Amino acid dipepetide frequency for Algoriphagus sanaruensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.113AlaAla: 5.113 ± 0.09
0.601AlaCys: 0.601 ± 0.032
3.458AlaAsp: 3.458 ± 0.061
4.605AlaGlu: 4.605 ± 0.076
3.587AlaPhe: 3.587 ± 0.06
5.341AlaGly: 5.341 ± 0.087
1.183AlaHis: 1.183 ± 0.036
5.037AlaIle: 5.037 ± 0.077
4.573AlaLys: 4.573 ± 0.068
6.704AlaLeu: 6.704 ± 0.097
1.776AlaMet: 1.776 ± 0.044
3.038AlaAsn: 3.038 ± 0.063
2.392AlaPro: 2.392 ± 0.057
2.935AlaGln: 2.935 ± 0.065
2.51AlaArg: 2.51 ± 0.05
4.466AlaSer: 4.466 ± 0.088
3.335AlaThr: 3.335 ± 0.123
4.191AlaVal: 4.191 ± 0.066
0.932AlaTrp: 0.932 ± 0.027
2.434AlaTyr: 2.434 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.453CysAla: 0.453 ± 0.038
0.079CysCys: 0.079 ± 0.009
0.343CysAsp: 0.343 ± 0.018
0.434CysGlu: 0.434 ± 0.03
0.376CysPhe: 0.376 ± 0.019
0.568CysGly: 0.568 ± 0.028
0.281CysHis: 0.281 ± 0.064
0.425CysIle: 0.425 ± 0.028
0.332CysLys: 0.332 ± 0.018
0.572CysLeu: 0.572 ± 0.023
0.124CysMet: 0.124 ± 0.01
0.245CysAsn: 0.245 ± 0.016
0.323CysPro: 0.323 ± 0.018
0.287CysGln: 0.287 ± 0.016
0.249CysArg: 0.249 ± 0.016
0.441CysSer: 0.441 ± 0.023
0.373CysThr: 0.373 ± 0.029
0.371CysVal: 0.371 ± 0.018
0.072CysTrp: 0.072 ± 0.008
0.211CysTyr: 0.211 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.22AspAla: 3.22 ± 0.068
0.41AspCys: 0.41 ± 0.058
1.955AspAsp: 1.955 ± 0.043
3.354AspGlu: 3.354 ± 0.055
3.679AspPhe: 3.679 ± 0.071
3.725AspGly: 3.725 ± 0.093
1.127AspHis: 1.127 ± 0.05
3.228AspIle: 3.228 ± 0.065
2.691AspLys: 2.691 ± 0.058
5.982AspLeu: 5.982 ± 0.084
1.094AspMet: 1.094 ± 0.031
1.815AspAsn: 1.815 ± 0.049
2.622AspPro: 2.622 ± 0.052
2.799AspGln: 2.799 ± 0.062
2.608AspArg: 2.608 ± 0.047
3.188AspSer: 3.188 ± 0.053
2.051AspThr: 2.051 ± 0.044
2.772AspVal: 2.772 ± 0.057
0.919AspTrp: 0.919 ± 0.027
2.251AspTyr: 2.251 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
4.739GluAla: 4.739 ± 0.075
0.278GluCys: 0.278 ± 0.018
3.405GluAsp: 3.405 ± 0.05
5.561GluGlu: 5.561 ± 0.096
3.453GluPhe: 3.453 ± 0.058
4.505GluGly: 4.505 ± 0.071
1.043GluHis: 1.043 ± 0.033
5.599GluIle: 5.599 ± 0.072
5.927GluLys: 5.927 ± 0.098
6.907GluLeu: 6.907 ± 0.086
1.687GluMet: 1.687 ± 0.041
3.841GluAsn: 3.841 ± 0.067
1.843GluPro: 1.843 ± 0.043
2.431GluGln: 2.431 ± 0.051
2.739GluArg: 2.739 ± 0.053
4.034GluSer: 4.034 ± 0.072
3.222GluThr: 3.222 ± 0.083
4.891GluVal: 4.891 ± 0.065
0.872GluTrp: 0.872 ± 0.026
2.059GluTyr: 2.059 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
3.454PheAla: 3.454 ± 0.059
0.385PheCys: 0.385 ± 0.017
3.121PheAsp: 3.121 ± 0.053
3.7PheGlu: 3.7 ± 0.061
3.105PhePhe: 3.105 ± 0.077
4.233PheGly: 4.233 ± 0.07
1.007PheHis: 1.007 ± 0.033
3.19PheIle: 3.19 ± 0.061
2.761PheLys: 2.761 ± 0.054
5.604PheLeu: 5.604 ± 0.092
1.063PheMet: 1.063 ± 0.03
2.415PheAsn: 2.415 ± 0.049
2.218PhePro: 2.218 ± 0.051
2.24PheGln: 2.24 ± 0.042
2.182PheArg: 2.182 ± 0.051
4.369PheSer: 4.369 ± 0.071
2.955PheThr: 2.955 ± 0.062
2.978PheVal: 2.978 ± 0.06
0.831PheTrp: 0.831 ± 0.031
1.966PheTyr: 1.966 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
4.852GlyAla: 4.852 ± 0.101
0.519GlyCys: 0.519 ± 0.028
3.567GlyAsp: 3.567 ± 0.1
4.505GlyGlu: 4.505 ± 0.096
4.177GlyPhe: 4.177 ± 0.06
5.422GlyGly: 5.422 ± 0.118
1.273GlyHis: 1.273 ± 0.037
5.978GlyIle: 5.978 ± 0.102
5.699GlyLys: 5.699 ± 0.079
7.176GlyLeu: 7.176 ± 0.11
2.012GlyMet: 2.012 ± 0.041
3.608GlyAsn: 3.608 ± 0.083
2.132GlyPro: 2.132 ± 0.075
2.631GlyGln: 2.631 ± 0.048
2.798GlyArg: 2.798 ± 0.065
4.459GlySer: 4.459 ± 0.086
4.113GlyThr: 4.113 ± 0.123
4.738GlyVal: 4.738 ± 0.07
1.022GlyTrp: 1.022 ± 0.029
2.873GlyTyr: 2.873 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
1.183HisAla: 1.183 ± 0.037
0.16HisCys: 0.16 ± 0.012
0.838HisAsp: 0.838 ± 0.044
1.154HisGlu: 1.154 ± 0.035
1.188HisPhe: 1.188 ± 0.035
1.301HisGly: 1.301 ± 0.042
0.578HisHis: 0.578 ± 0.026
1.08HisIle: 1.08 ± 0.035
0.806HisLys: 0.806 ± 0.029
2.115HisLeu: 2.115 ± 0.048
0.355HisMet: 0.355 ± 0.018
0.602HisAsn: 0.602 ± 0.022
1.214HisPro: 1.214 ± 0.036
0.926HisGln: 0.926 ± 0.048
0.864HisArg: 0.864 ± 0.031
1.15HisSer: 1.15 ± 0.036
0.904HisThr: 0.904 ± 0.034
1.068HisVal: 1.068 ± 0.03
0.296HisTrp: 0.296 ± 0.015
0.725HisTyr: 0.725 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
4.957IleAla: 4.957 ± 0.075
0.573IleCys: 0.573 ± 0.025
3.796IleAsp: 3.796 ± 0.065
4.501IleGlu: 4.501 ± 0.072
3.468IlePhe: 3.468 ± 0.064
5.11IleGly: 5.11 ± 0.08
1.58IleHis: 1.58 ± 0.039
4.145IleIle: 4.145 ± 0.07
4.121IleLys: 4.121 ± 0.067
7.528IleLeu: 7.528 ± 0.105
1.206IleMet: 1.206 ± 0.036
3.262IleAsn: 3.262 ± 0.054
3.557IlePro: 3.557 ± 0.055
3.663IleGln: 3.663 ± 0.09
3.34IleArg: 3.34 ± 0.062
5.567IleSer: 5.567 ± 0.079
3.831IleThr: 3.831 ± 0.118
3.565IleVal: 3.565 ± 0.063
0.901IleTrp: 0.901 ± 0.032
2.389IleTyr: 2.389 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
4.744LysAla: 4.744 ± 0.074
0.242LysCys: 0.242 ± 0.016
3.384LysAsp: 3.384 ± 0.063
4.98LysGlu: 4.98 ± 0.086
2.63LysPhe: 2.63 ± 0.04
4.546LysGly: 4.546 ± 0.102
1.024LysHis: 1.024 ± 0.027
5.054LysIle: 5.054 ± 0.075
4.998LysLys: 4.998 ± 0.083
5.789LysLeu: 5.789 ± 0.074
1.731LysMet: 1.731 ± 0.038
3.591LysAsn: 3.591 ± 0.062
2.501LysPro: 2.501 ± 0.05
1.966LysGln: 1.966 ± 0.045
2.536LysArg: 2.536 ± 0.058
4.55LysSer: 4.55 ± 0.072
3.54LysThr: 3.54 ± 0.058
4.373LysVal: 4.373 ± 0.068
0.78LysTrp: 0.78 ± 0.027
2.103LysTyr: 2.103 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
7.502LeuAla: 7.502 ± 0.083
0.627LeuCys: 0.627 ± 0.029
5.547LeuAsp: 5.547 ± 0.07
7.348LeuGlu: 7.348 ± 0.104
4.97LeuPhe: 4.97 ± 0.073
7.591LeuGly: 7.591 ± 0.093
1.654LeuHis: 1.654 ± 0.039
7.672LeuIle: 7.672 ± 0.098
6.644LeuLys: 6.644 ± 0.081
9.322LeuLeu: 9.322 ± 0.126
2.301LeuMet: 2.301 ± 0.044
4.746LeuAsn: 4.746 ± 0.076
4.325LeuPro: 4.325 ± 0.061
3.504LeuGln: 3.504 ± 0.064
3.802LeuArg: 3.802 ± 0.06
7.035LeuSer: 7.035 ± 0.086
5.395LeuThr: 5.395 ± 0.121
6.427LeuVal: 6.427 ± 0.08
1.084LeuTrp: 1.084 ± 0.035
2.824LeuTyr: 2.824 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
1.853MetAla: 1.853 ± 0.043
0.116MetCys: 0.116 ± 0.009
1.398MetAsp: 1.398 ± 0.034
1.684MetGlu: 1.684 ± 0.041
0.746MetPhe: 0.746 ± 0.027
1.838MetGly: 1.838 ± 0.041
0.401MetHis: 0.401 ± 0.02
1.681MetIle: 1.681 ± 0.038
1.981MetLys: 1.981 ± 0.041
1.888MetLeu: 1.888 ± 0.044
0.652MetMet: 0.652 ± 0.025
1.257MetAsn: 1.257 ± 0.03
0.985MetPro: 0.985 ± 0.029
0.786MetGln: 0.786 ± 0.027
0.989MetArg: 0.989 ± 0.032
1.344MetSer: 1.344 ± 0.038
1.192MetThr: 1.192 ± 0.033
1.518MetVal: 1.518 ± 0.036
0.195MetTrp: 0.195 ± 0.012
0.584MetTyr: 0.584 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.979AsnAla: 2.979 ± 0.058
0.311AsnCys: 0.311 ± 0.016
1.983AsnAsp: 1.983 ± 0.051
2.792AsnGlu: 2.792 ± 0.047
2.751AsnPhe: 2.751 ± 0.049
3.503AsnGly: 3.503 ± 0.095
0.994AsnHis: 0.994 ± 0.031
2.535AsnIle: 2.535 ± 0.052
2.195AsnLys: 2.195 ± 0.043
5.351AsnLeu: 5.351 ± 0.082
0.989AsnMet: 0.989 ± 0.029
1.833AsnAsn: 1.833 ± 0.056
3.249AsnPro: 3.249 ± 0.06
2.517AsnGln: 2.517 ± 0.058
2.218AsnArg: 2.218 ± 0.046
3.323AsnSer: 3.323 ± 0.053
2.368AsnThr: 2.368 ± 0.048
2.504AsnVal: 2.504 ± 0.077
0.802AsnTrp: 0.802 ± 0.028
2.055AsnTyr: 2.055 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
2.789ProAla: 2.789 ± 0.052
0.209ProCys: 0.209 ± 0.023
2.714ProAsp: 2.714 ± 0.08
3.737ProGlu: 3.737 ± 0.06
2.215ProPhe: 2.215 ± 0.046
2.994ProGly: 2.994 ± 0.054
0.741ProHis: 0.741 ± 0.03
2.996ProIle: 2.996 ± 0.057
2.698ProLys: 2.698 ± 0.062
3.484ProLeu: 3.484 ± 0.062
0.956ProMet: 0.956 ± 0.027
2.218ProAsn: 2.218 ± 0.05
1.056ProPro: 1.056 ± 0.038
1.482ProGln: 1.482 ± 0.041
1.3ProArg: 1.3 ± 0.032
2.832ProSer: 2.832 ± 0.053
2.085ProThr: 2.085 ± 0.052
3.011ProVal: 3.011 ± 0.047
0.539ProTrp: 0.539 ± 0.024
1.422ProTyr: 1.422 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.987GlnAla: 2.987 ± 0.058
0.158GlnCys: 0.158 ± 0.013
1.98GlnAsp: 1.98 ± 0.047
3.087GlnGlu: 3.087 ± 0.051
1.975GlnPhe: 1.975 ± 0.044
2.81GlnGly: 2.81 ± 0.162
0.579GlnHis: 0.579 ± 0.022
3.126GlnIle: 3.126 ± 0.055
2.922GlnLys: 2.922 ± 0.052
4.19GlnLeu: 4.19 ± 0.067
0.915GlnMet: 0.915 ± 0.032
2.048GlnAsn: 2.048 ± 0.048
1.48GlnPro: 1.48 ± 0.038
1.502GlnGln: 1.502 ± 0.041
1.59GlnArg: 1.59 ± 0.042
2.446GlnSer: 2.446 ± 0.054
2.132GlnThr: 2.132 ± 0.046
2.934GlnVal: 2.934 ± 0.053
0.432GlnTrp: 0.432 ± 0.021
1.121GlnTyr: 1.121 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
2.477ArgAla: 2.477 ± 0.046
0.194ArgCys: 0.194 ± 0.012
2.013ArgAsp: 2.013 ± 0.04
2.897ArgGlu: 2.897 ± 0.054
2.433ArgPhe: 2.433 ± 0.046
2.467ArgGly: 2.467 ± 0.053
0.673ArgHis: 0.673 ± 0.022
3.476ArgIle: 3.476 ± 0.061
3.069ArgLys: 3.069 ± 0.057
3.994ArgLeu: 3.994 ± 0.067
1.229ArgMet: 1.229 ± 0.035
2.068ArgAsn: 2.068 ± 0.043
1.601ArgPro: 1.601 ± 0.037
1.461ArgGln: 1.461 ± 0.041
1.646ArgArg: 1.646 ± 0.042
2.341ArgSer: 2.341 ± 0.048
2.03ArgThr: 2.03 ± 0.039
2.606ArgVal: 2.606 ± 0.051
0.533ArgTrp: 0.533 ± 0.022
1.542ArgTyr: 1.542 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
4.088SerAla: 4.088 ± 0.057
0.552SerCys: 0.552 ± 0.031
3.376SerAsp: 3.376 ± 0.064
4.363SerGlu: 4.363 ± 0.064
3.924SerPhe: 3.924 ± 0.055
5.456SerGly: 5.456 ± 0.085
1.21SerHis: 1.21 ± 0.031
4.749SerIle: 4.749 ± 0.076
4.336SerLys: 4.336 ± 0.066
7.056SerLeu: 7.056 ± 0.085
1.482SerMet: 1.482 ± 0.041
3.228SerAsn: 3.228 ± 0.071
2.808SerPro: 2.808 ± 0.049
2.686SerGln: 2.686 ± 0.058
2.697SerArg: 2.697 ± 0.046
4.703SerSer: 4.703 ± 0.08
3.424SerThr: 3.424 ± 0.054
3.804SerVal: 3.804 ± 0.057
0.992SerTrp: 0.992 ± 0.034
2.486SerTyr: 2.486 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
3.634ThrAla: 3.634 ± 0.132
0.345ThrCys: 0.345 ± 0.023
2.602ThrAsp: 2.602 ± 0.051
3.147ThrGlu: 3.147 ± 0.063
2.781ThrPhe: 2.781 ± 0.056
4.42ThrGly: 4.42 ± 0.148
0.972ThrHis: 0.972 ± 0.029
3.549ThrIle: 3.549 ± 0.078
2.653ThrLys: 2.653 ± 0.051
5.45ThrLeu: 5.45 ± 0.112
0.89ThrMet: 0.89 ± 0.027
2.23ThrAsn: 2.23 ± 0.062
2.672ThrPro: 2.672 ± 0.076
2.072ThrGln: 2.072 ± 0.043
1.866ThrArg: 1.866 ± 0.039
3.427ThrSer: 3.427 ± 0.071
2.649ThrThr: 2.649 ± 0.089
3.288ThrVal: 3.288 ± 0.104
0.823ThrTrp: 0.823 ± 0.035
2.119ThrTyr: 2.119 ± 0.095
0.0ThrXaa: 0.0 ± 0.0
Val
4.194ValAla: 4.194 ± 0.069
0.47ValCys: 0.47 ± 0.022
3.413ValAsp: 3.413 ± 0.055
4.083ValGlu: 4.083 ± 0.068
3.383ValPhe: 3.383 ± 0.055
4.373ValGly: 4.373 ± 0.079
1.138ValHis: 1.138 ± 0.037
4.607ValIle: 4.607 ± 0.064
3.902ValLys: 3.902 ± 0.057
6.074ValLeu: 6.074 ± 0.082
1.462ValMet: 1.462 ± 0.044
3.066ValAsn: 3.066 ± 0.067
2.463ValPro: 2.463 ± 0.042
2.174ValGln: 2.174 ± 0.048
2.462ValArg: 2.462 ± 0.05
4.328ValSer: 4.328 ± 0.069
3.334ValThr: 3.334 ± 0.107
3.987ValVal: 3.987 ± 0.081
0.751ValTrp: 0.751 ± 0.026
2.131ValTyr: 2.131 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.827TrpAla: 0.827 ± 0.028
0.079TrpCys: 0.079 ± 0.009
0.757TrpAsp: 0.757 ± 0.029
1.009TrpGlu: 1.009 ± 0.031
0.612TrpPhe: 0.612 ± 0.027
0.863TrpGly: 0.863 ± 0.028
0.248TrpHis: 0.248 ± 0.015
1.094TrpIle: 1.094 ± 0.035
1.035TrpLys: 1.035 ± 0.034
1.166TrpLeu: 1.166 ± 0.037
0.508TrpMet: 0.508 ± 0.021
0.727TrpAsn: 0.727 ± 0.026
0.386TrpPro: 0.386 ± 0.019
0.453TrpGln: 0.453 ± 0.021
0.518TrpArg: 0.518 ± 0.023
0.815TrpSer: 0.815 ± 0.033
0.774TrpThr: 0.774 ± 0.027
0.951TrpVal: 0.951 ± 0.029
0.206TrpTrp: 0.206 ± 0.015
0.47TrpTyr: 0.47 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.165TyrAla: 2.165 ± 0.048
0.253TyrCys: 0.253 ± 0.014
1.838TyrAsp: 1.838 ± 0.043
2.093TyrGlu: 2.093 ± 0.045
2.327TyrPhe: 2.327 ± 0.053
2.485TyrGly: 2.485 ± 0.055
0.798TyrHis: 0.798 ± 0.026
1.84TyrIle: 1.84 ± 0.036
1.718TyrLys: 1.718 ± 0.043
3.971TyrLeu: 3.971 ± 0.074
0.655TyrMet: 0.655 ± 0.022
1.412TyrAsn: 1.412 ± 0.035
1.651TyrPro: 1.651 ± 0.044
1.903TyrGln: 1.903 ± 0.048
1.838TyrArg: 1.838 ± 0.04
2.604TyrSer: 2.604 ± 0.052
1.882TyrThr: 1.882 ± 0.078
1.815TyrVal: 1.815 ± 0.047
0.516TyrTrp: 0.516 ± 0.024
1.374TyrTyr: 1.374 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3377 proteins (1184144 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski