Amino acid dipepetide frequency for Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.853AlaAla: 2.853 ± 0.092	1.044AlaCys: 1.044 ± 0.041	2.417AlaAsp: 2.417 ± 0.058	3.867AlaGlu: 3.867 ± 0.075	2.425AlaPhe: 2.425 ± 0.069	3.193AlaGly: 3.193 ± 0.083	0.943AlaHis: 0.943 ± 0.036	3.475AlaIle: 3.475 ± 0.077	3.248AlaLys: 3.248 ± 0.07	5.486AlaLeu: 5.486 ± 0.094	1.544AlaMet: 1.544 ± 0.048	1.64AlaAsn: 1.64 ± 0.046	1.601AlaPro: 1.601 ± 0.057	1.26AlaGln: 1.26 ± 0.044	3.275AlaArg: 3.275 ± 0.074	4.06AlaSer: 4.06 ± 0.086	1.966AlaThr: 1.966 ± 0.056	3.835AlaVal: 3.835 ± 0.083	0.366AlaTrp: 0.366 ± 0.023	1.658AlaTyr: 1.658 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.821CysAla: 0.821 ± 0.036	0.461CysCys: 0.461 ± 0.026	1.025CysAsp: 1.025 ± 0.044	1.205CysGlu: 1.205 ± 0.049	0.994CysPhe: 0.994 ± 0.046	1.643CysGly: 1.643 ± 0.054	0.343CysHis: 0.343 ± 0.021	1.564CysIle: 1.564 ± 0.047	1.309CysLys: 1.309 ± 0.045	1.974CysLeu: 1.974 ± 0.054	0.575CysMet: 0.575 ± 0.027	0.83CysAsn: 0.83 ± 0.035	0.73CysPro: 0.73 ± 0.032	0.364CysGln: 0.364 ± 0.023	1.501CysArg: 1.501 ± 0.044	1.748CysSer: 1.748 ± 0.051	0.915CysThr: 0.915 ± 0.036	1.397CysVal: 1.397 ± 0.049	0.141CysTrp: 0.141 ± 0.014	0.696CysTyr: 0.696 ± 0.034	0.0CysXaa: 0.0 ± 0.0
Asp	3.187AspAla: 3.187 ± 0.068	0.887AspCys: 0.887 ± 0.038	2.974AspAsp: 2.974 ± 0.061	4.866AspGlu: 4.866 ± 0.094	2.952AspPhe: 2.952 ± 0.074	4.429AspGly: 4.429 ± 0.088	0.866AspHis: 0.866 ± 0.037	4.143AspIle: 4.143 ± 0.071	3.252AspLys: 3.252 ± 0.07	5.573AspLeu: 5.573 ± 0.101	1.623AspMet: 1.623 ± 0.043	1.596AspAsn: 1.596 ± 0.05	2.016AspPro: 2.016 ± 0.06	1.031AspGln: 1.031 ± 0.035	3.206AspArg: 3.206 ± 0.072	3.852AspSer: 3.852 ± 0.08	2.183AspThr: 2.183 ± 0.058	4.679AspVal: 4.679 ± 0.094	0.383AspTrp: 0.383 ± 0.026	1.796AspTyr: 1.796 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	4.593GluAla: 4.593 ± 0.091	1.61GluCys: 1.61 ± 0.05	5.164GluAsp: 5.164 ± 0.087	8.818GluGlu: 8.818 ± 0.184	3.131GluPhe: 3.131 ± 0.066	4.735GluGly: 4.735 ± 0.086	1.463GluHis: 1.463 ± 0.049	6.08GluIle: 6.08 ± 0.112	6.989GluLys: 6.989 ± 0.125	6.193GluLeu: 6.193 ± 0.095	3.026GluMet: 3.026 ± 0.069	3.353GluAsn: 3.353 ± 0.074	1.652GluPro: 1.652 ± 0.049	1.531GluGln: 1.531 ± 0.048	5.304GluArg: 5.304 ± 0.106	5.702GluSer: 5.702 ± 0.108	3.094GluThr: 3.094 ± 0.078	5.54GluVal: 5.54 ± 0.093	0.698GluTrp: 0.698 ± 0.033	3.121GluTyr: 3.121 ± 0.071	0.0GluXaa: 0.0 ± 0.0
