Amino acid dipepetide frequency for Xanthomonas phage f20-Xaj

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.199AlaAla: 14.199 ± 1.856
0.374AlaCys: 0.374 ± 0.156
6.427AlaAsp: 6.427 ± 0.77
6.427AlaGlu: 6.427 ± 0.765
3.064AlaPhe: 3.064 ± 0.511
7.772AlaGly: 7.772 ± 1.242
2.093AlaHis: 2.093 ± 0.497
5.157AlaIle: 5.157 ± 0.584
5.829AlaLys: 5.829 ± 0.556
7.623AlaLeu: 7.623 ± 0.719
3.811AlaMet: 3.811 ± 0.618
3.737AlaAsn: 3.737 ± 0.629
4.409AlaPro: 4.409 ± 1.023
5.381AlaGln: 5.381 ± 0.621
5.53AlaArg: 5.53 ± 0.683
5.904AlaSer: 5.904 ± 0.563
5.68AlaThr: 5.68 ± 0.782
6.95AlaVal: 6.95 ± 0.747
2.018AlaTrp: 2.018 ± 0.433
2.69AlaTyr: 2.69 ± 0.549
0.0AlaXaa: 0.0 ± 0.0
Cys
0.523CysAla: 0.523 ± 0.193
0.0CysCys: 0.0 ± 0.0
0.598CysAsp: 0.598 ± 0.205
0.598CysGlu: 0.598 ± 0.277
0.598CysPhe: 0.598 ± 0.237
0.822CysGly: 0.822 ± 0.355
0.0CysHis: 0.0 ± 0.0
0.523CysIle: 0.523 ± 0.201
0.374CysLys: 0.374 ± 0.171
0.598CysLeu: 0.598 ± 0.209
0.149CysMet: 0.149 ± 0.145
0.598CysAsn: 0.598 ± 0.191
0.374CysPro: 0.374 ± 0.164
0.448CysGln: 0.448 ± 0.226
0.523CysArg: 0.523 ± 0.232
0.224CysSer: 0.224 ± 0.147
0.673CysThr: 0.673 ± 0.272
0.299CysVal: 0.299 ± 0.139
0.0CysTrp: 0.0 ± 0.0
0.299CysTyr: 0.299 ± 0.155
0.0CysXaa: 0.0 ± 0.0
Asp
7.025AspAla: 7.025 ± 0.55
0.448AspCys: 0.448 ± 0.194
4.409AspAsp: 4.409 ± 0.658
3.139AspGlu: 3.139 ± 0.443
2.765AspPhe: 2.765 ± 0.456
4.559AspGly: 4.559 ± 0.609
0.972AspHis: 0.972 ± 0.317
3.438AspIle: 3.438 ± 0.416
3.139AspLys: 3.139 ± 0.435
4.633AspLeu: 4.633 ± 0.627
1.42AspMet: 1.42 ± 0.299
2.69AspAsn: 2.69 ± 0.477
2.616AspPro: 2.616 ± 0.374
2.765AspGln: 2.765 ± 0.526
3.811AspArg: 3.811 ± 0.535
3.662AspSer: 3.662 ± 0.542
2.915AspThr: 2.915 ± 0.443
4.484AspVal: 4.484 ± 0.605
1.196AspTrp: 1.196 ± 0.251
1.794AspTyr: 1.794 ± 0.418
0.0AspXaa: 0.0 ± 0.0
Glu
6.053GluAla: 6.053 ± 0.613
0.374GluCys: 0.374 ± 0.194
3.512GluAsp: 3.512 ± 0.469
4.335GluGlu: 4.335 ± 0.641
2.317GluPhe: 2.317 ± 0.443
4.484GluGly: 4.484 ± 0.474
1.644GluHis: 1.644 ± 0.37
2.317GluIle: 2.317 ± 0.361
2.69GluLys: 2.69 ± 0.499
6.128GluLeu: 6.128 ± 0.64
1.644GluMet: 1.644 ± 0.317
2.84GluAsn: 2.84 ± 0.575
1.868GluPro: 1.868 ± 0.374
2.69GluGln: 2.69 ± 0.468
2.989GluArg: 2.989 ± 0.606
2.765GluSer: 2.765 ± 0.501
2.915GluThr: 2.915 ± 0.342
3.662GluVal: 3.662 ± 0.455
1.345GluTrp: 1.345 ± 0.395
2.541GluTyr: 2.541 ± 0.396
0.0GluXaa: 0.0 ± 0.0
Phe
3.214PheAla: 3.214 ± 0.57
0.374PheCys: 0.374 ± 0.158
2.391PheAsp: 2.391 ± 0.446
1.345PheGlu: 1.345 ± 0.353
0.747PhePhe: 0.747 ± 0.231
3.363PheGly: 3.363 ± 0.385
0.972PheHis: 0.972 ± 0.278
1.719PheIle: 1.719 ± 0.379
1.27PheLys: 1.27 ± 0.384
2.391PheLeu: 2.391 ± 0.361
0.747PheMet: 0.747 ± 0.198
1.495PheAsn: 1.495 ± 0.416
1.27PhePro: 1.27 ± 0.291
1.42PheGln: 1.42 ± 0.283
1.794PheArg: 1.794 ± 0.337
2.541PheSer: 2.541 ± 0.352
1.719PheThr: 1.719 ± 0.429
2.317PheVal: 2.317 ± 0.603
0.149PheTrp: 0.149 ± 0.102
1.794PheTyr: 1.794 ± 0.351
0.0PheXaa: 0.0 ± 0.0
Gly
7.996GlyAla: 7.996 ± 0.913
0.822GlyCys: 0.822 ± 0.318
4.708GlyAsp: 4.708 ± 0.697
4.559GlyGlu: 4.559 ± 0.498
2.765GlyPhe: 2.765 ± 0.312
7.922GlyGly: 7.922 ± 0.901
1.121GlyHis: 1.121 ± 0.44
3.587GlyIle: 3.587 ± 0.654
5.007GlyLys: 5.007 ± 0.747
5.904GlyLeu: 5.904 ± 0.511
2.989GlyMet: 2.989 ± 0.523
4.11GlyAsn: 4.11 ± 0.472
2.616GlyPro: 2.616 ± 0.455
3.587GlyGln: 3.587 ± 0.659
4.783GlyArg: 4.783 ± 0.684
5.381GlySer: 5.381 ± 0.694
5.605GlyThr: 5.605 ± 0.807
5.306GlyVal: 5.306 ± 0.473
1.27GlyTrp: 1.27 ± 0.323
2.84GlyTyr: 2.84 ± 0.456
0.0GlyXaa: 0.0 ± 0.0
His
1.569HisAla: 1.569 ± 0.351
0.075HisCys: 0.075 ± 0.08
1.644HisAsp: 1.644 ± 0.333
1.42HisGlu: 1.42 ± 0.291
0.523HisPhe: 0.523 ± 0.208
1.42HisGly: 1.42 ± 0.253
0.598HisHis: 0.598 ± 0.262
0.972HisIle: 0.972 ± 0.239
0.897HisLys: 0.897 ± 0.33
1.046HisLeu: 1.046 ± 0.286
0.673HisMet: 0.673 ± 0.217
0.897HisAsn: 0.897 ± 0.297
1.121HisPro: 1.121 ± 0.299
0.523HisGln: 0.523 ± 0.259
1.495HisArg: 1.495 ± 0.375
1.121HisSer: 1.121 ± 0.261
1.046HisThr: 1.046 ± 0.319
1.196HisVal: 1.196 ± 0.382
0.299HisTrp: 0.299 ± 0.148
1.046HisTyr: 1.046 ± 0.283
0.0HisXaa: 0.0 ± 0.0
Ile
5.157IleAla: 5.157 ± 0.571
0.299IleCys: 0.299 ± 0.131
3.214IleAsp: 3.214 ± 0.424
3.737IleGlu: 3.737 ± 0.549
1.42IlePhe: 1.42 ± 0.393
3.139IleGly: 3.139 ± 0.511
1.27IleHis: 1.27 ± 0.361
1.868IleIle: 1.868 ± 0.39
2.391IleLys: 2.391 ± 0.554
2.765IleLeu: 2.765 ± 0.461
0.972IleMet: 0.972 ± 0.24
2.989IleAsn: 2.989 ± 0.47
2.616IlePro: 2.616 ± 0.446
1.719IleGln: 1.719 ± 0.328
3.064IleArg: 3.064 ± 0.494
1.719IleSer: 1.719 ± 0.324
2.915IleThr: 2.915 ± 0.488
3.139IleVal: 3.139 ± 0.581
0.374IleTrp: 0.374 ± 0.186
1.121IleTyr: 1.121 ± 0.288
0.0IleXaa: 0.0 ± 0.0
Lys
5.605LysAla: 5.605 ± 0.693
0.224LysCys: 0.224 ± 0.131
3.438LysAsp: 3.438 ± 0.555
2.915LysGlu: 2.915 ± 0.586
1.868LysPhe: 1.868 ± 0.308
3.363LysGly: 3.363 ± 0.591
1.121LysHis: 1.121 ± 0.242
1.868LysIle: 1.868 ± 0.327
1.644LysLys: 1.644 ± 0.432
4.932LysLeu: 4.932 ± 0.761
1.196LysMet: 1.196 ± 0.29
1.495LysAsn: 1.495 ± 0.29
2.466LysPro: 2.466 ± 0.47
2.391LysGln: 2.391 ± 0.37
4.185LysArg: 4.185 ± 0.829
1.868LysSer: 1.868 ± 0.348
2.69LysThr: 2.69 ± 0.399
2.915LysVal: 2.915 ± 0.545
1.121LysTrp: 1.121 ± 0.245
2.242LysTyr: 2.242 ± 0.369
0.0LysXaa: 0.0 ± 0.0
Leu
7.548LeuAla: 7.548 ± 1.051
1.121LeuCys: 1.121 ± 0.332
5.455LeuAsp: 5.455 ± 0.535
5.381LeuGlu: 5.381 ± 0.837
1.345LeuPhe: 1.345 ± 0.29
5.605LeuGly: 5.605 ± 0.486
1.794LeuHis: 1.794 ± 0.453
3.438LeuIle: 3.438 ± 0.543
4.335LeuLys: 4.335 ± 0.552
6.95LeuLeu: 6.95 ± 0.757
1.794LeuMet: 1.794 ± 0.277
3.288LeuAsn: 3.288 ± 0.446
3.587LeuPro: 3.587 ± 0.57
3.363LeuGln: 3.363 ± 0.649
6.128LeuArg: 6.128 ± 0.66
5.231LeuSer: 5.231 ± 0.666
5.605LeuThr: 5.605 ± 0.555
4.783LeuVal: 4.783 ± 0.845
0.897LeuTrp: 0.897 ± 0.233
2.391LeuTyr: 2.391 ± 0.411
0.0LeuXaa: 0.0 ± 0.0
Met
2.541MetAla: 2.541 ± 0.412
0.224MetCys: 0.224 ± 0.127
2.391MetAsp: 2.391 ± 0.439
1.495MetGlu: 1.495 ± 0.393
1.046MetPhe: 1.046 ± 0.268
2.167MetGly: 2.167 ± 0.434
0.374MetHis: 0.374 ± 0.151
0.822MetIle: 0.822 ± 0.213
1.121MetLys: 1.121 ± 0.333
2.69MetLeu: 2.69 ± 0.323
0.598MetMet: 0.598 ± 0.269
0.598MetAsn: 0.598 ± 0.205
0.897MetPro: 0.897 ± 0.235
1.345MetGln: 1.345 ± 0.381
2.317MetArg: 2.317 ± 0.586
2.541MetSer: 2.541 ± 0.281
1.644MetThr: 1.644 ± 0.382
1.569MetVal: 1.569 ± 0.351
0.299MetTrp: 0.299 ± 0.158
0.897MetTyr: 0.897 ± 0.296
0.0MetXaa: 0.0 ± 0.0
Asn
4.11AsnAla: 4.11 ± 0.584
0.374AsnCys: 0.374 ± 0.189
2.541AsnAsp: 2.541 ± 0.456
2.093AsnGlu: 2.093 ± 0.298
1.121AsnPhe: 1.121 ± 0.229
4.708AsnGly: 4.708 ± 0.526
0.822AsnHis: 0.822 ± 0.265
2.167AsnIle: 2.167 ± 0.534
2.391AsnLys: 2.391 ± 0.441
2.989AsnLeu: 2.989 ± 0.449
1.345AsnMet: 1.345 ± 0.321
1.42AsnAsn: 1.42 ± 0.424
2.242AsnPro: 2.242 ± 0.305
1.794AsnGln: 1.794 ± 0.427
2.541AsnArg: 2.541 ± 0.475
2.765AsnSer: 2.765 ± 0.417
3.139AsnThr: 3.139 ± 0.671
2.093AsnVal: 2.093 ± 0.365
0.747AsnTrp: 0.747 ± 0.169
1.345AsnTyr: 1.345 ± 0.277
0.0AsnXaa: 0.0 ± 0.0
Pro
4.409ProAla: 4.409 ± 1.129
0.448ProCys: 0.448 ± 0.162
2.84ProAsp: 2.84 ± 0.42
2.616ProGlu: 2.616 ± 0.544
0.972ProPhe: 0.972 ± 0.259
3.438ProGly: 3.438 ± 0.678
0.673ProHis: 0.673 ± 0.289
1.27ProIle: 1.27 ± 0.367
2.242ProLys: 2.242 ± 0.539
3.512ProLeu: 3.512 ± 0.52
1.196ProMet: 1.196 ± 0.334
2.018ProAsn: 2.018 ± 0.373
1.569ProPro: 1.569 ± 0.405
1.196ProGln: 1.196 ± 0.333
1.42ProArg: 1.42 ± 0.299
2.317ProSer: 2.317 ± 0.399
3.438ProThr: 3.438 ± 0.65
3.512ProVal: 3.512 ± 0.545
0.747ProTrp: 0.747 ± 0.215
0.972ProTyr: 0.972 ± 0.259
0.0ProXaa: 0.0 ± 0.0
Gln
5.754GlnAla: 5.754 ± 0.842
0.224GlnCys: 0.224 ± 0.124
1.943GlnAsp: 1.943 ± 0.395
2.317GlnGlu: 2.317 ± 0.416
2.093GlnPhe: 2.093 ± 0.324
3.811GlnGly: 3.811 ± 0.491
0.448GlnHis: 0.448 ± 0.182
2.167GlnIle: 2.167 ± 0.338
1.794GlnLys: 1.794 ± 0.367
4.036GlnLeu: 4.036 ± 0.472
1.121GlnMet: 1.121 ± 0.269
1.644GlnAsn: 1.644 ± 0.396
1.345GlnPro: 1.345 ± 0.436
2.69GlnGln: 2.69 ± 0.667
3.214GlnArg: 3.214 ± 0.698
2.616GlnSer: 2.616 ± 0.506
3.288GlnThr: 3.288 ± 0.66
2.69GlnVal: 2.69 ± 0.517
0.822GlnTrp: 0.822 ± 0.27
1.121GlnTyr: 1.121 ± 0.287
0.0GlnXaa: 0.0 ± 0.0
Arg
5.904ArgAla: 5.904 ± 0.741
0.822ArgCys: 0.822 ± 0.259
2.989ArgAsp: 2.989 ± 0.536
3.363ArgGlu: 3.363 ± 0.656
2.018ArgPhe: 2.018 ± 0.372
4.484ArgGly: 4.484 ± 0.627
1.27ArgHis: 1.27 ± 0.276
3.512ArgIle: 3.512 ± 0.647
4.559ArgLys: 4.559 ± 0.667
4.633ArgLeu: 4.633 ± 0.67
2.093ArgMet: 2.093 ± 0.385
2.69ArgAsn: 2.69 ± 0.413
2.018ArgPro: 2.018 ± 0.436
2.69ArgGln: 2.69 ± 0.466
3.214ArgArg: 3.214 ± 0.513
3.139ArgSer: 3.139 ± 0.446
3.139ArgThr: 3.139 ± 0.535
5.007ArgVal: 5.007 ± 0.704
0.972ArgTrp: 0.972 ± 0.241
2.616ArgTyr: 2.616 ± 0.466
0.0ArgXaa: 0.0 ± 0.0
Ser
6.128SerAla: 6.128 ± 0.697
0.598SerCys: 0.598 ± 0.245
3.288SerAsp: 3.288 ± 0.543
3.139SerGlu: 3.139 ± 0.409
1.794SerPhe: 1.794 ± 0.339
5.904SerGly: 5.904 ± 0.902
0.822SerHis: 0.822 ± 0.274
3.064SerIle: 3.064 ± 0.498
1.794SerLys: 1.794 ± 0.373
4.484SerLeu: 4.484 ± 0.63
1.569SerMet: 1.569 ± 0.267
2.84SerAsn: 2.84 ± 0.336
2.466SerPro: 2.466 ± 0.421
2.167SerGln: 2.167 ± 0.359
3.587SerArg: 3.587 ± 0.466
3.288SerSer: 3.288 ± 0.56
4.185SerThr: 4.185 ± 0.582
4.036SerVal: 4.036 ± 0.551
1.121SerTrp: 1.121 ± 0.291
1.794SerTyr: 1.794 ± 0.394
0.0SerXaa: 0.0 ± 0.0
Thr
7.249ThrAla: 7.249 ± 0.885
0.374ThrCys: 0.374 ± 0.211
2.84ThrAsp: 2.84 ± 0.476
3.587ThrGlu: 3.587 ± 0.612
2.317ThrPhe: 2.317 ± 0.348
6.576ThrGly: 6.576 ± 0.64
0.822ThrHis: 0.822 ± 0.201
2.466ThrIle: 2.466 ± 0.449
2.989ThrLys: 2.989 ± 0.637
4.559ThrLeu: 4.559 ± 0.49
1.196ThrMet: 1.196 ± 0.345
2.242ThrAsn: 2.242 ± 0.428
2.84ThrPro: 2.84 ± 0.474
3.512ThrGln: 3.512 ± 0.538
3.064ThrArg: 3.064 ± 0.536
4.036ThrSer: 4.036 ± 0.761
4.26ThrThr: 4.26 ± 0.726
4.335ThrVal: 4.335 ± 0.645
0.972ThrTrp: 0.972 ± 0.291
2.167ThrTyr: 2.167 ± 0.427
0.0ThrXaa: 0.0 ± 0.0
Val
5.68ValAla: 5.68 ± 0.723
0.374ValCys: 0.374 ± 0.16
3.886ValAsp: 3.886 ± 0.515
3.587ValGlu: 3.587 ± 0.471
1.868ValPhe: 1.868 ± 0.299
5.754ValGly: 5.754 ± 0.613
1.719ValHis: 1.719 ± 0.386
2.84ValIle: 2.84 ± 0.488
2.915ValLys: 2.915 ± 0.445
5.829ValLeu: 5.829 ± 0.649
1.943ValMet: 1.943 ± 0.427
3.064ValAsn: 3.064 ± 0.765
3.214ValPro: 3.214 ± 0.367
2.915ValGln: 2.915 ± 0.498
4.185ValArg: 4.185 ± 0.579
4.633ValSer: 4.633 ± 0.73
4.26ValThr: 4.26 ± 0.676
4.708ValVal: 4.708 ± 0.623
1.196ValTrp: 1.196 ± 0.328
2.317ValTyr: 2.317 ± 0.454
0.0ValXaa: 0.0 ± 0.0
Trp
1.27TrpAla: 1.27 ± 0.276
0.448TrpCys: 0.448 ± 0.192
0.747TrpAsp: 0.747 ± 0.239
0.822TrpGlu: 0.822 ± 0.244
1.046TrpPhe: 1.046 ± 0.219
0.747TrpGly: 0.747 ± 0.265
0.523TrpHis: 0.523 ± 0.166
0.822TrpIle: 0.822 ± 0.283
0.972TrpLys: 0.972 ± 0.291
1.868TrpLeu: 1.868 ± 0.381
0.523TrpMet: 0.523 ± 0.211
0.523TrpAsn: 0.523 ± 0.163
0.374TrpPro: 0.374 ± 0.166
0.972TrpGln: 0.972 ± 0.234
0.897TrpArg: 0.897 ± 0.224
0.972TrpSer: 0.972 ± 0.23
0.673TrpThr: 0.673 ± 0.262
1.27TrpVal: 1.27 ± 0.278
0.224TrpTrp: 0.224 ± 0.112
0.747TrpTyr: 0.747 ± 0.199
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.139TyrAla: 3.139 ± 0.527
0.224TyrCys: 0.224 ± 0.142
2.616TyrAsp: 2.616 ± 0.476
2.242TyrGlu: 2.242 ± 0.342
1.345TyrPhe: 1.345 ± 0.287
2.84TyrGly: 2.84 ± 0.479
0.523TyrHis: 0.523 ± 0.188
1.868TyrIle: 1.868 ± 0.521
1.196TyrLys: 1.196 ± 0.286
2.466TyrLeu: 2.466 ± 0.411
0.523TyrMet: 0.523 ± 0.235
1.569TyrAsn: 1.569 ± 0.381
0.972TyrPro: 0.972 ± 0.253
1.569TyrGln: 1.569 ± 0.392
2.391TyrArg: 2.391 ± 0.398
1.345TyrSer: 1.345 ± 0.258
2.616TyrThr: 2.616 ± 0.55
2.616TyrVal: 2.616 ± 0.543
0.673TyrTrp: 0.673 ± 0.284
0.822TyrTyr: 0.822 ± 0.223
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 53 proteins (13382 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski