Amino acid dipepetide frequency for Klebsiella variicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.715AlaAla: 11.715 ± 0.129	1.206AlaCys: 1.206 ± 0.031	5.376AlaAsp: 5.376 ± 0.062	5.977AlaGlu: 5.977 ± 0.069	3.749AlaPhe: 3.749 ± 0.049	8.342AlaGly: 8.342 ± 0.089	2.011AlaHis: 2.011 ± 0.033	6.142AlaIle: 6.142 ± 0.064	3.613AlaLys: 3.613 ± 0.052	12.977AlaLeu: 12.977 ± 0.119	3.169AlaMet: 3.169 ± 0.044	2.939AlaAsn: 2.939 ± 0.043	4.025AlaPro: 4.025 ± 0.059	4.755AlaGln: 4.755 ± 0.065	6.32AlaArg: 6.32 ± 0.075	5.795AlaSer: 5.795 ± 0.063	5.027AlaThr: 5.027 ± 0.066	7.302AlaVal: 7.302 ± 0.065	1.892AlaTrp: 1.892 ± 0.038	1.903AlaTyr: 1.903 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	1.057CysAla: 1.057 ± 0.03	0.18CysCys: 0.18 ± 0.011	0.607CysAsp: 0.607 ± 0.022	0.585CysGlu: 0.585 ± 0.018	0.446CysPhe: 0.446 ± 0.017	1.066CysGly: 1.066 ± 0.025	0.313CysHis: 0.313 ± 0.015	0.524CysIle: 0.524 ± 0.018	0.306CysLys: 0.306 ± 0.014	1.038CysLeu: 1.038 ± 0.027	0.256CysMet: 0.256 ± 0.011	0.303CysAsn: 0.303 ± 0.013	0.526CysPro: 0.526 ± 0.019	0.467CysGln: 0.467 ± 0.016	0.707CysArg: 0.707 ± 0.02	0.664CysSer: 0.664 ± 0.02	0.479CysThr: 0.479 ± 0.016	0.731CysVal: 0.731 ± 0.027	0.193CysTrp: 0.193 ± 0.012	0.326CysTyr: 0.326 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.322AspAla: 5.322 ± 0.061	0.469AspCys: 0.469 ± 0.017	2.968AspAsp: 2.968 ± 0.05	3.424AspGlu: 3.424 ± 0.048	2.058AspPhe: 2.058 ± 0.036	3.818AspGly: 3.818 ± 0.049	1.017AspHis: 1.017 ± 0.026	3.304AspIle: 3.304 ± 0.045	2.326AspLys: 2.326 ± 0.041	4.728AspLeu: 4.728 ± 0.057	1.265AspMet: 1.265 ± 0.027	2.096AspAsn: 2.096 ± 0.036	2.4AspPro: 2.4 ± 0.039	1.553AspGln: 1.553 ± 0.029	2.83AspArg: 2.83 ± 0.043	2.742AspSer: 2.742 ± 0.04	2.451AspThr: 2.451 ± 0.04	3.64AspVal: 3.64 ± 0.05	0.836AspTrp: 0.836 ± 0.021	1.813AspTyr: 1.813 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.719GluAla: 5.719 ± 0.07	0.437GluCys: 0.437 ± 0.018	2.194GluAsp: 2.194 ± 0.041	3.229GluGlu: 3.229 ± 0.049	1.725GluPhe: 1.725 ± 0.03	3.643GluGly: 3.643 ± 0.048	1.371GluHis: 1.371 ± 0.032	3.05GluIle: 3.05 ± 0.044	2.974GluLys: 2.974 ± 0.054	5.569GluLeu: 5.569 ± 0.06	1.767GluMet: 1.767 ± 0.034	2.091GluAsn: 2.091 ± 0.037	2.051GluPro: 2.051 ± 0.039	3.235GluGln: 3.235 ± 0.045	3.623GluArg: 3.623 ± 0.043	2.859GluSer: 2.859 ± 0.043	2.857GluThr: 2.857 ± 0.044	3.686GluVal: 3.686 ± 0.056	0.779GluTrp: 0.779 ± 0.02	1.383GluTyr: 1.383 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.93PheAla: 3.93 ± 0.052	0.545PheCys: 0.545 ± 0.02	2.275PheAsp: 2.275 ± 0.041	1.604PheGlu: 1.604 ± 0.03	1.704PhePhe: 1.704 ± 0.036	3.145PheGly: 3.145 ± 0.053	0.849PheHis: 0.849 ± 0.024	2.533PheIle: 2.533 ± 0.039	1.147PheLys: 1.147 ± 0.029	3.347PheLeu: 3.347 ± 0.053	0.951PheMet: 0.951 ± 0.024	1.647PheAsn: 1.647 ± 0.033	1.586PhePro: 1.586 ± 0.031	1.152PheGln: 1.152 ± 0.024	1.947PheArg: 1.947 ± 0.029	3.042PheSer: 3.042 ± 0.044	2.467PheThr: 2.467 ± 0.037	2.523PheVal: 2.523 ± 0.041	0.637PheTrp: 0.637 ± 0.023	1.207PheTyr: 1.207 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	6.64GlyAla: 6.64 ± 0.078	1.027GlyCys: 1.027 ± 0.026	3.684GlyAsp: 3.684 ± 0.056	4.678GlyGlu: 4.678 ± 0.058	3.333GlyPhe: 3.333 ± 0.048	5.618GlyGly: 5.618 ± 0.074	1.675GlyHis: 1.675 ± 0.031	4.962GlyIle: 4.962 ± 0.058	3.82GlyLys: 3.82 ± 0.05	8.021GlyLeu: 8.021 ± 0.086	2.51GlyMet: 2.51 ± 0.04	2.554GlyAsn: 2.554 ± 0.044	2.217GlyPro: 2.217 ± 0.037	3.084GlyGln: 3.084 ± 0.047	3.973GlyArg: 3.973 ± 0.053	4.241GlySer: 4.241 ± 0.053	3.7GlyThr: 3.7 ± 0.052	5.904GlyVal: 5.904 ± 0.066	1.382GlyTrp: 1.382 ± 0.03	2.631GlyTyr: 2.631 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.041HisAla: 2.041 ± 0.036	0.306HisCys: 0.306 ± 0.013	1.243HisAsp: 1.243 ± 0.03	1.086HisGlu: 1.086 ± 0.026	1.065HisPhe: 1.065 ± 0.026	1.864HisGly: 1.864 ± 0.034	0.833HisHis: 0.833 ± 0.026	1.303HisIle: 1.303 ± 0.029	0.717HisLys: 0.717 ± 0.019	2.367HisLeu: 2.367 ± 0.043	0.528HisMet: 0.528 ± 0.016	0.77HisAsn: 0.77 ± 0.021	1.408HisPro: 1.408 ± 0.029	1.246HisGln: 1.246 ± 0.027	1.314HisArg: 1.314 ± 0.032	1.307HisSer: 1.307 ± 0.029	1.086HisThr: 1.086 ± 0.031	1.294HisVal: 1.294 ± 0.024	0.423HisTrp: 0.423 ± 0.017	0.927HisTyr: 0.927 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.828IleAla: 6.828 ± 0.063	0.664IleCys: 0.664 ± 0.019	3.501IleAsp: 3.501 ± 0.044	2.968IleGlu: 2.968 ± 0.039	2.036IlePhe: 2.036 ± 0.037	4.585IleGly: 4.585 ± 0.057	1.202IleHis: 1.202 ± 0.025	3.241IleIle: 3.241 ± 0.058	2.088IleLys: 2.088 ± 0.038	4.87IleLeu: 4.87 ± 0.065	1.161IleMet: 1.161 ± 0.029	2.439IleAsn: 2.439 ± 0.042	2.735IlePro: 2.735 ± 0.039	1.713IleGln: 1.713 ± 0.032	2.969IleArg: 2.969 ± 0.043	3.617IleSer: 3.617 ± 0.05	3.277IleThr: 3.277 ± 0.049	3.991IleVal: 3.991 ± 0.054	0.68IleTrp: 0.68 ± 0.021	1.484IleTyr: 1.484 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.141LysAla: 4.141 ± 0.065	0.233LysCys: 0.233 ± 0.014	1.794LysAsp: 1.794 ± 0.038	2.138LysGlu: 2.138 ± 0.048	1.014LysPhe: 1.014 ± 0.025	2.728LysGly: 2.728 ± 0.045	0.798LysHis: 0.798 ± 0.023	2.183LysIle: 2.183 ± 0.041	2.041LysLys: 2.041 ± 0.039	3.883LysLeu: 3.883 ± 0.057	1.168LysMet: 1.168 ± 0.027	1.517LysAsn: 1.517 ± 0.034	1.98LysPro: 1.98 ± 0.036	1.81LysGln: 1.81 ± 0.033	2.34LysArg: 2.34 ± 0.039	2.132LysSer: 2.132 ± 0.032	2.361LysThr: 2.361 ± 0.04	2.769LysVal: 2.769 ± 0.043	0.423LysTrp: 0.423 ± 0.018	1.079LysTyr: 1.079 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.729LeuAla: 12.729 ± 0.123	1.359LeuCys: 1.359 ± 0.034	5.282LeuAsp: 5.282 ± 0.066	5.288LeuGlu: 5.288 ± 0.063	4.29LeuPhe: 4.29 ± 0.062	7.621LeuGly: 7.621 ± 0.091	2.341LeuHis: 2.341 ± 0.035	5.801LeuIle: 5.801 ± 0.073	4.18LeuLys: 4.18 ± 0.059	12.694LeuLeu: 12.694 ± 0.148	2.93LeuMet: 2.93 ± 0.041	4.04LeuAsn: 4.04 ± 0.051	5.963LeuPro: 5.963 ± 0.062	4.516LeuGln: 4.516 ± 0.061	6.644LeuArg: 6.644 ± 0.064	7.438LeuSer: 7.438 ± 0.068	6.559LeuThr: 6.559 ± 0.063	7.175LeuVal: 7.175 ± 0.072	1.551LeuTrp: 1.551 ± 0.033	2.527LeuTyr: 2.527 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.074MetAla: 3.074 ± 0.052	0.188MetCys: 0.188 ± 0.01	1.093MetAsp: 1.093 ± 0.028	1.181MetGlu: 1.181 ± 0.025	0.862MetPhe: 0.862 ± 0.023	1.871MetGly: 1.871 ± 0.033	0.544MetHis: 0.544 ± 0.017	1.461MetIle: 1.461 ± 0.027	1.355MetLys: 1.355 ± 0.028	3.145MetLeu: 3.145 ± 0.045	0.929MetMet: 0.929 ± 0.027	1.103MetAsn: 1.103 ± 0.025	1.361MetPro: 1.361 ± 0.028	1.175MetGln: 1.175 ± 0.027	1.507MetArg: 1.507 ± 0.029	1.826MetSer: 1.826 ± 0.036	1.833MetThr: 1.833 ± 0.03	1.943MetVal: 1.943 ± 0.031	0.272MetTrp: 0.272 ± 0.013	0.502MetTyr: 0.502 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.364AsnAla: 3.364 ± 0.048	0.308AsnCys: 0.308 ± 0.015	1.943AsnAsp: 1.943 ± 0.035	1.732AsnGlu: 1.732 ± 0.031	1.231AsnPhe: 1.231 ± 0.028	2.819AsnGly: 2.819 ± 0.053	0.83AsnHis: 0.83 ± 0.023	2.131AsnIle: 2.131 ± 0.036	1.366AsnLys: 1.366 ± 0.032	3.281AsnLeu: 3.281 ± 0.047	0.874AsnMet: 0.874 ± 0.027	1.392AsnAsn: 1.392 ± 0.034	2.038AsnPro: 2.038 ± 0.034	1.464AsnGln: 1.464 ± 0.032	1.931AsnArg: 1.931 ± 0.039	1.818AsnSer: 1.818 ± 0.038	1.814AsnThr: 1.814 ± 0.036	2.401AsnVal: 2.401 ± 0.04	0.51AsnTrp: 0.51 ± 0.021	1.064AsnTyr: 1.064 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.134ProAla: 5.134 ± 0.065	0.405ProCys: 0.405 ± 0.016	2.813ProAsp: 2.813 ± 0.05	3.251ProGlu: 3.251 ± 0.046	1.9ProPhe: 1.9 ± 0.031	3.745ProGly: 3.745 ± 0.055	1.126ProHis: 1.126 ± 0.026	1.775ProIle: 1.775 ± 0.037	1.334ProLys: 1.334 ± 0.03	5.554ProLeu: 5.554 ± 0.073	1.11ProMet: 1.11 ± 0.029	1.169ProAsn: 1.169 ± 0.023	1.878ProPro: 1.878 ± 0.043	2.602ProGln: 2.602 ± 0.043	2.231ProArg: 2.231 ± 0.037	2.204ProSer: 2.204 ± 0.034	2.107ProThr: 2.107 ± 0.034	3.912ProVal: 3.912 ± 0.053	0.851ProTrp: 0.851 ± 0.025	1.184ProTyr: 1.184 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	5.152GlnAla: 5.152 ± 0.062	0.391GlnCys: 0.391 ± 0.016	1.761GlnAsp: 1.761 ± 0.032	2.137GlnGlu: 2.137 ± 0.047	1.465GlnPhe: 1.465 ± 0.032	3.197GlnGly: 3.197 ± 0.043	1.263GlnHis: 1.263 ± 0.027	2.196GlnIle: 2.196 ± 0.034	1.693GlnLys: 1.693 ± 0.03	5.127GlnLeu: 5.127 ± 0.07	1.201GlnMet: 1.201 ± 0.029	1.302GlnAsn: 1.302 ± 0.033	2.371GlnPro: 2.371 ± 0.046	3.475GlnGln: 3.475 ± 0.065	3.375GlnArg: 3.375 ± 0.05	2.265GlnSer: 2.265 ± 0.039	2.219GlnThr: 2.219 ± 0.039	3.05GlnVal: 3.05 ± 0.048	0.678GlnTrp: 0.678 ± 0.022	1.172GlnTyr: 1.172 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	5.06ArgAla: 5.06 ± 0.059	0.639ArgCys: 0.639 ± 0.02	3.175ArgAsp: 3.175 ± 0.043	3.939ArgGlu: 3.939 ± 0.056	2.647ArgPhe: 2.647 ± 0.038	3.657ArgGly: 3.657 ± 0.052	1.79ArgHis: 1.79 ± 0.034	3.311ArgIle: 3.311 ± 0.045	2.195ArgLys: 2.195 ± 0.036	7.031ArgLeu: 7.031 ± 0.081	1.587ArgMet: 1.587 ± 0.029	1.914ArgAsn: 1.914 ± 0.037	2.483ArgPro: 2.483 ± 0.042	3.517ArgGln: 3.517 ± 0.056	3.984ArgArg: 3.984 ± 0.057	2.801ArgSer: 2.801 ± 0.037	2.497ArgThr: 2.497 ± 0.043	3.908ArgVal: 3.908 ± 0.056	1.079ArgTrp: 1.079 ± 0.028	2.255ArgTyr: 2.255 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.946SerAla: 5.946 ± 0.058	0.565SerCys: 0.565 ± 0.019	3.046SerAsp: 3.046 ± 0.045	3.054SerGlu: 3.054 ± 0.046	2.273SerPhe: 2.273 ± 0.045	5.358SerGly: 5.358 ± 0.062	1.471SerHis: 1.471 ± 0.031	2.866SerIle: 2.866 ± 0.047	1.837SerLys: 1.837 ± 0.039	6.827SerLeu: 6.827 ± 0.074	1.451SerMet: 1.451 ± 0.025	1.7SerAsn: 1.7 ± 0.036	2.746SerPro: 2.746 ± 0.039	2.556SerGln: 2.556 ± 0.044	3.591SerArg: 3.591 ± 0.048	3.33SerSer: 3.33 ± 0.058	2.868SerThr: 2.868 ± 0.045	4.108SerVal: 4.108 ± 0.047	1.035SerTrp: 1.035 ± 0.024	1.581SerTyr: 1.581 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	5.235ThrAla: 5.235 ± 0.069	0.514ThrCys: 0.514 ± 0.02	2.461ThrAsp: 2.461 ± 0.041	2.435ThrGlu: 2.435 ± 0.041	2.07ThrPhe: 2.07 ± 0.037	4.458ThrGly: 4.458 ± 0.054	1.194ThrHis: 1.194 ± 0.029	2.783ThrIle: 2.783 ± 0.042	1.31ThrLys: 1.31 ± 0.034	7.64ThrLeu: 7.64 ± 0.072	1.132ThrMet: 1.132 ± 0.025	1.332ThrAsn: 1.332 ± 0.028	3.319ThrPro: 3.319 ± 0.044	1.964ThrGln: 1.964 ± 0.037	3.182ThrArg: 3.182 ± 0.046	2.899ThrSer: 2.899 ± 0.048	2.876ThrThr: 2.876 ± 0.046	3.907ThrVal: 3.907 ± 0.05	0.869ThrTrp: 0.869 ± 0.024	1.109ThrTyr: 1.109 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	7.563ValAla: 7.563 ± 0.075	0.787ValCys: 0.787 ± 0.022	3.687ValAsp: 3.687 ± 0.05	3.822ValGlu: 3.822 ± 0.063	2.532ValPhe: 2.532 ± 0.041	4.909ValGly: 4.909 ± 0.056	1.274ValHis: 1.274 ± 0.028	4.422ValIle: 4.422 ± 0.055	2.894ValLys: 2.894 ± 0.042	7.243ValLeu: 7.243 ± 0.081	2.221ValMet: 2.221 ± 0.041	2.617ValAsn: 2.617 ± 0.041	3.079ValPro: 3.079 ± 0.043	2.368ValGln: 2.368 ± 0.034	3.805ValArg: 3.805 ± 0.051	4.672ValSer: 4.672 ± 0.062	4.205ValThr: 4.205 ± 0.054	5.674ValVal: 5.674 ± 0.062	1.006ValTrp: 1.006 ± 0.024	1.721ValTyr: 1.721 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.046TrpAla: 1.046 ± 0.026	0.197TrpCys: 0.197 ± 0.011	0.655TrpAsp: 0.655 ± 0.02	0.569TrpGlu: 0.569 ± 0.019	0.711TrpPhe: 0.711 ± 0.02	1.011TrpGly: 1.011 ± 0.025	0.471TrpHis: 0.471 ± 0.016	0.737TrpIle: 0.737 ± 0.022	0.483TrpLys: 0.483 ± 0.015	2.55TrpLeu: 2.55 ± 0.043	0.437TrpMet: 0.437 ± 0.017	0.486TrpAsn: 0.486 ± 0.019	0.734TrpPro: 0.734 ± 0.024	1.257TrpGln: 1.257 ± 0.029	1.27TrpArg: 1.27 ± 0.028	0.899TrpSer: 0.899 ± 0.024	0.631TrpThr: 0.631 ± 0.024	0.964TrpVal: 0.964 ± 0.024	0.239TrpTrp: 0.239 ± 0.015	0.431TrpTyr: 0.431 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.54TyrAla: 2.54 ± 0.039	0.354TyrCys: 0.354 ± 0.014	1.504TyrAsp: 1.504 ± 0.031	1.145TyrGlu: 1.145 ± 0.025	1.125TyrPhe: 1.125 ± 0.026	2.199TyrGly: 2.199 ± 0.042	0.753TyrHis: 0.753 ± 0.023	1.323TyrIle: 1.323 ± 0.028	0.853TyrLys: 0.853 ± 0.025	3.034TyrLeu: 3.034 ± 0.043	0.578TyrMet: 0.578 ± 0.018	0.9TyrAsn: 0.9 ± 0.026	1.385TyrPro: 1.385 ± 0.031	1.581TyrGln: 1.581 ± 0.037	1.923TyrArg: 1.923 ± 0.036	1.66TyrSer: 1.66 ± 0.034	1.381TyrThr: 1.381 ± 0.035	1.62TyrVal: 1.62 ± 0.033	0.442TyrTrp: 0.442 ± 0.018	0.904TyrTyr: 0.904 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5560 proteins (1696576 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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