Phe	1.93PheAla: 1.93 ± 0.059	1.106PheCys: 1.106 ± 0.041	2.899PheAsp: 2.899 ± 0.066	3.276PheGlu: 3.276 ± 0.086	2.653PhePhe: 2.653 ± 0.074	3.098PheGly: 3.098 ± 0.067	0.974PheHis: 0.974 ± 0.041	3.062PheIle: 3.062 ± 0.075	2.86PheLys: 2.86 ± 0.059	5.3PheLeu: 5.3 ± 0.099	1.253PheMet: 1.253 ± 0.04	1.982PheAsn: 1.982 ± 0.052	1.675PhePro: 1.675 ± 0.052	1.038PheGln: 1.038 ± 0.037	2.818PheArg: 2.818 ± 0.066	3.946PheSer: 3.946 ± 0.09	1.914PheThr: 1.914 ± 0.056	3.723PheVal: 3.723 ± 0.078	0.344PheTrp: 0.344 ± 0.023	2.108PheTyr: 2.108 ± 0.059	0.0PheXaa: 0.0 ± 0.0
Gly	3.055GlyAla: 3.055 ± 0.072	1.537GlyCys: 1.537 ± 0.051	3.808GlyAsp: 3.808 ± 0.076	4.871GlyGlu: 4.871 ± 0.103	3.082GlyPhe: 3.082 ± 0.069	4.272GlyGly: 4.272 ± 0.108	1.325GlyHis: 1.325 ± 0.045	4.751GlyIle: 4.751 ± 0.092	4.884GlyLys: 4.884 ± 0.083	5.611GlyLeu: 5.611 ± 0.097	2.191GlyMet: 2.191 ± 0.066	2.623GlyAsn: 2.623 ± 0.057	1.666GlyPro: 1.666 ± 0.051	1.365GlyGln: 1.365 ± 0.049	4.418GlyArg: 4.418 ± 0.09	5.166GlySer: 5.166 ± 0.093	2.987GlyThr: 2.987 ± 0.068	4.378GlyVal: 4.378 ± 0.087	0.495GlyTrp: 0.495 ± 0.026	2.431GlyTyr: 2.431 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	0.894HisAla: 0.894 ± 0.033	0.361HisCys: 0.361 ± 0.025	0.886HisAsp: 0.886 ± 0.039	1.275HisGlu: 1.275 ± 0.041	0.962HisPhe: 0.962 ± 0.039	1.42HisGly: 1.42 ± 0.047	0.475HisHis: 0.475 ± 0.029	1.159HisIle: 1.159 ± 0.041	1.132HisLys: 1.132 ± 0.034	2.11HisLeu: 2.11 ± 0.057	0.506HisMet: 0.506 ± 0.028	0.677HisAsn: 0.677 ± 0.037	0.989HisPro: 0.989 ± 0.045	0.501HisGln: 0.501 ± 0.03	1.387HisArg: 1.387 ± 0.046	1.455HisSer: 1.455 ± 0.041	0.806HisThr: 0.806 ± 0.042	1.328HisVal: 1.328 ± 0.046	0.132HisTrp: 0.132 ± 0.013	0.531HisTyr: 0.531 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	3.125IleAla: 3.125 ± 0.071	1.518IleCys: 1.518 ± 0.047	4.12IleAsp: 4.12 ± 0.073	5.461IleGlu: 5.461 ± 0.09	3.18IlePhe: 3.18 ± 0.07	4.079IleGly: 4.079 ± 0.08	1.475IleHis: 1.475 ± 0.048	3.474IleIle: 3.474 ± 0.082	4.365IleLys: 4.365 ± 0.091	7.269IleLeu: 7.269 ± 0.126	1.393IleMet: 1.393 ± 0.041	2.708IleAsn: 2.708 ± 0.066	2.765IlePro: 2.765 ± 0.065	1.747IleGln: 1.747 ± 0.049	4.521IleArg: 4.521 ± 0.072	5.828IleSer: 5.828 ± 0.111	2.6IleThr: 2.6 ± 0.073	4.776IleVal: 4.776 ± 0.09	0.459IleTrp: 0.459 ± 0.028	2.483IleTyr: 2.483 ± 0.065	0.0IleXaa: 0.0 ± 0.0
Lys	4.151LysAla: 4.151 ± 0.086	1.09LysCys: 1.09 ± 0.043	4.247LysAsp: 4.247 ± 0.082	6.92LysGlu: 6.92 ± 0.122	2.235LysPhe: 2.235 ± 0.053	4.256LysGly: 4.256 ± 0.085	1.378LysHis: 1.378 ± 0.05	5.461LysIle: 5.461 ± 0.096	6.573LysLys: 6.573 ± 0.146	5.078LysLeu: 5.078 ± 0.089	2.597LysMet: 2.597 ± 0.074	3.284LysAsn: 3.284 ± 0.073	1.856LysPro: 1.856 ± 0.059	1.534LysGln: 1.534 ± 0.055	4.947LysArg: 4.947 ± 0.088	5.002LysSer: 5.002 ± 0.088	3.321LysThr: 3.321 ± 0.08	4.312LysVal: 4.312 ± 0.074	0.478LysTrp: 0.478 ± 0.026	2.844LysTyr: 2.844 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	4.59LeuAla: 4.59 ± 0.091	2.229LeuCys: 2.229 ± 0.058	5.293LeuAsp: 5.293 ± 0.083	7.848LeuGlu: 7.848 ± 0.115	4.901LeuPhe: 4.901 ± 0.091	6.186LeuGly: 6.186 ± 0.099	1.797LeuHis: 1.797 ± 0.053	5.111LeuIle: 5.111 ± 0.089	6.799LeuLys: 6.799 ± 0.114	9.96LeuLeu: 9.96 ± 0.175	2.509LeuMet: 2.509 ± 0.058	3.658LeuAsn: 3.658 ± 0.081	2.931LeuPro: 2.931 ± 0.076	2.287LeuGln: 2.287 ± 0.059	6.556LeuArg: 6.556 ± 0.1	7.98LeuSer: 7.98 ± 0.103	3.17LeuThr: 3.17 ± 0.069	6.937LeuVal: 6.937 ± 0.098	0.776LeuTrp: 0.776 ± 0.035	3.503LeuTyr: 3.503 ± 0.073	0.0LeuXaa: 0.0 ± 0.0
Met	1.718MetAla: 1.718 ± 0.043	0.599MetCys: 0.599 ± 0.033	1.974MetAsp: 1.974 ± 0.055	2.769MetGlu: 2.769 ± 0.074	1.584MetPhe: 1.584 ± 0.049	1.741MetGly: 1.741 ± 0.049	0.504MetHis: 0.504 ± 0.026	1.686MetIle: 1.686 ± 0.053	2.489MetLys: 2.489 ± 0.06	2.49MetLeu: 2.49 ± 0.058	0.837MetMet: 0.837 ± 0.034	1.321MetAsn: 1.321 ± 0.049	0.866MetPro: 0.866 ± 0.038	0.616MetGln: 0.616 ± 0.029	1.689MetArg: 1.689 ± 0.055	2.255MetSer: 2.255 ± 0.053	1.037MetThr: 1.037 ± 0.042	2.3MetVal: 2.3 ± 0.059	0.216MetTrp: 0.216 ± 0.02	1.057MetTyr: 1.057 ± 0.045	0.0MetXaa: 0.0 ± 0.0
Asn	2.27AsnAla: 2.27 ± 0.062	0.601AsnCys: 0.601 ± 0.031	1.937AsnAsp: 1.937 ± 0.054	3.063AsnGlu: 3.063 ± 0.079	1.728AsnPhe: 1.728 ± 0.057	2.829AsnGly: 2.829 ± 0.048	0.67AsnHis: 0.67 ± 0.028	3.124AsnIle: 3.124 ± 0.075	2.648AsnLys: 2.648 ± 0.059	3.6AsnLeu: 3.6 ± 0.072	1.18AsnMet: 1.18 ± 0.043	1.581AsnAsn: 1.581 ± 0.055	1.737AsnPro: 1.737 ± 0.057	0.956AsnGln: 0.956 ± 0.036	2.556AsnArg: 2.556 ± 0.067	2.823AsnSer: 2.823 ± 0.064	1.792AsnThr: 1.792 ± 0.054	2.741AsnVal: 2.741 ± 0.059	0.279AsnTrp: 0.279 ± 0.022	1.308AsnTyr: 1.308 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	1.557ProAla: 1.557 ± 0.049	0.595ProCys: 0.595 ± 0.029	1.623ProAsp: 1.623 ± 0.05	2.725ProGlu: 2.725 ± 0.06	1.724ProPhe: 1.724 ± 0.056	2.322ProGly: 2.322 ± 0.066	0.736ProHis: 0.736 ± 0.034	1.737ProIle: 1.737 ± 0.05	2.048ProLys: 2.048 ± 0.056	2.83ProLeu: 2.83 ± 0.07	0.796ProMet: 0.796 ± 0.033	1.164ProAsn: 1.164 ± 0.042	1.393ProPro: 1.393 ± 0.064	0.932ProGln: 0.932 ± 0.041	2.202ProArg: 2.202 ± 0.067	3.23ProSer: 3.23 ± 0.075	1.381ProThr: 1.381 ± 0.049	2.257ProVal: 2.257 ± 0.065	0.266ProTrp: 0.266 ± 0.02	1.172ProTyr: 1.172 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.272GlnAla: 1.272 ± 0.047	0.387GlnCys: 0.387 ± 0.027	1.218GlnAsp: 1.218 ± 0.046	1.996GlnGlu: 1.996 ± 0.052	0.723GlnPhe: 0.723 ± 0.032	1.439GlnGly: 1.439 ± 0.049	0.426GlnHis: 0.426 ± 0.026	1.627GlnIle: 1.627 ± 0.048	2.13GlnLys: 2.13 ± 0.059	1.727GlnLeu: 1.727 ± 0.052	0.845GlnMet: 0.845 ± 0.044	0.933GlnAsn: 0.933 ± 0.035	0.732GlnPro: 0.732 ± 0.042	0.675GlnGln: 0.675 ± 0.041	1.756GlnArg: 1.756 ± 0.049	1.583GlnSer: 1.583 ± 0.054	0.939GlnThr: 0.939 ± 0.041	1.393GlnVal: 1.393 ± 0.042	0.141GlnTrp: 0.141 ± 0.015	0.732GlnTyr: 0.732 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.187ArgAla: 3.187 ± 0.07	1.4ArgCys: 1.4 ± 0.047	3.376ArgAsp: 3.376 ± 0.073	5.368ArgGlu: 5.368 ± 0.102	3.07ArgPhe: 3.07 ± 0.068	3.818ArgGly: 3.818 ± 0.084	1.285ArgHis: 1.285 ± 0.044	5.3ArgIle: 5.3 ± 0.09	5.301ArgLys: 5.301 ± 0.102	5.634ArgLeu: 5.634 ± 0.081	2.355ArgMet: 2.355 ± 0.067	3.226ArgAsn: 3.226 ± 0.068	1.828ArgPro: 1.828 ± 0.056	1.426ArgGln: 1.426 ± 0.05	5.293ArgArg: 5.293 ± 0.11	4.861ArgSer: 4.861 ± 0.091	2.702ArgThr: 2.702 ± 0.071	4.073ArgVal: 4.073 ± 0.072	0.575ArgTrp: 0.575 ± 0.03	2.669ArgTyr: 2.669 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	3.655SerAla: 3.655 ± 0.079	1.469SerCys: 1.469 ± 0.05	4.021SerAsp: 4.021 ± 0.081	5.699SerGlu: 5.699 ± 0.101	3.937SerPhe: 3.937 ± 0.075	5.385SerGly: 5.385 ± 0.107	1.413SerHis: 1.413 ± 0.047	5.946SerIle: 5.946 ± 0.097	5.519SerLys: 5.519 ± 0.094	7.973SerLeu: 7.973 ± 0.107	2.34SerMet: 2.34 ± 0.06	2.993SerAsn: 2.993 ± 0.074	2.81SerPro: 2.81 ± 0.081	1.866SerGln: 1.866 ± 0.05	5.48SerArg: 5.48 ± 0.092	7.307SerSer: 7.307 ± 0.163	3.572SerThr: 3.572 ± 0.08	5.157SerVal: 5.157 ± 0.082	0.589SerTrp: 0.589 ± 0.033	2.528SerTyr: 2.528 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	2.106ThrAla: 2.106 ± 0.058	0.727ThrCys: 0.727 ± 0.035	1.92ThrAsp: 1.92 ± 0.06	2.755ThrGlu: 2.755 ± 0.064	2.093ThrPhe: 2.093 ± 0.063	2.793ThrGly: 2.793 ± 0.076	0.799ThrHis: 0.799 ± 0.038	2.808ThrIle: 2.808 ± 0.069	2.749ThrLys: 2.749 ± 0.075	4.014ThrLeu: 4.014 ± 0.082	1.08ThrMet: 1.08 ± 0.038	1.583ThrAsn: 1.583 ± 0.048	1.702ThrPro: 1.702 ± 0.058	0.961ThrGln: 0.961 ± 0.041	2.608ThrArg: 2.608 ± 0.063	3.456ThrSer: 3.456 ± 0.072	1.914ThrThr: 1.914 ± 0.058	2.926ThrVal: 2.926 ± 0.063	0.271ThrTrp: 0.271 ± 0.02	1.437ThrTyr: 1.437 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	3.266ValAla: 3.266 ± 0.08	1.711ValCys: 1.711 ± 0.053	4.207ValAsp: 4.207 ± 0.08	5.913ValGlu: 5.913 ± 0.103	4.155ValPhe: 4.155 ± 0.07	4.499ValGly: 4.499 ± 0.091	1.319ValHis: 1.319 ± 0.045	3.877ValIle: 3.877 ± 0.081	4.148ValLys: 4.148 ± 0.078	7.6ValLeu: 7.6 ± 0.095	1.781ValMet: 1.781 ± 0.046	2.383ValAsn: 2.383 ± 0.06	2.342ValPro: 2.342 ± 0.058	1.691ValGln: 1.691 ± 0.059	4.038ValArg: 4.038 ± 0.08	5.762ValSer: 5.762 ± 0.099	2.383ValThr: 2.383 ± 0.059	6.124ValVal: 6.124 ± 0.106	0.608ValTrp: 0.608 ± 0.034	2.924ValTyr: 2.924 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.311TrpAla: 0.311 ± 0.023	0.154TrpCys: 0.154 ± 0.014	0.513TrpAsp: 0.513 ± 0.026	0.494TrpGlu: 0.494 ± 0.03	0.284TrpPhe: 0.284 ± 0.02	0.423TrpGly: 0.423 ± 0.023	0.115TrpHis: 0.115 ± 0.013	0.611TrpIle: 0.611 ± 0.034	0.678TrpLys: 0.678 ± 0.031	0.517TrpLeu: 0.517 ± 0.031	0.311TrpMet: 0.311 ± 0.019	0.421TrpAsn: 0.421 ± 0.023	0.2TrpPro: 0.2 ± 0.016	0.108TrpGln: 0.108 ± 0.012	0.694TrpArg: 0.694 ± 0.041	0.625TrpSer: 0.625 ± 0.03	0.338TrpThr: 0.338 ± 0.022	0.421TrpVal: 0.421 ± 0.027	0.062TrpTrp: 0.062 ± 0.009	0.259TrpTyr: 0.259 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.616TyrAla: 1.616 ± 0.05	0.749TyrCys: 0.749 ± 0.03	1.874TyrAsp: 1.874 ± 0.052	2.608TyrGlu: 2.608 ± 0.061	2.146TyrPhe: 2.146 ± 0.059	2.358TyrGly: 2.358 ± 0.067	0.681TyrHis: 0.681 ± 0.035	2.346TyrIle: 2.346 ± 0.061	2.444TyrLys: 2.444 ± 0.056	4.081TyrLeu: 4.081 ± 0.077	1.008TyrMet: 1.008 ± 0.045	1.469TyrAsn: 1.469 ± 0.051	1.198TyrPro: 1.198 ± 0.043	0.783TyrGln: 0.783 ± 0.034	2.494TyrArg: 2.494 ± 0.056	3.017TyrSer: 3.017 ± 0.063	1.689TyrThr: 1.689 ± 0.045	2.435TyrVal: 2.435 ± 0.066	0.258TyrTrp: 0.258 ± 0.017	1.36TyrTyr: 1.36 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2041 proteins (694360 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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