Amino acid dipepetide frequency for Moraxella phage Mcat15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.912AlaAla: 4.912 ± 1.38
0.614AlaCys: 0.614 ± 0.359
5.22AlaAsp: 5.22 ± 0.649
6.345AlaGlu: 6.345 ± 1.022
4.298AlaPhe: 4.298 ± 0.875
5.527AlaGly: 5.527 ± 0.829
1.228AlaHis: 1.228 ± 0.367
6.038AlaIle: 6.038 ± 0.939
7.88AlaLys: 7.88 ± 0.933
7.983AlaLeu: 7.983 ± 0.859
2.661AlaMet: 2.661 ± 0.687
4.401AlaAsn: 4.401 ± 0.676
1.842AlaPro: 1.842 ± 0.4
4.503AlaGln: 4.503 ± 0.786
3.173AlaArg: 3.173 ± 0.545
7.471AlaSer: 7.471 ± 0.958
5.731AlaThr: 5.731 ± 0.818
6.755AlaVal: 6.755 ± 0.834
1.126AlaTrp: 1.126 ± 0.427
2.047AlaTyr: 2.047 ± 0.4
0.0AlaXaa: 0.0 ± 0.0
Cys
0.205CysAla: 0.205 ± 0.197
0.205CysCys: 0.205 ± 0.134
0.512CysAsp: 0.512 ± 0.208
0.205CysGlu: 0.205 ± 0.153
0.205CysPhe: 0.205 ± 0.152
0.716CysGly: 0.716 ± 0.331
0.409CysHis: 0.409 ± 0.203
0.307CysIle: 0.307 ± 0.202
0.819CysLys: 0.819 ± 0.42
0.819CysLeu: 0.819 ± 0.304
0.205CysMet: 0.205 ± 0.154
0.102CysAsn: 0.102 ± 0.094
0.512CysPro: 0.512 ± 0.222
0.512CysGln: 0.512 ± 0.226
0.921CysArg: 0.921 ± 0.248
0.819CysSer: 0.819 ± 0.433
0.409CysThr: 0.409 ± 0.23
0.512CysVal: 0.512 ± 0.245
0.0CysTrp: 0.0 ± 0.0
0.409CysTyr: 0.409 ± 0.243
0.0CysXaa: 0.0 ± 0.0
Asp
4.605AspAla: 4.605 ± 0.533
0.614AspCys: 0.614 ± 0.333
4.81AspAsp: 4.81 ± 0.622
4.912AspGlu: 4.912 ± 0.751
2.661AspPhe: 2.661 ± 0.577
5.936AspGly: 5.936 ± 0.557
0.819AspHis: 0.819 ± 0.295
4.298AspIle: 4.298 ± 0.645
4.708AspLys: 4.708 ± 0.549
4.401AspLeu: 4.401 ± 0.68
1.433AspMet: 1.433 ± 0.456
3.991AspAsn: 3.991 ± 0.667
1.126AspPro: 1.126 ± 0.427
0.921AspGln: 0.921 ± 0.32
2.354AspArg: 2.354 ± 0.496
2.866AspSer: 2.866 ± 0.623
2.354AspThr: 2.354 ± 0.509
3.07AspVal: 3.07 ± 0.462
0.716AspTrp: 0.716 ± 0.262
1.842AspTyr: 1.842 ± 0.443
0.0AspXaa: 0.0 ± 0.0
Glu
4.196GluAla: 4.196 ± 0.854
0.819GluCys: 0.819 ± 0.341
2.456GluAsp: 2.456 ± 0.708
2.968GluGlu: 2.968 ± 0.813
2.456GluPhe: 2.456 ± 0.434
1.945GluGly: 1.945 ± 0.408
1.33GluHis: 1.33 ± 0.422
4.912GluIle: 4.912 ± 0.579
3.889GluLys: 3.889 ± 0.84
7.369GluLeu: 7.369 ± 0.689
1.74GluMet: 1.74 ± 0.345
3.377GluAsn: 3.377 ± 0.755
2.047GluPro: 2.047 ± 0.542
4.708GluGln: 4.708 ± 0.624
4.401GluArg: 4.401 ± 0.684
2.763GluSer: 2.763 ± 0.533
3.173GluThr: 3.173 ± 0.613
3.173GluVal: 3.173 ± 0.731
0.716GluTrp: 0.716 ± 0.257
2.354GluTyr: 2.354 ± 0.376
0.0GluXaa: 0.0 ± 0.0
Phe
3.377PheAla: 3.377 ± 0.584
0.716PheCys: 0.716 ± 0.239
2.763PheAsp: 2.763 ± 0.661
3.275PheGlu: 3.275 ± 0.701
1.023PhePhe: 1.023 ± 0.363
4.094PheGly: 4.094 ± 0.734
0.614PheHis: 0.614 ± 0.288
2.149PheIle: 2.149 ± 0.596
1.535PheLys: 1.535 ± 0.387
2.252PheLeu: 2.252 ± 0.598
0.921PheMet: 0.921 ± 0.334
2.149PheAsn: 2.149 ± 0.43
0.614PhePro: 0.614 ± 0.239
0.614PheGln: 0.614 ± 0.346
1.637PheArg: 1.637 ± 0.394
2.149PheSer: 2.149 ± 0.422
1.228PheThr: 1.228 ± 0.295
2.149PheVal: 2.149 ± 0.5
0.614PheTrp: 0.614 ± 0.258
1.535PheTyr: 1.535 ± 0.398
0.0PheXaa: 0.0 ± 0.0
Gly
5.015GlyAla: 5.015 ± 0.809
0.307GlyCys: 0.307 ± 0.16
4.912GlyAsp: 4.912 ± 0.801
4.196GlyGlu: 4.196 ± 0.611
3.173GlyPhe: 3.173 ± 0.636
5.117GlyGly: 5.117 ± 0.851
0.921GlyHis: 0.921 ± 0.306
4.708GlyIle: 4.708 ± 0.945
5.527GlyLys: 5.527 ± 1.037
6.345GlyLeu: 6.345 ± 0.919
1.842GlyMet: 1.842 ± 0.492
3.582GlyAsn: 3.582 ± 0.471
0.102GlyPro: 0.102 ± 0.09
2.354GlyGln: 2.354 ± 0.676
3.275GlyArg: 3.275 ± 0.543
3.377GlySer: 3.377 ± 0.526
3.684GlyThr: 3.684 ± 0.97
7.266GlyVal: 7.266 ± 0.697
1.228GlyTrp: 1.228 ± 0.379
2.047GlyTyr: 2.047 ± 0.535
0.0GlyXaa: 0.0 ± 0.0
His
1.842HisAla: 1.842 ± 0.425
0.205HisCys: 0.205 ± 0.177
1.637HisAsp: 1.637 ± 0.448
1.433HisGlu: 1.433 ± 0.331
0.205HisPhe: 0.205 ± 0.136
2.149HisGly: 2.149 ± 0.451
0.921HisHis: 0.921 ± 0.415
1.433HisIle: 1.433 ± 0.444
1.023HisLys: 1.023 ± 0.38
2.047HisLeu: 2.047 ± 0.594
0.614HisMet: 0.614 ± 0.219
0.921HisAsn: 0.921 ± 0.28
0.716HisPro: 0.716 ± 0.359
0.614HisGln: 0.614 ± 0.21
0.409HisArg: 0.409 ± 0.211
0.921HisSer: 0.921 ± 0.39
1.433HisThr: 1.433 ± 0.393
0.205HisVal: 0.205 ± 0.134
0.512HisTrp: 0.512 ± 0.228
0.716HisTyr: 0.716 ± 0.288
0.0HisXaa: 0.0 ± 0.0
Ile
5.834IleAla: 5.834 ± 0.761
0.409IleCys: 0.409 ± 0.206
5.117IleAsp: 5.117 ± 0.706
3.377IleGlu: 3.377 ± 0.577
1.535IlePhe: 1.535 ± 0.46
5.424IleGly: 5.424 ± 0.823
0.819IleHis: 0.819 ± 0.235
5.117IleIle: 5.117 ± 0.788
6.345IleLys: 6.345 ± 1.011
3.787IleLeu: 3.787 ± 0.764
1.126IleMet: 1.126 ± 0.389
4.605IleAsn: 4.605 ± 0.806
1.228IlePro: 1.228 ± 0.265
2.559IleGln: 2.559 ± 0.609
2.047IleArg: 2.047 ± 0.394
5.834IleSer: 5.834 ± 1.168
5.834IleThr: 5.834 ± 1.077
3.684IleVal: 3.684 ± 0.681
0.307IleTrp: 0.307 ± 0.201
1.74IleTyr: 1.74 ± 0.435
0.0IleXaa: 0.0 ± 0.0
Lys
7.573LysAla: 7.573 ± 1.046
0.102LysCys: 0.102 ± 0.108
3.275LysAsp: 3.275 ± 0.733
3.889LysGlu: 3.889 ± 0.737
2.661LysPhe: 2.661 ± 0.459
4.196LysGly: 4.196 ± 0.751
1.433LysHis: 1.433 ± 0.47
4.401LysIle: 4.401 ± 0.481
6.448LysLys: 6.448 ± 1.217
6.345LysLeu: 6.345 ± 1.007
1.74LysMet: 1.74 ± 0.405
3.48LysAsn: 3.48 ± 0.804
2.047LysPro: 2.047 ± 0.434
4.298LysGln: 4.298 ± 0.682
4.094LysArg: 4.094 ± 0.933
6.345LysSer: 6.345 ± 1.016
4.401LysThr: 4.401 ± 0.676
2.559LysVal: 2.559 ± 0.583
1.023LysTrp: 1.023 ± 0.331
2.252LysTyr: 2.252 ± 0.5
0.0LysXaa: 0.0 ± 0.0
Leu
8.904LeuAla: 8.904 ± 0.998
0.921LeuCys: 0.921 ± 0.413
5.322LeuAsp: 5.322 ± 0.672
4.81LeuGlu: 4.81 ± 1.254
1.637LeuPhe: 1.637 ± 0.376
6.243LeuGly: 6.243 ± 0.797
1.535LeuHis: 1.535 ± 0.458
4.196LeuIle: 4.196 ± 0.653
7.676LeuLys: 7.676 ± 1.01
5.731LeuLeu: 5.731 ± 0.991
1.842LeuMet: 1.842 ± 0.684
4.708LeuAsn: 4.708 ± 0.952
4.298LeuPro: 4.298 ± 0.743
3.787LeuGln: 3.787 ± 0.571
4.298LeuArg: 4.298 ± 0.535
6.141LeuSer: 6.141 ± 0.71
5.834LeuThr: 5.834 ± 0.814
3.48LeuVal: 3.48 ± 0.577
1.228LeuTrp: 1.228 ± 0.313
3.173LeuTyr: 3.173 ± 0.45
0.0LeuXaa: 0.0 ± 0.0
Met
2.456MetAla: 2.456 ± 0.492
0.102MetCys: 0.102 ± 0.126
0.921MetAsp: 0.921 ± 0.367
0.512MetGlu: 0.512 ± 0.263
1.126MetPhe: 1.126 ± 0.327
1.535MetGly: 1.535 ± 0.318
0.614MetHis: 0.614 ± 0.289
1.33MetIle: 1.33 ± 0.362
1.842MetLys: 1.842 ± 0.419
1.433MetLeu: 1.433 ± 0.52
0.716MetMet: 0.716 ± 0.296
1.33MetAsn: 1.33 ± 0.459
0.921MetPro: 0.921 ± 0.356
1.433MetGln: 1.433 ± 0.43
0.921MetArg: 0.921 ± 0.355
2.559MetSer: 2.559 ± 0.634
1.74MetThr: 1.74 ± 0.459
2.149MetVal: 2.149 ± 0.718
0.102MetTrp: 0.102 ± 0.125
0.716MetTyr: 0.716 ± 0.274
0.0MetXaa: 0.0 ± 0.0
Asn
5.424AsnAla: 5.424 ± 1.049
0.0AsnCys: 0.0 ± 0.0
2.456AsnAsp: 2.456 ± 0.542
2.559AsnGlu: 2.559 ± 0.463
2.149AsnPhe: 2.149 ± 0.464
3.582AsnGly: 3.582 ± 0.821
1.126AsnHis: 1.126 ± 0.343
3.07AsnIle: 3.07 ± 0.665
3.582AsnLys: 3.582 ± 0.776
5.015AsnLeu: 5.015 ± 0.775
1.023AsnMet: 1.023 ± 0.545
2.866AsnAsn: 2.866 ± 0.593
2.866AsnPro: 2.866 ± 0.733
2.661AsnGln: 2.661 ± 0.545
2.354AsnArg: 2.354 ± 0.447
3.684AsnSer: 3.684 ± 0.825
3.07AsnThr: 3.07 ± 1.067
2.354AsnVal: 2.354 ± 0.707
0.409AsnTrp: 0.409 ± 0.139
1.74AsnTyr: 1.74 ± 0.319
0.0AsnXaa: 0.0 ± 0.0
Pro
2.354ProAla: 2.354 ± 0.377
0.409ProCys: 0.409 ± 0.227
1.945ProAsp: 1.945 ± 0.509
1.637ProGlu: 1.637 ± 0.383
1.433ProPhe: 1.433 ± 0.358
0.307ProGly: 0.307 ± 0.185
0.307ProHis: 0.307 ± 0.206
2.866ProIle: 2.866 ± 0.467
2.456ProLys: 2.456 ± 0.667
2.047ProLeu: 2.047 ± 0.436
1.126ProMet: 1.126 ± 0.293
1.637ProAsn: 1.637 ± 0.429
1.74ProPro: 1.74 ± 0.372
1.126ProGln: 1.126 ± 0.347
1.228ProArg: 1.228 ± 0.417
2.559ProSer: 2.559 ± 0.71
2.559ProThr: 2.559 ± 0.75
1.74ProVal: 1.74 ± 0.39
0.512ProTrp: 0.512 ± 0.206
0.614ProTyr: 0.614 ± 0.228
0.0ProXaa: 0.0 ± 0.0
Gln
5.629GlnAla: 5.629 ± 0.795
0.307GlnCys: 0.307 ± 0.197
2.252GlnAsp: 2.252 ± 0.511
2.149GlnGlu: 2.149 ± 0.404
1.228GlnPhe: 1.228 ± 0.362
2.456GlnGly: 2.456 ± 0.589
0.921GlnHis: 0.921 ± 0.271
4.196GlnIle: 4.196 ± 0.456
3.173GlnLys: 3.173 ± 0.505
4.708GlnLeu: 4.708 ± 0.574
0.921GlnMet: 0.921 ± 0.334
2.149GlnAsn: 2.149 ± 0.396
1.228GlnPro: 1.228 ± 0.374
1.637GlnGln: 1.637 ± 0.495
1.637GlnArg: 1.637 ± 0.392
3.889GlnSer: 3.889 ± 1.08
2.252GlnThr: 2.252 ± 0.524
2.456GlnVal: 2.456 ± 0.578
0.512GlnTrp: 0.512 ± 0.26
1.433GlnTyr: 1.433 ± 0.298
0.0GlnXaa: 0.0 ± 0.0
Arg
5.117ArgAla: 5.117 ± 1.025
0.409ArgCys: 0.409 ± 0.198
2.252ArgAsp: 2.252 ± 0.467
3.582ArgGlu: 3.582 ± 0.78
2.149ArgPhe: 2.149 ± 0.576
2.866ArgGly: 2.866 ± 0.639
1.228ArgHis: 1.228 ± 0.306
3.07ArgIle: 3.07 ± 0.838
2.149ArgLys: 2.149 ± 0.392
4.81ArgLeu: 4.81 ± 1.009
0.921ArgMet: 0.921 ± 0.253
1.228ArgAsn: 1.228 ± 0.411
1.228ArgPro: 1.228 ± 0.31
2.661ArgGln: 2.661 ± 0.445
2.456ArgArg: 2.456 ± 0.716
2.763ArgSer: 2.763 ± 0.51
2.968ArgThr: 2.968 ± 0.535
2.559ArgVal: 2.559 ± 0.52
0.409ArgTrp: 0.409 ± 0.238
2.456ArgTyr: 2.456 ± 0.577
0.0ArgXaa: 0.0 ± 0.0
Ser
7.062SerAla: 7.062 ± 1.195
0.512SerCys: 0.512 ± 0.216
3.684SerAsp: 3.684 ± 0.689
4.708SerGlu: 4.708 ± 0.717
2.354SerPhe: 2.354 ± 0.54
4.708SerGly: 4.708 ± 0.955
1.842SerHis: 1.842 ± 0.41
4.298SerIle: 4.298 ± 1.149
4.094SerLys: 4.094 ± 0.519
6.345SerLeu: 6.345 ± 1.104
1.74SerMet: 1.74 ± 0.568
3.991SerAsn: 3.991 ± 0.992
1.637SerPro: 1.637 ± 0.496
3.582SerGln: 3.582 ± 0.642
2.866SerArg: 2.866 ± 0.468
4.298SerSer: 4.298 ± 1.115
2.968SerThr: 2.968 ± 0.481
5.322SerVal: 5.322 ± 0.926
0.614SerTrp: 0.614 ± 0.255
1.637SerTyr: 1.637 ± 0.384
0.0SerXaa: 0.0 ± 0.0
Thr
6.345ThrAla: 6.345 ± 0.801
0.205ThrCys: 0.205 ± 0.145
3.07ThrAsp: 3.07 ± 0.563
4.298ThrGlu: 4.298 ± 0.698
1.535ThrPhe: 1.535 ± 0.323
4.912ThrGly: 4.912 ± 0.977
1.433ThrHis: 1.433 ± 0.358
3.889ThrIle: 3.889 ± 0.74
3.377ThrLys: 3.377 ± 0.638
5.015ThrLeu: 5.015 ± 0.933
1.228ThrMet: 1.228 ± 0.392
2.763ThrAsn: 2.763 ± 0.607
2.968ThrPro: 2.968 ± 0.617
2.456ThrGln: 2.456 ± 0.456
2.149ThrArg: 2.149 ± 0.663
3.275ThrSer: 3.275 ± 1.39
3.48ThrThr: 3.48 ± 0.706
4.912ThrVal: 4.912 ± 0.955
0.716ThrTrp: 0.716 ± 0.292
1.023ThrTyr: 1.023 ± 0.342
0.0ThrXaa: 0.0 ± 0.0
Val
5.629ValAla: 5.629 ± 0.645
0.819ValCys: 0.819 ± 0.382
3.173ValAsp: 3.173 ± 0.427
3.684ValGlu: 3.684 ± 0.615
2.252ValPhe: 2.252 ± 0.399
3.377ValGly: 3.377 ± 0.775
1.228ValHis: 1.228 ± 0.4
3.991ValIle: 3.991 ± 0.484
3.684ValLys: 3.684 ± 0.578
5.015ValLeu: 5.015 ± 0.72
1.74ValMet: 1.74 ± 0.483
3.582ValAsn: 3.582 ± 0.678
2.047ValPro: 2.047 ± 0.375
2.763ValGln: 2.763 ± 0.431
3.889ValArg: 3.889 ± 0.553
3.991ValSer: 3.991 ± 0.703
3.48ValThr: 3.48 ± 0.796
3.582ValVal: 3.582 ± 0.986
1.33ValTrp: 1.33 ± 0.372
2.047ValTyr: 2.047 ± 0.477
0.0ValXaa: 0.0 ± 0.0
Trp
1.33TrpAla: 1.33 ± 0.404
0.307TrpCys: 0.307 ± 0.214
0.716TrpAsp: 0.716 ± 0.242
0.512TrpGlu: 0.512 ± 0.195
0.512TrpPhe: 0.512 ± 0.259
0.819TrpGly: 0.819 ± 0.35
0.205TrpHis: 0.205 ± 0.131
0.409TrpIle: 0.409 ± 0.18
0.307TrpLys: 0.307 ± 0.226
1.637TrpLeu: 1.637 ± 0.46
0.205TrpMet: 0.205 ± 0.165
0.409TrpAsn: 0.409 ± 0.174
0.102TrpPro: 0.102 ± 0.1
1.126TrpGln: 1.126 ± 0.388
0.409TrpArg: 0.409 ± 0.224
0.921TrpSer: 0.921 ± 0.393
0.614TrpThr: 0.614 ± 0.234
1.535TrpVal: 1.535 ± 0.446
0.205TrpTrp: 0.205 ± 0.154
0.512TrpTyr: 0.512 ± 0.258
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.945TyrAla: 1.945 ± 0.428
0.819TyrCys: 0.819 ± 0.326
1.945TyrAsp: 1.945 ± 0.576
1.74TyrGlu: 1.74 ± 0.405
0.819TyrPhe: 0.819 ± 0.431
3.07TyrGly: 3.07 ± 0.464
1.023TyrHis: 1.023 ± 0.362
2.047TyrIle: 2.047 ± 0.44
2.047TyrLys: 2.047 ± 0.548
2.661TyrLeu: 2.661 ± 0.54
0.614TyrMet: 0.614 ± 0.219
0.819TyrAsn: 0.819 ± 0.245
1.33TyrPro: 1.33 ± 0.393
0.819TyrGln: 0.819 ± 0.3
2.763TyrArg: 2.763 ± 0.378
1.637TyrSer: 1.637 ± 0.396
1.842TyrThr: 1.842 ± 0.417
1.842TyrVal: 1.842 ± 0.544
0.512TyrTrp: 0.512 ± 0.188
1.637TyrTyr: 1.637 ± 0.47
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 42 proteins (9772 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski