Amino acid dipepetide frequency for Circoviridae 14 LDMD-2013

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.435AlaAla: 7.435 ± 1.776
0.0AlaCys: 0.0 ± 0.0
3.717AlaAsp: 3.717 ± 2.295
2.478AlaGlu: 2.478 ± 0.708
3.717AlaPhe: 3.717 ± 2.295
3.717AlaGly: 3.717 ± 2.295
3.717AlaHis: 3.717 ± 1.636
4.957AlaIle: 4.957 ± 1.416
2.478AlaLys: 2.478 ± 1.696
2.478AlaLeu: 2.478 ± 2.126
1.239AlaMet: 1.239 ± 0.765
6.196AlaAsn: 6.196 ± 1.582
4.957AlaPro: 4.957 ± 1.416
1.239AlaGln: 1.239 ± 0.765
4.957AlaArg: 4.957 ± 1.416
6.196AlaSer: 6.196 ± 2.833
6.196AlaThr: 6.196 ± 2.374
1.239AlaVal: 1.239 ± 0.765
2.478AlaTrp: 2.478 ± 3.741
1.239AlaTyr: 1.239 ± 0.765
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.239CysAsp: 1.239 ± 1.063
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
1.239CysLys: 1.239 ± 1.063
0.0CysLeu: 0.0 ± 0.0
1.239CysMet: 1.239 ± 1.87
0.0CysAsn: 0.0 ± 0.0
1.239CysPro: 1.239 ± 0.765
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
1.239CysSer: 1.239 ± 0.765
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
7.435AspAla: 7.435 ± 4.59
0.0AspCys: 0.0 ± 0.0
6.196AspAsp: 6.196 ± 4.993
3.717AspGlu: 3.717 ± 1.283
4.957AspPhe: 4.957 ± 3.2
2.478AspGly: 2.478 ± 0.708
0.0AspHis: 0.0 ± 0.0
0.0AspIle: 0.0 ± 0.0
1.239AspLys: 1.239 ± 0.765
2.478AspLeu: 2.478 ± 1.696
2.478AspMet: 2.478 ± 0.708
2.478AspAsn: 2.478 ± 2.126
2.478AspPro: 2.478 ± 1.696
1.239AspGln: 1.239 ± 1.87
2.478AspArg: 2.478 ± 2.126
3.717AspSer: 3.717 ± 1.283
0.0AspThr: 0.0 ± 0.0
8.674AspVal: 8.674 ± 4.067
1.239AspTrp: 1.239 ± 1.87
1.239AspTyr: 1.239 ± 0.765
0.0AspXaa: 0.0 ± 0.0
Glu
2.478GluAla: 2.478 ± 0.708
0.0GluCys: 0.0 ± 0.0
4.957GluAsp: 4.957 ± 1.659
2.478GluGlu: 2.478 ± 1.696
1.239GluPhe: 1.239 ± 0.765
6.196GluGly: 6.196 ± 0.893
0.0GluHis: 0.0 ± 0.0
6.196GluIle: 6.196 ± 2.286
0.0GluLys: 0.0 ± 0.0
7.435GluLeu: 7.435 ± 2.566
0.0GluMet: 0.0 ± 0.0
2.478GluAsn: 2.478 ± 0.708
1.239GluPro: 1.239 ± 0.765
2.478GluGln: 2.478 ± 0.708
2.478GluArg: 2.478 ± 1.867
4.957GluSer: 4.957 ± 1.637
3.717GluThr: 3.717 ± 1.636
7.435GluVal: 7.435 ± 3.439
1.239GluTrp: 1.239 ± 1.87
2.478GluTyr: 2.478 ± 1.53
0.0GluXaa: 0.0 ± 0.0
Phe
2.478PheAla: 2.478 ± 1.53
1.239PheCys: 1.239 ± 0.765
4.957PheAsp: 4.957 ± 3.2
3.717PheGlu: 3.717 ± 1.636
1.239PhePhe: 1.239 ± 1.063
1.239PheGly: 1.239 ± 0.765
0.0PheHis: 0.0 ± 0.0
1.239PheIle: 1.239 ± 1.063
2.478PheLys: 2.478 ± 0.708
2.478PheLeu: 2.478 ± 1.53
0.0PheMet: 0.0 ± 0.0
1.239PheAsn: 1.239 ± 0.765
1.239PhePro: 1.239 ± 1.063
0.0PheGln: 0.0 ± 0.0
2.478PheArg: 2.478 ± 0.708
0.0PheSer: 0.0 ± 0.0
2.478PheThr: 2.478 ± 0.708
4.957PheVal: 4.957 ± 1.637
1.239PheTrp: 1.239 ± 1.87
3.717PheTyr: 3.717 ± 2.295
0.0PheXaa: 0.0 ± 0.0
Gly
9.913GlyAla: 9.913 ± 3.164
0.0GlyCys: 0.0 ± 0.0
4.957GlyAsp: 4.957 ± 0.99
3.717GlyGlu: 3.717 ± 2.295
1.239GlyPhe: 1.239 ± 0.765
3.717GlyGly: 3.717 ± 1.021
1.239GlyHis: 1.239 ± 0.765
6.196GlyIle: 6.196 ± 3.717
8.674GlyLys: 8.674 ± 2.963
3.717GlyLeu: 3.717 ± 1.021
0.0GlyMet: 0.0 ± 0.0
0.0GlyAsn: 0.0 ± 0.0
3.717GlyPro: 3.717 ± 1.283
2.478GlyGln: 2.478 ± 0.708
2.478GlyArg: 2.478 ± 0.708
4.957GlySer: 4.957 ± 3.06
7.435GlyThr: 7.435 ± 2.124
3.717GlyVal: 3.717 ± 2.295
2.478GlyTrp: 2.478 ± 1.53
2.478GlyTyr: 2.478 ± 1.53
0.0GlyXaa: 0.0 ± 0.0
His
2.478HisAla: 2.478 ± 0.708
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
2.478HisGlu: 2.478 ± 0.708
0.0HisPhe: 0.0 ± 0.0
1.239HisGly: 1.239 ± 1.063
0.0HisHis: 0.0 ± 0.0
1.239HisIle: 1.239 ± 0.765
3.717HisLys: 3.717 ± 1.85
6.196HisLeu: 6.196 ± 2.286
0.0HisMet: 0.0 ± 0.0
1.239HisAsn: 1.239 ± 1.87
1.239HisPro: 1.239 ± 1.87
3.717HisGln: 3.717 ± 1.021
1.239HisArg: 1.239 ± 0.765
1.239HisSer: 1.239 ± 0.765
0.0HisThr: 0.0 ± 0.0
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
4.957IleAla: 4.957 ± 4.253
0.0IleCys: 0.0 ± 0.0
3.717IleAsp: 3.717 ± 1.636
2.478IleGlu: 2.478 ± 0.708
2.478IlePhe: 2.478 ± 0.708
4.957IleGly: 4.957 ± 1.659
2.478IleHis: 2.478 ± 0.708
1.239IleIle: 1.239 ± 1.063
3.717IleLys: 3.717 ± 1.636
1.239IleLeu: 1.239 ± 0.765
0.0IleMet: 0.0 ± 0.0
2.478IleAsn: 2.478 ± 0.708
1.239IlePro: 1.239 ± 1.87
0.0IleGln: 0.0 ± 0.0
2.478IleArg: 2.478 ± 0.708
4.957IleSer: 4.957 ± 0.99
3.717IleThr: 3.717 ± 1.021
1.239IleVal: 1.239 ± 0.765
2.478IleTrp: 2.478 ± 1.696
4.957IleTyr: 4.957 ± 1.416
0.0IleXaa: 0.0 ± 0.0
Lys
3.717LysAla: 3.717 ± 1.021
0.0LysCys: 0.0 ± 0.0
2.478LysAsp: 2.478 ± 0.708
3.717LysGlu: 3.717 ± 1.283
0.0LysPhe: 0.0 ± 0.0
4.957LysGly: 4.957 ± 3.06
1.239LysHis: 1.239 ± 1.87
0.0LysIle: 0.0 ± 0.0
11.152LysLys: 11.152 ± 3.076
4.957LysLeu: 4.957 ± 3.2
1.239LysMet: 1.239 ± 0.765
2.478LysAsn: 2.478 ± 0.708
1.239LysPro: 1.239 ± 1.063
4.957LysGln: 4.957 ± 5.333
3.717LysArg: 3.717 ± 1.85
6.196LysSer: 6.196 ± 3.717
3.717LysThr: 3.717 ± 3.19
8.674LysVal: 8.674 ± 2.647
0.0LysTrp: 0.0 ± 0.0
6.196LysTyr: 6.196 ± 3.825
0.0LysXaa: 0.0 ± 0.0
Leu
1.239LeuAla: 1.239 ± 1.87
1.239LeuCys: 1.239 ± 1.063
0.0LeuAsp: 0.0 ± 0.0
3.717LeuGlu: 3.717 ± 2.394
1.239LeuPhe: 1.239 ± 1.063
4.957LeuGly: 4.957 ± 1.659
0.0LeuHis: 0.0 ± 0.0
2.478LeuIle: 2.478 ± 2.126
3.717LeuLys: 3.717 ± 1.283
6.196LeuLeu: 6.196 ± 3.717
2.478LeuMet: 2.478 ± 0.708
7.435LeuAsn: 7.435 ± 3.273
2.478LeuPro: 2.478 ± 1.53
2.478LeuGln: 2.478 ± 2.126
3.717LeuArg: 3.717 ± 1.021
8.674LeuSer: 8.674 ± 2.16
3.717LeuThr: 3.717 ± 1.85
7.435LeuVal: 7.435 ± 2.566
2.478LeuTrp: 2.478 ± 0.708
1.239LeuTyr: 1.239 ± 1.063
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
1.239MetCys: 1.239 ± 1.87
1.239MetAsp: 1.239 ± 1.87
2.478MetGlu: 2.478 ± 0.708
1.239MetPhe: 1.239 ± 1.063
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
1.239MetLeu: 1.239 ± 0.765
0.0MetMet: 0.0 ± 0.0
3.717MetAsn: 3.717 ± 1.85
4.957MetPro: 4.957 ± 0.99
0.0MetGln: 0.0 ± 0.0
2.478MetArg: 2.478 ± 1.53
2.478MetSer: 2.478 ± 1.696
0.0MetThr: 0.0 ± 0.0
1.239MetVal: 1.239 ± 0.765
0.0MetTrp: 0.0 ± 0.0
1.239MetTyr: 1.239 ± 1.87
0.0MetXaa: 0.0 ± 0.0
Asn
4.957AsnAla: 4.957 ± 3.06
1.239AsnCys: 1.239 ± 0.765
0.0AsnAsp: 0.0 ± 0.0
3.717AsnGlu: 3.717 ± 1.021
2.478AsnPhe: 2.478 ± 1.53
3.717AsnGly: 3.717 ± 3.19
1.239AsnHis: 1.239 ± 1.87
2.478AsnIle: 2.478 ± 1.53
2.478AsnLys: 2.478 ± 1.696
3.717AsnLeu: 3.717 ± 1.636
0.0AsnMet: 0.0 ± 0.0
2.478AsnAsn: 2.478 ± 2.126
1.239AsnPro: 1.239 ± 1.063
2.478AsnGln: 2.478 ± 1.53
2.478AsnArg: 2.478 ± 1.696
2.478AsnSer: 2.478 ± 0.708
2.478AsnThr: 2.478 ± 1.867
4.957AsnVal: 4.957 ± 1.416
1.239AsnTrp: 1.239 ± 1.063
7.435AsnTyr: 7.435 ± 5.103
0.0AsnXaa: 0.0 ± 0.0
Pro
2.478ProAla: 2.478 ± 1.53
0.0ProCys: 0.0 ± 0.0
3.717ProAsp: 3.717 ± 3.583
3.717ProGlu: 3.717 ± 3.19
0.0ProPhe: 0.0 ± 0.0
6.196ProGly: 6.196 ± 2.813
1.239ProHis: 1.239 ± 1.063
1.239ProIle: 1.239 ± 0.765
2.478ProLys: 2.478 ± 0.708
3.717ProLeu: 3.717 ± 1.636
2.478ProMet: 2.478 ± 1.286
0.0ProAsn: 0.0 ± 0.0
0.0ProPro: 0.0 ± 0.0
2.478ProGln: 2.478 ± 1.53
2.478ProArg: 2.478 ± 0.708
3.717ProSer: 3.717 ± 1.021
3.717ProThr: 3.717 ± 1.85
2.478ProVal: 2.478 ± 0.708
0.0ProTrp: 0.0 ± 0.0
1.239ProTyr: 1.239 ± 1.063
0.0ProXaa: 0.0 ± 0.0
Gln
1.239GlnAla: 1.239 ± 0.765
0.0GlnCys: 0.0 ± 0.0
2.478GlnAsp: 2.478 ± 1.53
2.478GlnGlu: 2.478 ± 2.126
1.239GlnPhe: 1.239 ± 1.063
2.478GlnGly: 2.478 ± 1.53
2.478GlnHis: 2.478 ± 1.53
3.717GlnIle: 3.717 ± 1.021
3.717GlnLys: 3.717 ± 1.283
3.717GlnLeu: 3.717 ± 1.283
2.478GlnMet: 2.478 ± 1.696
1.239GlnAsn: 1.239 ± 1.063
0.0GlnPro: 0.0 ± 0.0
2.478GlnGln: 2.478 ± 2.126
0.0GlnArg: 0.0 ± 0.0
4.957GlnSer: 4.957 ± 0.99
0.0GlnThr: 0.0 ± 0.0
2.478GlnVal: 2.478 ± 1.696
1.239GlnTrp: 1.239 ± 1.063
1.239GlnTyr: 1.239 ± 0.765
0.0GlnXaa: 0.0 ± 0.0
Arg
2.478ArgAla: 2.478 ± 0.708
0.0ArgCys: 0.0 ± 0.0
1.239ArgAsp: 1.239 ± 1.063
2.478ArgGlu: 2.478 ± 1.696
2.478ArgPhe: 2.478 ± 1.53
2.478ArgGly: 2.478 ± 0.708
1.239ArgHis: 1.239 ± 1.87
4.957ArgIle: 4.957 ± 0.99
7.435ArgLys: 7.435 ± 3.112
1.239ArgLeu: 1.239 ± 0.765
0.0ArgMet: 0.0 ± 0.0
1.239ArgAsn: 1.239 ± 1.063
1.239ArgPro: 1.239 ± 1.063
1.239ArgGln: 1.239 ± 1.063
7.435ArgArg: 7.435 ± 2.124
1.239ArgSer: 1.239 ± 1.87
4.957ArgThr: 4.957 ± 2.267
1.239ArgVal: 1.239 ± 0.765
2.478ArgTrp: 2.478 ± 2.126
6.196ArgTyr: 6.196 ± 1.582
0.0ArgXaa: 0.0 ± 0.0
Ser
4.957SerAla: 4.957 ± 1.659
0.0SerCys: 0.0 ± 0.0
1.239SerAsp: 1.239 ± 1.87
3.717SerGlu: 3.717 ± 3.487
4.957SerPhe: 4.957 ± 1.416
7.435SerGly: 7.435 ± 2.042
3.717SerHis: 3.717 ± 1.636
2.478SerIle: 2.478 ± 2.126
4.957SerLys: 4.957 ± 2.267
4.957SerLeu: 4.957 ± 1.416
2.478SerMet: 2.478 ± 3.622
6.196SerAsn: 6.196 ± 3.466
1.239SerPro: 1.239 ± 0.765
2.478SerGln: 2.478 ± 1.696
4.957SerArg: 4.957 ± 0.99
6.196SerSer: 6.196 ± 1.218
4.957SerThr: 4.957 ± 1.659
0.0SerVal: 0.0 ± 0.0
0.0SerTrp: 0.0 ± 0.0
2.478SerTyr: 2.478 ± 0.708
0.0SerXaa: 0.0 ± 0.0
Thr
3.717ThrAla: 3.717 ± 2.295
0.0ThrCys: 0.0 ± 0.0
1.239ThrAsp: 1.239 ± 0.765
7.435ThrGlu: 7.435 ± 3.439
6.196ThrPhe: 6.196 ± 0.893
7.435ThrGly: 7.435 ± 2.042
3.717ThrHis: 3.717 ± 1.021
3.717ThrIle: 3.717 ± 2.295
2.478ThrLys: 2.478 ± 0.708
3.717ThrLeu: 3.717 ± 1.636
1.239ThrMet: 1.239 ± 1.87
3.717ThrAsn: 3.717 ± 1.636
1.239ThrPro: 1.239 ± 1.063
2.478ThrGln: 2.478 ± 2.126
0.0ThrArg: 0.0 ± 0.0
3.717ThrSer: 3.717 ± 1.85
3.717ThrThr: 3.717 ± 1.021
4.957ThrVal: 4.957 ± 2.267
0.0ThrTrp: 0.0 ± 0.0
1.239ThrTyr: 1.239 ± 0.765
0.0ThrXaa: 0.0 ± 0.0
Val
4.957ValAla: 4.957 ± 1.637
0.0ValCys: 0.0 ± 0.0
7.435ValAsp: 7.435 ± 3.7
1.239ValGlu: 1.239 ± 0.765
1.239ValPhe: 1.239 ± 1.87
3.717ValGly: 3.717 ± 2.295
1.239ValHis: 1.239 ± 0.765
3.717ValIle: 3.717 ± 1.283
4.957ValLys: 4.957 ± 3.2
1.239ValLeu: 1.239 ± 0.765
2.478ValMet: 2.478 ± 1.53
3.717ValAsn: 3.717 ± 1.283
4.957ValPro: 4.957 ± 1.637
4.957ValGln: 4.957 ± 3.06
4.957ValArg: 4.957 ± 2.267
3.717ValSer: 3.717 ± 1.021
4.957ValThr: 4.957 ± 0.99
6.196ValVal: 6.196 ± 2.374
1.239ValTrp: 1.239 ± 0.765
1.239ValTyr: 1.239 ± 1.063
0.0ValXaa: 0.0 ± 0.0
Trp
1.239TrpAla: 1.239 ± 1.87
0.0TrpCys: 0.0 ± 0.0
1.239TrpAsp: 1.239 ± 1.87
1.239TrpGlu: 1.239 ± 0.765
1.239TrpPhe: 1.239 ± 1.063
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
2.478TrpIle: 2.478 ± 1.867
0.0TrpLys: 0.0 ± 0.0
1.239TrpLeu: 1.239 ± 1.87
1.239TrpMet: 1.239 ± 0.765
1.239TrpAsn: 1.239 ± 0.765
1.239TrpPro: 1.239 ± 0.765
0.0TrpGln: 0.0 ± 0.0
1.239TrpArg: 1.239 ± 1.063
0.0TrpSer: 0.0 ± 0.0
3.717TrpThr: 3.717 ± 1.283
1.239TrpVal: 1.239 ± 1.87
0.0TrpTrp: 0.0 ± 0.0
1.239TrpTyr: 1.239 ± 1.063
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.478TyrAla: 2.478 ± 2.126
1.239TyrCys: 1.239 ± 1.063
2.478TyrAsp: 2.478 ± 1.53
2.478TyrGlu: 2.478 ± 1.53
1.239TyrPhe: 1.239 ± 0.765
6.196TyrGly: 6.196 ± 1.582
2.478TyrHis: 2.478 ± 1.53
2.478TyrIle: 2.478 ± 1.53
3.717TyrLys: 3.717 ± 1.021
4.957TyrLeu: 4.957 ± 3.733
1.239TyrMet: 1.239 ± 0.765
3.717TyrAsn: 3.717 ± 1.021
6.196TyrPro: 6.196 ± 2.286
2.478TyrGln: 2.478 ± 0.708
1.239TyrArg: 1.239 ± 0.765
0.0TyrSer: 0.0 ± 0.0
2.478TyrThr: 2.478 ± 0.708
0.0TyrVal: 0.0 ± 0.0
0.0TyrTrp: 0.0 ± 0.0
3.717TyrTyr: 3.717 ± 1.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (808 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski