Amino acid dipepetide frequency for Lutibaculum baratangense AMV1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.859AlaAla: 17.859 ± 0.187	1.08AlaCys: 1.08 ± 0.033	6.578AlaAsp: 6.578 ± 0.087	8.804AlaGlu: 8.804 ± 0.129	4.489AlaPhe: 4.489 ± 0.063	11.584AlaGly: 11.584 ± 0.13	2.253AlaHis: 2.253 ± 0.044	5.879AlaIle: 5.879 ± 0.072	2.95AlaLys: 2.95 ± 0.052	13.349AlaLeu: 13.349 ± 0.133	3.527AlaMet: 3.527 ± 0.05	2.332AlaAsn: 2.332 ± 0.044	5.727AlaPro: 5.727 ± 0.086	3.501AlaGln: 3.501 ± 0.057	9.884AlaArg: 9.884 ± 0.113	6.19AlaSer: 6.19 ± 0.09	6.078AlaThr: 6.078 ± 0.081	9.469AlaVal: 9.469 ± 0.092	1.534AlaTrp: 1.534 ± 0.039	2.538AlaTyr: 2.538 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.896CysAla: 0.896 ± 0.027	0.107CysCys: 0.107 ± 0.01	0.526CysAsp: 0.526 ± 0.022	0.487CysGlu: 0.487 ± 0.021	0.307CysPhe: 0.307 ± 0.015	0.93CysGly: 0.93 ± 0.03	0.256CysHis: 0.256 ± 0.014	0.343CysIle: 0.343 ± 0.017	0.123CysLys: 0.123 ± 0.011	0.788CysLeu: 0.788 ± 0.025	0.148CysMet: 0.148 ± 0.011	0.162CysAsn: 0.162 ± 0.012	0.439CysPro: 0.439 ± 0.022	0.19CysGln: 0.19 ± 0.013	0.779CysArg: 0.779 ± 0.025	0.407CysSer: 0.407 ± 0.018	0.405CysThr: 0.405 ± 0.02	0.616CysVal: 0.616 ± 0.021	0.093CysTrp: 0.093 ± 0.009	0.183CysTyr: 0.183 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.521AspAla: 6.521 ± 0.083	0.46AspCys: 0.46 ± 0.02	2.993AspAsp: 2.993 ± 0.049	4.298AspGlu: 4.298 ± 0.065	1.96AspPhe: 1.96 ± 0.042	5.398AspGly: 5.398 ± 0.067	1.198AspHis: 1.198 ± 0.036	2.616AspIle: 2.616 ± 0.052	1.095AspLys: 1.095 ± 0.032	6.246AspLeu: 6.246 ± 0.073	1.303AspMet: 1.303 ± 0.033	0.969AspAsn: 0.969 ± 0.03	3.626AspPro: 3.626 ± 0.053	1.482AspGln: 1.482 ± 0.036	4.899AspArg: 4.899 ± 0.073	1.759AspSer: 1.759 ± 0.036	2.491AspThr: 2.491 ± 0.046	4.406AspVal: 4.406 ± 0.066	0.926AspTrp: 0.926 ± 0.029	1.316AspTyr: 1.316 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	9.717GluAla: 9.717 ± 0.129	0.352GluCys: 0.352 ± 0.017	3.352GluAsp: 3.352 ± 0.056	4.907GluGlu: 4.907 ± 0.087	1.918GluPhe: 1.918 ± 0.041	5.536GluGly: 5.536 ± 0.073	1.41GluHis: 1.41 ± 0.03	4.026GluIle: 4.026 ± 0.068	2.015GluLys: 2.015 ± 0.054	6.038GluLeu: 6.038 ± 0.078	1.798GluMet: 1.798 ± 0.045	1.527GluAsn: 1.527 ± 0.034	3.526GluPro: 3.526 ± 0.066	2.034GluGln: 2.034 ± 0.047	6.224GluArg: 6.224 ± 0.089	2.434GluSer: 2.434 ± 0.051	4.01GluThr: 4.01 ± 0.064	4.809GluVal: 4.809 ± 0.066	0.778GluTrp: 0.778 ± 0.026	0.983GluTyr: 0.983 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.533PheAla: 4.533 ± 0.064	0.367PheCys: 0.367 ± 0.018	2.503PheAsp: 2.503 ± 0.049	2.318PheGlu: 2.318 ± 0.046	1.386PhePhe: 1.386 ± 0.037	3.721PheGly: 3.721 ± 0.063	0.724PheHis: 0.724 ± 0.027	1.424PheIle: 1.424 ± 0.036	0.665PheLys: 0.665 ± 0.023	3.513PheLeu: 3.513 ± 0.066	0.791PheMet: 0.791 ± 0.025	0.834PheAsn: 0.834 ± 0.026	1.649PhePro: 1.649 ± 0.036	0.944PheGln: 0.944 ± 0.029	2.471PheArg: 2.471 ± 0.05	1.955PheSer: 1.955 ± 0.046	1.827PheThr: 1.827 ± 0.034	3.128PheVal: 3.128 ± 0.052	0.558PheTrp: 0.558 ± 0.027	0.899PheTyr: 0.899 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.862GlyAla: 9.862 ± 0.093	0.855GlyCys: 0.855 ± 0.028	4.686GlyAsp: 4.686 ± 0.061	6.114GlyGlu: 6.114 ± 0.084	3.65GlyPhe: 3.65 ± 0.056	8.222GlyGly: 8.222 ± 0.096	2.129GlyHis: 2.129 ± 0.046	4.53GlyIle: 4.53 ± 0.058	2.436GlyLys: 2.436 ± 0.05	9.452GlyLeu: 9.452 ± 0.111	2.384GlyMet: 2.384 ± 0.046	1.884GlyAsn: 1.884 ± 0.042	3.922GlyPro: 3.922 ± 0.059	2.76GlyGln: 2.76 ± 0.05	7.629GlyArg: 7.629 ± 0.074	4.779GlySer: 4.779 ± 0.065	4.77GlyThr: 4.77 ± 0.061	6.434GlyVal: 6.434 ± 0.071	1.451GlyTrp: 1.451 ± 0.038	2.189GlyTyr: 2.189 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.431HisAla: 2.431 ± 0.049	0.212HisCys: 0.212 ± 0.014	1.315HisAsp: 1.315 ± 0.036	1.377HisGlu: 1.377 ± 0.037	0.805HisPhe: 0.805 ± 0.023	2.117HisGly: 2.117 ± 0.044	0.605HisHis: 0.605 ± 0.024	0.791HisIle: 0.791 ± 0.026	0.372HisLys: 0.372 ± 0.016	2.123HisLeu: 2.123 ± 0.043	0.502HisMet: 0.502 ± 0.02	0.38HisAsn: 0.38 ± 0.019	1.382HisPro: 1.382 ± 0.034	0.525HisGln: 0.525 ± 0.021	1.608HisArg: 1.608 ± 0.04	0.812HisSer: 0.812 ± 0.021	0.808HisThr: 0.808 ± 0.026	1.725HisVal: 1.725 ± 0.039	0.313HisTrp: 0.313 ± 0.017	0.553HisTyr: 0.553 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.457IleAla: 6.457 ± 0.083	0.47IleCys: 0.47 ± 0.02	3.129IleAsp: 3.129 ± 0.049	3.716IleGlu: 3.716 ± 0.06	1.584IlePhe: 1.584 ± 0.039	4.799IleGly: 4.799 ± 0.059	0.843IleHis: 0.843 ± 0.025	1.8IleIle: 1.8 ± 0.04	0.914IleLys: 0.914 ± 0.029	4.55IleLeu: 4.55 ± 0.078	0.903IleMet: 0.903 ± 0.031	1.029IleAsn: 1.029 ± 0.029	2.151IlePro: 2.151 ± 0.043	0.964IleGln: 0.964 ± 0.032	3.146IleArg: 3.146 ± 0.048	2.53IleSer: 2.53 ± 0.051	2.207IleThr: 2.207 ± 0.043	4.42IleVal: 4.42 ± 0.074	0.515IleTrp: 0.515 ± 0.023	1.017IleTyr: 1.017 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.325LysAla: 3.325 ± 0.057	0.13LysCys: 0.13 ± 0.011	1.313LysAsp: 1.313 ± 0.032	1.487LysGlu: 1.487 ± 0.034	0.596LysPhe: 0.596 ± 0.022	2.207LysGly: 2.207 ± 0.045	0.496LysHis: 0.496 ± 0.021	1.237LysIle: 1.237 ± 0.036	0.896LysLys: 0.896 ± 0.031	2.403LysLeu: 2.403 ± 0.052	0.561LysMet: 0.561 ± 0.022	0.594LysAsn: 0.594 ± 0.021	1.596LysPro: 1.596 ± 0.04	0.666LysGln: 0.666 ± 0.025	2.113LysArg: 2.113 ± 0.047	1.316LysSer: 1.316 ± 0.038	1.444LysThr: 1.444 ± 0.037	1.996LysVal: 1.996 ± 0.041	0.295LysTrp: 0.295 ± 0.015	0.419LysTyr: 0.419 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.834LeuAla: 13.834 ± 0.132	0.812LeuCys: 0.812 ± 0.027	6.13LeuAsp: 6.13 ± 0.072	5.998LeuGlu: 5.998 ± 0.085	3.628LeuPhe: 3.628 ± 0.064	8.88LeuGly: 8.88 ± 0.09	1.841LeuHis: 1.841 ± 0.04	4.342LeuIle: 4.342 ± 0.079	3.108LeuLys: 3.108 ± 0.054	9.685LeuLeu: 9.685 ± 0.126	2.436LeuMet: 2.436 ± 0.046	2.073LeuAsn: 2.073 ± 0.042	5.745LeuPro: 5.745 ± 0.083	2.715LeuGln: 2.715 ± 0.053	7.504LeuArg: 7.504 ± 0.083	6.248LeuSer: 6.248 ± 0.071	5.013LeuThr: 5.013 ± 0.062	8.724LeuVal: 8.724 ± 0.102	1.142LeuTrp: 1.142 ± 0.038	1.979LeuTyr: 1.979 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.111MetAla: 3.111 ± 0.054	0.158MetCys: 0.158 ± 0.013	1.108MetAsp: 1.108 ± 0.028	1.24MetGlu: 1.24 ± 0.034	0.721MetPhe: 0.721 ± 0.024	1.898MetGly: 1.898 ± 0.043	0.463MetHis: 0.463 ± 0.017	1.311MetIle: 1.311 ± 0.034	0.87MetLys: 0.87 ± 0.027	2.437MetLeu: 2.437 ± 0.042	0.708MetMet: 0.708 ± 0.03	0.728MetAsn: 0.728 ± 0.024	1.546MetPro: 1.546 ± 0.038	0.738MetGln: 0.738 ± 0.025	2.047MetArg: 2.047 ± 0.045	1.713MetSer: 1.713 ± 0.037	1.728MetThr: 1.728 ± 0.038	1.668MetVal: 1.668 ± 0.035	0.248MetTrp: 0.248 ± 0.014	0.287MetTyr: 0.287 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.503AsnAla: 2.503 ± 0.047	0.197AsnCys: 0.197 ± 0.013	1.14AsnAsp: 1.14 ± 0.032	1.282AsnGlu: 1.282 ± 0.035	0.772AsnPhe: 0.772 ± 0.026	1.989AsnGly: 1.989 ± 0.044	0.419AsnHis: 0.419 ± 0.018	1.025AsnIle: 1.025 ± 0.027	0.473AsnLys: 0.473 ± 0.021	2.194AsnLeu: 2.194 ± 0.041	0.539AsnMet: 0.539 ± 0.021	0.508AsnAsn: 0.508 ± 0.023	1.545AsnPro: 1.545 ± 0.039	0.57AsnGln: 0.57 ± 0.024	1.642AsnArg: 1.642 ± 0.035	0.906AsnSer: 0.906 ± 0.029	0.98AsnThr: 0.98 ± 0.032	1.788AsnVal: 1.788 ± 0.041	0.339AsnTrp: 0.339 ± 0.015	0.541AsnTyr: 0.541 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.526ProAla: 6.526 ± 0.086	0.314ProCys: 0.314 ± 0.014	3.697ProAsp: 3.697 ± 0.057	4.45ProGlu: 4.45 ± 0.064	2.034ProPhe: 2.034 ± 0.045	4.96ProGly: 4.96 ± 0.059	1.236ProHis: 1.236 ± 0.034	2.184ProIle: 2.184 ± 0.05	1.336ProLys: 1.336 ± 0.035	4.871ProLeu: 4.871 ± 0.064	1.195ProMet: 1.195 ± 0.028	1.149ProAsn: 1.149 ± 0.035	2.789ProPro: 2.789 ± 0.052	1.632ProGln: 1.632 ± 0.038	3.501ProArg: 3.501 ± 0.048	2.815ProSer: 2.815 ± 0.047	2.414ProThr: 2.414 ± 0.046	4.428ProVal: 4.428 ± 0.06	0.725ProTrp: 0.725 ± 0.027	1.166ProTyr: 1.166 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.936GlnAla: 3.936 ± 0.065	0.172GlnCys: 0.172 ± 0.012	1.414GlnAsp: 1.414 ± 0.037	1.794GlnGlu: 1.794 ± 0.039	0.867GlnPhe: 0.867 ± 0.024	2.341GlnGly: 2.341 ± 0.048	0.537GlnHis: 0.537 ± 0.023	1.475GlnIle: 1.475 ± 0.035	0.8GlnLys: 0.8 ± 0.025	2.451GlnLeu: 2.451 ± 0.055	0.833GlnMet: 0.833 ± 0.03	0.67GlnAsn: 0.67 ± 0.024	1.523GlnPro: 1.523 ± 0.038	0.997GlnGln: 0.997 ± 0.039	2.309GlnArg: 2.309 ± 0.043	1.522GlnSer: 1.522 ± 0.036	1.48GlnThr: 1.48 ± 0.036	2.134GlnVal: 2.134 ± 0.047	0.343GlnTrp: 0.343 ± 0.017	0.489GlnTyr: 0.489 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.598ArgAla: 8.598 ± 0.107	0.572ArgCys: 0.572 ± 0.02	4.463ArgAsp: 4.463 ± 0.065	5.501ArgGlu: 5.501 ± 0.074	3.094ArgPhe: 3.094 ± 0.05	5.788ArgGly: 5.788 ± 0.07	2.062ArgHis: 2.062 ± 0.043	4.023ArgIle: 4.023 ± 0.058	2.045ArgLys: 2.045 ± 0.042	9.11ArgLeu: 9.11 ± 0.097	2.012ArgMet: 2.012 ± 0.044	1.782ArgAsn: 1.782 ± 0.039	4.324ArgPro: 4.324 ± 0.067	2.697ArgGln: 2.697 ± 0.047	7.599ArgArg: 7.599 ± 0.094	4.104ArgSer: 4.104 ± 0.074	3.613ArgThr: 3.613 ± 0.058	5.44ArgVal: 5.44 ± 0.072	1.053ArgTrp: 1.053 ± 0.033	1.746ArgTyr: 1.746 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.75SerAla: 5.75 ± 0.073	0.448SerCys: 0.448 ± 0.019	2.735SerAsp: 2.735 ± 0.054	3.118SerGlu: 3.118 ± 0.057	2.205SerPhe: 2.205 ± 0.049	5.482SerGly: 5.482 ± 0.067	1.094SerHis: 1.094 ± 0.029	2.453SerIle: 2.453 ± 0.05	1.098SerLys: 1.098 ± 0.031	5.367SerLeu: 5.367 ± 0.077	1.217SerMet: 1.217 ± 0.029	1.065SerAsn: 1.065 ± 0.034	2.882SerPro: 2.882 ± 0.048	1.425SerGln: 1.425 ± 0.037	3.995SerArg: 3.995 ± 0.062	2.711SerSer: 2.711 ± 0.064	2.381SerThr: 2.381 ± 0.047	3.79SerVal: 3.79 ± 0.053	0.735SerTrp: 0.735 ± 0.025	1.19SerTyr: 1.19 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.886ThrAla: 5.886 ± 0.068	0.433ThrCys: 0.433 ± 0.018	2.519ThrAsp: 2.519 ± 0.041	2.795ThrGlu: 2.795 ± 0.052	1.957ThrPhe: 1.957 ± 0.046	5.127ThrGly: 5.127 ± 0.063	0.917ThrHis: 0.917 ± 0.029	2.662ThrIle: 2.662 ± 0.051	1.196ThrLys: 1.196 ± 0.035	5.544ThrLeu: 5.544 ± 0.066	1.212ThrMet: 1.212 ± 0.032	1.087ThrAsn: 1.087 ± 0.027	3.069ThrPro: 3.069 ± 0.051	1.239ThrGln: 1.239 ± 0.037	3.446ThrArg: 3.446 ± 0.057	2.723ThrSer: 2.723 ± 0.048	2.67ThrThr: 2.67 ± 0.051	4.366ThrVal: 4.366 ± 0.059	0.588ThrTrp: 0.588 ± 0.023	1.164ThrTyr: 1.164 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.251ValAla: 10.251 ± 0.104	0.685ValCys: 0.685 ± 0.023	4.316ValAsp: 4.316 ± 0.057	5.659ValGlu: 5.659 ± 0.067	2.948ValPhe: 2.948 ± 0.057	6.185ValGly: 6.185 ± 0.079	1.48ValHis: 1.48 ± 0.035	3.636ValIle: 3.636 ± 0.059	1.929ValLys: 1.929 ± 0.047	7.809ValLeu: 7.809 ± 0.092	1.92ValMet: 1.92 ± 0.04	1.734ValAsn: 1.734 ± 0.043	4.21ValPro: 4.21 ± 0.058	1.9ValGln: 1.9 ± 0.042	5.563ValArg: 5.563 ± 0.075	4.436ValSer: 4.436 ± 0.061	4.586ValThr: 4.586 ± 0.059	6.756ValVal: 6.756 ± 0.094	0.976ValTrp: 0.976 ± 0.027	1.552ValTyr: 1.552 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.282TrpAla: 1.282 ± 0.038	0.141TrpCys: 0.141 ± 0.011	0.66TrpAsp: 0.66 ± 0.026	0.614TrpGlu: 0.614 ± 0.023	0.481TrpPhe: 0.481 ± 0.018	0.926TrpGly: 0.926 ± 0.026	0.332TrpHis: 0.332 ± 0.016	0.655TrpIle: 0.655 ± 0.025	0.347TrpLys: 0.347 ± 0.018	1.632TrpLeu: 1.632 ± 0.039	0.338TrpMet: 0.338 ± 0.019	0.364TrpAsn: 0.364 ± 0.017	0.749TrpPro: 0.749 ± 0.026	0.527TrpGln: 0.527 ± 0.019	1.337TrpArg: 1.337 ± 0.032	0.795TrpSer: 0.795 ± 0.029	0.729TrpThr: 0.729 ± 0.028	0.787TrpVal: 0.787 ± 0.027	0.22TrpTrp: 0.22 ± 0.014	0.264TrpTyr: 0.264 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.325TyrAla: 2.325 ± 0.048	0.215TyrCys: 0.215 ± 0.015	1.386TyrAsp: 1.386 ± 0.037	1.434TyrGlu: 1.434 ± 0.036	0.809TyrPhe: 0.809 ± 0.029	2.049TyrGly: 2.049 ± 0.041	0.464TyrHis: 0.464 ± 0.02	0.732TyrIle: 0.732 ± 0.028	0.422TyrLys: 0.422 ± 0.021	2.278TyrLeu: 2.278 ± 0.051	0.402TyrMet: 0.402 ± 0.017	0.481TyrAsn: 0.481 ± 0.02	1.022TyrPro: 1.022 ± 0.03	0.583TyrGln: 0.583 ± 0.021	1.927TyrArg: 1.927 ± 0.041	0.985TyrSer: 0.985 ± 0.028	0.969TyrThr: 0.969 ± 0.032	1.648TyrVal: 1.648 ± 0.039	0.346TyrTrp: 0.346 ± 0.019	0.537TyrTyr: 0.537 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4164 proteins (1287530 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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