Amino acid dipepetide frequency for Mesorhizobium oceanicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.911AlaAla: 16.911 ± 0.151	0.997AlaCys: 0.997 ± 0.028	6.828AlaAsp: 6.828 ± 0.072	8.228AlaGlu: 8.228 ± 0.101	4.672AlaPhe: 4.672 ± 0.067	11.144AlaGly: 11.144 ± 0.098	2.043AlaHis: 2.043 ± 0.037	6.853AlaIle: 6.853 ± 0.083	3.773AlaLys: 3.773 ± 0.071	12.326AlaLeu: 12.326 ± 0.115	3.686AlaMet: 3.686 ± 0.048	2.887AlaAsn: 2.887 ± 0.049	5.163AlaPro: 5.163 ± 0.068	3.399AlaGln: 3.399 ± 0.057	8.728AlaArg: 8.728 ± 0.09	6.541AlaSer: 6.541 ± 0.07	5.761AlaThr: 5.761 ± 0.059	8.824AlaVal: 8.824 ± 0.086	1.534AlaTrp: 1.534 ± 0.036	2.581AlaTyr: 2.581 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.923CysAla: 0.923 ± 0.026	0.1CysCys: 0.1 ± 0.01	0.501CysAsp: 0.501 ± 0.018	0.455CysGlu: 0.455 ± 0.018	0.348CysPhe: 0.348 ± 0.015	0.921CysGly: 0.921 ± 0.03	0.241CysHis: 0.241 ± 0.013	0.358CysIle: 0.358 ± 0.015	0.163CysLys: 0.163 ± 0.01	0.739CysLeu: 0.739 ± 0.025	0.159CysMet: 0.159 ± 0.01	0.193CysAsn: 0.193 ± 0.011	0.41CysPro: 0.41 ± 0.018	0.182CysGln: 0.182 ± 0.01	0.613CysArg: 0.613 ± 0.022	0.431CysSer: 0.431 ± 0.016	0.386CysThr: 0.386 ± 0.016	0.627CysVal: 0.627 ± 0.018	0.116CysTrp: 0.116 ± 0.008	0.183CysTyr: 0.183 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.916AspAla: 6.916 ± 0.075	0.47AspCys: 0.47 ± 0.017	3.257AspAsp: 3.257 ± 0.059	3.933AspGlu: 3.933 ± 0.062	2.283AspPhe: 2.283 ± 0.033	5.412AspGly: 5.412 ± 0.073	1.23AspHis: 1.23 ± 0.029	3.064AspIle: 3.064 ± 0.052	1.578AspLys: 1.578 ± 0.036	5.816AspLeu: 5.816 ± 0.067	1.512AspMet: 1.512 ± 0.033	1.243AspAsn: 1.243 ± 0.028	3.54AspPro: 3.54 ± 0.052	1.602AspGln: 1.602 ± 0.06	4.713AspArg: 4.713 ± 0.065	2.018AspSer: 2.018 ± 0.035	2.533AspThr: 2.533 ± 0.042	4.283AspVal: 4.283 ± 0.064	0.923AspTrp: 0.923 ± 0.024	1.468AspTyr: 1.468 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	8.325GluAla: 8.325 ± 0.103	0.385GluCys: 0.385 ± 0.017	3.131GluAsp: 3.131 ± 0.05	4.059GluGlu: 4.059 ± 0.065	2.017GluPhe: 2.017 ± 0.033	4.844GluGly: 4.844 ± 0.063	1.248GluHis: 1.248 ± 0.027	3.933GluIle: 3.933 ± 0.053	2.673GluLys: 2.673 ± 0.048	5.427GluLeu: 5.427 ± 0.063	1.712GluMet: 1.712 ± 0.039	1.799GluAsn: 1.799 ± 0.033	3.094GluPro: 3.094 ± 0.052	2.032GluGln: 2.032 ± 0.045	5.471GluArg: 5.471 ± 0.07	2.475GluSer: 2.475 ± 0.042	3.918GluThr: 3.918 ± 0.049	4.124GluVal: 4.124 ± 0.047	0.844GluTrp: 0.844 ± 0.027	1.119GluTyr: 1.119 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.859PheAla: 4.859 ± 0.061	0.409PheCys: 0.409 ± 0.018	2.801PheAsp: 2.801 ± 0.046	2.384PheGlu: 2.384 ± 0.041	1.566PhePhe: 1.566 ± 0.039	3.986PheGly: 3.986 ± 0.058	0.79PheHis: 0.79 ± 0.021	1.735PheIle: 1.735 ± 0.04	0.893PheLys: 0.893 ± 0.027	3.53PheLeu: 3.53 ± 0.055	0.883PheMet: 0.883 ± 0.025	0.959PheAsn: 0.959 ± 0.024	1.699PhePro: 1.699 ± 0.036	1.027PheGln: 1.027 ± 0.026	2.558PheArg: 2.558 ± 0.037	2.427PheSer: 2.427 ± 0.038	1.892PheThr: 1.892 ± 0.038	3.159PheVal: 3.159 ± 0.049	0.59PheTrp: 0.59 ± 0.024	0.908PheTyr: 0.908 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.173GlyAla: 9.173 ± 0.102	0.809GlyCys: 0.809 ± 0.027	4.68GlyAsp: 4.68 ± 0.059	5.475GlyGlu: 5.475 ± 0.068	3.881GlyPhe: 3.881 ± 0.055	7.494GlyGly: 7.494 ± 0.088	1.873GlyHis: 1.873 ± 0.037	5.064GlyIle: 5.064 ± 0.065	3.318GlyLys: 3.318 ± 0.054	8.677GlyLeu: 8.677 ± 0.098	2.653GlyMet: 2.653 ± 0.046	2.183GlyAsn: 2.183 ± 0.039	3.522GlyPro: 3.522 ± 0.044	2.533GlyGln: 2.533 ± 0.043	6.419GlyArg: 6.419 ± 0.062	5.001GlySer: 5.001 ± 0.074	4.563GlyThr: 4.563 ± 0.054	6.12GlyVal: 6.12 ± 0.059	1.412GlyTrp: 1.412 ± 0.033	2.457GlyTyr: 2.457 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.243HisAla: 2.243 ± 0.044	0.234HisCys: 0.234 ± 0.013	1.231HisAsp: 1.231 ± 0.029	1.148HisGlu: 1.148 ± 0.03	0.89HisPhe: 0.89 ± 0.022	1.924HisGly: 1.924 ± 0.031	0.539HisHis: 0.539 ± 0.022	0.885HisIle: 0.885 ± 0.021	0.427HisLys: 0.427 ± 0.015	1.914HisLeu: 1.914 ± 0.039	0.503HisMet: 0.503 ± 0.016	0.408HisAsn: 0.408 ± 0.015	1.273HisPro: 1.273 ± 0.028	0.533HisGln: 0.533 ± 0.019	1.387HisArg: 1.387 ± 0.032	0.961HisSer: 0.961 ± 0.026	0.844HisThr: 0.844 ± 0.024	1.569HisVal: 1.569 ± 0.031	0.31HisTrp: 0.31 ± 0.014	0.55HisTyr: 0.55 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.586IleAla: 7.586 ± 0.091	0.489IleCys: 0.489 ± 0.02	3.671IleAsp: 3.671 ± 0.05	3.777IleGlu: 3.777 ± 0.06	1.824IlePhe: 1.824 ± 0.042	5.212IleGly: 5.212 ± 0.071	0.964IleHis: 0.964 ± 0.023	2.251IleIle: 2.251 ± 0.048	1.275IleLys: 1.275 ± 0.034	4.659IleLeu: 4.659 ± 0.069	1.092IleMet: 1.092 ± 0.028	1.278IleAsn: 1.278 ± 0.029	2.386IlePro: 2.386 ± 0.039	1.111IleGln: 1.111 ± 0.025	3.513IleArg: 3.513 ± 0.052	2.968IleSer: 2.968 ± 0.046	2.538IleThr: 2.538 ± 0.04	4.846IleVal: 4.846 ± 0.068	0.599IleTrp: 0.599 ± 0.02	1.228IleTyr: 1.228 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.189LysAla: 4.189 ± 0.07	0.165LysCys: 0.165 ± 0.012	1.705LysAsp: 1.705 ± 0.037	1.718LysGlu: 1.718 ± 0.041	0.912LysPhe: 0.912 ± 0.024	2.615LysGly: 2.615 ± 0.051	0.606LysHis: 0.606 ± 0.02	1.664LysIle: 1.664 ± 0.033	1.325LysLys: 1.325 ± 0.04	3.188LysLeu: 3.188 ± 0.056	0.771LysMet: 0.771 ± 0.023	0.868LysAsn: 0.868 ± 0.024	2.018LysPro: 2.018 ± 0.044	0.902LysGln: 0.902 ± 0.028	2.393LysArg: 2.393 ± 0.045	1.925LysSer: 1.925 ± 0.041	1.833LysThr: 1.833 ± 0.045	2.49LysVal: 2.49 ± 0.05	0.376LysTrp: 0.376 ± 0.017	0.615LysTyr: 0.615 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	12.989LeuAla: 12.989 ± 0.118	0.824LeuCys: 0.824 ± 0.023	5.929LeuAsp: 5.929 ± 0.066	5.504LeuGlu: 5.504 ± 0.065	3.79LeuPhe: 3.79 ± 0.065	7.97LeuGly: 7.97 ± 0.095	1.695LeuHis: 1.695 ± 0.036	4.766LeuIle: 4.766 ± 0.067	3.468LeuLys: 3.468 ± 0.048	8.968LeuLeu: 8.968 ± 0.107	2.324LeuMet: 2.324 ± 0.044	2.28LeuAsn: 2.28 ± 0.04	5.124LeuPro: 5.124 ± 0.063	2.408LeuGln: 2.408 ± 0.04	6.527LeuArg: 6.527 ± 0.071	6.486LeuSer: 6.486 ± 0.075	5.038LeuThr: 5.038 ± 0.079	7.613LeuVal: 7.613 ± 0.078	1.067LeuTrp: 1.067 ± 0.029	1.988LeuTyr: 1.988 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.304MetAla: 3.304 ± 0.05	0.15MetCys: 0.15 ± 0.009	1.259MetAsp: 1.259 ± 0.028	1.357MetGlu: 1.357 ± 0.03	0.779MetPhe: 0.779 ± 0.025	1.929MetGly: 1.929 ± 0.044	0.479MetHis: 0.479 ± 0.019	1.512MetIle: 1.512 ± 0.031	1.086MetLys: 1.086 ± 0.033	2.605MetLeu: 2.605 ± 0.05	0.747MetMet: 0.747 ± 0.025	0.9MetAsn: 0.9 ± 0.024	1.617MetPro: 1.617 ± 0.031	0.827MetGln: 0.827 ± 0.026	2.001MetArg: 2.001 ± 0.037	1.698MetSer: 1.698 ± 0.035	1.865MetThr: 1.865 ± 0.036	1.796MetVal: 1.796 ± 0.035	0.236MetTrp: 0.236 ± 0.012	0.311MetTyr: 0.311 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.055AsnAla: 3.055 ± 0.046	0.226AsnCys: 0.226 ± 0.014	1.374AsnAsp: 1.374 ± 0.036	1.335AsnGlu: 1.335 ± 0.029	0.941AsnPhe: 0.941 ± 0.027	2.306AsnGly: 2.306 ± 0.041	0.498AsnHis: 0.498 ± 0.016	1.27AsnIle: 1.27 ± 0.029	0.618AsnLys: 0.618 ± 0.023	2.495AsnLeu: 2.495 ± 0.04	0.63AsnMet: 0.63 ± 0.019	0.575AsnAsn: 0.575 ± 0.02	1.808AsnPro: 1.808 ± 0.037	0.72AsnGln: 0.72 ± 0.023	1.833AsnArg: 1.833 ± 0.036	1.219AsnSer: 1.219 ± 0.028	1.173AsnThr: 1.173 ± 0.029	1.975AsnVal: 1.975 ± 0.04	0.391AsnTrp: 0.391 ± 0.016	0.623AsnTyr: 0.623 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.112ProAla: 6.112 ± 0.076	0.325ProCys: 0.325 ± 0.013	3.677ProAsp: 3.677 ± 0.052	3.951ProGlu: 3.951 ± 0.061	2.072ProPhe: 2.072 ± 0.039	4.516ProGly: 4.516 ± 0.059	1.064ProHis: 1.064 ± 0.031	2.31ProIle: 2.31 ± 0.042	1.634ProLys: 1.634 ± 0.037	4.585ProLeu: 4.585 ± 0.061	1.168ProMet: 1.168 ± 0.027	1.251ProAsn: 1.251 ± 0.03	2.373ProPro: 2.373 ± 0.044	1.518ProGln: 1.518 ± 0.035	2.969ProArg: 2.969 ± 0.04	2.74ProSer: 2.74 ± 0.045	2.205ProThr: 2.205 ± 0.035	4.303ProVal: 4.303 ± 0.056	0.688ProTrp: 0.688 ± 0.021	1.172ProTyr: 1.172 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.546GlnAla: 3.546 ± 0.054	0.174GlnCys: 0.174 ± 0.01	1.357GlnAsp: 1.357 ± 0.029	1.537GlnGlu: 1.537 ± 0.037	0.967GlnPhe: 0.967 ± 0.023	2.166GlnGly: 2.166 ± 0.039	0.519GlnHis: 0.519 ± 0.016	1.677GlnIle: 1.677 ± 0.057	1.085GlnLys: 1.085 ± 0.03	2.469GlnLeu: 2.469 ± 0.043	0.88GlnMet: 0.88 ± 0.028	0.803GlnAsn: 0.803 ± 0.024	1.595GlnPro: 1.595 ± 0.035	0.984GlnGln: 0.984 ± 0.03	2.156GlnArg: 2.156 ± 0.037	1.588GlnSer: 1.588 ± 0.037	1.534GlnThr: 1.534 ± 0.036	2.109GlnVal: 2.109 ± 0.055	0.326GlnTrp: 0.326 ± 0.016	0.57GlnTyr: 0.57 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.65ArgAla: 7.65 ± 0.085	0.484ArgCys: 0.484 ± 0.019	4.233ArgAsp: 4.233 ± 0.051	4.729ArgGlu: 4.729 ± 0.054	3.086ArgPhe: 3.086 ± 0.048	4.972ArgGly: 4.972 ± 0.06	1.721ArgHis: 1.721 ± 0.034	4.227ArgIle: 4.227 ± 0.056	2.582ArgLys: 2.582 ± 0.044	7.657ArgLeu: 7.657 ± 0.077	2.149ArgMet: 2.149 ± 0.041	1.967ArgAsn: 1.967 ± 0.038	3.594ArgPro: 3.594 ± 0.05	2.501ArgGln: 2.501 ± 0.049	5.983ArgArg: 5.983 ± 0.081	3.943ArgSer: 3.943 ± 0.056	3.52ArgThr: 3.52 ± 0.052	4.664ArgVal: 4.664 ± 0.057	1.017ArgTrp: 1.017 ± 0.027	1.734ArgTyr: 1.734 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.22SerAla: 6.22 ± 0.067	0.417SerCys: 0.417 ± 0.019	3.112SerAsp: 3.112 ± 0.048	3.157SerGlu: 3.157 ± 0.047	2.397SerPhe: 2.397 ± 0.047	5.886SerGly: 5.886 ± 0.064	1.101SerHis: 1.101 ± 0.027	2.973SerIle: 2.973 ± 0.051	1.587SerLys: 1.587 ± 0.033	5.321SerLeu: 5.321 ± 0.066	1.463SerMet: 1.463 ± 0.033	1.326SerAsn: 1.326 ± 0.029	2.809SerPro: 2.809 ± 0.049	1.51SerGln: 1.51 ± 0.038	3.844SerArg: 3.844 ± 0.053	3.016SerSer: 3.016 ± 0.054	2.758SerThr: 2.758 ± 0.069	4.067SerVal: 4.067 ± 0.052	0.71SerTrp: 0.71 ± 0.021	1.299SerTyr: 1.299 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	5.926ThrAla: 5.926 ± 0.071	0.396ThrCys: 0.396 ± 0.016	2.78ThrAsp: 2.78 ± 0.072	2.778ThrGlu: 2.778 ± 0.042	2.023ThrPhe: 2.023 ± 0.039	5.201ThrGly: 5.201 ± 0.058	0.944ThrHis: 0.944 ± 0.026	3.147ThrIle: 3.147 ± 0.053	1.401ThrLys: 1.401 ± 0.034	5.243ThrLeu: 5.243 ± 0.057	1.312ThrMet: 1.312 ± 0.027	1.172ThrAsn: 1.172 ± 0.03	2.922ThrPro: 2.922 ± 0.042	1.25ThrGln: 1.25 ± 0.033	3.224ThrArg: 3.224 ± 0.05	2.775ThrSer: 2.775 ± 0.045	2.734ThrThr: 2.734 ± 0.064	4.283ThrVal: 4.283 ± 0.057	0.649ThrTrp: 0.649 ± 0.02	1.183ThrTyr: 1.183 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	9.351ValAla: 9.351 ± 0.091	0.63ValCys: 0.63 ± 0.02	4.155ValAsp: 4.155 ± 0.061	5.106ValGlu: 5.106 ± 0.06	3.08ValPhe: 3.08 ± 0.048	5.749ValGly: 5.749 ± 0.068	1.435ValHis: 1.435 ± 0.03	3.998ValIle: 3.998 ± 0.054	2.261ValLys: 2.261 ± 0.042	7.386ValLeu: 7.386 ± 0.075	1.95ValMet: 1.95 ± 0.036	1.922ValAsn: 1.922 ± 0.037	3.853ValPro: 3.853 ± 0.052	1.83ValGln: 1.83 ± 0.03	5.132ValArg: 5.132 ± 0.055	4.621ValSer: 4.621 ± 0.061	4.38ValThr: 4.38 ± 0.055	6.145ValVal: 6.145 ± 0.078	0.978ValTrp: 0.978 ± 0.028	1.558ValTyr: 1.558 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.176TrpAla: 1.176 ± 0.028	0.125TrpCys: 0.125 ± 0.009	0.651TrpAsp: 0.651 ± 0.021	0.632TrpGlu: 0.632 ± 0.02	0.569TrpPhe: 0.569 ± 0.019	0.898TrpGly: 0.898 ± 0.027	0.295TrpHis: 0.295 ± 0.014	0.715TrpIle: 0.715 ± 0.023	0.513TrpLys: 0.513 ± 0.019	1.549TrpLeu: 1.549 ± 0.034	0.371TrpMet: 0.371 ± 0.012	0.481TrpAsn: 0.481 ± 0.017	0.713TrpPro: 0.713 ± 0.023	0.5TrpGln: 0.5 ± 0.02	1.157TrpArg: 1.157 ± 0.031	0.904TrpSer: 0.904 ± 0.025	0.79TrpThr: 0.79 ± 0.022	0.792TrpVal: 0.792 ± 0.022	0.224TrpTrp: 0.224 ± 0.014	0.297TrpTyr: 0.297 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.423TyrAla: 2.423 ± 0.041	0.241TyrCys: 0.241 ± 0.013	1.461TyrAsp: 1.461 ± 0.035	1.368TyrGlu: 1.368 ± 0.033	0.957TyrPhe: 0.957 ± 0.022	2.161TyrGly: 2.161 ± 0.037	0.488TyrHis: 0.488 ± 0.018	0.864TyrIle: 0.864 ± 0.025	0.615TyrLys: 0.615 ± 0.02	2.204TyrLeu: 2.204 ± 0.046	0.492TyrMet: 0.492 ± 0.018	0.569TyrAsn: 0.569 ± 0.024	1.121TyrPro: 1.121 ± 0.027	0.675TyrGln: 0.675 ± 0.021	1.792TyrArg: 1.792 ± 0.035	1.237TyrSer: 1.237 ± 0.03	1.079TyrThr: 1.079 ± 0.027	1.734TyrVal: 1.734 ± 0.033	0.361TyrTrp: 0.361 ± 0.018	0.573TyrTyr: 0.573 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5014 proteins (1537093 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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