Amino acid dipepetide frequency for Mycoplasma sp. (ex Biomphalaria glabrata)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.858AlaAla: 2.858 ± 0.153
0.558AlaCys: 0.558 ± 0.055
2.101AlaAsp: 2.101 ± 0.111
2.198AlaGlu: 2.198 ± 0.109
2.746AlaPhe: 2.746 ± 0.118
2.548AlaGly: 2.548 ± 0.129
0.924AlaHis: 0.924 ± 0.083
5.725AlaIle: 5.725 ± 0.179
4.908AlaLys: 4.908 ± 0.169
4.71AlaLeu: 4.71 ± 0.164
0.909AlaMet: 0.909 ± 0.076
3.731AlaAsn: 3.731 ± 0.147
1.157AlaPro: 1.157 ± 0.081
1.751AlaGln: 1.751 ± 0.104
1.685AlaArg: 1.685 ± 0.091
3.183AlaSer: 3.183 ± 0.143
3.294AlaThr: 3.294 ± 0.173
2.34AlaVal: 2.34 ± 0.125
0.442AlaTrp: 0.442 ± 0.044
1.802AlaTyr: 1.802 ± 0.092
0.0AlaXaa: 0.0 ± 0.0
Cys
0.457CysAla: 0.457 ± 0.045
0.127CysCys: 0.127 ± 0.026
0.487CysAsp: 0.487 ± 0.061
0.721CysGlu: 0.721 ± 0.073
0.487CysPhe: 0.487 ± 0.047
0.624CysGly: 0.624 ± 0.065
0.249CysHis: 0.249 ± 0.038
0.711CysIle: 0.711 ± 0.07
0.634CysLys: 0.634 ± 0.063
0.858CysLeu: 0.858 ± 0.063
0.178CysMet: 0.178 ± 0.033
0.589CysAsn: 0.589 ± 0.068
0.34CysPro: 0.34 ± 0.045
0.254CysGln: 0.254 ± 0.037
0.198CysArg: 0.198 ± 0.032
0.64CysSer: 0.64 ± 0.062
0.401CysThr: 0.401 ± 0.042
0.528CysVal: 0.528 ± 0.059
0.086CysTrp: 0.086 ± 0.019
0.406CysTyr: 0.406 ± 0.054
0.0CysXaa: 0.0 ± 0.0
Asp
2.655AspAla: 2.655 ± 0.147
0.472AspCys: 0.472 ± 0.053
2.741AspAsp: 2.741 ± 0.139
3.685AspGlu: 3.685 ± 0.168
3.452AspPhe: 3.452 ± 0.162
2.69AspGly: 2.69 ± 0.117
0.934AspHis: 0.934 ± 0.062
5.091AspIle: 5.091 ± 0.198
4.487AspLys: 4.487 ± 0.157
5.213AspLeu: 5.213 ± 0.174
0.883AspMet: 0.883 ± 0.059
3.837AspAsn: 3.837 ± 0.168
1.573AspPro: 1.573 ± 0.107
1.614AspGln: 1.614 ± 0.094
1.264AspArg: 1.264 ± 0.086
3.355AspSer: 3.355 ± 0.162
2.071AspThr: 2.071 ± 0.105
3.416AspVal: 3.416 ± 0.128
0.609AspTrp: 0.609 ± 0.057
2.36AspTyr: 2.36 ± 0.116
0.0AspXaa: 0.0 ± 0.0
Glu
2.69GluAla: 2.69 ± 0.147
0.604GluCys: 0.604 ± 0.063
2.619GluAsp: 2.619 ± 0.136
4.157GluGlu: 4.157 ± 0.216
2.782GluPhe: 2.782 ± 0.119
2.507GluGly: 2.507 ± 0.111
1.107GluHis: 1.107 ± 0.084
7.071GluIle: 7.071 ± 0.252
7.0GluLys: 7.0 ± 0.274
6.162GluLeu: 6.162 ± 0.207
1.376GluMet: 1.376 ± 0.09
4.913GluAsn: 4.913 ± 0.183
1.238GluPro: 1.238 ± 0.08
2.533GluGln: 2.533 ± 0.14
1.898GluArg: 1.898 ± 0.108
3.162GluSer: 3.162 ± 0.131
2.939GluThr: 2.939 ± 0.118
3.37GluVal: 3.37 ± 0.146
0.619GluTrp: 0.619 ± 0.061
2.355GluTyr: 2.355 ± 0.098
0.0GluXaa: 0.0 ± 0.0
Phe
2.868PheAla: 2.868 ± 0.127
0.487PheCys: 0.487 ± 0.056
3.188PheAsp: 3.188 ± 0.126
2.985PheGlu: 2.985 ± 0.139
3.314PhePhe: 3.314 ± 0.159
3.04PheGly: 3.04 ± 0.121
0.863PheHis: 0.863 ± 0.066
5.01PheIle: 5.01 ± 0.193
3.863PheLys: 3.863 ± 0.158
5.949PheLeu: 5.949 ± 0.202
0.914PheMet: 0.914 ± 0.066
4.182PheAsn: 4.182 ± 0.159
1.639PhePro: 1.639 ± 0.101
1.756PheGln: 1.756 ± 0.096
1.345PheArg: 1.345 ± 0.081
4.396PheSer: 4.396 ± 0.21
2.893PheThr: 2.893 ± 0.132
3.335PheVal: 3.335 ± 0.136
0.563PheTrp: 0.563 ± 0.053
2.203PheTyr: 2.203 ± 0.111
0.0PheXaa: 0.0 ± 0.0
Gly
2.817GlyAla: 2.817 ± 0.153
0.492GlyCys: 0.492 ± 0.056
2.436GlyAsp: 2.436 ± 0.123
2.629GlyGlu: 2.629 ± 0.107
3.0GlyPhe: 3.0 ± 0.124
3.223GlyGly: 3.223 ± 0.185
1.152GlyHis: 1.152 ± 0.079
5.548GlyIle: 5.548 ± 0.203
4.609GlyLys: 4.609 ± 0.177
4.639GlyLeu: 4.639 ± 0.18
1.152GlyMet: 1.152 ± 0.072
3.02GlyAsn: 3.02 ± 0.121
1.167GlyPro: 1.167 ± 0.085
1.645GlyGln: 1.645 ± 0.082
1.482GlyArg: 1.482 ± 0.089
3.106GlySer: 3.106 ± 0.126
3.269GlyThr: 3.269 ± 0.133
3.462GlyVal: 3.462 ± 0.15
0.711GlyTrp: 0.711 ± 0.091
2.771GlyTyr: 2.771 ± 0.207
0.0GlyXaa: 0.0 ± 0.0
His
0.919HisAla: 0.919 ± 0.065
0.162HisCys: 0.162 ± 0.034
0.975HisAsp: 0.975 ± 0.067
1.294HisGlu: 1.294 ± 0.09
0.924HisPhe: 0.924 ± 0.063
1.157HisGly: 1.157 ± 0.081
0.497HisHis: 0.497 ± 0.05
1.523HisIle: 1.523 ± 0.106
1.167HisLys: 1.167 ± 0.084
1.68HisLeu: 1.68 ± 0.108
0.239HisMet: 0.239 ± 0.038
1.406HisAsn: 1.406 ± 0.089
0.695HisPro: 0.695 ± 0.059
0.711HisGln: 0.711 ± 0.063
0.503HisArg: 0.503 ± 0.058
1.061HisSer: 1.061 ± 0.079
0.761HisThr: 0.761 ± 0.057
0.929HisVal: 0.929 ± 0.081
0.162HisTrp: 0.162 ± 0.03
0.954HisTyr: 0.954 ± 0.068
0.0HisXaa: 0.0 ± 0.0
Ile
5.878IleAla: 5.878 ± 0.178
1.051IleCys: 1.051 ± 0.078
6.208IleAsp: 6.208 ± 0.18
6.644IleGlu: 6.644 ± 0.233
5.264IlePhe: 5.264 ± 0.221
5.248IleGly: 5.248 ± 0.214
1.528IleHis: 1.528 ± 0.095
10.36IleIle: 10.36 ± 0.326
8.177IleLys: 8.177 ± 0.297
8.548IleLeu: 8.548 ± 0.234
1.949IleMet: 1.949 ± 0.107
7.979IleAsn: 7.979 ± 0.211
3.111IlePro: 3.111 ± 0.143
2.68IleGln: 2.68 ± 0.124
2.873IleArg: 2.873 ± 0.136
7.812IleSer: 7.812 ± 0.202
5.578IleThr: 5.578 ± 0.192
5.756IleVal: 5.756 ± 0.188
0.944IleTrp: 0.944 ± 0.078
3.726IleTyr: 3.726 ± 0.148
0.005IleXaa: 0.005 ± 0.005
Lys
3.198LysAla: 3.198 ± 0.14
0.675LysCys: 0.675 ± 0.073
4.426LysAsp: 4.426 ± 0.164
6.228LysGlu: 6.228 ± 0.239
3.741LysPhe: 3.741 ± 0.147
3.518LysGly: 3.518 ± 0.169
1.639LysHis: 1.639 ± 0.099
10.258LysIle: 10.258 ± 0.303
9.319LysLys: 9.319 ± 0.38
7.598LysLeu: 7.598 ± 0.243
2.096LysMet: 2.096 ± 0.124
8.796LysAsn: 8.796 ± 0.238
2.335LysPro: 2.335 ± 0.118
2.685LysGln: 2.685 ± 0.119
2.629LysArg: 2.629 ± 0.141
5.324LysSer: 5.324 ± 0.174
4.984LysThr: 4.984 ± 0.171
4.045LysVal: 4.045 ± 0.165
0.944LysTrp: 0.944 ± 0.066
4.203LysTyr: 4.203 ± 0.146
0.0LysXaa: 0.0 ± 0.0
Leu
5.071LeuAla: 5.071 ± 0.158
0.751LeuCys: 0.751 ± 0.069
5.015LeuAsp: 5.015 ± 0.147
5.812LeuGlu: 5.812 ± 0.195
4.858LeuPhe: 4.858 ± 0.185
5.289LeuGly: 5.289 ± 0.187
1.523LeuHis: 1.523 ± 0.08
9.05LeuIle: 9.05 ± 0.254
8.268LeuLys: 8.268 ± 0.232
7.812LeuLeu: 7.812 ± 0.242
1.766LeuMet: 1.766 ± 0.098
7.086LeuAsn: 7.086 ± 0.17
3.183LeuPro: 3.183 ± 0.146
2.954LeuGln: 2.954 ± 0.126
2.716LeuArg: 2.716 ± 0.139
6.624LeuSer: 6.624 ± 0.211
5.644LeuThr: 5.644 ± 0.208
5.482LeuVal: 5.482 ± 0.184
0.838LeuTrp: 0.838 ± 0.064
2.832LeuTyr: 2.832 ± 0.118
0.005LeuXaa: 0.005 ± 0.005
Met
0.985MetAla: 0.985 ± 0.07
0.178MetCys: 0.178 ± 0.029
0.878MetAsp: 0.878 ± 0.066
1.152MetGlu: 1.152 ± 0.082
1.076MetPhe: 1.076 ± 0.08
1.051MetGly: 1.051 ± 0.072
0.325MetHis: 0.325 ± 0.039
1.792MetIle: 1.792 ± 0.117
1.807MetLys: 1.807 ± 0.092
1.716MetLeu: 1.716 ± 0.089
0.35MetMet: 0.35 ± 0.048
1.68MetAsn: 1.68 ± 0.087
0.69MetPro: 0.69 ± 0.064
0.665MetGln: 0.665 ± 0.056
0.584MetArg: 0.584 ± 0.054
1.436MetSer: 1.436 ± 0.086
1.142MetThr: 1.142 ± 0.078
1.152MetVal: 1.152 ± 0.077
0.198MetTrp: 0.198 ± 0.031
0.594MetTyr: 0.594 ± 0.053
0.0MetXaa: 0.0 ± 0.0
Asn
3.477AsnAla: 3.477 ± 0.137
0.568AsnCys: 0.568 ± 0.051
4.523AsnAsp: 4.523 ± 0.173
4.766AsnGlu: 4.766 ± 0.161
4.842AsnPhe: 4.842 ± 0.244
3.512AsnGly: 3.512 ± 0.172
1.396AsnHis: 1.396 ± 0.083
7.167AsnIle: 7.167 ± 0.2
7.02AsnLys: 7.02 ± 0.196
7.436AsnLeu: 7.436 ± 0.272
1.386AsnMet: 1.386 ± 0.079
7.025AsnAsn: 7.025 ± 0.254
2.924AsnPro: 2.924 ± 0.127
3.061AsnGln: 3.061 ± 0.152
2.228AsnArg: 2.228 ± 0.103
5.091AsnSer: 5.091 ± 0.19
3.472AsnThr: 3.472 ± 0.169
4.213AsnVal: 4.213 ± 0.16
1.051AsnTrp: 1.051 ± 0.099
4.035AsnTyr: 4.035 ± 0.217
0.0AsnXaa: 0.0 ± 0.0
Pro
1.259ProAla: 1.259 ± 0.087
0.203ProCys: 0.203 ± 0.031
1.365ProAsp: 1.365 ± 0.093
1.675ProGlu: 1.675 ± 0.092
1.639ProPhe: 1.639 ± 0.091
1.65ProGly: 1.65 ± 0.089
0.538ProHis: 0.538 ± 0.043
3.228ProIle: 3.228 ± 0.144
2.477ProLys: 2.477 ± 0.154
2.624ProLeu: 2.624 ± 0.122
0.543ProMet: 0.543 ± 0.053
2.502ProAsn: 2.502 ± 0.115
0.497ProPro: 0.497 ± 0.047
0.909ProGln: 0.909 ± 0.078
0.64ProArg: 0.64 ± 0.062
2.325ProSer: 2.325 ± 0.099
2.096ProThr: 2.096 ± 0.15
1.548ProVal: 1.548 ± 0.084
0.294ProTrp: 0.294 ± 0.036
1.096ProTyr: 1.096 ± 0.079
0.0ProXaa: 0.0 ± 0.0
Gln
1.695GlnAla: 1.695 ± 0.102
0.152GlnCys: 0.152 ± 0.027
1.573GlnAsp: 1.573 ± 0.083
2.33GlnGlu: 2.33 ± 0.106
1.65GlnPhe: 1.65 ± 0.089
1.614GlnGly: 1.614 ± 0.088
0.558GlnHis: 0.558 ± 0.051
3.142GlnIle: 3.142 ± 0.105
3.482GlnLys: 3.482 ± 0.133
2.812GlnLeu: 2.812 ± 0.114
0.736GlnMet: 0.736 ± 0.065
2.99GlnAsn: 2.99 ± 0.152
0.751GlnPro: 0.751 ± 0.059
1.132GlnGln: 1.132 ± 0.09
1.056GlnArg: 1.056 ± 0.069
1.893GlnSer: 1.893 ± 0.108
1.858GlnThr: 1.858 ± 0.113
1.868GlnVal: 1.868 ± 0.096
0.391GlnTrp: 0.391 ± 0.048
1.34GlnTyr: 1.34 ± 0.09
0.0GlnXaa: 0.0 ± 0.0
Arg
1.274ArgAla: 1.274 ± 0.087
0.289ArgCys: 0.289 ± 0.038
1.538ArgAsp: 1.538 ± 0.097
2.01ArgGlu: 2.01 ± 0.153
1.35ArgPhe: 1.35 ± 0.083
1.538ArgGly: 1.538 ± 0.091
0.528ArgHis: 0.528 ± 0.055
2.929ArgIle: 2.929 ± 0.125
2.812ArgLys: 2.812 ± 0.154
2.568ArgLeu: 2.568 ± 0.107
0.711ArgMet: 0.711 ± 0.063
2.101ArgAsn: 2.101 ± 0.104
0.878ArgPro: 0.878 ± 0.08
0.873ArgGln: 0.873 ± 0.071
1.046ArgArg: 1.046 ± 0.082
1.685ArgSer: 1.685 ± 0.093
1.467ArgThr: 1.467 ± 0.08
1.629ArgVal: 1.629 ± 0.107
0.239ArgTrp: 0.239 ± 0.032
1.188ArgTyr: 1.188 ± 0.081
0.0ArgXaa: 0.0 ± 0.0
Ser
2.985SerAla: 2.985 ± 0.119
0.665SerCys: 0.665 ± 0.058
3.523SerAsp: 3.523 ± 0.181
3.665SerGlu: 3.665 ± 0.156
4.228SerPhe: 4.228 ± 0.176
3.609SerGly: 3.609 ± 0.161
1.173SerHis: 1.173 ± 0.078
7.071SerIle: 7.071 ± 0.181
5.944SerLys: 5.944 ± 0.173
6.771SerLeu: 6.771 ± 0.194
1.213SerMet: 1.213 ± 0.071
5.03SerAsn: 5.03 ± 0.186
1.832SerPro: 1.832 ± 0.11
2.381SerGln: 2.381 ± 0.112
1.832SerArg: 1.832 ± 0.091
5.304SerSer: 5.304 ± 0.228
4.101SerThr: 4.101 ± 0.223
3.38SerVal: 3.38 ± 0.132
0.873SerTrp: 0.873 ± 0.069
2.792SerTyr: 2.792 ± 0.115
0.0SerXaa: 0.0 ± 0.0
Thr
2.655ThrAla: 2.655 ± 0.2
0.442ThrCys: 0.442 ± 0.045
2.614ThrAsp: 2.614 ± 0.126
2.594ThrGlu: 2.594 ± 0.137
3.243ThrPhe: 3.243 ± 0.169
3.243ThrGly: 3.243 ± 0.158
1.193ThrHis: 1.193 ± 0.072
5.634ThrIle: 5.634 ± 0.146
4.457ThrLys: 4.457 ± 0.176
5.116ThrLeu: 5.116 ± 0.143
0.919ThrMet: 0.919 ± 0.061
4.472ThrAsn: 4.472 ± 0.228
2.193ThrPro: 2.193 ± 0.118
1.985ThrGln: 1.985 ± 0.116
1.558ThrArg: 1.558 ± 0.102
4.482ThrSer: 4.482 ± 0.25
4.005ThrThr: 4.005 ± 0.253
2.183ThrVal: 2.183 ± 0.126
0.558ThrTrp: 0.558 ± 0.064
2.178ThrTyr: 2.178 ± 0.149
0.0ThrXaa: 0.0 ± 0.0
Val
3.228ValAla: 3.228 ± 0.16
0.518ValCys: 0.518 ± 0.059
3.289ValAsp: 3.289 ± 0.139
3.38ValGlu: 3.38 ± 0.165
2.66ValPhe: 2.66 ± 0.124
3.33ValGly: 3.33 ± 0.144
0.766ValHis: 0.766 ± 0.075
5.624ValIle: 5.624 ± 0.165
4.218ValLys: 4.218 ± 0.184
5.096ValLeu: 5.096 ± 0.188
1.152ValMet: 1.152 ± 0.078
3.868ValAsn: 3.868 ± 0.164
1.477ValPro: 1.477 ± 0.076
1.614ValGln: 1.614 ± 0.08
1.508ValArg: 1.508 ± 0.099
3.959ValSer: 3.959 ± 0.155
3.152ValThr: 3.152 ± 0.123
3.853ValVal: 3.853 ± 0.174
0.538ValTrp: 0.538 ± 0.055
1.777ValTyr: 1.777 ± 0.1
0.0ValXaa: 0.0 ± 0.0
Trp
0.513TrpAla: 0.513 ± 0.051
0.086TrpCys: 0.086 ± 0.021
0.513TrpAsp: 0.513 ± 0.05
0.589TrpGlu: 0.589 ± 0.055
0.695TrpPhe: 0.695 ± 0.07
0.65TrpGly: 0.65 ± 0.065
0.122TrpHis: 0.122 ± 0.022
1.142TrpIle: 1.142 ± 0.088
0.934TrpLys: 0.934 ± 0.07
0.909TrpLeu: 0.909 ± 0.07
0.239TrpMet: 0.239 ± 0.038
0.929TrpAsn: 0.929 ± 0.083
0.254TrpPro: 0.254 ± 0.038
0.279TrpGln: 0.279 ± 0.041
0.32TrpArg: 0.32 ± 0.036
0.731TrpSer: 0.731 ± 0.065
0.66TrpThr: 0.66 ± 0.067
0.553TrpVal: 0.553 ± 0.054
0.178TrpTrp: 0.178 ± 0.033
0.472TrpTyr: 0.472 ± 0.058
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.091TyrAla: 2.091 ± 0.093
0.492TyrCys: 0.492 ± 0.049
2.391TyrAsp: 2.391 ± 0.127
2.589TyrGlu: 2.589 ± 0.118
2.842TyrPhe: 2.842 ± 0.136
2.289TyrGly: 2.289 ± 0.16
0.706TyrHis: 0.706 ± 0.071
3.249TyrIle: 3.249 ± 0.145
3.061TyrLys: 3.061 ± 0.132
4.355TyrLeu: 4.355 ± 0.149
0.736TyrMet: 0.736 ± 0.058
3.051TyrAsn: 3.051 ± 0.153
1.173TyrPro: 1.173 ± 0.088
1.543TyrGln: 1.543 ± 0.099
1.289TyrArg: 1.289 ± 0.076
2.802TyrSer: 2.802 ± 0.128
1.934TyrThr: 1.934 ± 0.125
1.964TyrVal: 1.964 ± 0.101
0.528TyrTrp: 0.528 ± 0.063
2.167TyrTyr: 2.167 ± 0.176
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.005XaaLeu: 0.005 ± 0.005
0.0XaaMet: 0.0 ± 0.0
0.005XaaAsn: 0.005 ± 0.005
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.015XaaXaa: 0.015 ± 0.012
Statistics based on 555 proteins (197015 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski