Amino acid dipepetide frequency for Dyella soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.659AlaAla: 15.659 ± 0.136
1.238AlaCys: 1.238 ± 0.025
6.614AlaAsp: 6.614 ± 0.059
6.139AlaGlu: 6.139 ± 0.062
4.018AlaPhe: 4.018 ± 0.046
10.24AlaGly: 10.24 ± 0.091
2.817AlaHis: 2.817 ± 0.038
5.436AlaIle: 5.436 ± 0.052
3.471AlaLys: 3.471 ± 0.047
14.108AlaLeu: 14.108 ± 0.106
3.659AlaMet: 3.659 ± 0.044
3.115AlaAsn: 3.115 ± 0.045
5.831AlaPro: 5.831 ± 0.065
5.136AlaGln: 5.136 ± 0.051
8.858AlaArg: 8.858 ± 0.072
7.101AlaSer: 7.101 ± 0.067
6.273AlaThr: 6.273 ± 0.067
8.541AlaVal: 8.541 ± 0.075
2.132AlaTrp: 2.132 ± 0.036
2.58AlaTyr: 2.58 ± 0.035
0.0AlaXaa: 0.0 ± 0.0
Cys
0.979CysAla: 0.979 ± 0.023
0.105CysCys: 0.105 ± 0.007
0.46CysAsp: 0.46 ± 0.016
0.42CysGlu: 0.42 ± 0.015
0.283CysPhe: 0.283 ± 0.01
0.856CysGly: 0.856 ± 0.018
0.282CysHis: 0.282 ± 0.013
0.369CysIle: 0.369 ± 0.013
0.195CysLys: 0.195 ± 0.009
0.859CysLeu: 0.859 ± 0.023
0.183CysMet: 0.183 ± 0.008
0.207CysAsn: 0.207 ± 0.009
0.405CysPro: 0.405 ± 0.013
0.245CysGln: 0.245 ± 0.011
0.549CysArg: 0.549 ± 0.013
0.464CysSer: 0.464 ± 0.017
0.427CysThr: 0.427 ± 0.014
0.67CysVal: 0.67 ± 0.018
0.115CysTrp: 0.115 ± 0.006
0.228CysTyr: 0.228 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.864AspAla: 7.864 ± 0.064
0.389AspCys: 0.389 ± 0.013
3.445AspAsp: 3.445 ± 0.044
3.279AspGlu: 3.279 ± 0.043
2.109AspPhe: 2.109 ± 0.032
5.349AspGly: 5.349 ± 0.068
1.404AspHis: 1.404 ± 0.025
2.645AspIle: 2.645 ± 0.035
1.766AspLys: 1.766 ± 0.031
5.609AspLeu: 5.609 ± 0.06
1.213AspMet: 1.213 ± 0.024
1.454AspAsn: 1.454 ± 0.026
3.114AspPro: 3.114 ± 0.041
1.948AspGln: 1.948 ± 0.029
3.681AspArg: 3.681 ± 0.048
2.598AspSer: 2.598 ± 0.039
2.721AspThr: 2.721 ± 0.036
4.474AspVal: 4.474 ± 0.043
1.045AspTrp: 1.045 ± 0.019
1.63AspTyr: 1.63 ± 0.028
0.0AspXaa: 0.0 ± 0.0
Glu
6.285GluAla: 6.285 ± 0.062
0.351GluCys: 0.351 ± 0.013
2.317GluAsp: 2.317 ± 0.032
2.319GluGlu: 2.319 ± 0.042
1.663GluPhe: 1.663 ± 0.029
3.827GluGly: 3.827 ± 0.046
1.558GluHis: 1.558 ± 0.026
2.177GluIle: 2.177 ± 0.032
1.688GluLys: 1.688 ± 0.028
5.992GluLeu: 5.992 ± 0.06
1.055GluMet: 1.055 ± 0.022
1.225GluAsn: 1.225 ± 0.025
2.422GluPro: 2.422 ± 0.034
2.608GluGln: 2.608 ± 0.037
4.694GluArg: 4.694 ± 0.05
2.657GluSer: 2.657 ± 0.033
2.377GluThr: 2.377 ± 0.032
3.632GluVal: 3.632 ± 0.045
0.688GluTrp: 0.688 ± 0.018
1.08GluTyr: 1.08 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
4.278PheAla: 4.278 ± 0.049
0.308PheCys: 0.308 ± 0.011
2.596PheAsp: 2.596 ± 0.034
1.812PheGlu: 1.812 ± 0.029
1.271PhePhe: 1.271 ± 0.025
3.408PheGly: 3.408 ± 0.041
0.81PheHis: 0.81 ± 0.02
1.357PheIle: 1.357 ± 0.026
0.943PheLys: 0.943 ± 0.021
3.053PheLeu: 3.053 ± 0.04
0.723PheMet: 0.723 ± 0.015
1.158PheAsn: 1.158 ± 0.023
1.499PhePro: 1.499 ± 0.026
1.055PheGln: 1.055 ± 0.02
2.212PheArg: 2.212 ± 0.034
2.023PheSer: 2.023 ± 0.027
1.808PheThr: 1.808 ± 0.028
2.744PheVal: 2.744 ± 0.034
0.497PheTrp: 0.497 ± 0.015
0.928PheTyr: 0.928 ± 0.019
0.0PheXaa: 0.0 ± 0.0
Gly
8.828GlyAla: 8.828 ± 0.083
0.796GlyCys: 0.796 ± 0.019
4.73GlyAsp: 4.73 ± 0.054
4.557GlyGlu: 4.557 ± 0.055
3.228GlyPhe: 3.228 ± 0.039
6.947GlyGly: 6.947 ± 0.101
2.229GlyHis: 2.229 ± 0.034
4.017GlyIle: 4.017 ± 0.048
3.572GlyLys: 3.572 ± 0.044
8.326GlyLeu: 8.326 ± 0.073
2.477GlyMet: 2.477 ± 0.037
2.504GlyAsn: 2.504 ± 0.047
3.107GlyPro: 3.107 ± 0.042
3.312GlyGln: 3.312 ± 0.039
5.536GlyArg: 5.536 ± 0.056
5.072GlySer: 5.072 ± 0.065
4.597GlyThr: 4.597 ± 0.09
6.616GlyVal: 6.616 ± 0.062
1.618GlyTrp: 1.618 ± 0.026
2.569GlyTyr: 2.569 ± 0.035
0.0GlyXaa: 0.0 ± 0.0
His
3.293HisAla: 3.293 ± 0.038
0.248HisCys: 0.248 ± 0.01
1.48HisAsp: 1.48 ± 0.025
1.285HisGlu: 1.285 ± 0.023
0.932HisPhe: 0.932 ± 0.02
2.524HisGly: 2.524 ± 0.036
0.699HisHis: 0.699 ± 0.02
0.938HisIle: 0.938 ± 0.018
0.534HisLys: 0.534 ± 0.016
2.346HisLeu: 2.346 ± 0.034
0.613HisMet: 0.613 ± 0.017
0.521HisAsn: 0.521 ± 0.016
1.561HisPro: 1.561 ± 0.028
0.776HisGln: 0.776 ± 0.019
1.711HisArg: 1.711 ± 0.026
1.1HisSer: 1.1 ± 0.02
1.087HisThr: 1.087 ± 0.02
1.928HisVal: 1.928 ± 0.028
0.5HisTrp: 0.5 ± 0.014
0.718HisTyr: 0.718 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
6.038IleAla: 6.038 ± 0.052
0.382IleCys: 0.382 ± 0.015
3.339IleAsp: 3.339 ± 0.031
2.869IleGlu: 2.869 ± 0.042
1.257IlePhe: 1.257 ± 0.027
4.322IleGly: 4.322 ± 0.055
0.984IleHis: 0.984 ± 0.022
1.566IleIle: 1.566 ± 0.027
1.286IleLys: 1.286 ± 0.023
3.162IleLeu: 3.162 ± 0.041
0.666IleMet: 0.666 ± 0.018
1.452IleAsn: 1.452 ± 0.029
2.039IlePro: 2.039 ± 0.032
1.235IleGln: 1.235 ± 0.025
2.727IleArg: 2.727 ± 0.035
2.375IleSer: 2.375 ± 0.036
2.492IleThr: 2.492 ± 0.038
3.546IleVal: 3.546 ± 0.044
0.502IleTrp: 0.502 ± 0.014
1.04IleTyr: 1.04 ± 0.02
0.0IleXaa: 0.0 ± 0.0
Lys
3.755LysAla: 3.755 ± 0.047
0.147LysCys: 0.147 ± 0.008
1.72LysAsp: 1.72 ± 0.026
1.372LysGlu: 1.372 ± 0.028
0.807LysPhe: 0.807 ± 0.02
2.351LysGly: 2.351 ± 0.035
0.693LysHis: 0.693 ± 0.017
1.2LysIle: 1.2 ± 0.026
1.104LysLys: 1.104 ± 0.028
3.327LysLeu: 3.327 ± 0.039
0.638LysMet: 0.638 ± 0.016
0.791LysAsn: 0.791 ± 0.02
2.063LysPro: 2.063 ± 0.033
1.294LysGln: 1.294 ± 0.023
2.111LysArg: 2.111 ± 0.031
1.665LysSer: 1.665 ± 0.031
1.543LysThr: 1.543 ± 0.025
2.36LysVal: 2.36 ± 0.033
0.338LysTrp: 0.338 ± 0.012
0.691LysTyr: 0.691 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
14.434LeuAla: 14.434 ± 0.1
0.969LeuCys: 0.969 ± 0.02
6.413LeuAsp: 6.413 ± 0.058
5.051LeuGlu: 5.051 ± 0.052
3.431LeuPhe: 3.431 ± 0.046
8.811LeuGly: 8.811 ± 0.067
2.534LeuHis: 2.534 ± 0.034
4.357LeuIle: 4.357 ± 0.047
3.329LeuLys: 3.329 ± 0.042
11.27LeuLeu: 11.27 ± 0.112
2.321LeuMet: 2.321 ± 0.034
2.612LeuAsn: 2.612 ± 0.035
6.3LeuPro: 6.3 ± 0.055
3.638LeuGln: 3.638 ± 0.045
7.985LeuArg: 7.985 ± 0.072
6.3LeuSer: 6.3 ± 0.058
5.289LeuThr: 5.289 ± 0.052
7.752LeuVal: 7.752 ± 0.064
1.401LeuTrp: 1.401 ± 0.025
2.188LeuTyr: 2.188 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
2.939MetAla: 2.939 ± 0.037
0.159MetCys: 0.159 ± 0.008
1.214MetAsp: 1.214 ± 0.023
1.02MetGlu: 1.02 ± 0.021
0.729MetPhe: 0.729 ± 0.019
1.752MetGly: 1.752 ± 0.032
0.614MetHis: 0.614 ± 0.016
0.991MetIle: 0.991 ± 0.02
0.857MetLys: 0.857 ± 0.02
2.662MetLeu: 2.662 ± 0.038
0.506MetMet: 0.506 ± 0.014
0.731MetAsn: 0.731 ± 0.017
1.499MetPro: 1.499 ± 0.025
1.02MetGln: 1.02 ± 0.021
1.851MetArg: 1.851 ± 0.03
1.747MetSer: 1.747 ± 0.026
1.467MetThr: 1.467 ± 0.02
1.623MetVal: 1.623 ± 0.027
0.252MetTrp: 0.252 ± 0.011
0.419MetTyr: 0.419 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.333AsnAla: 3.333 ± 0.043
0.186AsnCys: 0.186 ± 0.009
1.592AsnAsp: 1.592 ± 0.028
1.242AsnGlu: 1.242 ± 0.026
0.974AsnPhe: 0.974 ± 0.024
2.658AsnGly: 2.658 ± 0.052
0.61AsnHis: 0.61 ± 0.015
1.217AsnIle: 1.217 ± 0.027
0.693AsnLys: 0.693 ± 0.018
2.711AsnLeu: 2.711 ± 0.035
0.521AsnMet: 0.521 ± 0.015
0.854AsnAsn: 0.854 ± 0.03
1.687AsnPro: 1.687 ± 0.025
0.962AsnGln: 0.962 ± 0.02
1.656AsnArg: 1.656 ± 0.027
1.281AsnSer: 1.281 ± 0.031
1.452AsnThr: 1.452 ± 0.033
2.031AsnVal: 2.031 ± 0.036
0.431AsnTrp: 0.431 ± 0.015
0.82AsnTyr: 0.82 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
6.726ProAla: 6.726 ± 0.064
0.336ProCys: 0.336 ± 0.013
3.377ProAsp: 3.377 ± 0.041
3.017ProGlu: 3.017 ± 0.037
1.743ProPhe: 1.743 ± 0.027
4.723ProGly: 4.723 ± 0.05
1.169ProHis: 1.169 ± 0.022
1.914ProIle: 1.914 ± 0.031
1.401ProLys: 1.401 ± 0.029
5.097ProLeu: 5.097 ± 0.055
1.39ProMet: 1.39 ± 0.028
1.34ProAsn: 1.34 ± 0.027
2.754ProPro: 2.754 ± 0.043
2.007ProGln: 2.007 ± 0.031
3.143ProArg: 3.143 ± 0.04
2.983ProSer: 2.983 ± 0.038
2.57ProThr: 2.57 ± 0.034
4.177ProVal: 4.177 ± 0.04
0.908ProTrp: 0.908 ± 0.02
1.236ProTyr: 1.236 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
5.169GlnAla: 5.169 ± 0.053
0.241GlnCys: 0.241 ± 0.011
1.652GlnAsp: 1.652 ± 0.027
1.458GlnGlu: 1.458 ± 0.028
1.253GlnPhe: 1.253 ± 0.024
3.073GlnGly: 3.073 ± 0.039
1.001GlnHis: 1.001 ± 0.02
1.63GlnIle: 1.63 ± 0.028
1.014GlnLys: 1.014 ± 0.023
4.412GlnLeu: 4.412 ± 0.051
0.879GlnMet: 0.879 ± 0.021
0.852GlnAsn: 0.852 ± 0.021
2.238GlnPro: 2.238 ± 0.03
1.956GlnGln: 1.956 ± 0.035
3.431GlnArg: 3.431 ± 0.037
2.045GlnSer: 2.045 ± 0.032
1.704GlnThr: 1.704 ± 0.027
2.996GlnVal: 2.996 ± 0.039
0.665GlnTrp: 0.665 ± 0.015
0.869GlnTyr: 0.869 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
7.721ArgAla: 7.721 ± 0.063
0.58ArgCys: 0.58 ± 0.016
4.22ArgAsp: 4.22 ± 0.054
4.353ArgGlu: 4.353 ± 0.05
2.697ArgPhe: 2.697 ± 0.033
4.989ArgGly: 4.989 ± 0.053
2.081ArgHis: 2.081 ± 0.033
3.476ArgIle: 3.476 ± 0.044
2.151ArgLys: 2.151 ± 0.032
8.062ArgLeu: 8.062 ± 0.069
1.932ArgMet: 1.932 ± 0.03
1.814ArgAsn: 1.814 ± 0.028
3.245ArgPro: 3.245 ± 0.042
3.059ArgGln: 3.059 ± 0.038
5.608ArgArg: 5.608 ± 0.063
3.691ArgSer: 3.691 ± 0.04
3.225ArgThr: 3.225 ± 0.039
5.216ArgVal: 5.216 ± 0.052
1.364ArgTrp: 1.364 ± 0.026
2.094ArgTyr: 2.094 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.243SerAla: 6.243 ± 0.063
0.449SerCys: 0.449 ± 0.013
3.028SerAsp: 3.028 ± 0.046
2.52SerGlu: 2.52 ± 0.039
2.149SerPhe: 2.149 ± 0.031
5.278SerGly: 5.278 ± 0.069
1.359SerHis: 1.359 ± 0.024
2.518SerIle: 2.518 ± 0.041
1.552SerLys: 1.552 ± 0.032
6.084SerLeu: 6.084 ± 0.052
1.445SerMet: 1.445 ± 0.027
1.545SerAsn: 1.545 ± 0.032
2.956SerPro: 2.956 ± 0.038
2.053SerGln: 2.053 ± 0.034
3.85SerArg: 3.85 ± 0.044
3.384SerSer: 3.384 ± 0.055
3.116SerThr: 3.116 ± 0.05
4.169SerVal: 4.169 ± 0.05
0.886SerTrp: 0.886 ± 0.021
1.489SerTyr: 1.489 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
5.751ThrAla: 5.751 ± 0.071
0.422ThrCys: 0.422 ± 0.015
2.806ThrAsp: 2.806 ± 0.038
2.202ThrGlu: 2.202 ± 0.029
1.788ThrPhe: 1.788 ± 0.031
4.643ThrGly: 4.643 ± 0.063
1.276ThrHis: 1.276 ± 0.021
2.186ThrIle: 2.186 ± 0.031
1.167ThrLys: 1.167 ± 0.02
6.129ThrLeu: 6.129 ± 0.068
1.071ThrMet: 1.071 ± 0.02
1.26ThrAsn: 1.26 ± 0.031
3.404ThrPro: 3.404 ± 0.044
1.893ThrGln: 1.893 ± 0.03
3.454ThrArg: 3.454 ± 0.045
2.907ThrSer: 2.907 ± 0.051
2.886ThrThr: 2.886 ± 0.058
4.114ThrVal: 4.114 ± 0.052
0.753ThrTrp: 0.753 ± 0.019
1.325ThrTyr: 1.325 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
9.457ValAla: 9.457 ± 0.074
0.639ValCys: 0.639 ± 0.018
4.61ValAsp: 4.61 ± 0.052
3.988ValGlu: 3.988 ± 0.042
2.547ValPhe: 2.547 ± 0.034
5.634ValGly: 5.634 ± 0.051
1.691ValHis: 1.691 ± 0.029
3.648ValIle: 3.648 ± 0.044
2.115ValLys: 2.115 ± 0.033
8.289ValLeu: 8.289 ± 0.065
1.833ValMet: 1.833 ± 0.03
2.197ValAsn: 2.197 ± 0.041
3.881ValPro: 3.881 ± 0.039
2.57ValGln: 2.57 ± 0.03
5.111ValArg: 5.111 ± 0.054
4.445ValSer: 4.445 ± 0.047
4.261ValThr: 4.261 ± 0.053
6.248ValVal: 6.248 ± 0.058
0.921ValTrp: 0.921 ± 0.019
1.679ValTyr: 1.679 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.283TrpAla: 1.283 ± 0.026
0.154TrpCys: 0.154 ± 0.008
0.662TrpAsp: 0.662 ± 0.018
0.545TrpGlu: 0.545 ± 0.015
0.635TrpPhe: 0.635 ± 0.017
0.953TrpGly: 0.953 ± 0.024
0.466TrpHis: 0.466 ± 0.013
0.736TrpIle: 0.736 ± 0.017
0.501TrpLys: 0.501 ± 0.013
2.306TrpLeu: 2.306 ± 0.031
0.478TrpMet: 0.478 ± 0.014
0.537TrpAsn: 0.537 ± 0.016
0.783TrpPro: 0.783 ± 0.018
0.806TrpGln: 0.806 ± 0.019
1.355TrpArg: 1.355 ± 0.027
0.959TrpSer: 0.959 ± 0.02
0.837TrpThr: 0.837 ± 0.02
1.028TrpVal: 1.028 ± 0.021
0.336TrpTrp: 0.336 ± 0.013
0.386TrpTyr: 0.386 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.931TyrAla: 2.931 ± 0.034
0.204TyrCys: 0.204 ± 0.009
1.463TyrAsp: 1.463 ± 0.028
1.166TyrGlu: 1.166 ± 0.023
0.965TyrPhe: 0.965 ± 0.022
2.3TyrGly: 2.3 ± 0.037
0.517TyrHis: 0.517 ± 0.014
0.901TyrIle: 0.901 ± 0.022
0.625TyrLys: 0.625 ± 0.019
2.58TyrLeu: 2.58 ± 0.033
0.449TyrMet: 0.449 ± 0.013
0.742TyrAsn: 0.742 ± 0.024
1.225TyrPro: 1.225 ± 0.025
0.966TyrGln: 0.966 ± 0.019
2.054TyrArg: 2.054 ± 0.027
1.28TyrSer: 1.28 ± 0.025
1.305TyrThr: 1.305 ± 0.03
1.902TyrVal: 1.902 ± 0.031
0.394TyrTrp: 0.394 ± 0.011
0.749TyrTyr: 0.749 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7160 proteins (2409684 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski