Amino acid dipepetide frequency for Phytophthora parasitica (strain INRA-310)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.331AlaAla: 9.331 ± 0.045	1.274AlaCys: 1.274 ± 0.012	4.218AlaAsp: 4.218 ± 0.022	5.299AlaGlu: 5.299 ± 0.031	3.171AlaPhe: 3.171 ± 0.018	4.627AlaGly: 4.627 ± 0.024	1.702AlaHis: 1.702 ± 0.013	3.783AlaIle: 3.783 ± 0.02	4.58AlaLys: 4.58 ± 0.028	8.362AlaLeu: 8.362 ± 0.035	2.24AlaMet: 2.24 ± 0.013	3.015AlaAsn: 3.015 ± 0.017	3.998AlaPro: 3.998 ± 0.029	3.455AlaGln: 3.455 ± 0.022	4.877AlaArg: 4.877 ± 0.026	7.474AlaSer: 7.474 ± 0.037	5.63AlaThr: 5.63 ± 0.028	6.19AlaVal: 6.19 ± 0.03	0.884AlaTrp: 0.884 ± 0.01	1.877AlaTyr: 1.877 ± 0.015	0.0AlaXaa: 0.0 ± 0.0
Cys	1.269CysAla: 1.269 ± 0.012	0.449CysCys: 0.449 ± 0.008	0.853CysAsp: 0.853 ± 0.01	0.937CysGlu: 0.937 ± 0.01	0.705CysPhe: 0.705 ± 0.008	1.222CysGly: 1.222 ± 0.012	0.399CysHis: 0.399 ± 0.007	0.798CysIle: 0.798 ± 0.009	0.723CysLys: 0.723 ± 0.009	1.412CysLeu: 1.412 ± 0.014	0.418CysMet: 0.418 ± 0.006	0.548CysAsn: 0.548 ± 0.008	0.763CysPro: 0.763 ± 0.018	0.571CysGln: 0.571 ± 0.006	1.041CysArg: 1.041 ± 0.011	1.466CysSer: 1.466 ± 0.015	0.979CysThr: 0.979 ± 0.012	1.265CysVal: 1.265 ± 0.011	0.238CysTrp: 0.238 ± 0.005	0.472CysTyr: 0.472 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	5.119AspAla: 5.119 ± 0.022	0.82AspCys: 0.82 ± 0.009	4.417AspAsp: 4.417 ± 0.034	4.935AspGlu: 4.935 ± 0.03	2.175AspPhe: 2.175 ± 0.014	3.835AspGly: 3.835 ± 0.021	1.126AspHis: 1.126 ± 0.012	2.599AspIle: 2.599 ± 0.018	2.563AspLys: 2.563 ± 0.019	4.741AspLeu: 4.741 ± 0.025	1.318AspMet: 1.318 ± 0.013	2.017AspAsn: 2.017 ± 0.016	2.518AspPro: 2.518 ± 0.015	1.919AspGln: 1.919 ± 0.013	2.812AspArg: 2.812 ± 0.019	4.311AspSer: 4.311 ± 0.024	3.112AspThr: 3.112 ± 0.018	4.339AspVal: 4.339 ± 0.023	0.633AspTrp: 0.633 ± 0.009	1.445AspTyr: 1.445 ± 0.012	0.0AspXaa: 0.0 ± 0.0
Glu	5.789GluAla: 5.789 ± 0.031	0.933GluCys: 0.933 ± 0.01	4.36GluAsp: 4.36 ± 0.024	6.114GluGlu: 6.114 ± 0.047	2.265GluPhe: 2.265 ± 0.016	3.208GluGly: 3.208 ± 0.019	1.512GluHis: 1.512 ± 0.013	3.066GluIle: 3.066 ± 0.02	3.975GluLys: 3.975 ± 0.031	6.758GluLeu: 6.758 ± 0.033	1.826GluMet: 1.826 ± 0.014	2.643GluAsn: 2.643 ± 0.017	2.299GluPro: 2.299 ± 0.015	3.038GluGln: 3.038 ± 0.023	4.303GluArg: 4.303 ± 0.029	4.549GluSer: 4.549 ± 0.027	3.685GluThr: 3.685 ± 0.02	4.172GluVal: 4.172 ± 0.021	0.769GluTrp: 0.769 ± 0.009	1.69GluTyr: 1.69 ± 0.013	0.0GluXaa: 0.0 ± 0.0
Phe	3.048PheAla: 3.048 ± 0.016	0.737PheCys: 0.737 ± 0.01	2.285PheAsp: 2.285 ± 0.015	2.273PheGlu: 2.273 ± 0.015	1.65PhePhe: 1.65 ± 0.016	2.68PheGly: 2.68 ± 0.019	0.946PheHis: 0.946 ± 0.01	1.573PheIle: 1.573 ± 0.014	1.557PheLys: 1.557 ± 0.013	3.533PheLeu: 3.533 ± 0.024	0.934PheMet: 0.934 ± 0.009	1.345PheAsn: 1.345 ± 0.013	1.637PhePro: 1.637 ± 0.014	1.521PheGln: 1.521 ± 0.011	2.132PheArg: 2.132 ± 0.012	3.007PheSer: 3.007 ± 0.018	2.118PheThr: 2.118 ± 0.015	2.88PheVal: 2.88 ± 0.021	0.454PheTrp: 0.454 ± 0.007	1.171PheTyr: 1.171 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	4.732GlyAla: 4.732 ± 0.028	1.055GlyCys: 1.055 ± 0.013	3.664GlyAsp: 3.664 ± 0.023	3.527GlyGlu: 3.527 ± 0.022	2.346GlyPhe: 2.346 ± 0.018	4.593GlyGly: 4.593 ± 0.042	1.424GlyHis: 1.424 ± 0.014	2.76GlyIle: 2.76 ± 0.019	3.147GlyLys: 3.147 ± 0.018	4.725GlyLeu: 4.725 ± 0.023	1.446GlyMet: 1.446 ± 0.015	2.395GlyAsn: 2.395 ± 0.017	1.954GlyPro: 1.954 ± 0.015	1.923GlyGln: 1.923 ± 0.017	3.398GlyArg: 3.398 ± 0.022	5.313GlySer: 5.313 ± 0.032	3.302GlyThr: 3.302 ± 0.023	4.346GlyVal: 4.346 ± 0.023	0.758GlyTrp: 0.758 ± 0.009	1.786GlyTyr: 1.786 ± 0.015	0.0GlyXaa: 0.0 ± 0.0
His	1.827HisAla: 1.827 ± 0.012	0.442HisCys: 0.442 ± 0.007	1.293HisAsp: 1.293 ± 0.011	1.507HisGlu: 1.507 ± 0.012	1.001HisPhe: 1.001 ± 0.01	1.525HisGly: 1.525 ± 0.013	0.731HisHis: 0.731 ± 0.01	0.975HisIle: 0.975 ± 0.01	1.013HisLys: 1.013 ± 0.01	2.229HisLeu: 2.229 ± 0.016	0.501HisMet: 0.501 ± 0.007	0.771HisAsn: 0.771 ± 0.009	1.222HisPro: 1.222 ± 0.012	1.033HisGln: 1.033 ± 0.01	1.61HisArg: 1.61 ± 0.013	1.798HisSer: 1.798 ± 0.013	1.184HisThr: 1.184 ± 0.011	1.71HisVal: 1.71 ± 0.011	0.3HisTrp: 0.3 ± 0.005	0.685HisTyr: 0.685 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	3.803IleAla: 3.803 ± 0.019	0.834IleCys: 0.834 ± 0.01	2.56IleAsp: 2.56 ± 0.015	2.765IleGlu: 2.765 ± 0.018	1.666IlePhe: 1.666 ± 0.014	2.51IleGly: 2.51 ± 0.019	0.987IleHis: 0.987 ± 0.01	1.807IleIle: 1.807 ± 0.017	2.045IleLys: 2.045 ± 0.013	3.786IleLeu: 3.786 ± 0.025	0.975IleMet: 0.975 ± 0.01	1.526IleAsn: 1.526 ± 0.012	2.221IlePro: 2.221 ± 0.016	1.819IleGln: 1.819 ± 0.015	2.594IleArg: 2.594 ± 0.016	3.395IleSer: 3.395 ± 0.022	2.466IleThr: 2.466 ± 0.019	3.227IleVal: 3.227 ± 0.022	0.501IleTrp: 0.501 ± 0.008	1.155IleTyr: 1.155 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	4.109LysAla: 4.109 ± 0.025	0.783LysCys: 0.783 ± 0.009	2.527LysAsp: 2.527 ± 0.017	3.57LysGlu: 3.57 ± 0.028	1.69LysPhe: 1.69 ± 0.015	2.313LysGly: 2.313 ± 0.017	1.268LysHis: 1.268 ± 0.012	2.188LysIle: 2.188 ± 0.015	4.138LysLys: 4.138 ± 0.034	5.185LysLeu: 5.185 ± 0.026	1.405LysMet: 1.405 ± 0.012	2.009LysAsn: 2.009 ± 0.019	2.315LysPro: 2.315 ± 0.017	2.467LysGln: 2.467 ± 0.019	4.005LysArg: 4.005 ± 0.024	3.653LysSer: 3.653 ± 0.022	3.287LysThr: 3.287 ± 0.02	3.036LysVal: 3.036 ± 0.018	0.727LysTrp: 0.727 ± 0.009	1.509LysTyr: 1.509 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	7.895LeuAla: 7.895 ± 0.034	1.608LeuCys: 1.608 ± 0.014	5.118LeuAsp: 5.118 ± 0.023	6.513LeuGlu: 6.513 ± 0.034	3.465LeuPhe: 3.465 ± 0.024	4.882LeuGly: 4.882 ± 0.023	2.567LeuHis: 2.567 ± 0.018	3.353LeuIle: 3.353 ± 0.022	4.803LeuLys: 4.803 ± 0.024	10.002LeuLeu: 10.002 ± 0.056	2.191LeuMet: 2.191 ± 0.018	3.275LeuAsn: 3.275 ± 0.019	4.605LeuPro: 4.605 ± 0.025	4.91LeuGln: 4.91 ± 0.028	6.474LeuArg: 6.474 ± 0.029	7.376LeuSer: 7.376 ± 0.034	4.995LeuThr: 4.995 ± 0.023	6.493LeuVal: 6.493 ± 0.032	1.066LeuTrp: 1.066 ± 0.011	2.301LeuTyr: 2.301 ± 0.015	0.0LeuXaa: 0.0 ± 0.0
Met	2.199MetAla: 2.199 ± 0.015	0.373MetCys: 0.373 ± 0.006	1.455MetAsp: 1.455 ± 0.015	1.859MetGlu: 1.859 ± 0.014	0.804MetPhe: 0.804 ± 0.008	1.332MetGly: 1.332 ± 0.013	0.576MetHis: 0.576 ± 0.007	0.972MetIle: 0.972 ± 0.011	1.415MetLys: 1.415 ± 0.011	2.488MetLeu: 2.488 ± 0.015	0.715MetMet: 0.715 ± 0.009	0.955MetAsn: 0.955 ± 0.011	1.097MetPro: 1.097 ± 0.012	1.157MetGln: 1.157 ± 0.011	1.501MetArg: 1.501 ± 0.011	1.849MetSer: 1.849 ± 0.014	1.491MetThr: 1.491 ± 0.012	1.541MetVal: 1.541 ± 0.012	0.297MetTrp: 0.297 ± 0.006	0.623MetTyr: 0.623 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	3.437AsnAla: 3.437 ± 0.02	0.634AsnCys: 0.634 ± 0.008	2.153AsnAsp: 2.153 ± 0.013	2.443AsnGlu: 2.443 ± 0.018	1.337AsnPhe: 1.337 ± 0.013	2.796AsnGly: 2.796 ± 0.02	0.793AsnHis: 0.793 ± 0.009	1.559AsnIle: 1.559 ± 0.011	1.711AsnLys: 1.711 ± 0.015	3.042AsnLeu: 3.042 ± 0.019	0.9AsnMet: 0.9 ± 0.01	1.486AsnAsn: 1.486 ± 0.015	1.801AsnPro: 1.801 ± 0.016	1.426AsnGln: 1.426 ± 0.013	2.012AsnArg: 2.012 ± 0.014	2.939AsnSer: 2.939 ± 0.018	2.144AsnThr: 2.144 ± 0.018	2.727AsnVal: 2.727 ± 0.018	0.444AsnTrp: 0.444 ± 0.007	0.996AsnTyr: 0.996 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	4.038ProAla: 4.038 ± 0.026	0.561ProCys: 0.561 ± 0.009	2.382ProAsp: 2.382 ± 0.015	2.974ProGlu: 2.974 ± 0.021	1.641ProPhe: 1.641 ± 0.014	2.487ProGly: 2.487 ± 0.019	1.03ProHis: 1.03 ± 0.01	1.827ProIle: 1.827 ± 0.016	2.235ProLys: 2.235 ± 0.019	3.963ProLeu: 3.963 ± 0.025	1.089ProMet: 1.089 ± 0.011	1.646ProAsn: 1.646 ± 0.015	3.272ProPro: 3.272 ± 0.031	1.822ProGln: 1.822 ± 0.016	2.817ProArg: 2.817 ± 0.02	4.532ProSer: 4.532 ± 0.025	3.438ProThr: 3.438 ± 0.026	3.424ProVal: 3.424 ± 0.021	0.487ProTrp: 0.487 ± 0.007	1.026ProTyr: 1.026 ± 0.01	0.0ProXaa: 0.0 ± 0.0
Gln	3.286GlnAla: 3.286 ± 0.022	0.641GlnCys: 0.641 ± 0.009	2.02GlnAsp: 2.02 ± 0.017	2.911GlnGlu: 2.911 ± 0.025	1.47GlnPhe: 1.47 ± 0.013	1.824GlnGly: 1.824 ± 0.016	1.22GlnHis: 1.22 ± 0.011	1.801GlnIle: 1.801 ± 0.014	2.166GlnLys: 2.166 ± 0.018	4.662GlnLeu: 4.662 ± 0.026	1.085GlnMet: 1.085 ± 0.011	1.461GlnAsn: 1.461 ± 0.012	1.851GlnPro: 1.851 ± 0.015	3.113GlnGln: 3.113 ± 0.033	3.33GlnArg: 3.33 ± 0.023	2.964GlnSer: 2.964 ± 0.017	2.373GlnThr: 2.373 ± 0.015	2.734GlnVal: 2.734 ± 0.016	0.592GlnTrp: 0.592 ± 0.008	1.119GlnTyr: 1.119 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	4.852ArgAla: 4.852 ± 0.024	1.065ArgCys: 1.065 ± 0.011	3.223ArgAsp: 3.223 ± 0.02	4.105ArgGlu: 4.105 ± 0.026	2.4ArgPhe: 2.4 ± 0.015	3.492ArgGly: 3.492 ± 0.022	1.652ArgHis: 1.652 ± 0.013	2.677ArgIle: 2.677 ± 0.016	3.645ArgLys: 3.645 ± 0.025	5.949ArgLeu: 5.949 ± 0.03	1.529ArgMet: 1.529 ± 0.014	2.24ArgAsn: 2.24 ± 0.015	2.523ArgPro: 2.523 ± 0.017	2.982ArgGln: 2.982 ± 0.022	5.573ArgArg: 5.573 ± 0.043	5.243ArgSer: 5.243 ± 0.03	3.184ArgThr: 3.184 ± 0.016	4.325ArgVal: 4.325 ± 0.021	0.875ArgTrp: 0.875 ± 0.009	1.669ArgTyr: 1.669 ± 0.013	0.0ArgXaa: 0.0 ± 0.0
Ser	6.766SerAla: 6.766 ± 0.03	1.3SerCys: 1.3 ± 0.013	4.744SerAsp: 4.744 ± 0.024	4.627SerGlu: 4.627 ± 0.027	3.111SerPhe: 3.111 ± 0.018	5.35SerGly: 5.35 ± 0.036	1.614SerHis: 1.614 ± 0.013	3.624SerIle: 3.624 ± 0.022	4.016SerLys: 4.016 ± 0.023	6.982SerLeu: 6.982 ± 0.032	1.975SerMet: 1.975 ± 0.013	3.158SerAsn: 3.158 ± 0.018	4.342SerPro: 4.342 ± 0.029	2.789SerGln: 2.789 ± 0.019	4.867SerArg: 4.867 ± 0.027	9.9SerSer: 9.9 ± 0.065	5.946SerThr: 5.946 ± 0.032	5.523SerVal: 5.523 ± 0.027	0.958SerTrp: 0.958 ± 0.01	1.945SerTyr: 1.945 ± 0.016	0.0SerXaa: 0.0 ± 0.0
Thr	5.274ThrAla: 5.274 ± 0.029	0.966ThrCys: 0.966 ± 0.011	2.952ThrAsp: 2.952 ± 0.018	3.516ThrGlu: 3.516 ± 0.023	2.126ThrPhe: 2.126 ± 0.017	3.66ThrGly: 3.66 ± 0.027	1.238ThrHis: 1.238 ± 0.01	2.683ThrIle: 2.683 ± 0.02	3.083ThrLys: 3.083 ± 0.022	5.447ThrLeu: 5.447 ± 0.024	1.405ThrMet: 1.405 ± 0.011	2.172ThrAsn: 2.172 ± 0.015	3.645ThrPro: 3.645 ± 0.026	2.349ThrGln: 2.349 ± 0.016	3.415ThrArg: 3.415 ± 0.019	5.581ThrSer: 5.581 ± 0.031	4.492ThrThr: 4.492 ± 0.037	3.912ThrVal: 3.912 ± 0.024	0.698ThrTrp: 0.698 ± 0.009	1.409ThrTyr: 1.409 ± 0.013	0.0ThrXaa: 0.0 ± 0.0
Val	6.409ValAla: 6.409 ± 0.024	1.273ValCys: 1.273 ± 0.013	4.3ValAsp: 4.3 ± 0.022	4.745ValGlu: 4.745 ± 0.024	2.795ValPhe: 2.795 ± 0.02	3.86ValGly: 3.86 ± 0.022	1.614ValHis: 1.614 ± 0.012	2.922ValIle: 2.922 ± 0.017	3.463ValLys: 3.463 ± 0.021	6.88ValLeu: 6.88 ± 0.034	1.688ValMet: 1.688 ± 0.013	2.546ValAsn: 2.546 ± 0.021	3.136ValPro: 3.136 ± 0.018	2.816ValGln: 2.816 ± 0.018	3.949ValArg: 3.949 ± 0.021	5.341ValSer: 5.341 ± 0.026	4.03ValThr: 4.03 ± 0.03	5.626ValVal: 5.626 ± 0.028	0.788ValTrp: 0.788 ± 0.008	1.877ValTyr: 1.877 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	0.711TrpAla: 0.711 ± 0.009	0.225TrpCys: 0.225 ± 0.005	0.669TrpAsp: 0.669 ± 0.009	0.685TrpGlu: 0.685 ± 0.009	0.478TrpPhe: 0.478 ± 0.007	0.653TrpGly: 0.653 ± 0.008	0.29TrpHis: 0.29 ± 0.006	0.611TrpIle: 0.611 ± 0.007	0.789TrpLys: 0.789 ± 0.009	1.24TrpLeu: 1.24 ± 0.013	0.407TrpMet: 0.407 ± 0.006	0.555TrpAsn: 0.555 ± 0.008	0.384TrpPro: 0.384 ± 0.006	0.495TrpGln: 0.495 ± 0.008	0.865TrpArg: 0.865 ± 0.009	0.923TrpSer: 0.923 ± 0.01	0.766TrpThr: 0.766 ± 0.009	0.718TrpVal: 0.718 ± 0.009	0.185TrpTrp: 0.185 ± 0.004	0.369TrpTyr: 0.369 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.09TyrAla: 2.09 ± 0.014	0.555TyrCys: 0.555 ± 0.009	1.559TyrAsp: 1.559 ± 0.013	1.648TyrGlu: 1.648 ± 0.012	1.187TyrPhe: 1.187 ± 0.013	1.746TyrGly: 1.746 ± 0.014	0.67TyrHis: 0.67 ± 0.009	1.064TyrIle: 1.064 ± 0.011	1.118TyrLys: 1.118 ± 0.01	2.506TyrLeu: 2.506 ± 0.017	0.655TyrMet: 0.655 ± 0.009	1.014TyrAsn: 1.014 ± 0.009	1.107TyrPro: 1.107 ± 0.011	1.018TyrGln: 1.018 ± 0.01	1.627TyrArg: 1.627 ± 0.012	1.924TyrSer: 1.924 ± 0.014	1.404TyrThr: 1.404 ± 0.014	1.87TyrVal: 1.87 ± 0.013	0.361TyrTrp: 0.361 ± 0.007	0.876TyrTyr: 0.876 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 26438 proteins (10900847 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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