Amino acid dipepetide frequency for Litoreibacter roseus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.347AlaAla: 14.347 ± 0.136	1.102AlaCys: 1.102 ± 0.029	7.027AlaAsp: 7.027 ± 0.08	7.397AlaGlu: 7.397 ± 0.088	4.4AlaPhe: 4.4 ± 0.061	9.26AlaGly: 9.26 ± 0.096	2.249AlaHis: 2.249 ± 0.041	6.095AlaIle: 6.095 ± 0.073	4.101AlaLys: 4.101 ± 0.06	12.682AlaLeu: 12.682 ± 0.114	3.439AlaMet: 3.439 ± 0.049	2.852AlaAsn: 2.852 ± 0.049	5.187AlaPro: 5.187 ± 0.071	4.259AlaGln: 4.259 ± 0.059	7.483AlaArg: 7.483 ± 0.074	5.763AlaSer: 5.763 ± 0.061	5.983AlaThr: 5.983 ± 0.077	8.016AlaVal: 8.016 ± 0.089	1.348AlaTrp: 1.348 ± 0.034	2.57AlaTyr: 2.57 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.07CysAla: 1.07 ± 0.031	0.111CysCys: 0.111 ± 0.01	0.622CysAsp: 0.622 ± 0.023	0.462CysGlu: 0.462 ± 0.018	0.373CysPhe: 0.373 ± 0.016	0.954CysGly: 0.954 ± 0.029	0.258CysHis: 0.258 ± 0.015	0.471CysIle: 0.471 ± 0.017	0.241CysLys: 0.241 ± 0.014	0.868CysLeu: 0.868 ± 0.026	0.162CysMet: 0.162 ± 0.011	0.225CysAsn: 0.225 ± 0.013	0.479CysPro: 0.479 ± 0.021	0.252CysGln: 0.252 ± 0.014	0.493CysArg: 0.493 ± 0.022	0.465CysSer: 0.465 ± 0.019	0.455CysThr: 0.455 ± 0.021	0.708CysVal: 0.708 ± 0.025	0.119CysTrp: 0.119 ± 0.009	0.216CysTyr: 0.216 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.603AspAla: 7.603 ± 0.098	0.516AspCys: 0.516 ± 0.019	3.813AspAsp: 3.813 ± 0.071	3.728AspGlu: 3.728 ± 0.061	2.36AspPhe: 2.36 ± 0.048	5.887AspGly: 5.887 ± 0.08	1.532AspHis: 1.532 ± 0.032	3.646AspIle: 3.646 ± 0.058	1.784AspLys: 1.784 ± 0.041	6.877AspLeu: 6.877 ± 0.078	1.724AspMet: 1.724 ± 0.038	1.426AspAsn: 1.426 ± 0.037	3.651AspPro: 3.651 ± 0.052	2.212AspGln: 2.212 ± 0.037	4.246AspArg: 4.246 ± 0.059	2.189AspSer: 2.189 ± 0.047	3.33AspThr: 3.33 ± 0.053	4.803AspVal: 4.803 ± 0.059	1.179AspTrp: 1.179 ± 0.032	1.527AspTyr: 1.527 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	7.342GluAla: 7.342 ± 0.086	0.355GluCys: 0.355 ± 0.017	3.862GluAsp: 3.862 ± 0.059	3.492GluGlu: 3.492 ± 0.073	1.972GluPhe: 1.972 ± 0.039	4.447GluGly: 4.447 ± 0.062	1.092GluHis: 1.092 ± 0.032	3.849GluIle: 3.849 ± 0.052	2.356GluLys: 2.356 ± 0.047	5.061GluLeu: 5.061 ± 0.068	1.861GluMet: 1.861 ± 0.035	2.093GluAsn: 2.093 ± 0.04	2.52GluPro: 2.52 ± 0.044	2.025GluGln: 2.025 ± 0.043	4.17GluArg: 4.17 ± 0.063	2.116GluSer: 2.116 ± 0.038	4.184GluThr: 4.184 ± 0.056	4.203GluVal: 4.203 ± 0.06	0.652GluTrp: 0.652 ± 0.02	1.083GluTyr: 1.083 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.526PheAla: 4.526 ± 0.06	0.459PheCys: 0.459 ± 0.017	3.001PheAsp: 3.001 ± 0.052	2.618PheGlu: 2.618 ± 0.045	1.592PhePhe: 1.592 ± 0.042	3.874PheGly: 3.874 ± 0.06	0.761PheHis: 0.761 ± 0.026	1.783PheIle: 1.783 ± 0.039	1.107PheLys: 1.107 ± 0.027	3.688PheLeu: 3.688 ± 0.053	0.944PheMet: 0.944 ± 0.026	1.081PheAsn: 1.081 ± 0.028	1.6PhePro: 1.6 ± 0.032	1.186PheGln: 1.186 ± 0.031	2.147PheArg: 2.147 ± 0.035	2.437PheSer: 2.437 ± 0.043	2.139PheThr: 2.139 ± 0.036	2.816PheVal: 2.816 ± 0.05	0.576PheTrp: 0.576 ± 0.021	0.948PheTyr: 0.948 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	8.774GlyAla: 8.774 ± 0.092	0.841GlyCys: 0.841 ± 0.028	4.728GlyAsp: 4.728 ± 0.074	4.413GlyGlu: 4.413 ± 0.059	3.824GlyPhe: 3.824 ± 0.049	6.881GlyGly: 6.881 ± 0.088	1.867GlyHis: 1.867 ± 0.037	4.497GlyIle: 4.497 ± 0.061	3.162GlyLys: 3.162 ± 0.046	8.842GlyLeu: 8.842 ± 0.091	2.38GlyMet: 2.38 ± 0.046	2.06GlyAsn: 2.06 ± 0.046	3.398GlyPro: 3.398 ± 0.045	3.202GlyGln: 3.202 ± 0.047	5.228GlyArg: 5.228 ± 0.066	4.309GlySer: 4.309 ± 0.064	4.761GlyThr: 4.761 ± 0.065	6.193GlyVal: 6.193 ± 0.071	1.392GlyTrp: 1.392 ± 0.035	2.212GlyTyr: 2.212 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.215HisAla: 2.215 ± 0.043	0.222HisCys: 0.222 ± 0.013	1.238HisAsp: 1.238 ± 0.031	1.072HisGlu: 1.072 ± 0.027	0.813HisPhe: 0.813 ± 0.025	1.822HisGly: 1.822 ± 0.042	0.596HisHis: 0.596 ± 0.027	1.074HisIle: 1.074 ± 0.026	0.577HisLys: 0.577 ± 0.022	2.149HisLeu: 2.149 ± 0.049	0.563HisMet: 0.563 ± 0.018	0.476HisAsn: 0.476 ± 0.02	1.288HisPro: 1.288 ± 0.033	0.666HisGln: 0.666 ± 0.022	1.282HisArg: 1.282 ± 0.03	0.946HisSer: 0.946 ± 0.028	0.929HisThr: 0.929 ± 0.026	1.516HisVal: 1.516 ± 0.034	0.345HisTrp: 0.345 ± 0.016	0.542HisTyr: 0.542 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.235IleAla: 7.235 ± 0.073	0.643IleCys: 0.643 ± 0.021	3.833IleAsp: 3.833 ± 0.055	3.778IleGlu: 3.778 ± 0.059	2.065IlePhe: 2.065 ± 0.038	5.004IleGly: 5.004 ± 0.062	0.93IleHis: 0.93 ± 0.024	2.546IleIle: 2.546 ± 0.047	1.686IleLys: 1.686 ± 0.032	5.057IleLeu: 5.057 ± 0.059	1.164IleMet: 1.164 ± 0.034	1.544IleAsn: 1.544 ± 0.037	2.492IlePro: 2.492 ± 0.05	1.357IleGln: 1.357 ± 0.035	3.169IleArg: 3.169 ± 0.051	3.42IleSer: 3.42 ± 0.05	3.032IleThr: 3.032 ± 0.05	4.035IleVal: 4.035 ± 0.055	0.766IleTrp: 0.766 ± 0.028	1.28IleTyr: 1.28 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.997LysAla: 3.997 ± 0.067	0.24LysCys: 0.24 ± 0.014	2.172LysAsp: 2.172 ± 0.044	1.708LysGlu: 1.708 ± 0.037	1.061LysPhe: 1.061 ± 0.028	2.671LysGly: 2.671 ± 0.048	0.689LysHis: 0.689 ± 0.025	1.929LysIle: 1.929 ± 0.038	1.4LysLys: 1.4 ± 0.035	3.318LysLeu: 3.318 ± 0.05	0.949LysMet: 0.949 ± 0.026	1.03LysAsn: 1.03 ± 0.028	1.94LysPro: 1.94 ± 0.036	1.015LysGln: 1.015 ± 0.029	2.417LysArg: 2.417 ± 0.042	2.246LysSer: 2.246 ± 0.044	2.293LysThr: 2.293 ± 0.044	2.322LysVal: 2.322 ± 0.045	0.399LysTrp: 0.399 ± 0.018	0.721LysTyr: 0.721 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	11.678LeuAla: 11.678 ± 0.114	0.972LeuCys: 0.972 ± 0.029	6.112LeuAsp: 6.112 ± 0.081	5.473LeuGlu: 5.473 ± 0.079	3.684LeuPhe: 3.684 ± 0.067	8.139LeuGly: 8.139 ± 0.089	1.809LeuHis: 1.809 ± 0.036	5.634LeuIle: 5.634 ± 0.072	3.749LeuLys: 3.749 ± 0.058	8.884LeuLeu: 8.884 ± 0.112	2.638LeuMet: 2.638 ± 0.043	2.969LeuAsn: 2.969 ± 0.046	5.108LeuPro: 5.108 ± 0.071	2.913LeuGln: 2.913 ± 0.045	6.356LeuArg: 6.356 ± 0.069	7.209LeuSer: 7.209 ± 0.076	6.179LeuThr: 6.179 ± 0.077	6.651LeuVal: 6.651 ± 0.087	1.271LeuTrp: 1.271 ± 0.03	2.006LeuTyr: 2.006 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.102MetAla: 3.102 ± 0.051	0.188MetCys: 0.188 ± 0.012	1.488MetAsp: 1.488 ± 0.034	1.335MetGlu: 1.335 ± 0.033	0.883MetPhe: 0.883 ± 0.032	2.158MetGly: 2.158 ± 0.046	0.446MetHis: 0.446 ± 0.019	1.637MetIle: 1.637 ± 0.032	1.126MetLys: 1.126 ± 0.028	2.511MetLeu: 2.511 ± 0.044	0.773MetMet: 0.773 ± 0.025	0.885MetAsn: 0.885 ± 0.028	1.438MetPro: 1.438 ± 0.035	0.944MetGln: 0.944 ± 0.027	1.786MetArg: 1.786 ± 0.034	1.947MetSer: 1.947 ± 0.034	2.092MetThr: 2.092 ± 0.036	1.85MetVal: 1.85 ± 0.039	0.249MetTrp: 0.249 ± 0.014	0.35MetTyr: 0.35 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.398AsnAla: 3.398 ± 0.055	0.288AsnCys: 0.288 ± 0.016	1.575AsnAsp: 1.575 ± 0.04	1.417AsnGlu: 1.417 ± 0.037	1.063AsnPhe: 1.063 ± 0.03	2.48AsnGly: 2.48 ± 0.041	0.555AsnHis: 0.555 ± 0.019	1.508AsnIle: 1.508 ± 0.033	0.762AsnLys: 0.762 ± 0.024	2.713AsnLeu: 2.713 ± 0.045	0.746AsnMet: 0.746 ± 0.027	0.729AsnAsn: 0.729 ± 0.025	1.875AsnPro: 1.875 ± 0.036	0.839AsnGln: 0.839 ± 0.024	1.764AsnArg: 1.764 ± 0.036	1.37AsnSer: 1.37 ± 0.034	1.538AsnThr: 1.538 ± 0.034	1.99AsnVal: 1.99 ± 0.039	0.49AsnTrp: 0.49 ± 0.021	0.678AsnTyr: 0.678 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.048ProAla: 5.048 ± 0.068	0.338ProCys: 0.338 ± 0.016	4.126ProAsp: 4.126 ± 0.06	3.718ProGlu: 3.718 ± 0.051	2.069ProPhe: 2.069 ± 0.032	3.827ProGly: 3.827 ± 0.05	1.025ProHis: 1.025 ± 0.027	2.47ProIle: 2.47 ± 0.046	1.881ProLys: 1.881 ± 0.038	4.444ProLeu: 4.444 ± 0.06	1.198ProMet: 1.198 ± 0.032	1.498ProAsn: 1.498 ± 0.031	2.086ProPro: 2.086 ± 0.047	1.599ProGln: 1.599 ± 0.036	2.502ProArg: 2.502 ± 0.047	2.733ProSer: 2.733 ± 0.046	2.6ProThr: 2.6 ± 0.047	3.841ProVal: 3.841 ± 0.061	0.654ProTrp: 0.654 ± 0.023	1.134ProTyr: 1.134 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.729GlnAla: 3.729 ± 0.056	0.196GlnCys: 0.196 ± 0.013	1.948GlnAsp: 1.948 ± 0.04	1.609GlnGlu: 1.609 ± 0.037	1.205GlnPhe: 1.205 ± 0.029	2.375GlnGly: 2.375 ± 0.044	0.607GlnHis: 0.607 ± 0.022	2.325GlnIle: 2.325 ± 0.038	1.212GlnLys: 1.212 ± 0.03	2.925GlnLeu: 2.925 ± 0.05	1.157GlnMet: 1.157 ± 0.026	1.107GlnAsn: 1.107 ± 0.03	1.61GlnPro: 1.61 ± 0.032	1.084GlnGln: 1.084 ± 0.032	2.186GlnArg: 2.186 ± 0.051	2.108GlnSer: 2.108 ± 0.043	2.203GlnThr: 2.203 ± 0.043	2.284GlnVal: 2.284 ± 0.04	0.388GlnTrp: 0.388 ± 0.017	0.654GlnTyr: 0.654 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.054ArgAla: 7.054 ± 0.082	0.475ArgCys: 0.475 ± 0.019	4.204ArgAsp: 4.204 ± 0.059	3.503ArgGlu: 3.503 ± 0.052	2.664ArgPhe: 2.664 ± 0.051	4.173ArgGly: 4.173 ± 0.053	1.386ArgHis: 1.386 ± 0.037	3.748ArgIle: 3.748 ± 0.057	2.373ArgLys: 2.373 ± 0.043	6.708ArgLeu: 6.708 ± 0.091	1.806ArgMet: 1.806 ± 0.037	1.747ArgAsn: 1.747 ± 0.038	2.939ArgPro: 2.939 ± 0.048	2.214ArgGln: 2.214 ± 0.038	4.476ArgArg: 4.476 ± 0.064	3.407ArgSer: 3.407 ± 0.055	3.223ArgThr: 3.223 ± 0.045	4.467ArgVal: 4.467 ± 0.058	0.871ArgTrp: 0.871 ± 0.027	1.559ArgTyr: 1.559 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.064SerAla: 6.064 ± 0.078	0.476SerCys: 0.476 ± 0.021	3.963SerAsp: 3.963 ± 0.058	3.41SerGlu: 3.41 ± 0.058	2.446SerPhe: 2.446 ± 0.042	5.322SerGly: 5.322 ± 0.07	1.139SerHis: 1.139 ± 0.032	2.841SerIle: 2.841 ± 0.047	1.829SerLys: 1.829 ± 0.037	5.238SerLeu: 5.238 ± 0.069	1.458SerMet: 1.458 ± 0.033	1.608SerAsn: 1.608 ± 0.033	2.585SerPro: 2.585 ± 0.047	1.805SerGln: 1.805 ± 0.035	3.197SerArg: 3.197 ± 0.053	2.879SerSer: 2.879 ± 0.054	2.9SerThr: 2.9 ± 0.046	4.115SerVal: 4.115 ± 0.056	0.7SerTrp: 0.7 ± 0.025	1.441SerTyr: 1.441 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.338ThrAla: 6.338 ± 0.073	0.534ThrCys: 0.534 ± 0.022	3.531ThrAsp: 3.531 ± 0.052	3.205ThrGlu: 3.205 ± 0.053	2.268ThrPhe: 2.268 ± 0.042	5.212ThrGly: 5.212 ± 0.066	1.192ThrHis: 1.192 ± 0.03	2.976ThrIle: 2.976 ± 0.052	1.801ThrLys: 1.801 ± 0.035	6.202ThrLeu: 6.202 ± 0.07	1.311ThrMet: 1.311 ± 0.033	1.478ThrAsn: 1.478 ± 0.034	3.414ThrPro: 3.414 ± 0.055	1.898ThrGln: 1.898 ± 0.035	3.381ThrArg: 3.381 ± 0.053	3.237ThrSer: 3.237 ± 0.046	3.102ThrThr: 3.102 ± 0.049	4.391ThrVal: 4.391 ± 0.059	0.782ThrTrp: 0.782 ± 0.025	1.38ThrTyr: 1.38 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.246ValAla: 8.246 ± 0.092	0.653ValCys: 0.653 ± 0.021	4.274ValAsp: 4.274 ± 0.055	4.485ValGlu: 4.485 ± 0.07	2.981ValPhe: 2.981 ± 0.048	5.441ValGly: 5.441 ± 0.071	1.342ValHis: 1.342 ± 0.033	4.224ValIle: 4.224 ± 0.063	2.277ValLys: 2.277 ± 0.044	7.414ValLeu: 7.414 ± 0.094	2.011ValMet: 2.011 ± 0.044	1.939ValAsn: 1.939 ± 0.044	3.486ValPro: 3.486 ± 0.05	2.174ValGln: 2.174 ± 0.042	4.152ValArg: 4.152 ± 0.057	4.568ValSer: 4.568 ± 0.061	4.633ValThr: 4.633 ± 0.058	5.462ValVal: 5.462 ± 0.075	0.944ValTrp: 0.944 ± 0.024	1.415ValTyr: 1.415 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.274TrpAla: 1.274 ± 0.034	0.147TrpCys: 0.147 ± 0.011	0.834TrpAsp: 0.834 ± 0.024	0.589TrpGlu: 0.589 ± 0.025	0.596TrpPhe: 0.596 ± 0.022	0.944TrpGly: 0.944 ± 0.024	0.328TrpHis: 0.328 ± 0.014	0.765TrpIle: 0.765 ± 0.026	0.445TrpLys: 0.445 ± 0.019	1.546TrpLeu: 1.546 ± 0.033	0.422TrpMet: 0.422 ± 0.02	0.433TrpAsn: 0.433 ± 0.019	0.648TrpPro: 0.648 ± 0.021	0.533TrpGln: 0.533 ± 0.02	1.065TrpArg: 1.065 ± 0.03	0.907TrpSer: 0.907 ± 0.027	0.87TrpThr: 0.87 ± 0.029	0.882TrpVal: 0.882 ± 0.029	0.244TrpTrp: 0.244 ± 0.013	0.269TrpTyr: 0.269 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.521TyrAla: 2.521 ± 0.048	0.247TyrCys: 0.247 ± 0.013	1.682TyrAsp: 1.682 ± 0.038	1.324TyrGlu: 1.324 ± 0.035	0.966TyrPhe: 0.966 ± 0.029	2.091TyrGly: 2.091 ± 0.046	0.527TyrHis: 0.527 ± 0.019	1.019TyrIle: 1.019 ± 0.031	0.646TyrLys: 0.646 ± 0.023	2.304TyrLeu: 2.304 ± 0.04	0.482TyrMet: 0.482 ± 0.019	0.597TyrAsn: 0.597 ± 0.023	1.046TyrPro: 1.046 ± 0.026	0.735TyrGln: 0.735 ± 0.023	1.498TyrArg: 1.498 ± 0.034	1.163TyrSer: 1.163 ± 0.026	1.187TyrThr: 1.187 ± 0.031	1.577TyrVal: 1.577 ± 0.033	0.374TyrTrp: 0.374 ± 0.017	0.541TyrTyr: 0.541 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4462 proteins (1347393 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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