Amino acid dipepetide frequency for Shimia marina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.321AlaAla: 15.321 ± 0.155	1.096AlaCys: 1.096 ± 0.03	6.627AlaAsp: 6.627 ± 0.081	8.139AlaGlu: 8.139 ± 0.113	4.327AlaPhe: 4.327 ± 0.058	9.459AlaGly: 9.459 ± 0.091	2.457AlaHis: 2.457 ± 0.044	5.624AlaIle: 5.624 ± 0.072	4.459AlaLys: 4.459 ± 0.068	13.464AlaLeu: 13.464 ± 0.137	3.631AlaMet: 3.631 ± 0.06	2.892AlaAsn: 2.892 ± 0.05	5.557AlaPro: 5.557 ± 0.087	5.329AlaGln: 5.329 ± 0.07	7.53AlaArg: 7.53 ± 0.092	5.653AlaSer: 5.653 ± 0.066	5.917AlaThr: 5.917 ± 0.069	8.067AlaVal: 8.067 ± 0.093	1.286AlaTrp: 1.286 ± 0.037	2.58AlaTyr: 2.58 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.124CysAla: 1.124 ± 0.036	0.122CysCys: 0.122 ± 0.009	0.66CysAsp: 0.66 ± 0.024	0.45CysGlu: 0.45 ± 0.02	0.371CysPhe: 0.371 ± 0.017	0.886CysGly: 0.886 ± 0.029	0.291CysHis: 0.291 ± 0.015	0.402CysIle: 0.402 ± 0.02	0.235CysLys: 0.235 ± 0.014	0.858CysLeu: 0.858 ± 0.028	0.186CysMet: 0.186 ± 0.013	0.249CysAsn: 0.249 ± 0.016	0.5CysPro: 0.5 ± 0.022	0.278CysGln: 0.278 ± 0.015	0.498CysArg: 0.498 ± 0.023	0.482CysSer: 0.482 ± 0.018	0.452CysThr: 0.452 ± 0.022	0.699CysVal: 0.699 ± 0.028	0.112CysTrp: 0.112 ± 0.01	0.21CysTyr: 0.21 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.883AspAla: 6.883 ± 0.092	0.515AspCys: 0.515 ± 0.022	3.157AspAsp: 3.157 ± 0.074	3.326AspGlu: 3.326 ± 0.061	2.433AspPhe: 2.433 ± 0.054	5.178AspGly: 5.178 ± 0.081	1.427AspHis: 1.427 ± 0.034	3.271AspIle: 3.271 ± 0.054	1.847AspLys: 1.847 ± 0.045	6.25AspLeu: 6.25 ± 0.071	1.853AspMet: 1.853 ± 0.037	1.438AspAsn: 1.438 ± 0.038	3.201AspPro: 3.201 ± 0.046	2.085AspGln: 2.085 ± 0.038	3.609AspArg: 3.609 ± 0.056	2.446AspSer: 2.446 ± 0.051	3.152AspThr: 3.152 ± 0.07	4.838AspVal: 4.838 ± 0.061	1.055AspTrp: 1.055 ± 0.033	1.518AspTyr: 1.518 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.255GluAla: 8.255 ± 0.112	0.357GluCys: 0.357 ± 0.016	3.806GluAsp: 3.806 ± 0.065	4.114GluGlu: 4.114 ± 0.08	1.9GluPhe: 1.9 ± 0.044	5.029GluGly: 5.029 ± 0.075	1.222GluHis: 1.222 ± 0.033	3.872GluIle: 3.872 ± 0.064	2.475GluLys: 2.475 ± 0.055	5.333GluLeu: 5.333 ± 0.074	1.942GluMet: 1.942 ± 0.039	2.032GluAsn: 2.032 ± 0.043	2.179GluPro: 2.179 ± 0.045	2.163GluGln: 2.163 ± 0.042	4.016GluArg: 4.016 ± 0.064	2.43GluSer: 2.43 ± 0.057	3.912GluThr: 3.912 ± 0.056	4.463GluVal: 4.463 ± 0.069	0.69GluTrp: 0.69 ± 0.024	1.082GluTyr: 1.082 ± 0.035	0.001GluXaa: 0.001 ± 0.001
Phe	4.537PheAla: 4.537 ± 0.067	0.439PheCys: 0.439 ± 0.02	2.943PheAsp: 2.943 ± 0.051	2.601PheGlu: 2.601 ± 0.05	1.57PhePhe: 1.57 ± 0.044	3.831PheGly: 3.831 ± 0.072	0.8PheHis: 0.8 ± 0.025	1.65PheIle: 1.65 ± 0.045	1.11PheLys: 1.11 ± 0.035	3.66PheLeu: 3.66 ± 0.066	0.994PheMet: 0.994 ± 0.029	1.097PheAsn: 1.097 ± 0.031	1.51PhePro: 1.51 ± 0.038	1.157PheGln: 1.157 ± 0.034	1.91PheArg: 1.91 ± 0.042	2.238PheSer: 2.238 ± 0.041	2.027PheThr: 2.027 ± 0.041	2.908PheVal: 2.908 ± 0.063	0.617PheTrp: 0.617 ± 0.026	1.005PheTyr: 1.005 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.493GlyAla: 9.493 ± 0.112	0.827GlyCys: 0.827 ± 0.033	4.633GlyAsp: 4.633 ± 0.076	4.665GlyGlu: 4.665 ± 0.073	3.796GlyPhe: 3.796 ± 0.07	7.099GlyGly: 7.099 ± 0.113	1.981GlyHis: 1.981 ± 0.042	4.174GlyIle: 4.174 ± 0.068	3.325GlyLys: 3.325 ± 0.065	8.593GlyLeu: 8.593 ± 0.082	2.58GlyMet: 2.58 ± 0.053	2.338GlyAsn: 2.338 ± 0.077	3.202GlyPro: 3.202 ± 0.052	3.145GlyGln: 3.145 ± 0.058	4.937GlyArg: 4.937 ± 0.059	3.94GlySer: 3.94 ± 0.068	4.636GlyThr: 4.636 ± 0.07	6.455GlyVal: 6.455 ± 0.074	1.348GlyTrp: 1.348 ± 0.034	2.251GlyTyr: 2.251 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.365HisAla: 2.365 ± 0.045	0.257HisCys: 0.257 ± 0.014	1.313HisAsp: 1.313 ± 0.038	1.16HisGlu: 1.16 ± 0.029	0.875HisPhe: 0.875 ± 0.028	1.923HisGly: 1.923 ± 0.041	0.646HisHis: 0.646 ± 0.024	1.135HisIle: 1.135 ± 0.032	0.696HisLys: 0.696 ± 0.024	2.178HisLeu: 2.178 ± 0.046	0.645HisMet: 0.645 ± 0.022	0.543HisAsn: 0.543 ± 0.023	1.355HisPro: 1.355 ± 0.032	0.671HisGln: 0.671 ± 0.026	1.297HisArg: 1.297 ± 0.034	1.078HisSer: 1.078 ± 0.03	0.928HisThr: 0.928 ± 0.028	1.632HisVal: 1.632 ± 0.044	0.407HisTrp: 0.407 ± 0.019	0.612HisTyr: 0.612 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.689IleAla: 6.689 ± 0.077	0.611IleCys: 0.611 ± 0.025	3.257IleAsp: 3.257 ± 0.049	3.455IleGlu: 3.455 ± 0.061	1.841IlePhe: 1.841 ± 0.044	4.785IleGly: 4.785 ± 0.079	0.95IleHis: 0.95 ± 0.029	2.187IleIle: 2.187 ± 0.052	1.726IleLys: 1.726 ± 0.043	4.814IleLeu: 4.814 ± 0.073	1.172IleMet: 1.172 ± 0.028	1.549IleAsn: 1.549 ± 0.036	2.161IlePro: 2.161 ± 0.042	1.323IleGln: 1.323 ± 0.034	2.917IleArg: 2.917 ± 0.053	3.296IleSer: 3.296 ± 0.054	3.059IleThr: 3.059 ± 0.057	3.676IleVal: 3.676 ± 0.056	0.768IleTrp: 0.768 ± 0.029	1.157IleTyr: 1.157 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.491LysAla: 4.491 ± 0.063	0.225LysCys: 0.225 ± 0.015	2.147LysAsp: 2.147 ± 0.044	2.059LysGlu: 2.059 ± 0.041	1.106LysPhe: 1.106 ± 0.032	2.966LysGly: 2.966 ± 0.057	0.763LysHis: 0.763 ± 0.025	1.923LysIle: 1.923 ± 0.039	1.526LysLys: 1.526 ± 0.04	3.387LysLeu: 3.387 ± 0.058	1.041LysMet: 1.041 ± 0.029	0.945LysAsn: 0.945 ± 0.028	1.871LysPro: 1.871 ± 0.038	1.187LysGln: 1.187 ± 0.03	2.44LysArg: 2.44 ± 0.051	2.108LysSer: 2.108 ± 0.048	2.27LysThr: 2.27 ± 0.048	2.515LysVal: 2.515 ± 0.051	0.413LysTrp: 0.413 ± 0.018	0.73LysTyr: 0.73 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.919LeuAla: 11.919 ± 0.107	1.033LeuCys: 1.033 ± 0.031	5.508LeuAsp: 5.508 ± 0.073	5.695LeuGlu: 5.695 ± 0.073	3.712LeuPhe: 3.712 ± 0.064	7.957LeuGly: 7.957 ± 0.087	1.991LeuHis: 1.991 ± 0.045	5.261LeuIle: 5.261 ± 0.068	3.833LeuLys: 3.833 ± 0.057	9.063LeuLeu: 9.063 ± 0.115	2.8LeuMet: 2.8 ± 0.045	3.0LeuAsn: 3.0 ± 0.054	5.292LeuPro: 5.292 ± 0.072	3.216LeuGln: 3.216 ± 0.056	6.66LeuArg: 6.66 ± 0.088	7.042LeuSer: 7.042 ± 0.088	6.073LeuThr: 6.073 ± 0.064	6.493LeuVal: 6.493 ± 0.088	1.311LeuTrp: 1.311 ± 0.036	2.001LeuTyr: 2.001 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.536MetAla: 3.536 ± 0.065	0.215MetCys: 0.215 ± 0.014	1.477MetAsp: 1.477 ± 0.036	1.492MetGlu: 1.492 ± 0.032	0.897MetPhe: 0.897 ± 0.029	2.364MetGly: 2.364 ± 0.051	0.532MetHis: 0.532 ± 0.024	1.562MetIle: 1.562 ± 0.041	1.141MetLys: 1.141 ± 0.029	2.651MetLeu: 2.651 ± 0.05	0.878MetMet: 0.878 ± 0.036	0.816MetAsn: 0.816 ± 0.026	1.562MetPro: 1.562 ± 0.037	1.169MetGln: 1.169 ± 0.03	1.974MetArg: 1.974 ± 0.04	1.954MetSer: 1.954 ± 0.038	2.048MetThr: 2.048 ± 0.044	1.977MetVal: 1.977 ± 0.038	0.261MetTrp: 0.261 ± 0.014	0.355MetTyr: 0.355 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.475AsnAla: 3.475 ± 0.055	0.292AsnCys: 0.292 ± 0.018	1.663AsnAsp: 1.663 ± 0.059	1.303AsnGlu: 1.303 ± 0.033	1.049AsnPhe: 1.049 ± 0.028	2.637AsnGly: 2.637 ± 0.051	0.606AsnHis: 0.606 ± 0.021	1.559AsnIle: 1.559 ± 0.038	0.815AsnLys: 0.815 ± 0.027	2.751AsnLeu: 2.751 ± 0.043	0.772AsnMet: 0.772 ± 0.024	0.783AsnAsn: 0.783 ± 0.027	1.799AsnPro: 1.799 ± 0.044	0.826AsnGln: 0.826 ± 0.028	1.767AsnArg: 1.767 ± 0.041	1.315AsnSer: 1.315 ± 0.038	1.598AsnThr: 1.598 ± 0.04	1.974AsnVal: 1.974 ± 0.048	0.497AsnTrp: 0.497 ± 0.018	0.683AsnTyr: 0.683 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.872ProAla: 4.872 ± 0.07	0.353ProCys: 0.353 ± 0.016	3.377ProAsp: 3.377 ± 0.056	4.122ProGlu: 4.122 ± 0.061	1.95ProPhe: 1.95 ± 0.045	3.515ProGly: 3.515 ± 0.054	1.083ProHis: 1.083 ± 0.027	2.295ProIle: 2.295 ± 0.045	1.913ProLys: 1.913 ± 0.037	4.433ProLeu: 4.433 ± 0.063	1.358ProMet: 1.358 ± 0.038	1.453ProAsn: 1.453 ± 0.034	1.927ProPro: 1.927 ± 0.049	1.815ProGln: 1.815 ± 0.044	2.331ProArg: 2.331 ± 0.054	2.559ProSer: 2.559 ± 0.051	2.492ProThr: 2.492 ± 0.05	3.828ProVal: 3.828 ± 0.061	0.608ProTrp: 0.608 ± 0.02	1.17ProTyr: 1.17 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.428GlnAla: 4.428 ± 0.066	0.239GlnCys: 0.239 ± 0.015	2.019GlnAsp: 2.019 ± 0.043	2.087GlnGlu: 2.087 ± 0.044	1.232GlnPhe: 1.232 ± 0.033	2.705GlnGly: 2.705 ± 0.048	0.729GlnHis: 0.729 ± 0.026	2.093GlnIle: 2.093 ± 0.038	1.432GlnLys: 1.432 ± 0.035	3.17GlnLeu: 3.17 ± 0.049	1.252GlnMet: 1.252 ± 0.032	1.175GlnAsn: 1.175 ± 0.036	1.589GlnPro: 1.589 ± 0.034	1.256GlnGln: 1.256 ± 0.037	2.302GlnArg: 2.302 ± 0.047	2.16GlnSer: 2.16 ± 0.041	2.085GlnThr: 2.085 ± 0.041	2.543GlnVal: 2.543 ± 0.053	0.441GlnTrp: 0.441 ± 0.021	0.632GlnTyr: 0.632 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.126ArgAla: 7.126 ± 0.089	0.458ArgCys: 0.458 ± 0.021	3.813ArgAsp: 3.813 ± 0.06	3.493ArgGlu: 3.493 ± 0.063	2.648ArgPhe: 2.648 ± 0.042	4.217ArgGly: 4.217 ± 0.066	1.483ArgHis: 1.483 ± 0.036	3.358ArgIle: 3.358 ± 0.063	2.458ArgLys: 2.458 ± 0.051	6.567ArgLeu: 6.567 ± 0.088	1.819ArgMet: 1.819 ± 0.041	1.788ArgAsn: 1.788 ± 0.04	2.784ArgPro: 2.784 ± 0.052	2.298ArgGln: 2.298 ± 0.05	4.338ArgArg: 4.338 ± 0.073	3.056ArgSer: 3.056 ± 0.056	2.712ArgThr: 2.712 ± 0.05	4.39ArgVal: 4.39 ± 0.062	0.879ArgTrp: 0.879 ± 0.031	1.51ArgTyr: 1.51 ± 0.04	0.001ArgXaa: 0.001 ± 0.001
Ser	6.088SerAla: 6.088 ± 0.078	0.495SerCys: 0.495 ± 0.022	3.464SerAsp: 3.464 ± 0.057	3.363SerGlu: 3.363 ± 0.06	2.466SerPhe: 2.466 ± 0.049	5.422SerGly: 5.422 ± 0.077	1.202SerHis: 1.202 ± 0.033	2.45SerIle: 2.45 ± 0.047	1.85SerLys: 1.85 ± 0.041	5.285SerLeu: 5.285 ± 0.071	1.504SerMet: 1.504 ± 0.038	1.551SerAsn: 1.551 ± 0.04	2.369SerPro: 2.369 ± 0.043	1.81SerGln: 1.81 ± 0.037	3.035SerArg: 3.035 ± 0.05	2.808SerSer: 2.808 ± 0.058	2.613SerThr: 2.613 ± 0.054	3.963SerVal: 3.963 ± 0.057	0.753SerTrp: 0.753 ± 0.024	1.415SerTyr: 1.415 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.174ThrAla: 6.174 ± 0.077	0.508ThrCys: 0.508 ± 0.021	3.098ThrAsp: 3.098 ± 0.055	3.132ThrGlu: 3.132 ± 0.056	1.987ThrPhe: 1.987 ± 0.041	4.971ThrGly: 4.971 ± 0.069	1.261ThrHis: 1.261 ± 0.031	2.702ThrIle: 2.702 ± 0.059	1.773ThrLys: 1.773 ± 0.034	6.196ThrLeu: 6.196 ± 0.089	1.34ThrMet: 1.34 ± 0.035	1.447ThrAsn: 1.447 ± 0.041	3.448ThrPro: 3.448 ± 0.059	1.971ThrGln: 1.971 ± 0.043	3.229ThrArg: 3.229 ± 0.052	2.967ThrSer: 2.967 ± 0.055	2.944ThrThr: 2.944 ± 0.048	4.211ThrVal: 4.211 ± 0.072	0.667ThrTrp: 0.667 ± 0.025	1.369ThrTyr: 1.369 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.789ValAla: 8.789 ± 0.085	0.64ValCys: 0.64 ± 0.023	4.176ValAsp: 4.176 ± 0.068	4.579ValGlu: 4.579 ± 0.068	2.965ValPhe: 2.965 ± 0.049	5.251ValGly: 5.251 ± 0.072	1.376ValHis: 1.376 ± 0.033	4.219ValIle: 4.219 ± 0.069	2.393ValLys: 2.393 ± 0.056	7.404ValLeu: 7.404 ± 0.095	2.194ValMet: 2.194 ± 0.045	2.006ValAsn: 2.006 ± 0.05	3.446ValPro: 3.446 ± 0.059	2.41ValGln: 2.41 ± 0.048	3.945ValArg: 3.945 ± 0.056	4.471ValSer: 4.471 ± 0.06	4.659ValThr: 4.659 ± 0.068	5.77ValVal: 5.77 ± 0.088	0.843ValTrp: 0.843 ± 0.03	1.437ValTyr: 1.437 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.35TrpAla: 1.35 ± 0.036	0.136TrpCys: 0.136 ± 0.01	0.736TrpAsp: 0.736 ± 0.026	0.67TrpGlu: 0.67 ± 0.024	0.531TrpPhe: 0.531 ± 0.021	1.033TrpGly: 1.033 ± 0.032	0.365TrpHis: 0.365 ± 0.017	0.707TrpIle: 0.707 ± 0.024	0.46TrpLys: 0.46 ± 0.021	1.535TrpLeu: 1.535 ± 0.041	0.422TrpMet: 0.422 ± 0.019	0.414TrpAsn: 0.414 ± 0.019	0.669TrpPro: 0.669 ± 0.026	0.678TrpGln: 0.678 ± 0.025	1.0TrpArg: 1.0 ± 0.033	0.77TrpSer: 0.77 ± 0.027	0.667TrpThr: 0.667 ± 0.023	0.919TrpVal: 0.919 ± 0.03	0.225TrpTrp: 0.225 ± 0.016	0.27TrpTyr: 0.27 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.503TyrAla: 2.503 ± 0.05	0.246TyrCys: 0.246 ± 0.016	1.612TyrAsp: 1.612 ± 0.035	1.365TyrGlu: 1.365 ± 0.034	0.947TyrPhe: 0.947 ± 0.03	2.189TyrGly: 2.189 ± 0.052	0.549TyrHis: 0.549 ± 0.023	0.949TyrIle: 0.949 ± 0.028	0.649TyrLys: 0.649 ± 0.021	2.27TyrLeu: 2.27 ± 0.046	0.476TyrMet: 0.476 ± 0.02	0.645TyrAsn: 0.645 ± 0.026	1.033TyrPro: 1.033 ± 0.029	0.778TyrGln: 0.778 ± 0.023	1.462TyrArg: 1.462 ± 0.037	1.134TyrSer: 1.134 ± 0.029	1.152TyrThr: 1.152 ± 0.032	1.652TyrVal: 1.652 ± 0.037	0.375TyrTrp: 0.375 ± 0.016	0.579TyrTyr: 0.579 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.005XaaXaa: 0.005 ± 0.003

Statistics based on 3874 proteins (1193212 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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