Amino acid dipepetide frequency for Solimicrobium silvestre

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.495AlaAla: 11.495 ± 0.13
1.087AlaCys: 1.087 ± 0.032
5.103AlaAsp: 5.103 ± 0.076
5.563AlaGlu: 5.563 ± 0.091
3.495AlaPhe: 3.495 ± 0.054
7.548AlaGly: 7.548 ± 0.096
2.202AlaHis: 2.202 ± 0.043
6.221AlaIle: 6.221 ± 0.068
4.67AlaLys: 4.67 ± 0.086
11.084AlaLeu: 11.084 ± 0.12
2.85AlaMet: 2.85 ± 0.055
4.198AlaAsn: 4.198 ± 0.096
4.167AlaPro: 4.167 ± 0.082
5.037AlaGln: 5.037 ± 0.076
4.677AlaArg: 4.677 ± 0.08
6.424AlaSer: 6.424 ± 0.097
5.923AlaThr: 5.923 ± 0.124
6.607AlaVal: 6.607 ± 0.072
1.189AlaTrp: 1.189 ± 0.032
2.636AlaTyr: 2.636 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
1.015CysAla: 1.015 ± 0.028
0.137CysCys: 0.137 ± 0.009
0.534CysAsp: 0.534 ± 0.019
0.487CysGlu: 0.487 ± 0.017
0.393CysPhe: 0.393 ± 0.019
0.908CysGly: 0.908 ± 0.028
0.255CysHis: 0.255 ± 0.013
0.546CysIle: 0.546 ± 0.019
0.381CysLys: 0.381 ± 0.02
0.888CysLeu: 0.888 ± 0.028
0.222CysMet: 0.222 ± 0.012
0.349CysAsn: 0.349 ± 0.016
0.45CysPro: 0.45 ± 0.022
0.319CysGln: 0.319 ± 0.016
0.458CysArg: 0.458 ± 0.018
0.691CysSer: 0.691 ± 0.025
0.501CysThr: 0.501 ± 0.023
0.706CysVal: 0.706 ± 0.021
0.151CysTrp: 0.151 ± 0.011
0.267CysTyr: 0.267 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
5.418AspAla: 5.418 ± 0.064
0.479AspCys: 0.479 ± 0.019
2.469AspAsp: 2.469 ± 0.044
2.85AspGlu: 2.85 ± 0.06
2.225AspPhe: 2.225 ± 0.043
4.029AspGly: 4.029 ± 0.123
1.057AspHis: 1.057 ± 0.034
3.123AspIle: 3.123 ± 0.048
2.275AspLys: 2.275 ± 0.05
4.989AspLeu: 4.989 ± 0.057
1.246AspMet: 1.246 ± 0.034
1.896AspAsn: 1.896 ± 0.036
2.329AspPro: 2.329 ± 0.049
2.123AspGln: 2.123 ± 0.04
2.259AspArg: 2.259 ± 0.047
2.921AspSer: 2.921 ± 0.06
2.583AspThr: 2.583 ± 0.052
3.626AspVal: 3.626 ± 0.06
0.823AspTrp: 0.823 ± 0.023
1.609AspTyr: 1.609 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
4.891GluAla: 4.891 ± 0.076
0.455GluCys: 0.455 ± 0.016
1.989GluAsp: 1.989 ± 0.04
2.521GluGlu: 2.521 ± 0.053
2.189GluPhe: 2.189 ± 0.046
2.777GluGly: 2.777 ± 0.05
1.401GluHis: 1.401 ± 0.035
3.724GluIle: 3.724 ± 0.069
2.753GluLys: 2.753 ± 0.058
6.02GluLeu: 6.02 ± 0.085
1.463GluMet: 1.463 ± 0.034
2.221GluAsn: 2.221 ± 0.041
1.858GluPro: 1.858 ± 0.038
3.173GluGln: 3.173 ± 0.067
3.165GluArg: 3.165 ± 0.068
2.827GluSer: 2.827 ± 0.045
2.683GluThr: 2.683 ± 0.048
3.635GluVal: 3.635 ± 0.059
0.715GluTrp: 0.715 ± 0.025
1.307GluTyr: 1.307 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
3.795PheAla: 3.795 ± 0.053
0.455PheCys: 0.455 ± 0.021
2.536PheAsp: 2.536 ± 0.037
2.057PheGlu: 2.057 ± 0.046
1.744PhePhe: 1.744 ± 0.041
3.353PheGly: 3.353 ± 0.057
0.777PheHis: 0.777 ± 0.027
2.414PheIle: 2.414 ± 0.047
1.82PheLys: 1.82 ± 0.042
3.351PheLeu: 3.351 ± 0.063
0.946PheMet: 0.946 ± 0.029
1.891PheAsn: 1.891 ± 0.038
1.632PhePro: 1.632 ± 0.038
1.326PheGln: 1.326 ± 0.034
1.616PheArg: 1.616 ± 0.035
3.238PheSer: 3.238 ± 0.051
2.35PheThr: 2.35 ± 0.049
2.65PheVal: 2.65 ± 0.054
0.551PheTrp: 0.551 ± 0.023
1.222PheTyr: 1.222 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
6.466GlyAla: 6.466 ± 0.081
0.788GlyCys: 0.788 ± 0.024
3.333GlyAsp: 3.333 ± 0.059
3.41GlyGlu: 3.41 ± 0.051
3.159GlyPhe: 3.159 ± 0.053
5.295GlyGly: 5.295 ± 0.088
1.609GlyHis: 1.609 ± 0.041
4.828GlyIle: 4.828 ± 0.067
3.728GlyLys: 3.728 ± 0.059
7.263GlyLeu: 7.263 ± 0.08
2.105GlyMet: 2.105 ± 0.043
3.064GlyAsn: 3.064 ± 0.108
1.905GlyPro: 1.905 ± 0.043
2.932GlyGln: 2.932 ± 0.087
3.282GlyArg: 3.282 ± 0.055
4.791GlySer: 4.791 ± 0.12
4.387GlyThr: 4.387 ± 0.186
5.498GlyVal: 5.498 ± 0.073
1.1GlyTrp: 1.1 ± 0.028
2.38GlyTyr: 2.38 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.229HisAla: 2.229 ± 0.045
0.283HisCys: 0.283 ± 0.015
1.128HisAsp: 1.128 ± 0.032
1.122HisGlu: 1.122 ± 0.031
1.057HisPhe: 1.057 ± 0.029
1.699HisGly: 1.699 ± 0.04
0.696HisHis: 0.696 ± 0.026
1.369HisIle: 1.369 ± 0.037
0.836HisLys: 0.836 ± 0.028
2.304HisLeu: 2.304 ± 0.05
0.516HisMet: 0.516 ± 0.02
0.764HisAsn: 0.764 ± 0.024
1.261HisPro: 1.261 ± 0.035
1.023HisGln: 1.023 ± 0.029
1.079HisArg: 1.079 ± 0.033
1.42HisSer: 1.42 ± 0.034
1.112HisThr: 1.112 ± 0.028
1.458HisVal: 1.458 ± 0.035
0.351HisTrp: 0.351 ± 0.016
0.818HisTyr: 0.818 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.17IleAla: 7.17 ± 0.078
0.682IleCys: 0.682 ± 0.025
3.67IleAsp: 3.67 ± 0.057
3.742IleGlu: 3.742 ± 0.062
2.237IlePhe: 2.237 ± 0.05
4.955IleGly: 4.955 ± 0.079
1.209IleHis: 1.209 ± 0.032
3.371IleIle: 3.371 ± 0.068
2.905IleLys: 2.905 ± 0.05
5.277IleLeu: 5.277 ± 0.08
1.242IleMet: 1.242 ± 0.033
2.944IleAsn: 2.944 ± 0.048
2.872IlePro: 2.872 ± 0.043
2.219IleGln: 2.219 ± 0.041
2.75IleArg: 2.75 ± 0.059
4.603IleSer: 4.603 ± 0.062
3.983IleThr: 3.983 ± 0.076
4.284IleVal: 4.284 ± 0.055
0.7IleTrp: 0.7 ± 0.024
1.62IleTyr: 1.62 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.035LysAla: 4.035 ± 0.087
0.264LysCys: 0.264 ± 0.012
1.982LysAsp: 1.982 ± 0.04
2.362LysGlu: 2.362 ± 0.048
1.608LysPhe: 1.608 ± 0.037
2.39LysGly: 2.39 ± 0.042
1.056LysHis: 1.056 ± 0.03
3.23LysIle: 3.23 ± 0.056
2.584LysLys: 2.584 ± 0.058
5.108LysLeu: 5.108 ± 0.081
1.424LysMet: 1.424 ± 0.038
2.357LysAsn: 2.357 ± 0.05
2.256LysPro: 2.256 ± 0.05
2.237LysGln: 2.237 ± 0.049
2.354LysArg: 2.354 ± 0.052
2.846LysSer: 2.846 ± 0.048
2.68LysThr: 2.68 ± 0.049
2.928LysVal: 2.928 ± 0.054
0.476LysTrp: 0.476 ± 0.021
1.091LysTyr: 1.091 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
11.249LeuAla: 11.249 ± 0.1
1.083LeuCys: 1.083 ± 0.034
5.342LeuAsp: 5.342 ± 0.076
5.083LeuGlu: 5.083 ± 0.083
4.07LeuPhe: 4.07 ± 0.079
7.02LeuGly: 7.02 ± 0.082
2.286LeuHis: 2.286 ± 0.051
6.498LeuIle: 6.498 ± 0.089
4.692LeuLys: 4.692 ± 0.078
10.558LeuLeu: 10.558 ± 0.139
2.526LeuMet: 2.526 ± 0.046
4.545LeuAsn: 4.545 ± 0.078
5.258LeuPro: 5.258 ± 0.062
4.423LeuGln: 4.423 ± 0.073
5.533LeuArg: 5.533 ± 0.095
7.511LeuSer: 7.511 ± 0.079
6.196LeuThr: 6.196 ± 0.081
6.545LeuVal: 6.545 ± 0.071
1.048LeuTrp: 1.048 ± 0.03
2.319LeuTyr: 2.319 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.448MetAla: 2.448 ± 0.047
0.175MetCys: 0.175 ± 0.011
1.121MetAsp: 1.121 ± 0.029
1.152MetGlu: 1.152 ± 0.033
0.848MetPhe: 0.848 ± 0.026
1.692MetGly: 1.692 ± 0.041
0.612MetHis: 0.612 ± 0.023
1.344MetIle: 1.344 ± 0.032
1.305MetLys: 1.305 ± 0.033
2.904MetLeu: 2.904 ± 0.052
0.748MetMet: 0.748 ± 0.028
1.216MetAsn: 1.216 ± 0.03
1.405MetPro: 1.405 ± 0.033
1.395MetGln: 1.395 ± 0.034
1.483MetArg: 1.483 ± 0.039
1.813MetSer: 1.813 ± 0.037
1.632MetThr: 1.632 ± 0.03
1.64MetVal: 1.64 ± 0.037
0.228MetTrp: 0.228 ± 0.012
0.487MetTyr: 0.487 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
4.284AsnAla: 4.284 ± 0.099
0.402AsnCys: 0.402 ± 0.016
2.014AsnAsp: 2.014 ± 0.045
1.985AsnGlu: 1.985 ± 0.032
1.711AsnPhe: 1.711 ± 0.041
3.381AsnGly: 3.381 ± 0.119
0.892AsnHis: 0.892 ± 0.026
2.444AsnIle: 2.444 ± 0.041
1.876AsnLys: 1.876 ± 0.039
4.329AsnLeu: 4.329 ± 0.062
1.009AsnMet: 1.009 ± 0.028
1.876AsnAsn: 1.876 ± 0.052
2.408AsnPro: 2.408 ± 0.053
1.96AsnGln: 1.96 ± 0.055
1.881AsnArg: 1.881 ± 0.039
2.999AsnSer: 2.999 ± 0.077
2.431AsnThr: 2.431 ± 0.066
2.755AsnVal: 2.755 ± 0.067
0.664AsnTrp: 0.664 ± 0.025
1.419AsnTyr: 1.419 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
4.567ProAla: 4.567 ± 0.067
0.325ProCys: 0.325 ± 0.017
2.723ProAsp: 2.723 ± 0.054
2.91ProGlu: 2.91 ± 0.047
1.739ProPhe: 1.739 ± 0.035
2.951ProGly: 2.951 ± 0.061
1.017ProHis: 1.017 ± 0.028
2.659ProIle: 2.659 ± 0.043
1.86ProLys: 1.86 ± 0.046
4.376ProLeu: 4.376 ± 0.053
1.115ProMet: 1.115 ± 0.026
1.959ProAsn: 1.959 ± 0.046
1.765ProPro: 1.765 ± 0.049
1.745ProGln: 1.745 ± 0.035
1.668ProArg: 1.668 ± 0.042
2.813ProSer: 2.813 ± 0.05
2.755ProThr: 2.755 ± 0.058
3.464ProVal: 3.464 ± 0.054
0.542ProTrp: 0.542 ± 0.021
1.234ProTyr: 1.234 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
4.803GlnAla: 4.803 ± 0.077
0.362GlnCys: 0.362 ± 0.018
1.769GlnAsp: 1.769 ± 0.039
2.087GlnGlu: 2.087 ± 0.045
1.848GlnPhe: 1.848 ± 0.039
2.684GlnGly: 2.684 ± 0.058
1.264GlnHis: 1.264 ± 0.034
3.017GlnIle: 3.017 ± 0.052
1.843GlnLys: 1.843 ± 0.043
5.103GlnLeu: 5.103 ± 0.071
1.101GlnMet: 1.101 ± 0.026
1.719GlnAsn: 1.719 ± 0.045
1.862GlnPro: 1.862 ± 0.049
2.819GlnGln: 2.819 ± 0.072
2.679GlnArg: 2.679 ± 0.056
2.642GlnSer: 2.642 ± 0.054
2.581GlnThr: 2.581 ± 0.064
3.08GlnVal: 3.08 ± 0.064
0.552GlnTrp: 0.552 ± 0.019
1.138GlnTyr: 1.138 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
4.61ArgAla: 4.61 ± 0.078
0.46ArgCys: 0.46 ± 0.02
2.596ArgAsp: 2.596 ± 0.057
2.81ArgGlu: 2.81 ± 0.061
2.157ArgPhe: 2.157 ± 0.052
2.848ArgGly: 2.848 ± 0.057
1.268ArgHis: 1.268 ± 0.034
3.357ArgIle: 3.357 ± 0.061
2.075ArgLys: 2.075 ± 0.047
5.334ArgLeu: 5.334 ± 0.088
1.33ArgMet: 1.33 ± 0.037
1.946ArgAsn: 1.946 ± 0.045
1.849ArgPro: 1.849 ± 0.045
2.188ArgGln: 2.188 ± 0.042
2.685ArgArg: 2.685 ± 0.058
2.98ArgSer: 2.98 ± 0.054
2.346ArgThr: 2.346 ± 0.045
3.264ArgVal: 3.264 ± 0.055
0.698ArgTrp: 0.698 ± 0.027
1.642ArgTyr: 1.642 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.912SerAla: 6.912 ± 0.103
0.606SerCys: 0.606 ± 0.022
3.449SerAsp: 3.449 ± 0.066
3.287SerGlu: 3.287 ± 0.062
2.671SerPhe: 2.671 ± 0.044
5.605SerGly: 5.605 ± 0.13
1.391SerHis: 1.391 ± 0.039
4.108SerIle: 4.108 ± 0.061
2.869SerLys: 2.869 ± 0.058
6.706SerLeu: 6.706 ± 0.071
1.737SerMet: 1.737 ± 0.031
2.836SerAsn: 2.836 ± 0.076
2.738SerPro: 2.738 ± 0.042
2.496SerGln: 2.496 ± 0.051
2.831SerArg: 2.831 ± 0.056
4.923SerSer: 4.923 ± 0.138
4.236SerThr: 4.236 ± 0.113
4.517SerVal: 4.517 ± 0.083
0.883SerTrp: 0.883 ± 0.026
2.043SerTyr: 2.043 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
5.76ThrAla: 5.76 ± 0.118
0.444ThrCys: 0.444 ± 0.018
2.97ThrAsp: 2.97 ± 0.078
2.83ThrGlu: 2.83 ± 0.044
2.073ThrPhe: 2.073 ± 0.047
4.558ThrGly: 4.558 ± 0.099
1.232ThrHis: 1.232 ± 0.029
3.581ThrIle: 3.581 ± 0.07
2.195ThrLys: 2.195 ± 0.044
6.467ThrLeu: 6.467 ± 0.089
1.305ThrMet: 1.305 ± 0.03
2.457ThrAsn: 2.457 ± 0.078
3.411ThrPro: 3.411 ± 0.074
2.582ThrGln: 2.582 ± 0.077
2.462ThrArg: 2.462 ± 0.035
3.987ThrSer: 3.987 ± 0.104
3.784ThrThr: 3.784 ± 0.135
4.307ThrVal: 4.307 ± 0.145
0.698ThrTrp: 0.698 ± 0.036
1.653ThrTyr: 1.653 ± 0.087
0.0ThrXaa: 0.0 ± 0.0
Val
7.386ValAla: 7.386 ± 0.084
0.697ValCys: 0.697 ± 0.026
3.623ValAsp: 3.623 ± 0.051
3.729ValGlu: 3.729 ± 0.055
2.62ValPhe: 2.62 ± 0.049
4.744ValGly: 4.744 ± 0.072
1.332ValHis: 1.332 ± 0.031
4.463ValIle: 4.463 ± 0.061
3.007ValLys: 3.007 ± 0.056
6.97ValLeu: 6.97 ± 0.101
1.824ValMet: 1.824 ± 0.035
2.903ValAsn: 2.903 ± 0.104
2.949ValPro: 2.949 ± 0.044
2.682ValGln: 2.682 ± 0.055
3.28ValArg: 3.28 ± 0.057
4.596ValSer: 4.596 ± 0.078
4.404ValThr: 4.404 ± 0.142
5.279ValVal: 5.279 ± 0.074
0.802ValTrp: 0.802 ± 0.023
1.627ValTyr: 1.627 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.966TrpAla: 0.966 ± 0.028
0.152TrpCys: 0.152 ± 0.01
0.55TrpAsp: 0.55 ± 0.02
0.552TrpGlu: 0.552 ± 0.022
0.534TrpPhe: 0.534 ± 0.021
0.793TrpGly: 0.793 ± 0.025
0.382TrpHis: 0.382 ± 0.017
0.777TrpIle: 0.777 ± 0.024
0.546TrpLys: 0.546 ± 0.022
1.714TrpLeu: 1.714 ± 0.039
0.408TrpMet: 0.408 ± 0.018
0.551TrpAsn: 0.551 ± 0.022
0.497TrpPro: 0.497 ± 0.018
0.837TrpGln: 0.837 ± 0.028
0.758TrpArg: 0.758 ± 0.028
0.842TrpSer: 0.842 ± 0.027
0.602TrpThr: 0.602 ± 0.038
0.816TrpVal: 0.816 ± 0.024
0.201TrpTrp: 0.201 ± 0.011
0.331TrpTyr: 0.331 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.676TyrAla: 2.676 ± 0.052
0.32TyrCys: 0.32 ± 0.015
1.431TyrAsp: 1.431 ± 0.058
1.228TyrGlu: 1.228 ± 0.032
1.346TyrPhe: 1.346 ± 0.029
2.094TyrGly: 2.094 ± 0.043
0.581TyrHis: 0.581 ± 0.022
1.364TyrIle: 1.364 ± 0.028
1.049TyrLys: 1.049 ± 0.03
3.04TyrLeu: 3.04 ± 0.047
0.529TyrMet: 0.529 ± 0.021
1.028TyrAsn: 1.028 ± 0.05
1.317TyrPro: 1.317 ± 0.034
1.438TyrGln: 1.438 ± 0.036
1.545TyrArg: 1.545 ± 0.038
1.977TyrSer: 1.977 ± 0.054
1.583TyrThr: 1.583 ± 0.074
1.86TyrVal: 1.86 ± 0.044
0.437TyrTrp: 0.437 ± 0.018
0.894TyrTyr: 0.894 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4741 proteins (1520618 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski