Amino acid dipepetide frequency for Gordonia iterans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.027AlaAla: 21.027 ± 0.171	0.934AlaCys: 0.934 ± 0.029	8.951AlaAsp: 8.951 ± 0.102	8.515AlaGlu: 8.515 ± 0.107	3.519AlaPhe: 3.519 ± 0.059	12.726AlaGly: 12.726 ± 0.11	2.468AlaHis: 2.468 ± 0.051	4.876AlaIle: 4.876 ± 0.072	2.92AlaLys: 2.92 ± 0.073	13.201AlaLeu: 13.201 ± 0.112	2.713AlaMet: 2.713 ± 0.054	2.127AlaAsn: 2.127 ± 0.045	6.804AlaPro: 6.804 ± 0.093	4.159AlaGln: 4.159 ± 0.068	9.416AlaArg: 9.416 ± 0.105	5.872AlaSer: 5.872 ± 0.076	6.909AlaThr: 6.909 ± 0.076	12.162AlaVal: 12.162 ± 0.129	1.579AlaTrp: 1.579 ± 0.04	2.351AlaTyr: 2.351 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.994CysAla: 0.994 ± 0.033	0.071CysCys: 0.071 ± 0.008	0.475CysAsp: 0.475 ± 0.02	0.376CysGlu: 0.376 ± 0.022	0.217CysPhe: 0.217 ± 0.013	0.91CysGly: 0.91 ± 0.029	0.15CysHis: 0.15 ± 0.01	0.236CysIle: 0.236 ± 0.017	0.095CysLys: 0.095 ± 0.009	0.603CysLeu: 0.603 ± 0.026	0.109CysMet: 0.109 ± 0.01	0.145CysAsn: 0.145 ± 0.012	0.4CysPro: 0.4 ± 0.018	0.151CysGln: 0.151 ± 0.012	0.564CysArg: 0.564 ± 0.022	0.442CysSer: 0.442 ± 0.018	0.471CysThr: 0.471 ± 0.024	0.566CysVal: 0.566 ± 0.022	0.13CysTrp: 0.13 ± 0.015	0.139CysTyr: 0.139 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.097AspAla: 8.097 ± 0.087	0.417AspCys: 0.417 ± 0.02	5.434AspAsp: 5.434 ± 0.091	4.497AspGlu: 4.497 ± 0.068	1.8AspPhe: 1.8 ± 0.04	6.478AspGly: 6.478 ± 0.079	1.386AspHis: 1.386 ± 0.03	1.905AspIle: 1.905 ± 0.037	1.194AspLys: 1.194 ± 0.03	6.726AspLeu: 6.726 ± 0.08	0.904AspMet: 0.904 ± 0.027	0.877AspAsn: 0.877 ± 0.028	4.977AspPro: 4.977 ± 0.076	1.798AspGln: 1.798 ± 0.043	5.199AspArg: 5.199 ± 0.073	2.901AspSer: 2.901 ± 0.058	2.98AspThr: 2.98 ± 0.051	5.641AspVal: 5.641 ± 0.091	0.967AspTrp: 0.967 ± 0.031	1.353AspTyr: 1.353 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.614GluAla: 6.614 ± 0.086	0.364GluCys: 0.364 ± 0.02	2.404GluAsp: 2.404 ± 0.053	2.723GluGlu: 2.723 ± 0.054	1.93GluPhe: 1.93 ± 0.042	3.532GluGly: 3.532 ± 0.057	1.439GluHis: 1.439 ± 0.042	2.803GluIle: 2.803 ± 0.053	1.481GluLys: 1.481 ± 0.042	6.684GluLeu: 6.684 ± 0.11	1.048GluMet: 1.048 ± 0.028	1.285GluAsn: 1.285 ± 0.032	3.196GluPro: 3.196 ± 0.057	2.256GluGln: 2.256 ± 0.045	4.883GluArg: 4.883 ± 0.071	2.973GluSer: 2.973 ± 0.064	2.887GluThr: 2.887 ± 0.055	4.879GluVal: 4.879 ± 0.079	0.769GluTrp: 0.769 ± 0.028	1.322GluTyr: 1.322 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	4.245PheAla: 4.245 ± 0.063	0.282PheCys: 0.282 ± 0.016	2.404PheAsp: 2.404 ± 0.067	1.468PheGlu: 1.468 ± 0.04	0.988PhePhe: 0.988 ± 0.033	3.499PheGly: 3.499 ± 0.063	0.56PheHis: 0.56 ± 0.02	0.903PheIle: 0.903 ± 0.035	0.446PheLys: 0.446 ± 0.021	2.591PheLeu: 2.591 ± 0.047	0.423PheMet: 0.423 ± 0.019	0.615PheAsn: 0.615 ± 0.025	1.353PhePro: 1.353 ± 0.035	0.619PheGln: 0.619 ± 0.024	1.667PheArg: 1.667 ± 0.041	1.659PheSer: 1.659 ± 0.039	1.979PheThr: 1.979 ± 0.041	2.623PheVal: 2.623 ± 0.052	0.446PheTrp: 0.446 ± 0.021	0.595PheTyr: 0.595 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	11.064GlyAla: 11.064 ± 0.101	0.723GlyCys: 0.723 ± 0.027	5.699GlyAsp: 5.699 ± 0.071	5.194GlyGlu: 5.194 ± 0.093	3.027GlyPhe: 3.027 ± 0.048	8.048GlyGly: 8.048 ± 0.106	1.888GlyHis: 1.888 ± 0.045	4.202GlyIle: 4.202 ± 0.068	2.383GlyLys: 2.383 ± 0.049	8.939GlyLeu: 8.939 ± 0.113	2.017GlyMet: 2.017 ± 0.039	1.758GlyAsn: 1.758 ± 0.041	4.848GlyPro: 4.848 ± 0.071	2.58GlyGln: 2.58 ± 0.052	6.858GlyArg: 6.858 ± 0.086	5.15GlySer: 5.15 ± 0.065	5.353GlyThr: 5.353 ± 0.089	7.819GlyVal: 7.819 ± 0.097	1.489GlyTrp: 1.489 ± 0.044	2.321GlyTyr: 2.321 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.321HisAla: 2.321 ± 0.047	0.172HisCys: 0.172 ± 0.013	1.415HisAsp: 1.415 ± 0.036	0.979HisGlu: 0.979 ± 0.03	0.575HisPhe: 0.575 ± 0.024	1.936HisGly: 1.936 ± 0.047	0.637HisHis: 0.637 ± 0.024	0.654HisIle: 0.654 ± 0.025	0.34HisLys: 0.34 ± 0.017	2.069HisLeu: 2.069 ± 0.045	0.293HisMet: 0.293 ± 0.016	0.388HisAsn: 0.388 ± 0.018	1.498HisPro: 1.498 ± 0.035	0.608HisGln: 0.608 ± 0.025	1.846HisArg: 1.846 ± 0.05	0.996HisSer: 0.996 ± 0.031	1.069HisThr: 1.069 ± 0.029	1.566HisVal: 1.566 ± 0.036	0.339HisTrp: 0.339 ± 0.017	0.446HisTyr: 0.446 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.361IleAla: 6.361 ± 0.081	0.335IleCys: 0.335 ± 0.016	3.289IleAsp: 3.289 ± 0.061	2.468IleGlu: 2.468 ± 0.053	0.976IlePhe: 0.976 ± 0.034	4.514IleGly: 4.514 ± 0.073	0.732IleHis: 0.732 ± 0.025	1.336IleIle: 1.336 ± 0.039	0.794IleLys: 0.794 ± 0.03	3.324IleLeu: 3.324 ± 0.06	0.613IleMet: 0.613 ± 0.023	0.911IleAsn: 0.911 ± 0.037	2.288IlePro: 2.288 ± 0.045	0.81IleGln: 0.81 ± 0.029	2.519IleArg: 2.519 ± 0.051	2.206IleSer: 2.206 ± 0.049	2.552IleThr: 2.552 ± 0.05	3.866IleVal: 3.866 ± 0.066	0.469IleTrp: 0.469 ± 0.019	0.68IleTyr: 0.68 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.641LysAla: 2.641 ± 0.069	0.106LysCys: 0.106 ± 0.012	1.091LysAsp: 1.091 ± 0.036	0.904LysGlu: 0.904 ± 0.03	0.572LysPhe: 0.572 ± 0.022	1.609LysGly: 1.609 ± 0.035	0.459LysHis: 0.459 ± 0.019	1.088LysIle: 1.088 ± 0.037	0.833LysLys: 0.833 ± 0.043	2.085LysLeu: 2.085 ± 0.049	0.439LysMet: 0.439 ± 0.023	0.602LysAsn: 0.602 ± 0.024	1.301LysPro: 1.301 ± 0.042	0.658LysGln: 0.658 ± 0.025	1.621LysArg: 1.621 ± 0.04	1.19LysSer: 1.19 ± 0.033	1.423LysThr: 1.423 ± 0.043	1.954LysVal: 1.954 ± 0.047	0.284LysTrp: 0.284 ± 0.016	0.525LysTyr: 0.525 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.28LeuAla: 14.28 ± 0.12	0.731LeuCys: 0.731 ± 0.024	6.874LeuAsp: 6.874 ± 0.096	4.503LeuGlu: 4.503 ± 0.065	2.64LeuPhe: 2.64 ± 0.052	9.086LeuGly: 9.086 ± 0.104	1.888LeuHis: 1.888 ± 0.044	4.471LeuIle: 4.471 ± 0.076	1.766LeuLys: 1.766 ± 0.044	9.655LeuLeu: 9.655 ± 0.125	1.641LeuMet: 1.641 ± 0.042	2.001LeuAsn: 2.001 ± 0.04	5.735LeuPro: 5.735 ± 0.079	2.174LeuGln: 2.174 ± 0.046	7.333LeuArg: 7.333 ± 0.09	5.466LeuSer: 5.466 ± 0.066	6.74LeuThr: 6.74 ± 0.077	8.57LeuVal: 8.57 ± 0.097	1.137LeuTrp: 1.137 ± 0.038	1.726LeuTyr: 1.726 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.256MetAla: 2.256 ± 0.048	0.153MetCys: 0.153 ± 0.013	0.864MetAsp: 0.864 ± 0.03	0.741MetGlu: 0.741 ± 0.028	0.557MetPhe: 0.557 ± 0.025	1.423MetGly: 1.423 ± 0.043	0.375MetHis: 0.375 ± 0.018	0.975MetIle: 0.975 ± 0.032	0.474MetLys: 0.474 ± 0.024	1.871MetLeu: 1.871 ± 0.041	0.424MetMet: 0.424 ± 0.023	0.533MetAsn: 0.533 ± 0.023	1.12MetPro: 1.12 ± 0.032	0.432MetGln: 0.432 ± 0.017	1.382MetArg: 1.382 ± 0.036	1.514MetSer: 1.514 ± 0.04	1.742MetThr: 1.742 ± 0.034	1.561MetVal: 1.561 ± 0.041	0.253MetTrp: 0.253 ± 0.015	0.334MetTyr: 0.334 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.251AsnAla: 2.251 ± 0.048	0.136AsnCys: 0.136 ± 0.012	1.223AsnAsp: 1.223 ± 0.033	0.941AsnGlu: 0.941 ± 0.031	0.531AsnPhe: 0.531 ± 0.02	1.853AsnGly: 1.853 ± 0.043	0.406AsnHis: 0.406 ± 0.021	0.832AsnIle: 0.832 ± 0.027	0.47AsnLys: 0.47 ± 0.022	1.981AsnLeu: 1.981 ± 0.037	0.353AsnMet: 0.353 ± 0.018	0.464AsnAsn: 0.464 ± 0.021	1.57AsnPro: 1.57 ± 0.04	0.596AsnGln: 0.596 ± 0.024	1.533AsnArg: 1.533 ± 0.036	1.021AsnSer: 1.021 ± 0.031	1.171AsnThr: 1.171 ± 0.035	1.602AsnVal: 1.602 ± 0.041	0.312AsnTrp: 0.312 ± 0.015	0.459AsnTyr: 0.459 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.905ProAla: 7.905 ± 0.1	0.273ProCys: 0.273 ± 0.016	4.707ProAsp: 4.707 ± 0.073	4.129ProGlu: 4.129 ± 0.074	1.598ProPhe: 1.598 ± 0.035	5.991ProGly: 5.991 ± 0.098	1.141ProHis: 1.141 ± 0.034	2.108ProIle: 2.108 ± 0.038	1.248ProLys: 1.248 ± 0.034	4.758ProLeu: 4.758 ± 0.07	1.09ProMet: 1.09 ± 0.026	1.156ProAsn: 1.156 ± 0.033	3.181ProPro: 3.181 ± 0.076	1.565ProGln: 1.565 ± 0.045	3.662ProArg: 3.662 ± 0.065	3.267ProSer: 3.267 ± 0.061	3.168ProThr: 3.168 ± 0.058	5.333ProVal: 5.333 ± 0.09	0.794ProTrp: 0.794 ± 0.033	1.1ProTyr: 1.1 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.447GlnAla: 3.447 ± 0.059	0.191GlnCys: 0.191 ± 0.014	1.025GlnAsp: 1.025 ± 0.031	1.158GlnGlu: 1.158 ± 0.032	0.857GlnPhe: 0.857 ± 0.028	1.859GlnGly: 1.859 ± 0.048	0.556GlnHis: 0.556 ± 0.024	1.487GlnIle: 1.487 ± 0.037	0.584GlnLys: 0.584 ± 0.024	2.991GlnLeu: 2.991 ± 0.056	0.602GlnMet: 0.602 ± 0.023	0.624GlnAsn: 0.624 ± 0.022	1.548GlnPro: 1.548 ± 0.046	1.123GlnGln: 1.123 ± 0.041	2.591GlnArg: 2.591 ± 0.05	1.391GlnSer: 1.391 ± 0.033	1.627GlnThr: 1.627 ± 0.042	2.704GlnVal: 2.704 ± 0.06	0.529GlnTrp: 0.529 ± 0.023	0.652GlnTyr: 0.652 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.872ArgAla: 8.872 ± 0.11	0.524ArgCys: 0.524 ± 0.024	4.34ArgAsp: 4.34 ± 0.071	4.382ArgGlu: 4.382 ± 0.069	2.312ArgPhe: 2.312 ± 0.046	5.587ArgGly: 5.587 ± 0.082	1.67ArgHis: 1.67 ± 0.043	3.566ArgIle: 3.566 ± 0.051	1.766ArgLys: 1.766 ± 0.046	7.617ArgLeu: 7.617 ± 0.1	1.788ArgMet: 1.788 ± 0.041	1.514ArgAsn: 1.514 ± 0.035	4.322ArgPro: 4.322 ± 0.068	2.006ArgGln: 2.006 ± 0.044	7.353ArgArg: 7.353 ± 0.125	4.147ArgSer: 4.147 ± 0.061	4.584ArgThr: 4.584 ± 0.066	5.738ArgVal: 5.738 ± 0.074	1.26ArgTrp: 1.26 ± 0.032	1.71ArgTyr: 1.71 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	7.005SerAla: 7.005 ± 0.083	0.406SerCys: 0.406 ± 0.021	3.222SerAsp: 3.222 ± 0.055	2.674SerGlu: 2.674 ± 0.051	1.626SerPhe: 1.626 ± 0.05	5.952SerGly: 5.952 ± 0.082	0.88SerHis: 0.88 ± 0.024	2.039SerIle: 2.039 ± 0.044	1.097SerLys: 1.097 ± 0.039	4.73SerLeu: 4.73 ± 0.072	1.266SerMet: 1.266 ± 0.036	0.965SerAsn: 0.965 ± 0.03	3.228SerPro: 3.228 ± 0.05	1.324SerGln: 1.324 ± 0.031	3.643SerArg: 3.643 ± 0.061	3.421SerSer: 3.421 ± 0.064	3.534SerThr: 3.534 ± 0.058	4.602SerVal: 4.602 ± 0.1	0.853SerTrp: 0.853 ± 0.028	1.13SerTyr: 1.13 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	8.185ThrAla: 8.185 ± 0.081	0.385ThrCys: 0.385 ± 0.019	3.708ThrAsp: 3.708 ± 0.057	3.311ThrGlu: 3.311 ± 0.055	1.739ThrPhe: 1.739 ± 0.041	6.3ThrGly: 6.3 ± 0.08	1.061ThrHis: 1.061 ± 0.032	2.083ThrIle: 2.083 ± 0.044	1.127ThrLys: 1.127 ± 0.036	5.422ThrLeu: 5.422 ± 0.073	1.086ThrMet: 1.086 ± 0.029	1.01ThrAsn: 1.01 ± 0.028	3.88ThrPro: 3.88 ± 0.058	1.374ThrGln: 1.374 ± 0.042	3.825ThrArg: 3.825 ± 0.067	3.185ThrSer: 3.185 ± 0.048	3.577ThrThr: 3.577 ± 0.073	6.367ThrVal: 6.367 ± 0.073	0.78ThrTrp: 0.78 ± 0.029	1.196ThrTyr: 1.196 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	11.779ValAla: 11.779 ± 0.133	0.697ValCys: 0.697 ± 0.024	6.226ValAsp: 6.226 ± 0.094	4.881ValGlu: 4.881 ± 0.084	2.596ValPhe: 2.596 ± 0.056	7.09ValGly: 7.09 ± 0.1	1.823ValHis: 1.823 ± 0.037	4.117ValIle: 4.117 ± 0.068	1.675ValLys: 1.675 ± 0.045	9.223ValLeu: 9.223 ± 0.108	1.55ValMet: 1.55 ± 0.038	1.912ValAsn: 1.912 ± 0.039	5.102ValPro: 5.102 ± 0.095	2.137ValGln: 2.137 ± 0.053	6.116ValArg: 6.116 ± 0.078	4.781ValSer: 4.781 ± 0.071	5.735ValThr: 5.735 ± 0.064	9.283ValVal: 9.283 ± 0.115	1.067ValTrp: 1.067 ± 0.037	1.663ValTyr: 1.663 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.527TrpAla: 1.527 ± 0.037	0.142TrpCys: 0.142 ± 0.011	0.68TrpAsp: 0.68 ± 0.027	0.627TrpGlu: 0.627 ± 0.025	0.588TrpPhe: 0.588 ± 0.025	0.966TrpGly: 0.966 ± 0.032	0.293TrpHis: 0.293 ± 0.017	0.729TrpIle: 0.729 ± 0.027	0.329TrpLys: 0.329 ± 0.018	1.598TrpLeu: 1.598 ± 0.049	0.342TrpMet: 0.342 ± 0.017	0.383TrpAsn: 0.383 ± 0.017	0.735TrpPro: 0.735 ± 0.026	0.572TrpGln: 0.572 ± 0.023	1.195TrpArg: 1.195 ± 0.034	0.885TrpSer: 0.885 ± 0.027	0.913TrpThr: 0.913 ± 0.032	0.976TrpVal: 0.976 ± 0.03	0.371TrpTrp: 0.371 ± 0.02	0.311TrpTyr: 0.311 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.356TyrAla: 2.356 ± 0.054	0.205TyrCys: 0.205 ± 0.015	1.499TyrAsp: 1.499 ± 0.042	1.001TyrGlu: 1.001 ± 0.037	0.717TyrPhe: 0.717 ± 0.025	2.001TyrGly: 2.001 ± 0.045	0.333TyrHis: 0.333 ± 0.016	0.633TyrIle: 0.633 ± 0.025	0.365TyrLys: 0.365 ± 0.017	2.347TyrLeu: 2.347 ± 0.048	0.284TyrMet: 0.284 ± 0.018	0.433TyrAsn: 0.433 ± 0.02	1.089TyrPro: 1.089 ± 0.036	0.603TyrGln: 0.603 ± 0.021	1.851TyrArg: 1.851 ± 0.043	1.133TyrSer: 1.133 ± 0.03	1.188TyrThr: 1.188 ± 0.033	1.64TyrVal: 1.64 ± 0.047	0.335TyrTrp: 0.335 ± 0.015	0.505TyrTyr: 0.505 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3450 proteins (1168669 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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