Amino acid dipepetide frequency for Nothophytophthora sp. Chile5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.902AlaAla: 12.902 ± 0.056	1.456AlaCys: 1.456 ± 0.012	5.049AlaAsp: 5.049 ± 0.024	6.098AlaGlu: 6.098 ± 0.029	3.752AlaPhe: 3.752 ± 0.02	5.853AlaGly: 5.853 ± 0.027	1.922AlaHis: 1.922 ± 0.012	3.847AlaIle: 3.847 ± 0.018	4.68AlaLys: 4.68 ± 0.023	10.314AlaLeu: 10.314 ± 0.04	2.53AlaMet: 2.53 ± 0.016	3.073AlaAsn: 3.073 ± 0.017	4.805AlaPro: 4.805 ± 0.028	3.981AlaGln: 3.981 ± 0.021	5.684AlaArg: 5.684 ± 0.028	9.245AlaSer: 9.245 ± 0.033	6.63AlaThr: 6.63 ± 0.024	7.38AlaVal: 7.38 ± 0.027	1.004AlaTrp: 1.004 ± 0.009	1.966AlaTyr: 1.966 ± 0.013	0.0AlaXaa: 0.0 ± 0.0
Cys	1.39CysAla: 1.39 ± 0.013	0.431CysCys: 0.431 ± 0.007	0.859CysAsp: 0.859 ± 0.011	0.938CysGlu: 0.938 ± 0.01	0.708CysPhe: 0.708 ± 0.008	1.188CysGly: 1.188 ± 0.011	0.394CysHis: 0.394 ± 0.005	0.672CysIle: 0.672 ± 0.007	0.578CysLys: 0.578 ± 0.008	1.52CysLeu: 1.52 ± 0.011	0.371CysMet: 0.371 ± 0.005	0.45CysAsn: 0.45 ± 0.007	0.753CysPro: 0.753 ± 0.014	0.565CysGln: 0.565 ± 0.006	0.957CysArg: 0.957 ± 0.008	1.39CysSer: 1.39 ± 0.013	0.875CysThr: 0.875 ± 0.01	1.377CysVal: 1.377 ± 0.013	0.235CysTrp: 0.235 ± 0.005	0.42CysTyr: 0.42 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	6.385AspAla: 6.385 ± 0.027	0.858AspCys: 0.858 ± 0.009	4.465AspAsp: 4.465 ± 0.025	4.862AspGlu: 4.862 ± 0.024	2.046AspPhe: 2.046 ± 0.013	4.391AspGly: 4.391 ± 0.02	1.076AspHis: 1.076 ± 0.009	1.93AspIle: 1.93 ± 0.013	1.959AspLys: 1.959 ± 0.014	4.766AspLeu: 4.766 ± 0.019	1.219AspMet: 1.219 ± 0.01	1.429AspAsn: 1.429 ± 0.012	2.567AspPro: 2.567 ± 0.015	1.879AspGln: 1.879 ± 0.011	2.905AspArg: 2.905 ± 0.018	4.081AspSer: 4.081 ± 0.02	2.65AspThr: 2.65 ± 0.017	4.554AspVal: 4.554 ± 0.02	0.657AspTrp: 0.657 ± 0.008	1.289AspTyr: 1.289 ± 0.011	0.0AspXaa: 0.0 ± 0.0
Glu	7.04GluAla: 7.04 ± 0.034	0.879GluCys: 0.879 ± 0.009	4.31GluAsp: 4.31 ± 0.022	6.325GluGlu: 6.325 ± 0.04	2.126GluPhe: 2.126 ± 0.013	3.647GluGly: 3.647 ± 0.016	1.468GluHis: 1.468 ± 0.011	2.507GluIle: 2.507 ± 0.014	3.353GluLys: 3.353 ± 0.019	7.076GluLeu: 7.076 ± 0.033	1.689GluMet: 1.689 ± 0.012	2.005GluAsn: 2.005 ± 0.015	2.438GluPro: 2.438 ± 0.017	3.172GluGln: 3.172 ± 0.021	4.503GluArg: 4.503 ± 0.024	4.237GluSer: 4.237 ± 0.018	3.692GluThr: 3.692 ± 0.021	4.197GluVal: 4.197 ± 0.02	0.779GluTrp: 0.779 ± 0.009	1.466GluTyr: 1.466 ± 0.011	0.0GluXaa: 0.0 ± 0.0
Phe	3.547PheAla: 3.547 ± 0.018	0.718PheCys: 0.718 ± 0.007	2.206PheAsp: 2.206 ± 0.014	2.225PheGlu: 2.225 ± 0.016	1.637PhePhe: 1.637 ± 0.015	2.713PheGly: 2.713 ± 0.019	0.972PheHis: 0.972 ± 0.009	1.259PheIle: 1.259 ± 0.013	1.231PheLys: 1.231 ± 0.011	3.717PheLeu: 3.717 ± 0.022	0.845PheMet: 0.845 ± 0.008	1.133PheAsn: 1.133 ± 0.011	1.736PhePro: 1.736 ± 0.013	1.56PheGln: 1.56 ± 0.011	2.154PheArg: 2.154 ± 0.013	2.805PheSer: 2.805 ± 0.015	1.936PheThr: 1.936 ± 0.012	3.019PheVal: 3.019 ± 0.017	0.462PheTrp: 0.462 ± 0.007	1.083PheTyr: 1.083 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	5.954GlyAla: 5.954 ± 0.025	1.109GlyCys: 1.109 ± 0.011	4.141GlyAsp: 4.141 ± 0.021	3.943GlyGlu: 3.943 ± 0.018	2.523GlyPhe: 2.523 ± 0.015	5.87GlyGly: 5.87 ± 0.039	1.522GlyHis: 1.522 ± 0.014	2.454GlyIle: 2.454 ± 0.015	3.007GlyLys: 3.007 ± 0.018	5.153GlyLeu: 5.153 ± 0.022	1.461GlyMet: 1.461 ± 0.013	2.271GlyAsn: 2.271 ± 0.014	2.083GlyPro: 2.083 ± 0.014	2.093GlyGln: 2.093 ± 0.012	3.651GlyArg: 3.651 ± 0.022	5.854GlySer: 5.854 ± 0.031	3.295GlyThr: 3.295 ± 0.019	4.866GlyVal: 4.866 ± 0.021	0.785GlyTrp: 0.785 ± 0.008	1.729GlyTyr: 1.729 ± 0.013	0.0GlyXaa: 0.0 ± 0.0
His	2.193HisAla: 2.193 ± 0.014	0.415HisCys: 0.415 ± 0.006	1.224HisAsp: 1.224 ± 0.011	1.574HisGlu: 1.574 ± 0.012	0.986HisPhe: 0.986 ± 0.008	1.643HisGly: 1.643 ± 0.014	0.732HisHis: 0.732 ± 0.009	0.814HisIle: 0.814 ± 0.008	0.852HisLys: 0.852 ± 0.008	2.285HisLeu: 2.285 ± 0.015	0.489HisMet: 0.489 ± 0.006	0.612HisAsn: 0.612 ± 0.007	1.256HisPro: 1.256 ± 0.009	1.012HisGln: 1.012 ± 0.01	1.637HisArg: 1.637 ± 0.012	1.693HisSer: 1.693 ± 0.01	1.116HisThr: 1.116 ± 0.009	1.821HisVal: 1.821 ± 0.011	0.303HisTrp: 0.303 ± 0.005	0.61HisTyr: 0.61 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	3.744IleAla: 3.744 ± 0.018	0.705IleCys: 0.705 ± 0.007	2.088IleAsp: 2.088 ± 0.014	2.229IleGlu: 2.229 ± 0.015	1.37IlePhe: 1.37 ± 0.013	2.237IleGly: 2.237 ± 0.016	0.845IleHis: 0.845 ± 0.009	1.268IleIle: 1.268 ± 0.012	1.454IleLys: 1.454 ± 0.011	3.146IleLeu: 3.146 ± 0.02	0.797IleMet: 0.797 ± 0.008	1.112IleAsn: 1.112 ± 0.011	1.848IlePro: 1.848 ± 0.013	1.535IleGln: 1.535 ± 0.013	2.18IleArg: 2.18 ± 0.012	2.699IleSer: 2.699 ± 0.017	1.927IleThr: 1.927 ± 0.013	2.876IleVal: 2.876 ± 0.017	0.442IleTrp: 0.442 ± 0.006	0.941IleTyr: 0.941 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	4.196LysAla: 4.196 ± 0.022	0.618LysCys: 0.618 ± 0.009	2.092LysAsp: 2.092 ± 0.016	2.944LysGlu: 2.944 ± 0.021	1.359LysPhe: 1.359 ± 0.011	2.131LysGly: 2.131 ± 0.014	1.123LysHis: 1.123 ± 0.01	1.554LysIle: 1.554 ± 0.011	3.33LysLys: 3.33 ± 0.03	4.499LysLeu: 4.499 ± 0.019	1.113LysMet: 1.113 ± 0.008	1.382LysAsn: 1.382 ± 0.011	2.089LysPro: 2.089 ± 0.014	2.226LysGln: 2.226 ± 0.016	3.704LysArg: 3.704 ± 0.021	2.907LysSer: 2.907 ± 0.018	2.713LysThr: 2.713 ± 0.016	2.644LysVal: 2.644 ± 0.016	0.589LysTrp: 0.589 ± 0.006	1.175LysTyr: 1.175 ± 0.01	0.0LysXaa: 0.0 ± 0.0
Leu	9.762LeuAla: 9.762 ± 0.041	1.644LeuCys: 1.644 ± 0.012	5.183LeuAsp: 5.183 ± 0.023	6.788LeuGlu: 6.788 ± 0.031	3.588LeuPhe: 3.588 ± 0.022	5.445LeuGly: 5.445 ± 0.021	2.654LeuHis: 2.654 ± 0.017	2.889LeuIle: 2.889 ± 0.017	4.145LeuLys: 4.145 ± 0.021	11.117LeuLeu: 11.117 ± 0.053	2.097LeuMet: 2.097 ± 0.013	2.792LeuAsn: 2.792 ± 0.015	5.089LeuPro: 5.089 ± 0.027	5.166LeuGln: 5.166 ± 0.025	6.875LeuArg: 6.875 ± 0.03	7.332LeuSer: 7.332 ± 0.025	5.12LeuThr: 5.12 ± 0.022	7.052LeuVal: 7.052 ± 0.029	1.092LeuTrp: 1.092 ± 0.01	2.245LeuTyr: 2.245 ± 0.013	0.0LeuXaa: 0.0 ± 0.0
Met	2.458MetAla: 2.458 ± 0.014	0.371MetCys: 0.371 ± 0.005	1.376MetAsp: 1.376 ± 0.012	1.766MetGlu: 1.766 ± 0.012	0.701MetPhe: 0.701 ± 0.007	1.429MetGly: 1.429 ± 0.01	0.535MetHis: 0.535 ± 0.006	0.762MetIle: 0.762 ± 0.008	1.134MetLys: 1.134 ± 0.009	2.364MetLeu: 2.364 ± 0.013	0.618MetMet: 0.618 ± 0.009	0.751MetAsn: 0.751 ± 0.008	1.04MetPro: 1.04 ± 0.01	1.096MetGln: 1.096 ± 0.009	1.45MetArg: 1.45 ± 0.011	1.558MetSer: 1.558 ± 0.011	1.368MetThr: 1.368 ± 0.01	1.443MetVal: 1.443 ± 0.011	0.271MetTrp: 0.271 ± 0.005	0.572MetTyr: 0.572 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	3.349AsnAla: 3.349 ± 0.02	0.542AsnCys: 0.542 ± 0.006	1.734AsnAsp: 1.734 ± 0.013	1.864AsnGlu: 1.864 ± 0.013	1.083AsnPhe: 1.083 ± 0.01	2.678AsnGly: 2.678 ± 0.017	0.663AsnHis: 0.663 ± 0.007	1.109AsnIle: 1.109 ± 0.01	1.164AsnLys: 1.164 ± 0.009	2.568AsnLeu: 2.568 ± 0.017	0.729AsnMet: 0.729 ± 0.008	0.999AsnAsn: 0.999 ± 0.009	1.583AsnPro: 1.583 ± 0.011	1.13AsnGln: 1.13 ± 0.009	1.696AsnArg: 1.696 ± 0.011	2.31AsnSer: 2.31 ± 0.015	1.542AsnThr: 1.542 ± 0.013	2.344AsnVal: 2.344 ± 0.013	0.396AsnTrp: 0.396 ± 0.005	0.777AsnTyr: 0.777 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	4.823ProAla: 4.823 ± 0.028	0.575ProCys: 0.575 ± 0.01	2.25ProAsp: 2.25 ± 0.013	3.12ProGlu: 3.12 ± 0.018	1.675ProPhe: 1.675 ± 0.013	2.567ProGly: 2.567 ± 0.016	1.074ProHis: 1.074 ± 0.011	1.604ProIle: 1.604 ± 0.013	1.942ProLys: 1.942 ± 0.014	4.496ProLeu: 4.496 ± 0.02	1.046ProMet: 1.046 ± 0.008	1.398ProAsn: 1.398 ± 0.011	3.793ProPro: 3.793 ± 0.029	1.918ProGln: 1.918 ± 0.012	2.953ProArg: 2.953 ± 0.015	4.943ProSer: 4.943 ± 0.025	3.455ProThr: 3.455 ± 0.023	3.426ProVal: 3.426 ± 0.019	0.5ProTrp: 0.5 ± 0.006	0.968ProTyr: 0.968 ± 0.009	0.0ProXaa: 0.0 ± 0.0
Gln	3.759GlnAla: 3.759 ± 0.02	0.605GlnCys: 0.605 ± 0.007	1.908GlnAsp: 1.908 ± 0.013	3.022GlnGlu: 3.022 ± 0.022	1.483GlnPhe: 1.483 ± 0.011	1.867GlnGly: 1.867 ± 0.013	1.259GlnHis: 1.259 ± 0.011	1.573GlnIle: 1.573 ± 0.011	1.947GlnLys: 1.947 ± 0.014	4.982GlnLeu: 4.982 ± 0.023	1.065GlnMet: 1.065 ± 0.009	1.131GlnAsn: 1.131 ± 0.01	1.958GlnPro: 1.958 ± 0.013	3.614GlnGln: 3.614 ± 0.031	3.506GlnArg: 3.506 ± 0.022	2.911GlnSer: 2.911 ± 0.016	2.376GlnThr: 2.376 ± 0.013	2.693GlnVal: 2.693 ± 0.015	0.635GlnTrp: 0.635 ± 0.007	1.009GlnTyr: 1.009 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	5.651ArgAla: 5.651 ± 0.029	1.012ArgCys: 1.012 ± 0.009	3.244ArgAsp: 3.244 ± 0.017	4.363ArgGlu: 4.363 ± 0.024	2.466ArgPhe: 2.466 ± 0.014	3.833ArgGly: 3.833 ± 0.019	1.702ArgHis: 1.702 ± 0.012	2.242ArgIle: 2.242 ± 0.013	3.383ArgLys: 3.383 ± 0.022	6.413ArgLeu: 6.413 ± 0.028	1.427ArgMet: 1.427 ± 0.011	1.927ArgAsn: 1.927 ± 0.013	2.664ArgPro: 2.664 ± 0.015	3.112ArgGln: 3.112 ± 0.022	5.742ArgArg: 5.742 ± 0.031	5.158ArgSer: 5.158 ± 0.025	2.954ArgThr: 2.954 ± 0.015	4.552ArgVal: 4.552 ± 0.021	0.887ArgTrp: 0.887 ± 0.009	1.539ArgTyr: 1.539 ± 0.01	0.0ArgXaa: 0.0 ± 0.0
Ser	8.008SerAla: 8.008 ± 0.031	1.227SerCys: 1.227 ± 0.01	4.542SerAsp: 4.542 ± 0.023	4.545SerGlu: 4.545 ± 0.019	3.032SerPhe: 3.032 ± 0.017	5.921SerGly: 5.921 ± 0.03	1.62SerHis: 1.62 ± 0.01	2.955SerIle: 2.955 ± 0.017	3.28SerLys: 3.28 ± 0.017	6.95SerLeu: 6.95 ± 0.027	1.788SerMet: 1.788 ± 0.012	2.588SerAsn: 2.588 ± 0.016	4.504SerPro: 4.504 ± 0.027	2.726SerGln: 2.726 ± 0.016	4.683SerArg: 4.683 ± 0.021	9.924SerSer: 9.924 ± 0.056	5.483SerThr: 5.483 ± 0.025	5.531SerVal: 5.531 ± 0.024	0.887SerTrp: 0.887 ± 0.008	1.772SerTyr: 1.772 ± 0.012	0.0SerXaa: 0.0 ± 0.0
Thr	6.158ThrAla: 6.158 ± 0.025	0.901ThrCys: 0.901 ± 0.009	2.867ThrAsp: 2.867 ± 0.018	3.259ThrGlu: 3.259 ± 0.023	2.059ThrPhe: 2.059 ± 0.013	3.611ThrGly: 3.611 ± 0.021	1.226ThrHis: 1.226 ± 0.01	2.157ThrIle: 2.157 ± 0.015	2.402ThrLys: 2.402 ± 0.013	5.471ThrLeu: 5.471 ± 0.023	1.248ThrMet: 1.248 ± 0.01	1.677ThrAsn: 1.677 ± 0.011	3.641ThrPro: 3.641 ± 0.029	2.262ThrGln: 2.262 ± 0.014	3.34ThrArg: 3.34 ± 0.018	5.141ThrSer: 5.141 ± 0.022	4.363ThrThr: 4.363 ± 0.04	3.747ThrVal: 3.747 ± 0.021	0.68ThrTrp: 0.68 ± 0.008	1.302ThrTyr: 1.302 ± 0.012	0.0ThrXaa: 0.0 ± 0.0
Val	7.881ValAla: 7.881 ± 0.026	1.301ValCys: 1.301 ± 0.01	4.336ValAsp: 4.336 ± 0.021	4.838ValGlu: 4.838 ± 0.022	2.839ValPhe: 2.839 ± 0.017	4.362ValGly: 4.362 ± 0.021	1.604ValHis: 1.604 ± 0.01	2.513ValIle: 2.513 ± 0.015	2.992ValLys: 2.992 ± 0.018	7.462ValLeu: 7.462 ± 0.031	1.599ValMet: 1.599 ± 0.011	2.256ValAsn: 2.256 ± 0.018	3.23ValPro: 3.23 ± 0.018	2.818ValGln: 2.818 ± 0.016	4.263ValArg: 4.263 ± 0.019	5.196ValSer: 5.196 ± 0.025	3.991ValThr: 3.991 ± 0.023	6.179ValVal: 6.179 ± 0.029	0.813ValTrp: 0.813 ± 0.009	1.833ValTyr: 1.833 ± 0.014	0.0ValXaa: 0.0 ± 0.0
Trp	0.801TrpAla: 0.801 ± 0.008	0.2TrpCys: 0.2 ± 0.003	0.665TrpAsp: 0.665 ± 0.008	0.7TrpGlu: 0.7 ± 0.009	0.476TrpPhe: 0.476 ± 0.007	0.68TrpGly: 0.68 ± 0.009	0.298TrpHis: 0.298 ± 0.005	0.488TrpIle: 0.488 ± 0.006	0.7TrpLys: 0.7 ± 0.008	1.405TrpLeu: 1.405 ± 0.015	0.362TrpMet: 0.362 ± 0.006	0.461TrpAsn: 0.461 ± 0.007	0.397TrpPro: 0.397 ± 0.005	0.522TrpGln: 0.522 ± 0.006	0.897TrpArg: 0.897 ± 0.008	0.882TrpSer: 0.882 ± 0.009	0.759TrpThr: 0.759 ± 0.008	0.731TrpVal: 0.731 ± 0.008	0.179TrpTrp: 0.179 ± 0.004	0.342TrpTyr: 0.342 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.171TyrAla: 2.171 ± 0.016	0.504TyrCys: 0.504 ± 0.007	1.43TyrAsp: 1.43 ± 0.012	1.51TyrGlu: 1.51 ± 0.011	1.05TyrPhe: 1.05 ± 0.011	1.699TyrGly: 1.699 ± 0.014	0.579TyrHis: 0.579 ± 0.007	0.844TyrIle: 0.844 ± 0.009	0.853TyrLys: 0.853 ± 0.008	2.373TyrLeu: 2.373 ± 0.016	0.567TyrMet: 0.567 ± 0.006	0.811TyrAsn: 0.811 ± 0.009	1.055TyrPro: 1.055 ± 0.01	0.916TyrGln: 0.916 ± 0.01	1.488TyrArg: 1.488 ± 0.01	1.698TyrSer: 1.698 ± 0.013	1.266TyrThr: 1.266 ± 0.012	1.873TyrVal: 1.873 ± 0.013	0.349TyrTrp: 0.349 ± 0.005	0.778TyrTyr: 0.778 ± 0.008	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.01XaaXaa: 0.01 ± 0.004

Statistics based on 26905 proteins (13882063 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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