Amino acid dipepetide frequency for Halospina denitrificans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.241AlaAla: 9.241 ± 0.118	0.98AlaCys: 0.98 ± 0.033	5.498AlaAsp: 5.498 ± 0.079	6.72AlaGlu: 6.72 ± 0.099	3.54AlaPhe: 3.54 ± 0.063	8.29AlaGly: 8.29 ± 0.1	1.976AlaHis: 1.976 ± 0.044	5.043AlaIle: 5.043 ± 0.084	2.369AlaLys: 2.369 ± 0.058	11.294AlaLeu: 11.294 ± 0.136	2.936AlaMet: 2.936 ± 0.057	2.598AlaAsn: 2.598 ± 0.053	3.973AlaPro: 3.973 ± 0.067	3.238AlaGln: 3.238 ± 0.061	7.24AlaArg: 7.24 ± 0.09	5.675AlaSer: 5.675 ± 0.08	4.777AlaThr: 4.777 ± 0.068	6.819AlaVal: 6.819 ± 0.09	1.402AlaTrp: 1.402 ± 0.042	2.148AlaTyr: 2.148 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.771CysAla: 0.771 ± 0.029	0.118CysCys: 0.118 ± 0.011	0.522CysAsp: 0.522 ± 0.024	0.589CysGlu: 0.589 ± 0.026	0.376CysPhe: 0.376 ± 0.022	0.877CysGly: 0.877 ± 0.033	0.339CysHis: 0.339 ± 0.02	0.396CysIle: 0.396 ± 0.019	0.212CysLys: 0.212 ± 0.015	0.916CysLeu: 0.916 ± 0.035	0.185CysMet: 0.185 ± 0.013	0.268CysAsn: 0.268 ± 0.014	0.492CysPro: 0.492 ± 0.025	0.358CysGln: 0.358 ± 0.019	0.692CysArg: 0.692 ± 0.03	0.564CysSer: 0.564 ± 0.023	0.404CysThr: 0.404 ± 0.019	0.615CysVal: 0.615 ± 0.024	0.129CysTrp: 0.129 ± 0.012	0.236CysTyr: 0.236 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.638AspAla: 5.638 ± 0.087	0.533AspCys: 0.533 ± 0.025	3.733AspAsp: 3.733 ± 0.076	4.858AspGlu: 4.858 ± 0.081	2.292AspPhe: 2.292 ± 0.053	4.761AspGly: 4.761 ± 0.09	1.46AspHis: 1.46 ± 0.037	2.897AspIle: 2.897 ± 0.061	1.619AspLys: 1.619 ± 0.047	5.77AspLeu: 5.77 ± 0.076	1.437AspMet: 1.437 ± 0.036	1.931AspAsn: 1.931 ± 0.046	3.427AspPro: 3.427 ± 0.066	2.557AspGln: 2.557 ± 0.057	4.253AspArg: 4.253 ± 0.062	3.373AspSer: 3.373 ± 0.067	3.011AspThr: 3.011 ± 0.059	3.925AspVal: 3.925 ± 0.077	1.065AspTrp: 1.065 ± 0.038	2.043AspTyr: 2.043 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	7.805GluAla: 7.805 ± 0.115	0.524GluCys: 0.524 ± 0.023	4.081GluAsp: 4.081 ± 0.066	5.09GluGlu: 5.09 ± 0.098	2.083GluPhe: 2.083 ± 0.05	5.346GluGly: 5.346 ± 0.081	1.753GluHis: 1.753 ± 0.049	3.192GluIle: 3.192 ± 0.06	2.872GluLys: 2.872 ± 0.061	7.319GluLeu: 7.319 ± 0.088	1.752GluMet: 1.752 ± 0.042	2.288GluAsn: 2.288 ± 0.046	3.583GluPro: 3.583 ± 0.104	3.753GluGln: 3.753 ± 0.065	5.905GluArg: 5.905 ± 0.086	4.257GluSer: 4.257 ± 0.069	4.281GluThr: 4.281 ± 0.07	4.6GluVal: 4.6 ± 0.072	1.003GluTrp: 1.003 ± 0.032	1.581GluTyr: 1.581 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.129PheAla: 3.129 ± 0.061	0.435PheCys: 0.435 ± 0.022	2.244PheAsp: 2.244 ± 0.042	2.539PheGlu: 2.539 ± 0.052	1.538PhePhe: 1.538 ± 0.04	3.083PheGly: 3.083 ± 0.067	0.868PheHis: 0.868 ± 0.034	1.752PheIle: 1.752 ± 0.044	0.849PheLys: 0.849 ± 0.033	3.543PheLeu: 3.543 ± 0.061	0.967PheMet: 0.967 ± 0.031	1.295PheAsn: 1.295 ± 0.041	1.632PhePro: 1.632 ± 0.039	1.309PheGln: 1.309 ± 0.038	2.621PheArg: 2.621 ± 0.055	2.553PheSer: 2.553 ± 0.047	1.876PheThr: 1.876 ± 0.044	2.336PheVal: 2.336 ± 0.053	0.559PheTrp: 0.559 ± 0.027	1.065PheTyr: 1.065 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.942GlyAla: 6.942 ± 0.084	0.962GlyCys: 0.962 ± 0.031	4.947GlyAsp: 4.947 ± 0.083	5.649GlyGlu: 5.649 ± 0.089	3.355GlyPhe: 3.355 ± 0.062	6.425GlyGly: 6.425 ± 0.105	2.005GlyHis: 2.005 ± 0.047	4.58GlyIle: 4.58 ± 0.067	2.78GlyLys: 2.78 ± 0.065	8.436GlyLeu: 8.436 ± 0.098	2.382GlyMet: 2.382 ± 0.049	2.615GlyAsn: 2.615 ± 0.061	2.73GlyPro: 2.73 ± 0.054	3.066GlyGln: 3.066 ± 0.057	5.132GlyArg: 5.132 ± 0.081	4.621GlySer: 4.621 ± 0.069	4.262GlyThr: 4.262 ± 0.066	5.82GlyVal: 5.82 ± 0.074	1.274GlyTrp: 1.274 ± 0.037	2.485GlyTyr: 2.485 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.906HisAla: 1.906 ± 0.044	0.342HisCys: 0.342 ± 0.019	1.265HisAsp: 1.265 ± 0.034	1.68HisGlu: 1.68 ± 0.041	1.016HisPhe: 1.016 ± 0.031	1.925HisGly: 1.925 ± 0.046	0.743HisHis: 0.743 ± 0.026	1.09HisIle: 1.09 ± 0.036	0.621HisLys: 0.621 ± 0.026	2.398HisLeu: 2.398 ± 0.053	0.55HisMet: 0.55 ± 0.024	0.738HisAsn: 0.738 ± 0.03	1.544HisPro: 1.544 ± 0.038	1.035HisGln: 1.035 ± 0.03	1.795HisArg: 1.795 ± 0.043	1.305HisSer: 1.305 ± 0.037	0.995HisThr: 0.995 ± 0.03	1.316HisVal: 1.316 ± 0.039	0.451HisTrp: 0.451 ± 0.022	0.943HisTyr: 0.943 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	4.967IleAla: 4.967 ± 0.096	0.426IleCys: 0.426 ± 0.018	3.056IleAsp: 3.056 ± 0.064	3.642IleGlu: 3.642 ± 0.068	1.508IlePhe: 1.508 ± 0.04	4.199IleGly: 4.199 ± 0.065	1.276IleHis: 1.276 ± 0.038	2.272IleIle: 2.272 ± 0.055	1.448IleLys: 1.448 ± 0.042	4.585IleLeu: 4.585 ± 0.073	1.065IleMet: 1.065 ± 0.037	1.916IleAsn: 1.916 ± 0.044	2.563IlePro: 2.563 ± 0.048	1.897IleGln: 1.897 ± 0.047	3.751IleArg: 3.751 ± 0.057	2.779IleSer: 2.779 ± 0.046	2.884IleThr: 2.884 ± 0.059	3.165IleVal: 3.165 ± 0.062	0.561IleTrp: 0.561 ± 0.02	1.132IleTyr: 1.132 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.381LysAla: 3.381 ± 0.068	0.176LysCys: 0.176 ± 0.013	1.77LysAsp: 1.77 ± 0.052	2.058LysGlu: 2.058 ± 0.052	0.663LysPhe: 0.663 ± 0.03	2.412LysGly: 2.412 ± 0.052	0.715LysHis: 0.715 ± 0.03	1.135LysIle: 1.135 ± 0.031	1.344LysLys: 1.344 ± 0.046	2.844LysLeu: 2.844 ± 0.059	0.611LysMet: 0.611 ± 0.022	0.859LysAsn: 0.859 ± 0.035	1.752LysPro: 1.752 ± 0.046	1.446LysGln: 1.446 ± 0.042	2.317LysArg: 2.317 ± 0.05	1.655LysSer: 1.655 ± 0.048	1.72LysThr: 1.72 ± 0.045	2.111LysVal: 2.111 ± 0.046	0.311LysTrp: 0.311 ± 0.019	0.656LysTyr: 0.656 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	11.108LeuAla: 11.108 ± 0.141	0.944LeuCys: 0.944 ± 0.035	6.604LeuAsp: 6.604 ± 0.096	7.848LeuGlu: 7.848 ± 0.099	3.731LeuPhe: 3.731 ± 0.069	8.137LeuGly: 8.137 ± 0.114	2.24LeuHis: 2.24 ± 0.05	5.198LeuIle: 5.198 ± 0.084	3.597LeuLys: 3.597 ± 0.072	10.432LeuLeu: 10.432 ± 0.159	2.698LeuMet: 2.698 ± 0.057	3.397LeuAsn: 3.397 ± 0.06	5.244LeuPro: 5.244 ± 0.082	3.618LeuGln: 3.618 ± 0.059	6.948LeuArg: 6.948 ± 0.089	6.811LeuSer: 6.811 ± 0.088	5.47LeuThr: 5.47 ± 0.081	7.493LeuVal: 7.493 ± 0.089	1.306LeuTrp: 1.306 ± 0.041	2.404LeuTyr: 2.404 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.05MetAla: 3.05 ± 0.054	0.137MetCys: 0.137 ± 0.012	1.555MetAsp: 1.555 ± 0.037	1.762MetGlu: 1.762 ± 0.045	0.632MetPhe: 0.632 ± 0.028	2.008MetGly: 2.008 ± 0.05	0.502MetHis: 0.502 ± 0.022	1.192MetIle: 1.192 ± 0.036	1.029MetLys: 1.029 ± 0.033	2.564MetLeu: 2.564 ± 0.055	0.646MetMet: 0.646 ± 0.027	0.907MetAsn: 0.907 ± 0.026	1.404MetPro: 1.404 ± 0.041	0.935MetGln: 0.935 ± 0.033	1.582MetArg: 1.582 ± 0.039	1.641MetSer: 1.641 ± 0.043	1.722MetThr: 1.722 ± 0.049	1.793MetVal: 1.793 ± 0.04	0.17MetTrp: 0.17 ± 0.012	0.396MetTyr: 0.396 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.975AsnAla: 2.975 ± 0.051	0.278AsnCys: 0.278 ± 0.017	1.809AsnAsp: 1.809 ± 0.041	2.045AsnGlu: 2.045 ± 0.046	0.966AsnPhe: 0.966 ± 0.036	2.592AsnGly: 2.592 ± 0.047	0.763AsnHis: 0.763 ± 0.027	1.438AsnIle: 1.438 ± 0.041	0.85AsnLys: 0.85 ± 0.033	3.313AsnLeu: 3.313 ± 0.065	0.69AsnMet: 0.69 ± 0.027	1.085AsnAsn: 1.085 ± 0.034	2.081AsnPro: 2.081 ± 0.052	1.379AsnGln: 1.379 ± 0.035	2.589AsnArg: 2.589 ± 0.051	1.621AsnSer: 1.621 ± 0.046	1.665AsnThr: 1.665 ± 0.043	1.957AsnVal: 1.957 ± 0.046	0.5AsnTrp: 0.5 ± 0.022	0.805AsnTyr: 0.805 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	4.311ProAla: 4.311 ± 0.071	0.336ProCys: 0.336 ± 0.02	3.848ProAsp: 3.848 ± 0.057	5.416ProGlu: 5.416 ± 0.106	1.735ProPhe: 1.735 ± 0.039	4.389ProGly: 4.389 ± 0.077	0.963ProHis: 0.963 ± 0.032	2.026ProIle: 2.026 ± 0.045	1.238ProLys: 1.238 ± 0.038	4.823ProLeu: 4.823 ± 0.074	1.213ProMet: 1.213 ± 0.036	1.283ProAsn: 1.283 ± 0.037	2.075ProPro: 2.075 ± 0.052	1.546ProGln: 1.546 ± 0.047	2.688ProArg: 2.688 ± 0.054	2.523ProSer: 2.523 ± 0.043	1.996ProThr: 1.996 ± 0.045	4.155ProVal: 4.155 ± 0.066	0.762ProTrp: 0.762 ± 0.027	1.176ProTyr: 1.176 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.31GlnAla: 4.31 ± 0.064	0.324GlnCys: 0.324 ± 0.018	2.005GlnAsp: 2.005 ± 0.05	2.478GlnGlu: 2.478 ± 0.049	1.291GlnPhe: 1.291 ± 0.036	3.16GlnGly: 3.16 ± 0.059	0.907GlnHis: 0.907 ± 0.028	1.645GlnIle: 1.645 ± 0.041	1.377GlnLys: 1.377 ± 0.042	4.112GlnLeu: 4.112 ± 0.063	0.982GlnMet: 0.982 ± 0.033	1.044GlnAsn: 1.044 ± 0.032	1.916GlnPro: 1.916 ± 0.045	2.102GlnGln: 2.102 ± 0.056	3.179GlnArg: 3.179 ± 0.062	2.321GlnSer: 2.321 ± 0.044	1.868GlnThr: 1.868 ± 0.044	2.841GlnVal: 2.841 ± 0.054	0.707GlnTrp: 0.707 ± 0.029	0.997GlnTyr: 0.997 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	5.825ArgAla: 5.825 ± 0.073	0.56ArgCys: 0.56 ± 0.022	4.338ArgAsp: 4.338 ± 0.057	5.747ArgGlu: 5.747 ± 0.088	3.262ArgPhe: 3.262 ± 0.06	4.283ArgGly: 4.283 ± 0.077	1.951ArgHis: 1.951 ± 0.047	4.222ArgIle: 4.222 ± 0.063	2.354ArgLys: 2.354 ± 0.053	8.071ArgLeu: 8.071 ± 0.085	1.955ArgMet: 1.955 ± 0.047	2.371ArgAsn: 2.371 ± 0.05	2.854ArgPro: 2.854 ± 0.055	3.298ArgGln: 3.298 ± 0.063	5.318ArgArg: 5.318 ± 0.087	3.608ArgSer: 3.608 ± 0.058	3.141ArgThr: 3.141 ± 0.061	5.296ArgVal: 5.296 ± 0.073	1.09ArgTrp: 1.09 ± 0.035	2.356ArgTyr: 2.356 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	5.389SerAla: 5.389 ± 0.08	0.465SerCys: 0.465 ± 0.022	3.622SerAsp: 3.622 ± 0.062	4.207SerGlu: 4.207 ± 0.067	2.073SerPhe: 2.073 ± 0.05	5.685SerGly: 5.685 ± 0.076	1.396SerHis: 1.396 ± 0.036	2.828SerIle: 2.828 ± 0.052	1.476SerLys: 1.476 ± 0.044	6.225SerLeu: 6.225 ± 0.093	1.594SerMet: 1.594 ± 0.04	1.719SerAsn: 1.719 ± 0.041	2.698SerPro: 2.698 ± 0.046	2.094SerGln: 2.094 ± 0.049	4.126SerArg: 4.126 ± 0.067	3.329SerSer: 3.329 ± 0.062	2.739SerThr: 2.739 ± 0.057	4.191SerVal: 4.191 ± 0.076	0.774SerTrp: 0.774 ± 0.026	1.4SerTyr: 1.4 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.914ThrAla: 4.914 ± 0.07	0.413ThrCys: 0.413 ± 0.021	3.16ThrAsp: 3.16 ± 0.066	3.441ThrGlu: 3.441 ± 0.061	1.742ThrPhe: 1.742 ± 0.039	4.924ThrGly: 4.924 ± 0.062	1.139ThrHis: 1.139 ± 0.029	2.515ThrIle: 2.515 ± 0.055	1.048ThrLys: 1.048 ± 0.031	6.487ThrLeu: 6.487 ± 0.076	1.169ThrMet: 1.169 ± 0.037	1.474ThrAsn: 1.474 ± 0.045	3.084ThrPro: 3.084 ± 0.052	1.695ThrGln: 1.695 ± 0.042	3.527ThrArg: 3.527 ± 0.063	2.608ThrSer: 2.608 ± 0.055	2.746ThrThr: 2.746 ± 0.061	3.699ThrVal: 3.699 ± 0.066	0.615ThrTrp: 0.615 ± 0.027	1.233ThrTyr: 1.233 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	6.975ValAla: 6.975 ± 0.096	0.661ValCys: 0.661 ± 0.027	4.337ValAsp: 4.337 ± 0.065	4.826ValGlu: 4.826 ± 0.081	2.725ValPhe: 2.725 ± 0.047	4.924ValGly: 4.924 ± 0.082	1.518ValHis: 1.518 ± 0.041	3.872ValIle: 3.872 ± 0.073	1.823ValLys: 1.823 ± 0.041	7.26ValLeu: 7.26 ± 0.104	1.876ValMet: 1.876 ± 0.044	2.285ValAsn: 2.285 ± 0.056	3.382ValPro: 3.382 ± 0.057	2.138ValGln: 2.138 ± 0.047	4.749ValArg: 4.749 ± 0.061	4.504ValSer: 4.504 ± 0.075	4.2ValThr: 4.2 ± 0.069	5.421ValVal: 5.421 ± 0.09	0.884ValTrp: 0.884 ± 0.034	1.703ValTyr: 1.703 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.012TrpAla: 1.012 ± 0.036	0.163TrpCys: 0.163 ± 0.013	0.678TrpAsp: 0.678 ± 0.032	0.805TrpGlu: 0.805 ± 0.03	0.634TrpPhe: 0.634 ± 0.028	0.91TrpGly: 0.91 ± 0.031	0.454TrpHis: 0.454 ± 0.024	0.7TrpIle: 0.7 ± 0.028	0.401TrpLys: 0.401 ± 0.019	2.061TrpLeu: 2.061 ± 0.055	0.375TrpMet: 0.375 ± 0.018	0.46TrpAsn: 0.46 ± 0.023	0.717TrpPro: 0.717 ± 0.026	0.845TrpGln: 0.845 ± 0.026	1.072TrpArg: 1.072 ± 0.034	0.741TrpSer: 0.741 ± 0.028	0.608TrpThr: 0.608 ± 0.028	0.98TrpVal: 0.98 ± 0.031	0.26TrpTrp: 0.26 ± 0.017	0.396TrpTyr: 0.396 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.108TyrAla: 2.108 ± 0.053	0.279TyrCys: 0.279 ± 0.019	1.511TyrAsp: 1.511 ± 0.051	1.671TyrGlu: 1.671 ± 0.037	1.031TyrPhe: 1.031 ± 0.032	2.14TyrGly: 2.14 ± 0.047	0.693TyrHis: 0.693 ± 0.027	1.098TyrIle: 1.098 ± 0.035	0.631TyrLys: 0.631 ± 0.03	2.777TyrLeu: 2.777 ± 0.058	0.542TyrMet: 0.542 ± 0.023	0.866TyrAsn: 0.866 ± 0.032	1.35TyrPro: 1.35 ± 0.037	1.258TyrGln: 1.258 ± 0.037	2.417TyrArg: 2.417 ± 0.052	1.539TyrSer: 1.539 ± 0.045	1.264TyrThr: 1.264 ± 0.037	1.528TyrVal: 1.528 ± 0.042	0.45TyrTrp: 0.45 ± 0.026	0.808TyrTyr: 0.808 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3014 proteins (1010808 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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