Amino acid dipepetide frequency for Eubacterium uniforme

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.039AlaAla: 4.039 ± 0.091	0.836AlaCys: 0.836 ± 0.029	3.777AlaAsp: 3.777 ± 0.065	3.709AlaGlu: 3.709 ± 0.082	2.834AlaPhe: 2.834 ± 0.064	4.178AlaGly: 4.178 ± 0.083	0.861AlaHis: 0.861 ± 0.035	5.132AlaIle: 5.132 ± 0.092	5.404AlaLys: 5.404 ± 0.085	5.029AlaLeu: 5.029 ± 0.086	1.782AlaMet: 1.782 ± 0.044	3.317AlaAsn: 3.317 ± 0.077	1.491AlaPro: 1.491 ± 0.053	1.341AlaGln: 1.341 ± 0.04	2.124AlaArg: 2.124 ± 0.058	3.55AlaSer: 3.55 ± 0.07	3.218AlaThr: 3.218 ± 0.075	4.336AlaVal: 4.336 ± 0.085	0.48AlaTrp: 0.48 ± 0.024	2.823AlaTyr: 2.823 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.8CysAla: 0.8 ± 0.03	0.175CysCys: 0.175 ± 0.014	0.989CysAsp: 0.989 ± 0.031	0.893CysGlu: 0.893 ± 0.034	0.62CysPhe: 0.62 ± 0.03	1.184CysGly: 1.184 ± 0.04	0.201CysHis: 0.201 ± 0.017	1.134CysIle: 1.134 ± 0.036	1.137CysLys: 1.137 ± 0.039	0.931CysLeu: 0.931 ± 0.034	0.398CysMet: 0.398 ± 0.02	0.704CysAsn: 0.704 ± 0.03	0.43CysPro: 0.43 ± 0.024	0.258CysGln: 0.258 ± 0.017	0.419CysArg: 0.419 ± 0.02	0.785CysSer: 0.785 ± 0.032	0.65CysThr: 0.65 ± 0.031	0.963CysVal: 0.963 ± 0.038	0.078CysTrp: 0.078 ± 0.01	0.552CysTyr: 0.552 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	3.772AspAla: 3.772 ± 0.086	0.791AspCys: 0.791 ± 0.033	4.646AspAsp: 4.646 ± 0.082	6.569AspGlu: 6.569 ± 0.105	3.07AspPhe: 3.07 ± 0.068	5.08AspGly: 5.08 ± 0.091	0.695AspHis: 0.695 ± 0.031	5.996AspIle: 5.996 ± 0.089	6.188AspLys: 6.188 ± 0.097	4.694AspLeu: 4.694 ± 0.087	1.871AspMet: 1.871 ± 0.051	3.965AspAsn: 3.965 ± 0.091	1.4AspPro: 1.4 ± 0.039	0.877AspGln: 0.877 ± 0.033	2.086AspArg: 2.086 ± 0.059	3.82AspSer: 3.82 ± 0.078	3.082AspThr: 3.082 ± 0.066	4.972AspVal: 4.972 ± 0.085	0.525AspTrp: 0.525 ± 0.027	3.55AspTyr: 3.55 ± 0.066	0.0AspXaa: 0.0 ± 0.0
Glu	4.347GluAla: 4.347 ± 0.091	0.889GluCys: 0.889 ± 0.035	5.214GluAsp: 5.214 ± 0.085	6.814GluGlu: 6.814 ± 0.152	3.067GluPhe: 3.067 ± 0.064	4.468GluGly: 4.468 ± 0.08	1.155GluHis: 1.155 ± 0.036	6.294GluIle: 6.294 ± 0.094	7.437GluLys: 7.437 ± 0.115	6.329GluLeu: 6.329 ± 0.101	2.003GluMet: 2.003 ± 0.048	4.783GluAsn: 4.783 ± 0.089	1.412GluPro: 1.412 ± 0.045	1.745GluGln: 1.745 ± 0.044	2.739GluArg: 2.739 ± 0.07	3.849GluSer: 3.849 ± 0.077	3.564GluThr: 3.564 ± 0.069	5.224GluVal: 5.224 ± 0.086	0.587GluTrp: 0.587 ± 0.027	4.056GluTyr: 4.056 ± 0.082	0.0GluXaa: 0.0 ± 0.0
Phe	2.947PheAla: 2.947 ± 0.063	0.597PheCys: 0.597 ± 0.027	3.324PheAsp: 3.324 ± 0.066	3.19PheGlu: 3.19 ± 0.052	1.798PhePhe: 1.798 ± 0.054	2.848PheGly: 2.848 ± 0.068	0.533PheHis: 0.533 ± 0.026	3.46PheIle: 3.46 ± 0.071	3.472PheLys: 3.472 ± 0.076	3.179PheLeu: 3.179 ± 0.072	1.207PheMet: 1.207 ± 0.044	2.269PheAsn: 2.269 ± 0.052	1.016PhePro: 1.016 ± 0.035	0.65PheGln: 0.65 ± 0.029	1.349PheArg: 1.349 ± 0.037	2.7PheSer: 2.7 ± 0.057	2.369PheThr: 2.369 ± 0.062	3.075PheVal: 3.075 ± 0.054	0.356PheTrp: 0.356 ± 0.02	1.989PheTyr: 1.989 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	3.851GlyAla: 3.851 ± 0.076	1.02GlyCys: 1.02 ± 0.042	4.103GlyAsp: 4.103 ± 0.082	4.499GlyGlu: 4.499 ± 0.093	3.129GlyPhe: 3.129 ± 0.058	4.145GlyGly: 4.145 ± 0.096	0.971GlyHis: 0.971 ± 0.035	5.637GlyIle: 5.637 ± 0.086	6.555GlyLys: 6.555 ± 0.106	5.062GlyLeu: 5.062 ± 0.085	1.884GlyMet: 1.884 ± 0.052	3.7GlyAsn: 3.7 ± 0.097	1.065GlyPro: 1.065 ± 0.042	1.366GlyGln: 1.366 ± 0.044	2.344GlyArg: 2.344 ± 0.056	3.905GlySer: 3.905 ± 0.077	3.556GlyThr: 3.556 ± 0.086	4.67GlyVal: 4.67 ± 0.075	0.56GlyTrp: 0.56 ± 0.031	3.358GlyTyr: 3.358 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	0.689HisAla: 0.689 ± 0.031	0.209HisCys: 0.209 ± 0.017	0.859HisAsp: 0.859 ± 0.034	0.874HisGlu: 0.874 ± 0.038	0.689HisPhe: 0.689 ± 0.025	1.005HisGly: 1.005 ± 0.034	0.257HisHis: 0.257 ± 0.021	1.256HisIle: 1.256 ± 0.044	1.017HisLys: 1.017 ± 0.036	1.048HisLeu: 1.048 ± 0.039	0.398HisMet: 0.398 ± 0.02	0.745HisAsn: 0.745 ± 0.035	0.538HisPro: 0.538 ± 0.024	0.321HisGln: 0.321 ± 0.017	0.533HisArg: 0.533 ± 0.024	0.79HisSer: 0.79 ± 0.035	0.71HisThr: 0.71 ± 0.035	0.874HisVal: 0.874 ± 0.031	0.117HisTrp: 0.117 ± 0.011	0.648HisTyr: 0.648 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.325IleAla: 5.325 ± 0.097	1.34IleCys: 1.34 ± 0.035	5.808IleAsp: 5.808 ± 0.095	6.108IleGlu: 6.108 ± 0.091	3.222IlePhe: 3.222 ± 0.076	5.166IleGly: 5.166 ± 0.09	1.045IleHis: 1.045 ± 0.038	6.995IleIle: 6.995 ± 0.126	7.736IleLys: 7.736 ± 0.115	6.213IleLeu: 6.213 ± 0.12	2.052IleMet: 2.052 ± 0.055	5.127IleAsn: 5.127 ± 0.087	2.842IlePro: 2.842 ± 0.059	1.515IleGln: 1.515 ± 0.051	2.945IleArg: 2.945 ± 0.067	5.809IleSer: 5.809 ± 0.078	4.571IleThr: 4.571 ± 0.08	5.483IleVal: 5.483 ± 0.092	0.544IleTrp: 0.544 ± 0.027	3.545IleTyr: 3.545 ± 0.07	0.0IleXaa: 0.0 ± 0.0
Lys	5.511LysAla: 5.511 ± 0.102	0.971LysCys: 0.971 ± 0.036	6.211LysAsp: 6.211 ± 0.098	8.013LysGlu: 8.013 ± 0.113	3.114LysPhe: 3.114 ± 0.066	5.151LysGly: 5.151 ± 0.092	1.15LysHis: 1.15 ± 0.035	7.205LysIle: 7.205 ± 0.101	10.31LysLys: 10.31 ± 0.148	7.0LysLeu: 7.0 ± 0.098	2.504LysMet: 2.504 ± 0.064	6.063LysAsn: 6.063 ± 0.108	2.075LysPro: 2.075 ± 0.063	2.018LysGln: 2.018 ± 0.053	3.115LysArg: 3.115 ± 0.064	5.059LysSer: 5.059 ± 0.089	4.976LysThr: 4.976 ± 0.09	6.607LysVal: 6.607 ± 0.123	0.652LysTrp: 0.652 ± 0.033	5.04LysTyr: 5.04 ± 0.086	0.0LysXaa: 0.0 ± 0.0
Leu	4.708LeuAla: 4.708 ± 0.078	1.176LeuCys: 1.176 ± 0.045	5.154LeuAsp: 5.154 ± 0.087	5.673LeuGlu: 5.673 ± 0.083	3.382LeuPhe: 3.382 ± 0.077	4.992LeuGly: 4.992 ± 0.077	1.044LeuHis: 1.044 ± 0.037	5.917LeuIle: 5.917 ± 0.114	7.144LeuLys: 7.144 ± 0.099	6.379LeuLeu: 6.379 ± 0.117	2.064LeuMet: 2.064 ± 0.046	4.347LeuAsn: 4.347 ± 0.074	2.504LeuPro: 2.504 ± 0.057	1.51LeuGln: 1.51 ± 0.046	2.901LeuArg: 2.901 ± 0.078	5.965LeuSer: 5.965 ± 0.093	4.244LeuThr: 4.244 ± 0.077	5.005LeuVal: 5.005 ± 0.085	0.538LeuTrp: 0.538 ± 0.03	3.326LeuTyr: 3.326 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	1.805MetAla: 1.805 ± 0.052	0.335MetCys: 0.335 ± 0.023	1.937MetAsp: 1.937 ± 0.043	1.836MetGlu: 1.836 ± 0.054	1.08MetPhe: 1.08 ± 0.043	1.722MetGly: 1.722 ± 0.046	0.404MetHis: 0.404 ± 0.025	2.22MetIle: 2.22 ± 0.061	2.531MetLys: 2.531 ± 0.064	2.29MetLeu: 2.29 ± 0.051	0.799MetMet: 0.799 ± 0.032	1.606MetAsn: 1.606 ± 0.045	0.915MetPro: 0.915 ± 0.037	0.71MetGln: 0.71 ± 0.028	0.894MetArg: 0.894 ± 0.032	1.729MetSer: 1.729 ± 0.046	1.278MetThr: 1.278 ± 0.043	1.772MetVal: 1.772 ± 0.046	0.16MetTrp: 0.16 ± 0.013	1.054MetTyr: 1.054 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	3.395AsnAla: 3.395 ± 0.077	0.773AsnCys: 0.773 ± 0.03	3.624AsnAsp: 3.624 ± 0.077	4.244AsnGlu: 4.244 ± 0.078	2.046AsnPhe: 2.046 ± 0.058	4.218AsnGly: 4.218 ± 0.102	0.842AsnHis: 0.842 ± 0.028	5.244AsnIle: 5.244 ± 0.079	5.427AsnLys: 5.427 ± 0.103	4.386AsnLeu: 4.386 ± 0.081	1.633AsnMet: 1.633 ± 0.048	3.925AsnAsn: 3.925 ± 0.124	2.045AsnPro: 2.045 ± 0.053	1.291AsnGln: 1.291 ± 0.045	1.996AsnArg: 1.996 ± 0.051	3.374AsnSer: 3.374 ± 0.073	3.055AsnThr: 3.055 ± 0.075	4.175AsnVal: 4.175 ± 0.084	0.433AsnTrp: 0.433 ± 0.022	2.685AsnTyr: 2.685 ± 0.072	0.0AsnXaa: 0.0 ± 0.0
Pro	1.482ProAla: 1.482 ± 0.05	0.328ProCys: 0.328 ± 0.018	1.96ProAsp: 1.96 ± 0.053	2.338ProGlu: 2.338 ± 0.057	1.236ProPhe: 1.236 ± 0.039	1.627ProGly: 1.627 ± 0.048	0.422ProHis: 0.422 ± 0.023	2.127ProIle: 2.127 ± 0.054	2.079ProLys: 2.079 ± 0.047	1.97ProLeu: 1.97 ± 0.044	0.655ProMet: 0.655 ± 0.032	1.331ProAsn: 1.331 ± 0.039	0.432ProPro: 0.432 ± 0.024	0.588ProGln: 0.588 ± 0.029	0.739ProArg: 0.739 ± 0.035	1.587ProSer: 1.587 ± 0.049	1.409ProThr: 1.409 ± 0.046	2.062ProVal: 2.062 ± 0.049	0.24ProTrp: 0.24 ± 0.017	1.296ProTyr: 1.296 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.327GlnAla: 1.327 ± 0.044	0.197GlnCys: 0.197 ± 0.016	1.019GlnAsp: 1.019 ± 0.038	1.283GlnGlu: 1.283 ± 0.043	0.823GlnPhe: 0.823 ± 0.027	1.242GlnGly: 1.242 ± 0.038	0.267GlnHis: 0.267 ± 0.015	1.925GlnIle: 1.925 ± 0.055	1.821GlnLys: 1.821 ± 0.049	1.626GlnLeu: 1.626 ± 0.046	0.709GlnMet: 0.709 ± 0.034	1.258GlnAsn: 1.258 ± 0.04	0.499GlnPro: 0.499 ± 0.029	0.504GlnGln: 0.504 ± 0.027	0.797GlnArg: 0.797 ± 0.029	1.178GlnSer: 1.178 ± 0.036	1.119GlnThr: 1.119 ± 0.044	1.429GlnVal: 1.429 ± 0.046	0.159GlnTrp: 0.159 ± 0.014	0.966GlnTyr: 0.966 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.016ArgAla: 2.016 ± 0.053	0.454ArgCys: 0.454 ± 0.025	2.131ArgAsp: 2.131 ± 0.058	2.79ArgGlu: 2.79 ± 0.071	1.629ArgPhe: 1.629 ± 0.047	1.825ArgGly: 1.825 ± 0.053	0.527ArgHis: 0.527 ± 0.028	3.078ArgIle: 3.078 ± 0.061	3.046ArgLys: 3.046 ± 0.058	2.651ArgLeu: 2.651 ± 0.067	1.093ArgMet: 1.093 ± 0.041	2.005ArgAsn: 2.005 ± 0.054	0.868ArgPro: 0.868 ± 0.033	0.812ArgGln: 0.812 ± 0.037	1.566ArgArg: 1.566 ± 0.048	1.784ArgSer: 1.784 ± 0.046	1.643ArgThr: 1.643 ± 0.041	2.425ArgVal: 2.425 ± 0.05	0.261ArgTrp: 0.261 ± 0.017	1.631ArgTyr: 1.631 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.495SerAla: 3.495 ± 0.066	0.681SerCys: 0.681 ± 0.029	4.383SerAsp: 4.383 ± 0.09	4.567SerGlu: 4.567 ± 0.078	2.776SerPhe: 2.776 ± 0.054	4.62SerGly: 4.62 ± 0.097	0.848SerHis: 0.848 ± 0.03	5.163SerIle: 5.163 ± 0.084	5.602SerLys: 5.602 ± 0.081	4.847SerLeu: 4.847 ± 0.079	1.639SerMet: 1.639 ± 0.049	3.424SerAsn: 3.424 ± 0.08	1.307SerPro: 1.307 ± 0.045	1.219SerGln: 1.219 ± 0.043	2.108SerArg: 2.108 ± 0.057	3.952SerSer: 3.952 ± 0.092	3.002SerThr: 3.002 ± 0.066	4.434SerVal: 4.434 ± 0.082	0.526SerTrp: 0.526 ± 0.029	2.978SerTyr: 2.978 ± 0.075	0.0SerXaa: 0.0 ± 0.0
Thr	2.999ThrAla: 2.999 ± 0.077	0.623ThrCys: 0.623 ± 0.027	3.375ThrAsp: 3.375 ± 0.08	3.459ThrGlu: 3.459 ± 0.094	2.285ThrPhe: 2.285 ± 0.064	3.964ThrGly: 3.964 ± 0.094	0.736ThrHis: 0.736 ± 0.029	4.544ThrIle: 4.544 ± 0.074	4.353ThrLys: 4.353 ± 0.082	4.299ThrLeu: 4.299 ± 0.08	1.235ThrMet: 1.235 ± 0.037	2.752ThrAsn: 2.752 ± 0.083	1.675ThrPro: 1.675 ± 0.043	1.099ThrGln: 1.099 ± 0.041	1.498ThrArg: 1.498 ± 0.043	3.313ThrSer: 3.313 ± 0.073	3.041ThrThr: 3.041 ± 0.098	4.145ThrVal: 4.145 ± 0.088	0.454ThrTrp: 0.454 ± 0.029	2.729ThrTyr: 2.729 ± 0.078	0.0ThrXaa: 0.0 ± 0.0
Val	4.404ValAla: 4.404 ± 0.082	1.125ValCys: 1.125 ± 0.042	4.883ValAsp: 4.883 ± 0.08	4.937ValGlu: 4.937 ± 0.081	3.135ValPhe: 3.135 ± 0.078	4.278ValGly: 4.278 ± 0.084	0.843ValHis: 0.843 ± 0.03	5.785ValIle: 5.785 ± 0.092	6.508ValLys: 6.508 ± 0.116	5.89ValLeu: 5.89 ± 0.105	1.721ValMet: 1.721 ± 0.046	4.039ValAsn: 4.039 ± 0.075	1.978ValPro: 1.978 ± 0.049	1.143ValGln: 1.143 ± 0.037	2.172ValArg: 2.172 ± 0.047	4.909ValSer: 4.909 ± 0.073	4.144ValThr: 4.144 ± 0.108	5.587ValVal: 5.587 ± 0.091	0.465ValTrp: 0.465 ± 0.023	3.222ValTyr: 3.222 ± 0.07	0.0ValXaa: 0.0 ± 0.0
Trp	0.454TrpAla: 0.454 ± 0.024	0.11TrpCys: 0.11 ± 0.01	0.552TrpAsp: 0.552 ± 0.029	0.508TrpGlu: 0.508 ± 0.025	0.334TrpPhe: 0.334 ± 0.021	0.514TrpGly: 0.514 ± 0.026	0.132TrpHis: 0.132 ± 0.014	0.611TrpIle: 0.611 ± 0.027	0.596TrpLys: 0.596 ± 0.029	0.623TrpLeu: 0.623 ± 0.027	0.196TrpMet: 0.196 ± 0.015	0.521TrpAsn: 0.521 ± 0.023	0.151TrpPro: 0.151 ± 0.013	0.223TrpGln: 0.223 ± 0.018	0.257TrpArg: 0.257 ± 0.019	0.463TrpSer: 0.463 ± 0.031	0.371TrpThr: 0.371 ± 0.022	0.472TrpVal: 0.472 ± 0.025	0.094TrpTrp: 0.094 ± 0.009	0.375TrpTyr: 0.375 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.893TyrAla: 2.893 ± 0.059	0.671TyrCys: 0.671 ± 0.031	3.702TyrAsp: 3.702 ± 0.117	3.673TyrGlu: 3.673 ± 0.077	2.059TyrPhe: 2.059 ± 0.047	3.155TyrGly: 3.155 ± 0.073	0.641TyrHis: 0.641 ± 0.028	3.665TyrIle: 3.665 ± 0.072	4.382TyrLys: 4.382 ± 0.082	3.527TyrLeu: 3.527 ± 0.064	1.236TyrMet: 1.236 ± 0.042	2.93TyrAsn: 2.93 ± 0.069	1.265TyrPro: 1.265 ± 0.043	0.958TyrGln: 0.958 ± 0.033	1.654TyrArg: 1.654 ± 0.049	3.051TyrSer: 3.051 ± 0.07	2.575TyrThr: 2.575 ± 0.074	3.459TyrVal: 3.459 ± 0.073	0.327TyrTrp: 0.327 ± 0.02	2.545TyrTyr: 2.545 ± 0.075	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2409 proteins (853700 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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