Amino acid dipepetide frequency for Mesobacillus zeae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.391AlaAla: 7.391 ± 0.117	0.622AlaCys: 0.622 ± 0.025	3.846AlaAsp: 3.846 ± 0.064	5.474AlaGlu: 5.474 ± 0.074	3.363AlaPhe: 3.363 ± 0.062	6.69AlaGly: 6.69 ± 0.09	1.238AlaHis: 1.238 ± 0.029	5.483AlaIle: 5.483 ± 0.074	4.899AlaLys: 4.899 ± 0.077	7.183AlaLeu: 7.183 ± 0.084	2.173AlaMet: 2.173 ± 0.049	2.611AlaAsn: 2.611 ± 0.048	2.163AlaPro: 2.163 ± 0.05	2.064AlaGln: 2.064 ± 0.049	3.134AlaArg: 3.134 ± 0.064	4.417AlaSer: 4.417 ± 0.074	3.187AlaThr: 3.187 ± 0.057	6.146AlaVal: 6.146 ± 0.083	0.626AlaTrp: 0.626 ± 0.022	2.252AlaTyr: 2.252 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.47CysAla: 0.47 ± 0.02	0.102CysCys: 0.102 ± 0.01	0.404CysAsp: 0.404 ± 0.02	0.499CysGlu: 0.499 ± 0.022	0.352CysPhe: 0.352 ± 0.02	0.78CysGly: 0.78 ± 0.032	0.242CysHis: 0.242 ± 0.019	0.532CysIle: 0.532 ± 0.022	0.398CysLys: 0.398 ± 0.017	0.738CysLeu: 0.738 ± 0.025	0.218CysMet: 0.218 ± 0.015	0.313CysAsn: 0.313 ± 0.018	0.384CysPro: 0.384 ± 0.021	0.227CysGln: 0.227 ± 0.014	0.414CysArg: 0.414 ± 0.022	0.561CysSer: 0.561 ± 0.025	0.423CysThr: 0.423 ± 0.02	0.398CysVal: 0.398 ± 0.019	0.066CysTrp: 0.066 ± 0.008	0.265CysTyr: 0.265 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.283AspAla: 3.283 ± 0.053	0.435AspCys: 0.435 ± 0.02	2.341AspAsp: 2.341 ± 0.056	4.154AspGlu: 4.154 ± 0.061	2.479AspPhe: 2.479 ± 0.053	3.635AspGly: 3.635 ± 0.065	1.096AspHis: 1.096 ± 0.028	4.068AspIle: 4.068 ± 0.064	3.204AspLys: 3.204 ± 0.06	4.818AspLeu: 4.818 ± 0.065	1.377AspMet: 1.377 ± 0.034	1.781AspAsn: 1.781 ± 0.042	1.944AspPro: 1.944 ± 0.038	1.648AspGln: 1.648 ± 0.04	2.49AspArg: 2.49 ± 0.048	2.941AspSer: 2.941 ± 0.05	2.376AspThr: 2.376 ± 0.05	3.377AspVal: 3.377 ± 0.058	0.609AspTrp: 0.609 ± 0.025	2.158AspTyr: 2.158 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.654GluAla: 5.654 ± 0.065	0.437GluCys: 0.437 ± 0.021	3.621GluAsp: 3.621 ± 0.062	7.031GluGlu: 7.031 ± 0.091	2.792GluPhe: 2.792 ± 0.051	4.645GluGly: 4.645 ± 0.074	1.475GluHis: 1.475 ± 0.041	5.613GluIle: 5.613 ± 0.084	7.072GluLys: 7.072 ± 0.091	7.184GluLeu: 7.184 ± 0.073	2.459GluMet: 2.459 ± 0.051	3.519GluAsn: 3.519 ± 0.059	1.958GluPro: 1.958 ± 0.039	2.96GluGln: 2.96 ± 0.057	3.566GluArg: 3.566 ± 0.061	3.704GluSer: 3.704 ± 0.058	3.993GluThr: 3.993 ± 0.059	4.815GluVal: 4.815 ± 0.067	0.794GluTrp: 0.794 ± 0.026	2.309GluTyr: 2.309 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.224PheAla: 3.224 ± 0.055	0.383PheCys: 0.383 ± 0.02	2.328PheAsp: 2.328 ± 0.045	2.897PheGlu: 2.897 ± 0.05	2.487PhePhe: 2.487 ± 0.058	3.387PheGly: 3.387 ± 0.064	1.005PheHis: 1.005 ± 0.028	3.683PheIle: 3.683 ± 0.067	2.52PheLys: 2.52 ± 0.047	4.835PheLeu: 4.835 ± 0.075	1.215PheMet: 1.215 ± 0.033	1.834PheAsn: 1.834 ± 0.041	1.702PhePro: 1.702 ± 0.038	1.411PheGln: 1.411 ± 0.035	1.793PheArg: 1.793 ± 0.044	3.529PheSer: 3.529 ± 0.059	2.55PheThr: 2.55 ± 0.047	2.947PheVal: 2.947 ± 0.053	0.486PheTrp: 0.486 ± 0.024	1.719PheTyr: 1.719 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.205GlyAla: 5.205 ± 0.084	0.692GlyCys: 0.692 ± 0.027	3.351GlyAsp: 3.351 ± 0.059	4.898GlyGlu: 4.898 ± 0.069	3.603GlyPhe: 3.603 ± 0.057	5.278GlyGly: 5.278 ± 0.083	1.412GlyHis: 1.412 ± 0.038	6.18GlyIle: 6.18 ± 0.08	5.847GlyLys: 5.847 ± 0.078	6.95GlyLeu: 6.95 ± 0.076	2.34GlyMet: 2.34 ± 0.05	2.94GlyAsn: 2.94 ± 0.054	1.855GlyPro: 1.855 ± 0.04	2.356GlyGln: 2.356 ± 0.056	3.208GlyArg: 3.208 ± 0.056	4.441GlySer: 4.441 ± 0.058	4.277GlyThr: 4.277 ± 0.067	4.958GlyVal: 4.958 ± 0.062	0.852GlyTrp: 0.852 ± 0.031	2.844GlyTyr: 2.844 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.333HisAla: 1.333 ± 0.033	0.215HisCys: 0.215 ± 0.015	1.052HisAsp: 1.052 ± 0.029	1.353HisGlu: 1.353 ± 0.035	1.047HisPhe: 1.047 ± 0.031	1.472HisGly: 1.472 ± 0.037	0.634HisHis: 0.634 ± 0.027	1.434HisIle: 1.434 ± 0.031	1.003HisLys: 1.003 ± 0.03	1.919HisLeu: 1.919 ± 0.036	0.525HisMet: 0.525 ± 0.023	0.698HisAsn: 0.698 ± 0.023	1.162HisPro: 1.162 ± 0.036	0.692HisGln: 0.692 ± 0.026	0.867HisArg: 0.867 ± 0.03	1.261HisSer: 1.261 ± 0.037	1.023HisThr: 1.023 ± 0.029	1.289HisVal: 1.289 ± 0.034	0.207HisTrp: 0.207 ± 0.014	0.836HisTyr: 0.836 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.893IleAla: 5.893 ± 0.091	0.632IleCys: 0.632 ± 0.026	4.066IleAsp: 4.066 ± 0.073	5.419IleGlu: 5.419 ± 0.08	3.176IlePhe: 3.176 ± 0.063	5.765IleGly: 5.765 ± 0.078	1.604IleHis: 1.604 ± 0.042	5.329IleIle: 5.329 ± 0.078	4.54IleLys: 4.54 ± 0.062	7.167IleLeu: 7.167 ± 0.081	1.896IleMet: 1.896 ± 0.042	3.018IleAsn: 3.018 ± 0.052	3.271IlePro: 3.271 ± 0.059	2.55IleGln: 2.55 ± 0.052	3.229IleArg: 3.229 ± 0.056	5.112IleSer: 5.112 ± 0.075	3.915IleThr: 3.915 ± 0.059	5.128IleVal: 5.128 ± 0.073	0.616IleTrp: 0.616 ± 0.024	2.29IleTyr: 2.29 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	5.16LysAla: 5.16 ± 0.076	0.378LysCys: 0.378 ± 0.019	3.895LysAsp: 3.895 ± 0.066	6.732LysGlu: 6.732 ± 0.074	2.087LysPhe: 2.087 ± 0.043	4.872LysGly: 4.872 ± 0.07	1.202LysHis: 1.202 ± 0.029	4.733LysIle: 4.733 ± 0.073	6.119LysLys: 6.119 ± 0.087	6.134LysLeu: 6.134 ± 0.075	2.258LysMet: 2.258 ± 0.045	3.355LysAsn: 3.355 ± 0.061	2.378LysPro: 2.378 ± 0.042	2.681LysGln: 2.681 ± 0.048	3.282LysArg: 3.282 ± 0.058	3.744LysSer: 3.744 ± 0.062	3.699LysThr: 3.699 ± 0.052	4.691LysVal: 4.691 ± 0.063	0.771LysTrp: 0.771 ± 0.025	2.212LysTyr: 2.212 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	7.944LeuAla: 7.944 ± 0.098	0.696LeuCys: 0.696 ± 0.024	4.915LeuAsp: 4.915 ± 0.076	6.778LeuGlu: 6.778 ± 0.092	4.796LeuPhe: 4.796 ± 0.086	6.874LeuGly: 6.874 ± 0.081	1.807LeuHis: 1.807 ± 0.04	6.734LeuIle: 6.734 ± 0.1	6.824LeuLys: 6.824 ± 0.093	10.102LeuLeu: 10.102 ± 0.121	2.592LeuMet: 2.592 ± 0.042	3.983LeuAsn: 3.983 ± 0.055	3.915LeuPro: 3.915 ± 0.056	3.266LeuGln: 3.266 ± 0.059	3.829LeuArg: 3.829 ± 0.068	6.818LeuSer: 6.818 ± 0.079	5.347LeuThr: 5.347 ± 0.07	6.368LeuVal: 6.368 ± 0.076	0.841LeuTrp: 0.841 ± 0.028	3.157LeuTyr: 3.157 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.336MetAla: 2.336 ± 0.05	0.148MetCys: 0.148 ± 0.011	1.58MetAsp: 1.58 ± 0.033	2.293MetGlu: 2.293 ± 0.052	1.149MetPhe: 1.149 ± 0.036	1.984MetGly: 1.984 ± 0.041	0.442MetHis: 0.442 ± 0.02	2.038MetIle: 2.038 ± 0.048	2.554MetLys: 2.554 ± 0.052	2.768MetLeu: 2.768 ± 0.056	0.919MetMet: 0.919 ± 0.029	1.501MetAsn: 1.501 ± 0.038	1.107MetPro: 1.107 ± 0.035	0.846MetGln: 0.846 ± 0.027	1.112MetArg: 1.112 ± 0.029	1.663MetSer: 1.663 ± 0.034	1.553MetThr: 1.553 ± 0.035	1.972MetVal: 1.972 ± 0.046	0.194MetTrp: 0.194 ± 0.013	0.735MetTyr: 0.735 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.69AsnAla: 2.69 ± 0.048	0.339AsnCys: 0.339 ± 0.019	2.023AsnAsp: 2.023 ± 0.043	3.243AsnGlu: 3.243 ± 0.054	1.59AsnPhe: 1.59 ± 0.038	3.317AsnGly: 3.317 ± 0.059	0.921AsnHis: 0.921 ± 0.029	3.263AsnIle: 3.263 ± 0.061	2.757AsnLys: 2.757 ± 0.056	3.678AsnLeu: 3.678 ± 0.052	1.175AsnMet: 1.175 ± 0.037	1.736AsnAsn: 1.736 ± 0.045	2.179AsnPro: 2.179 ± 0.043	1.443AsnGln: 1.443 ± 0.04	2.017AsnArg: 2.017 ± 0.035	2.369AsnSer: 2.369 ± 0.046	1.983AsnThr: 1.983 ± 0.048	2.742AsnVal: 2.742 ± 0.048	0.465AsnTrp: 0.465 ± 0.021	1.297AsnTyr: 1.297 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	2.963ProAla: 2.963 ± 0.052	0.241ProCys: 0.241 ± 0.017	2.13ProAsp: 2.13 ± 0.047	3.326ProGlu: 3.326 ± 0.063	2.051ProPhe: 2.051 ± 0.052	2.766ProGly: 2.766 ± 0.056	0.747ProHis: 0.747 ± 0.026	2.462ProIle: 2.462 ± 0.048	2.2ProLys: 2.2 ± 0.045	3.484ProLeu: 3.484 ± 0.051	0.82ProMet: 0.82 ± 0.03	1.393ProAsn: 1.393 ± 0.032	1.055ProPro: 1.055 ± 0.032	1.068ProGln: 1.068 ± 0.026	1.181ProArg: 1.181 ± 0.032	2.203ProSer: 2.203 ± 0.045	1.625ProThr: 1.625 ± 0.035	3.199ProVal: 3.199 ± 0.057	0.365ProTrp: 0.365 ± 0.018	1.331ProTyr: 1.331 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.59GlnAla: 2.59 ± 0.046	0.235GlnCys: 0.235 ± 0.014	1.501GlnAsp: 1.501 ± 0.035	2.599GlnGlu: 2.599 ± 0.052	1.485GlnPhe: 1.485 ± 0.035	2.095GlnGly: 2.095 ± 0.042	0.724GlnHis: 0.724 ± 0.025	2.207GlnIle: 2.207 ± 0.048	2.522GlnLys: 2.522 ± 0.05	3.396GlnLeu: 3.396 ± 0.06	1.069GlnMet: 1.069 ± 0.036	1.431GlnAsn: 1.431 ± 0.036	1.201GlnPro: 1.201 ± 0.032	1.555GlnGln: 1.555 ± 0.048	1.481GlnArg: 1.481 ± 0.04	1.992GlnSer: 1.992 ± 0.042	1.668GlnThr: 1.668 ± 0.036	2.064GlnVal: 2.064 ± 0.051	0.348GlnTrp: 0.348 ± 0.017	1.216GlnTyr: 1.216 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.627ArgAla: 2.627 ± 0.051	0.307ArgCys: 0.307 ± 0.017	2.1ArgAsp: 2.1 ± 0.049	3.703ArgGlu: 3.703 ± 0.066	2.039ArgPhe: 2.039 ± 0.038	2.727ArgGly: 2.727 ± 0.048	0.892ArgHis: 0.892 ± 0.029	3.243ArgIle: 3.243 ± 0.058	3.601ArgLys: 3.601 ± 0.051	4.359ArgLeu: 4.359 ± 0.06	1.507ArgMet: 1.507 ± 0.036	1.982ArgAsn: 1.982 ± 0.044	1.453ArgPro: 1.453 ± 0.05	1.674ArgGln: 1.674 ± 0.041	2.077ArgArg: 2.077 ± 0.049	2.366ArgSer: 2.366 ± 0.047	2.158ArgThr: 2.158 ± 0.045	2.712ArgVal: 2.712 ± 0.046	0.429ArgTrp: 0.429 ± 0.019	1.559ArgTyr: 1.559 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.252SerAla: 4.252 ± 0.063	0.543SerCys: 0.543 ± 0.025	2.854SerAsp: 2.854 ± 0.048	4.093SerGlu: 4.093 ± 0.062	3.322SerPhe: 3.322 ± 0.058	5.048SerGly: 5.048 ± 0.065	1.314SerHis: 1.314 ± 0.033	4.949SerIle: 4.949 ± 0.062	3.743SerLys: 3.743 ± 0.052	6.452SerLeu: 6.452 ± 0.079	1.812SerMet: 1.812 ± 0.041	2.288SerAsn: 2.288 ± 0.05	2.262SerPro: 2.262 ± 0.044	1.996SerGln: 1.996 ± 0.044	2.745SerArg: 2.745 ± 0.051	4.145SerSer: 4.145 ± 0.07	2.796SerThr: 2.796 ± 0.044	4.314SerVal: 4.314 ± 0.066	0.638SerTrp: 0.638 ± 0.026	2.22SerTyr: 2.22 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.264ThrAla: 4.264 ± 0.072	0.37ThrCys: 0.37 ± 0.019	2.548ThrAsp: 2.548 ± 0.045	3.467ThrGlu: 3.467 ± 0.057	2.428ThrPhe: 2.428 ± 0.052	4.542ThrGly: 4.542 ± 0.063	0.977ThrHis: 0.977 ± 0.03	3.964ThrIle: 3.964 ± 0.066	3.061ThrLys: 3.061 ± 0.052	4.951ThrLeu: 4.951 ± 0.063	1.375ThrMet: 1.375 ± 0.032	1.998ThrAsn: 1.998 ± 0.05	2.181ThrPro: 2.181 ± 0.046	1.237ThrGln: 1.237 ± 0.032	2.0ThrArg: 2.0 ± 0.037	2.953ThrSer: 2.953 ± 0.053	2.444ThrThr: 2.444 ± 0.051	4.338ThrVal: 4.338 ± 0.064	0.473ThrTrp: 0.473 ± 0.022	1.656ThrTyr: 1.656 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	4.998ValAla: 4.998 ± 0.076	0.631ValCys: 0.631 ± 0.022	3.421ValAsp: 3.421 ± 0.052	4.565ValGlu: 4.565 ± 0.07	3.334ValPhe: 3.334 ± 0.054	4.422ValGly: 4.422 ± 0.071	1.279ValHis: 1.279 ± 0.036	5.505ValIle: 5.505 ± 0.073	4.738ValLys: 4.738 ± 0.068	6.938ValLeu: 6.938 ± 0.071	1.92ValMet: 1.92 ± 0.04	2.944ValAsn: 2.944 ± 0.055	2.858ValPro: 2.858 ± 0.051	2.13ValGln: 2.13 ± 0.045	2.887ValArg: 2.887 ± 0.052	4.677ValSer: 4.677 ± 0.065	3.961ValThr: 3.961 ± 0.068	4.606ValVal: 4.606 ± 0.073	0.635ValTrp: 0.635 ± 0.028	2.281ValTyr: 2.281 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.618TrpAla: 0.618 ± 0.028	0.076TrpCys: 0.076 ± 0.01	0.471TrpAsp: 0.471 ± 0.024	0.681TrpGlu: 0.681 ± 0.026	0.496TrpPhe: 0.496 ± 0.023	0.701TrpGly: 0.701 ± 0.028	0.227TrpHis: 0.227 ± 0.014	0.76TrpIle: 0.76 ± 0.028	0.732TrpLys: 0.732 ± 0.027	1.116TrpLeu: 1.116 ± 0.034	0.343TrpMet: 0.343 ± 0.016	0.513TrpAsn: 0.513 ± 0.022	0.256TrpPro: 0.256 ± 0.015	0.343TrpGln: 0.343 ± 0.018	0.411TrpArg: 0.411 ± 0.019	0.589TrpSer: 0.589 ± 0.023	0.509TrpThr: 0.509 ± 0.02	0.636TrpVal: 0.636 ± 0.026	0.138TrpTrp: 0.138 ± 0.011	0.321TrpTyr: 0.321 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.065TyrAla: 2.065 ± 0.045	0.305TyrCys: 0.305 ± 0.017	1.768TyrAsp: 1.768 ± 0.045	2.396TyrGlu: 2.396 ± 0.048	1.856TyrPhe: 1.856 ± 0.041	2.486TyrGly: 2.486 ± 0.053	0.782TyrHis: 0.782 ± 0.026	2.436TyrIle: 2.436 ± 0.044	2.049TyrLys: 2.049 ± 0.048	3.413TyrLeu: 3.413 ± 0.062	0.899TyrMet: 0.899 ± 0.028	1.391TyrAsn: 1.391 ± 0.039	1.329TyrPro: 1.329 ± 0.039	1.232TyrGln: 1.232 ± 0.034	1.794TyrArg: 1.794 ± 0.042	2.305TyrSer: 2.305 ± 0.046	1.742TyrThr: 1.742 ± 0.037	2.028TyrVal: 2.028 ± 0.044	0.383TyrTrp: 0.383 ± 0.02	1.439TyrTyr: 1.439 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4175 proteins (1151873 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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