 0.079
5.126LeuAsn: 5.126 ± 0.095
4.402LeuPro: 4.402 ± 0.094
4.721LeuGln: 4.721 ± 0.109
3.958LeuArg: 3.958 ± 0.096
6.344LeuSer: 6.344 ± 0.116
7.66LeuThr: 7.66 ± 0.129
6.826LeuVal: 6.826 ± 0.126
0.842LeuTrp: 0.842 ± 0.039
2.724LeuTyr: 2.724 ± 0.085
0.0LeuXaa: 0.0 ± 0.0
Met
2.444MetAla: 2.444 ± 0.08
0.088MetCys: 0.088 ± 0.014
1.235MetAsp: 1.235 ± 0.047
1.018MetGlu: 1.018 ± 0.043
0.882MetPhe: 0.882 ± 0.043
1.587MetGly: 1.587 ± 0.06
0.451MetHis: 0.451 ± 0.03
2.008MetIle: 2.008 ± 0.07
1.643MetLys: 1.643 ± 0.06
2.352MetLeu: 2.352 ± 0.072
0.84MetMet: 0.84 ± 0.05
1.335MetAsn: 1.335 ± 0.045
1.11MetPro: 1.11 ± 0.044
1.034MetGln: 1.034 ± 0.041
0.976MetArg: 0.976 ± 0.041
1.562MetSer: 1.562 ± 0.051
2.096MetThr: 2.096 ± 0.055
1.654MetVal: 1.654 ± 0.06
0.158MetTrp: 0.158 ± 0.018
0.617MetTyr: 0.617 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.347AsnAla: 3.347 ± 0.083
0.232AsnCys: 0.232 ± 0.023
2.892AsnAsp: 2.892 ± 0.081
2.765AsnGlu: 2.765 ± 0.071
2.133AsnPhe: 2.133 ± 0.068
3.437AsnGly: 3.437 ± 0.098
1.241AsnHis: 1.241 ± 0.05
3.237AsnIle: 3.237 ± 0.078
2.565AsnLys: 2.565 ± 0.072
4.569AsnLeu: 4.569 ± 0.093
1.203AsnMet: 1.203 ± 0.044
2.419AsnAsn: 2.419 ± 0.086
2.144AsnPro: 2.144 ± 0.066
2.982AsnGln: 2.982 ± 0.083
1.967AsnArg: 1.967 ± 0.061
2.721AsnSer: 2.721 ± 0.103
2.396AsnThr: 2.396 ± 0.078
2.995AsnVal: 2.995 ± 0.074
0.676AsnTrp: 0.676 ± 0.036
1.99AsnTyr: 1.99 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.778ProAla: 2.778 ± 0.073
0.096ProCys: 0.096 ± 0.014
2.444ProAsp: 2.444 ± 0.066
3.228ProGlu: 3.228 ± 0.089
1.606ProPhe: 1.606 ± 0.053
2.09ProGly: 2.09 ± 0.063
0.684ProHis: 0.684 ± 0.035
2.813ProIle: 2.813 ± 0.078
2.192ProLys: 2.192 ± 0.06
3.514ProLeu: 3.514 ± 0.087
0.797ProMet: 0.797 ± 0.045
1.752ProAsn: 1.752 ± 0.059
0.632ProPro: 0.632 ± 0.037
1.808ProGln: 1.808 ± 0.057
1.233ProArg: 1.233 ± 0.056
1.973ProSer: 1.973 ± 0.068
2.44ProThr: 2.44 ± 0.069
2.772ProVal: 2.772 ± 0.077
0.361ProTrp: 0.361 ± 0.026
1.36ProTyr: 1.36 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
4.709GlnAla: 4.709 ± 0.127
0.136GlnCys: 0.136 ± 0.016
2.417GlnAsp: 2.417 ± 0.065
2.784GlnGlu: 2.784 ± 0.088
1.898GlnPhe: 1.898 ± 0.063
2.5GlnGly: 2.5 ± 0.071
1.251GlnHis: 1.251 ± 0.057
3.816GlnIle: 3.816 ± 0.086
3.283GlnLys: 3.283 ± 0.085
6.415GlnLeu: 6.415 ± 0.156
1.305GlnMet: 1.305 ± 0.059
2.45GlnAsn: 2.45 ± 0.078
2.085GlnPro: 2.085 ± 0.075
4.05GlnGln: 4.05 ± 0.196
2.592GlnArg: 2.592 ± 0.077
2.615GlnSer: 2.615 ± 0.073
3.41GlnThr: 3.41 ± 0.1
3.681GlnVal: 3.681 ± 0.089
0.49GlnTrp: 0.49 ± 0.038
1.716GlnTyr: 1.716 ± 0.058
0.0GlnXaa: 0.0 ± 0.0
Arg
2.911ArgAla: 2.911 ± 0.078
0.179ArgCys: 0.179 ± 0.018
2.292ArgAsp: 2.292 ± 0.072
2.446ArgGlu: 2.446 ± 0.079
1.808ArgPhe: 1.808 ± 0.065
2.115ArgGly: 2.115 ± 0.063
1.143ArgHis: 1.143 ± 0.047
2.692ArgIle: 2.692 ± 0.066
2.292ArgLys: 2.292 ± 0.07
4.136ArgLeu: 4.136 ± 0.097
0.989ArgMet: 0.989 ± 0.053
1.787ArgAsn: 1.787 ± 0.063
1.52ArgPro: 1.52 ± 0.064
2.865ArgGln: 2.865 ± 0.081
2.09ArgArg: 2.09 ± 0.069
2.048ArgSer: 2.048 ± 0.063
2.14ArgThr: 2.14 ± 0.063
2.496ArgVal: 2.496 ± 0.073
0.363ArgTrp: 0.363 ± 0.028
1.639ArgTyr: 1.639 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
4.382SerAla: 4.382 ± 0.097
0.254SerCys: 0.254 ± 0.022
3.26SerAsp: 3.26 ± 0.085
3.314SerGlu: 3.314 ± 0.086
2.58SerPhe: 2.58 ± 0.071
4.334SerGly: 4.334 ± 0.1
1.226SerHis: 1.226 ± 0.045
3.804SerIle: 3.804 ± 0.098
3.255SerLys: 3.255 ± 0.084
5.658SerLeu: 5.658 ± 0.101
1.33SerMet: 1.33 ± 0.049
2.526SerAsn: 2.526 ± 0.092
1.733SerPro: 1.733 ± 0.051
2.757SerGln: 2.757 ± 0.098
2.188SerArg: 2.188 ± 0.063
4.01SerSer: 4.01 ± 0.256
3.485SerThr: 3.485 ± 0.118
3.756SerVal: 3.756 ± 0.09
0.647SerTrp: 0.647 ± 0.037
2.025SerTyr: 2.025 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
5.322ThrAla: 5.322 ± 0.09
0.256ThrCys: 0.256 ± 0.024
3.935ThrAsp: 3.935 ± 0.088
3.577ThrGlu: 3.577 ± 0.087
2.659ThrPhe: 2.659 ± 0.07
4.457ThrGly: 4.457 ± 0.106
1.207ThrHis: 1.207 ± 0.045
4.857ThrIle: 4.857 ± 0.098
3.931ThrLys: 3.931 ± 0.103
5.941ThrLeu: 5.941 ± 0.112
1.403ThrMet: 1.403 ± 0.053
3.195ThrAsn: 3.195 ± 0.079
2.734ThrPro: 2.734 ± 0.072
2.573ThrGln: 2.573 ± 0.071
2.006ThrArg: 2.006 ± 0.062
3.581ThrSer: 3.581 ± 0.105
4.705ThrThr: 4.705 ± 0.116
4.578ThrVal: 4.578 ± 0.095
0.632ThrTrp: 0.632 ± 0.038
2.115ThrTyr: 2.115 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
6.281ValAla: 6.281 ± 0.12
0.361ValCys: 0.361 ± 0.029
4.194ValAsp: 4.194 ± 0.086
3.808ValGlu: 3.808 ± 0.105
2.674ValPhe: 2.674 ± 0.078
4.836ValGly: 4.836 ± 0.094
1.214ValHis: 1.214 ± 0.056
5.282ValIle: 5.282 ± 0.101
4.409ValLys: 4.409 ± 0.092
6.6ValLeu: 6.6 ± 0.115
1.675ValMet: 1.675 ± 0.06
3.333ValAsn: 3.333 ± 0.071
2.684ValPro: 2.684 ± 0.07
2.699ValGln: 2.699 ± 0.072
2.523ValArg: 2.523 ± 0.079
4.056ValSer: 4.056 ± 0.097
4.797ValThr: 4.797 ± 0.095
5.137ValVal: 5.137 ± 0.124
0.617ValTrp: 0.617 ± 0.041
2.136ValTyr: 2.136 ± 0.072
0.0ValXaa: 0.0 ± 0.0
Trp
0.5TrpAla: 0.5 ± 0.029
0.048TrpCys: 0.048 ± 0.009
0.453TrpAsp: 0.453 ± 0.03
0.428TrpGlu: 0.428 ± 0.028
0.467TrpPhe: 0.467 ± 0.034
0.63TrpGly: 0.63 ± 0.034
0.34TrpHis: 0.34 ± 0.025
0.601TrpIle: 0.601 ± 0.035
0.325TrpLys: 0.325 ± 0.026
1.514TrpLeu: 1.514 ± 0.067
0.211TrpMet: 0.211 ± 0.02
0.484TrpAsn: 0.484 ± 0.03
0.363TrpPro: 0.363 ± 0.027
0.968TrpGln: 0.968 ± 0.054
0.498TrpArg: 0.498 ± 0.03
0.559TrpSer: 0.559 ± 0.033
0.494TrpThr: 0.494 ± 0.032
0.528TrpVal: 0.528 ± 0.033
0.167TrpTrp: 0.167 ± 0.019
0.373TrpTyr: 0.373 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.511TyrAla: 2.511 ± 0.074
0.181TyrCys: 0.181 ± 0.019
2.127TyrAsp: 2.127 ± 0.062
1.7TyrGlu: 1.7 ± 0.058
1.821TyrPhe: 1.821 ± 0.056
2.344TyrGly: 2.344 ± 0.07
1.057TyrHis: 1.057 ± 0.051
1.883TyrIle: 1.883 ± 0.066
1.264TyrLys: 1.264 ± 0.054
4.29TyrLeu: 4.29 ± 0.09
0.634TyrMet: 0.634 ± 0.037
1.485TyrAsn: 1.485 ± 0.059
1.399TyrPro: 1.399 ± 0.06
2.861TyrGln: 2.861 ± 0.083
1.777TyrArg: 1.777 ± 0.057
1.848TyrSer: 1.848 ± 0.052
1.86TyrThr: 1.86 ± 0.07
2.213TyrVal: 2.213 ± 0.07
0.446TyrTrp: 0.446 ± 0.032
1.501TyrTyr: 1.501 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1691 proteins (520490 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski