Amino acid dipepetide frequency for Lake Sarah-associated circular virus-28

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.613AlaAla: 6.613 ± 1.415
0.735AlaCys: 0.735 ± 0.419
3.674AlaAsp: 3.674 ± 1.215
0.735AlaGlu: 0.735 ± 0.686
0.735AlaPhe: 0.735 ± 0.419
5.143AlaGly: 5.143 ± 0.755
2.939AlaHis: 2.939 ± 0.064
3.674AlaIle: 3.674 ± 0.658
2.939AlaLys: 2.939 ± 1.113
3.674AlaLeu: 3.674 ± 0.658
0.735AlaMet: 0.735 ± 0.675
3.674AlaAsn: 3.674 ± 2.472
1.47AlaPro: 1.47 ± 1.372
0.735AlaGln: 0.735 ± 0.419
5.143AlaArg: 5.143 ± 2.087
5.143AlaSer: 5.143 ± 0.553
2.939AlaThr: 2.939 ± 2.005
5.878AlaVal: 5.878 ± 2.714
1.47AlaTrp: 1.47 ± 0.557
1.47AlaTyr: 1.47 ± 0.861
0.0AlaXaa: 0.0 ± 0.0
Cys
2.939CysAla: 2.939 ± 0.064
0.0CysCys: 0.0 ± 0.0
2.939CysAsp: 2.939 ± 1.036
0.0CysGlu: 0.0 ± 0.0
2.204CysPhe: 2.204 ± 0.614
0.735CysGly: 0.735 ± 0.419
1.47CysHis: 1.47 ± 0.557
2.939CysIle: 2.939 ± 0.064
3.674CysLys: 3.674 ± 0.737
1.47CysLeu: 1.47 ± 0.839
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.735CysArg: 0.735 ± 0.675
0.735CysSer: 0.735 ± 0.419
2.939CysThr: 2.939 ± 0.926
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.735CysTyr: 0.735 ± 0.675
0.0CysXaa: 0.0 ± 0.0
Asp
3.674AspAla: 3.674 ± 0.737
5.878AspCys: 5.878 ± 2.612
8.817AspAsp: 8.817 ± 2.089
2.204AspGlu: 2.204 ± 0.718
4.409AspPhe: 4.409 ± 0.888
5.878AspGly: 5.878 ± 0.129
1.47AspHis: 1.47 ± 0.839
4.409AspIle: 4.409 ± 0.821
2.204AspLys: 2.204 ± 0.614
1.47AspLeu: 1.47 ± 0.498
2.204AspMet: 2.204 ± 1.387
4.409AspAsn: 4.409 ± 1.801
5.878AspPro: 5.878 ± 2.51
1.47AspGln: 1.47 ± 0.557
2.939AspArg: 2.939 ± 1.113
4.409AspSer: 4.409 ± 0.888
2.204AspThr: 2.204 ± 0.614
5.143AspVal: 5.143 ± 0.476
0.735AspTrp: 0.735 ± 0.419
1.47AspTyr: 1.47 ± 0.557
0.0AspXaa: 0.0 ± 0.0
Glu
1.47GluAla: 1.47 ± 0.861
0.735GluCys: 0.735 ± 0.419
2.204GluAsp: 2.204 ± 1.258
5.878GluGlu: 5.878 ± 1.173
3.674GluPhe: 3.674 ± 0.404
0.735GluGly: 0.735 ± 0.686
0.735GluHis: 0.735 ± 0.419
4.409GluIle: 4.409 ± 0.44
1.47GluLys: 1.47 ± 0.557
3.674GluLeu: 3.674 ± 2.651
1.47GluMet: 1.47 ± 0.839
3.674GluAsn: 3.674 ± 1.672
2.204GluPro: 2.204 ± 1.387
1.47GluGln: 1.47 ± 0.861
2.204GluArg: 2.204 ± 1.164
0.735GluSer: 0.735 ± 0.675
2.939GluThr: 2.939 ± 1.113
2.204GluVal: 2.204 ± 1.164
0.735GluTrp: 0.735 ± 0.675
5.143GluTyr: 5.143 ± 2.98
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
1.47PheCys: 1.47 ± 0.839
0.735PheAsp: 0.735 ± 0.419
2.939PheGlu: 2.939 ± 1.012
2.204PhePhe: 2.204 ± 1.258
2.204PheGly: 2.204 ± 1.403
0.0PheHis: 0.0 ± 0.0
3.674PheIle: 3.674 ± 1.682
2.204PheLys: 2.204 ± 0.718
1.47PheLeu: 1.47 ± 0.861
2.204PheMet: 2.204 ± 1.387
4.409PheAsn: 4.409 ± 1.801
3.674PhePro: 3.674 ± 1.215
3.674PheGln: 3.674 ± 0.404
2.939PheArg: 2.939 ± 1.036
3.674PheSer: 3.674 ± 0.658
2.204PheThr: 2.204 ± 1.258
2.204PheVal: 2.204 ± 1.403
0.735PheTrp: 0.735 ± 0.419
0.735PheTyr: 0.735 ± 0.419
0.0PheXaa: 0.0 ± 0.0
Gly
3.674GlyAla: 3.674 ± 0.404
1.47GlyCys: 1.47 ± 0.557
5.143GlyAsp: 5.143 ± 1.24
2.204GlyGlu: 2.204 ± 0.718
3.674GlyPhe: 3.674 ± 0.404
11.021GlyGly: 11.021 ± 2.414
0.0GlyHis: 0.0 ± 0.0
5.143GlyIle: 5.143 ± 1.24
6.613GlyLys: 6.613 ± 1.331
3.674GlyLeu: 3.674 ± 1.595
2.204GlyMet: 2.204 ± 0.444
5.878GlyAsn: 5.878 ± 1.054
2.939GlyPro: 2.939 ± 0.926
0.735GlyGln: 0.735 ± 0.419
0.735GlyArg: 0.735 ± 0.419
6.613GlySer: 6.613 ± 1.988
3.674GlyThr: 3.674 ± 1.672
5.143GlyVal: 5.143 ± 2.1
0.735GlyTrp: 0.735 ± 0.686
1.47GlyTyr: 1.47 ± 0.839
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.735HisCys: 0.735 ± 0.686
0.0HisAsp: 0.0 ± 0.0
0.735HisGlu: 0.735 ± 0.419
0.0HisPhe: 0.0 ± 0.0
0.735HisGly: 0.735 ± 0.419
0.0HisHis: 0.0 ± 0.0
2.204HisIle: 2.204 ± 1.123
0.735HisLys: 0.735 ± 0.419
2.204HisLeu: 2.204 ± 0.718
0.0HisMet: 0.0 ± 0.0
0.735HisAsn: 0.735 ± 0.419
2.204HisPro: 2.204 ± 1.164
0.0HisGln: 0.0 ± 0.0
1.47HisArg: 1.47 ± 0.498
1.47HisSer: 1.47 ± 0.498
1.47HisThr: 1.47 ± 1.372
5.143HisVal: 5.143 ± 1.229
0.735HisTrp: 0.735 ± 0.419
0.735HisTyr: 0.735 ± 0.686
0.0HisXaa: 0.0 ± 0.0
Ile
6.613IleAla: 6.613 ± 0.971
1.47IleCys: 1.47 ± 0.839
4.409IleAsp: 4.409 ± 1.437
2.939IleGlu: 2.939 ± 2.005
2.204IlePhe: 2.204 ± 1.403
4.409IleGly: 4.409 ± 0.821
1.47IleHis: 1.47 ± 0.498
3.674IleIle: 3.674 ± 0.658
5.143IleLys: 5.143 ± 1.433
0.735IleLeu: 0.735 ± 0.686
0.0IleMet: 0.0 ± 0.556
3.674IleAsn: 3.674 ± 1.3
8.082IlePro: 8.082 ± 2.993
0.735IleGln: 0.735 ± 0.419
2.939IleArg: 2.939 ± 2.744
1.47IleSer: 1.47 ± 0.498
4.409IleThr: 4.409 ± 1.343
2.939IleVal: 2.939 ± 0.064
0.0IleTrp: 0.0 ± 0.0
1.47IleTyr: 1.47 ± 0.557
0.0IleXaa: 0.0 ± 0.0
Lys
2.939LysAla: 2.939 ± 1.82
0.735LysCys: 0.735 ± 0.419
7.348LysAsp: 7.348 ± 1.472
2.204LysGlu: 2.204 ± 1.387
2.204LysPhe: 2.204 ± 1.164
2.204LysGly: 2.204 ± 0.718
0.735LysHis: 0.735 ± 0.686
2.204LysIle: 2.204 ± 1.403
3.674LysLys: 3.674 ± 0.737
5.143LysLeu: 5.143 ± 1.229
1.47LysMet: 1.47 ± 0.771
1.47LysAsn: 1.47 ± 0.498
5.878LysPro: 5.878 ± 1.852
1.47LysGln: 1.47 ± 0.557
2.939LysArg: 2.939 ± 1.82
5.143LysSer: 5.143 ± 0.476
2.204LysThr: 2.204 ± 1.258
1.47LysVal: 1.47 ± 0.557
0.735LysTrp: 0.735 ± 0.675
4.409LysTyr: 4.409 ± 0.617
0.0LysXaa: 0.0 ± 0.0
Leu
2.204LeuAla: 2.204 ± 0.444
0.735LeuCys: 0.735 ± 0.686
2.939LeuAsp: 2.939 ± 0.995
3.674LeuGlu: 3.674 ± 1.408
0.0LeuPhe: 0.0 ± 0.0
5.878LeuGly: 5.878 ± 0.877
2.204LeuHis: 2.204 ± 0.444
5.143LeuIle: 5.143 ± 0.476
2.939LeuLys: 2.939 ± 1.036
0.735LeuLeu: 0.735 ± 0.419
2.204LeuMet: 2.204 ± 0.718
2.939LeuAsn: 2.939 ± 1.113
2.939LeuPro: 2.939 ± 1.678
3.674LeuGln: 3.674 ± 1.304
3.674LeuArg: 3.674 ± 1.672
6.613LeuSer: 6.613 ± 1.655
2.939LeuThr: 2.939 ± 0.926
0.735LeuVal: 0.735 ± 0.686
0.735LeuTrp: 0.735 ± 0.419
3.674LeuTyr: 3.674 ± 0.737
0.0LeuXaa: 0.0 ± 0.0
Met
3.674MetAla: 3.674 ± 1.408
0.0MetCys: 0.0 ± 0.0
2.204MetAsp: 2.204 ± 0.444
0.735MetGlu: 0.735 ± 0.419
0.735MetPhe: 0.735 ± 0.675
1.47MetGly: 1.47 ± 0.498
0.735MetHis: 0.735 ± 0.419
0.735MetIle: 0.735 ± 0.686
0.735MetLys: 0.735 ± 0.675
1.47MetLeu: 1.47 ± 0.498
2.204MetMet: 2.204 ± 1.258
2.939MetAsn: 2.939 ± 1.012
1.47MetPro: 1.47 ± 0.839
0.0MetGln: 0.0 ± 0.0
0.735MetArg: 0.735 ± 0.419
2.204MetSer: 2.204 ± 1.403
2.204MetThr: 2.204 ± 0.444
1.47MetVal: 1.47 ± 0.557
0.735MetTrp: 0.735 ± 0.419
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.674AsnAla: 3.674 ± 1.672
0.735AsnCys: 0.735 ± 0.675
2.204AsnAsp: 2.204 ± 1.123
3.674AsnGlu: 3.674 ± 1.682
0.735AsnPhe: 0.735 ± 0.419
3.674AsnGly: 3.674 ± 1.3
0.735AsnHis: 0.735 ± 0.675
2.204AsnIle: 2.204 ± 0.614
3.674AsnLys: 3.674 ± 2.097
3.674AsnLeu: 3.674 ± 1.036
1.47AsnMet: 1.47 ± 0.839
6.613AsnAsn: 6.613 ± 0.971
5.878AsnPro: 5.878 ± 1.99
1.47AsnGln: 1.47 ± 0.839
2.939AsnArg: 2.939 ± 1.029
5.143AsnSer: 5.143 ± 0.755
3.674AsnThr: 3.674 ± 1.595
1.47AsnVal: 1.47 ± 0.839
1.47AsnTrp: 1.47 ± 0.498
2.204AsnTyr: 2.204 ± 0.718
0.0AsnXaa: 0.0 ± 0.0
Pro
0.735ProAla: 0.735 ± 0.419
0.0ProCys: 0.0 ± 0.0
5.143ProAsp: 5.143 ± 1.433
2.939ProGlu: 2.939 ± 1.036
0.735ProPhe: 0.735 ± 0.686
4.409ProGly: 4.409 ± 1.696
2.204ProHis: 2.204 ± 0.718
3.674ProIle: 3.674 ± 2.097
5.143ProLys: 5.143 ± 1.748
4.409ProLeu: 4.409 ± 1.801
2.204ProMet: 2.204 ± 1.258
1.47ProAsn: 1.47 ± 0.498
16.165ProPro: 16.165 ± 7.531
0.0ProGln: 0.0 ± 0.0
3.674ProArg: 3.674 ± 0.404
5.878ProSer: 5.878 ± 1.99
6.613ProThr: 6.613 ± 1.841
6.613ProVal: 6.613 ± 1.259
1.47ProTrp: 1.47 ± 0.839
2.204ProTyr: 2.204 ± 1.258
0.0ProXaa: 0.0 ± 0.0
Gln
0.735GlnAla: 0.735 ± 0.419
0.0GlnCys: 0.0 ± 0.0
2.204GlnAsp: 2.204 ± 1.164
0.735GlnGlu: 0.735 ± 0.419
2.204GlnPhe: 2.204 ± 0.614
2.939GlnGly: 2.939 ± 1.012
0.735GlnHis: 0.735 ± 0.686
0.735GlnIle: 0.735 ± 0.675
2.204GlnLys: 2.204 ± 1.123
2.204GlnLeu: 2.204 ± 0.444
0.0GlnMet: 0.0 ± 0.0
2.939GlnAsn: 2.939 ± 0.995
0.735GlnPro: 0.735 ± 0.675
0.0GlnGln: 0.0 ± 0.0
0.735GlnArg: 0.735 ± 0.419
2.939GlnSer: 2.939 ± 1.029
1.47GlnThr: 1.47 ± 0.557
0.735GlnVal: 0.735 ± 0.419
1.47GlnTrp: 1.47 ± 0.839
2.939GlnTyr: 2.939 ± 1.029
0.0GlnXaa: 0.0 ± 0.0
Arg
5.143ArgAla: 5.143 ± 1.433
2.939ArgCys: 2.939 ± 1.029
2.204ArgAsp: 2.204 ± 0.444
2.939ArgGlu: 2.939 ± 1.722
2.939ArgPhe: 2.939 ± 0.064
1.47ArgGly: 1.47 ± 0.839
0.735ArgHis: 0.735 ± 0.686
2.939ArgIle: 2.939 ± 1.012
2.939ArgLys: 2.939 ± 1.029
4.409ArgLeu: 4.409 ± 0.821
0.735ArgMet: 0.735 ± 0.419
2.204ArgAsn: 2.204 ± 0.444
5.143ArgPro: 5.143 ± 1.733
1.47ArgGln: 1.47 ± 0.557
5.143ArgArg: 5.143 ± 4.036
0.735ArgSer: 0.735 ± 0.675
2.939ArgThr: 2.939 ± 2.034
4.409ArgVal: 4.409 ± 1.412
0.0ArgTrp: 0.0 ± 0.0
2.204ArgTyr: 2.204 ± 1.403
0.0ArgXaa: 0.0 ± 0.0
Ser
2.939SerAla: 2.939 ± 1.793
2.204SerCys: 2.204 ± 0.614
5.878SerAsp: 5.878 ± 1.054
3.674SerGlu: 3.674 ± 1.304
2.939SerPhe: 2.939 ± 1.036
6.613SerGly: 6.613 ± 0.636
1.47SerHis: 1.47 ± 1.372
4.409SerIle: 4.409 ± 1.343
2.939SerLys: 2.939 ± 1.012
2.939SerLeu: 2.939 ± 0.926
1.47SerMet: 1.47 ± 0.498
2.204SerAsn: 2.204 ± 0.444
0.735SerPro: 0.735 ± 0.675
5.143SerGln: 5.143 ± 1.405
5.143SerArg: 5.143 ± 1.405
4.409SerSer: 4.409 ± 2.245
2.939SerThr: 2.939 ± 1.793
5.143SerVal: 5.143 ± 2.912
2.204SerTrp: 2.204 ± 0.718
2.939SerTyr: 2.939 ± 0.926
0.0SerXaa: 0.0 ± 0.0
Thr
5.878ThrAla: 5.878 ± 2.025
0.735ThrCys: 0.735 ± 0.686
2.204ThrAsp: 2.204 ± 0.614
1.47ThrGlu: 1.47 ± 1.35
4.409ThrPhe: 4.409 ± 0.617
4.409ThrGly: 4.409 ± 1.227
0.735ThrHis: 0.735 ± 0.419
1.47ThrIle: 1.47 ± 0.498
2.939ThrLys: 2.939 ± 1.113
5.878ThrLeu: 5.878 ± 1.628
2.204ThrMet: 2.204 ± 0.933
1.47ThrAsn: 1.47 ± 0.498
5.143ThrPro: 5.143 ± 1.24
4.409ThrGln: 4.409 ± 1.343
1.47ThrArg: 1.47 ± 0.498
2.939ThrSer: 2.939 ± 1.793
4.409ThrThr: 4.409 ± 1.343
1.47ThrVal: 1.47 ± 0.498
0.735ThrTrp: 0.735 ± 0.419
3.674ThrTyr: 3.674 ± 0.658
0.0ThrXaa: 0.0 ± 0.0
Val
3.674ValAla: 3.674 ± 1.672
0.0ValCys: 0.0 ± 0.0
6.613ValAsp: 6.613 ± 2.218
3.674ValGlu: 3.674 ± 1.682
3.674ValPhe: 3.674 ± 1.696
3.674ValGly: 3.674 ± 0.658
2.939ValHis: 2.939 ± 0.064
2.939ValIle: 2.939 ± 1.036
2.204ValLys: 2.204 ± 0.718
4.409ValLeu: 4.409 ± 0.888
0.735ValMet: 0.735 ± 0.686
3.674ValAsn: 3.674 ± 1.036
2.204ValPro: 2.204 ± 1.258
1.47ValGln: 1.47 ± 0.498
5.878ValArg: 5.878 ± 1.082
5.143ValSer: 5.143 ± 2.08
2.204ValThr: 2.204 ± 0.614
4.409ValVal: 4.409 ± 2.329
1.47ValTrp: 1.47 ± 0.498
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
0.735TrpAla: 0.735 ± 0.419
0.735TrpCys: 0.735 ± 0.675
1.47TrpAsp: 1.47 ± 0.839
1.47TrpGlu: 1.47 ± 0.839
0.735TrpPhe: 0.735 ± 0.686
1.47TrpGly: 1.47 ± 0.839
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
1.47TrpAsn: 1.47 ± 0.557
0.0TrpPro: 0.0 ± 0.0
0.735TrpGln: 0.735 ± 0.675
0.0TrpArg: 0.0 ± 0.0
1.47TrpSer: 1.47 ± 0.498
1.47TrpThr: 1.47 ± 0.839
2.204TrpVal: 2.204 ± 0.614
0.735TrpTrp: 0.735 ± 0.686
2.204TrpTyr: 2.204 ± 0.718
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.204TyrAla: 2.204 ± 1.164
2.204TyrCys: 2.204 ± 1.164
2.939TyrAsp: 2.939 ± 1.029
2.939TyrGlu: 2.939 ± 1.82
2.939TyrPhe: 2.939 ± 1.036
3.674TyrGly: 3.674 ± 0.404
0.0TyrHis: 0.0 ± 0.0
2.939TyrIle: 2.939 ± 0.926
2.204TyrLys: 2.204 ± 1.164
2.939TyrLeu: 2.939 ± 1.113
2.204TyrMet: 2.204 ± 1.123
1.47TyrAsn: 1.47 ± 0.839
2.939TyrPro: 2.939 ± 0.926
0.0TyrGln: 0.0 ± 0.0
2.204TyrArg: 2.204 ± 1.403
1.47TyrSer: 1.47 ± 0.861
2.204TyrThr: 2.204 ± 0.444
2.204TyrVal: 2.204 ± 0.718
0.0TyrTrp: 0.0 ± 0.0
2.939TyrTyr: 2.939 ± 1.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1362 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski