Amino acid dipepetide frequency for Vibrio phage vB_VmeM-Yong XC31

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.195AlaAla: 6.195 ± 0.412
0.779AlaCys: 0.779 ± 0.084
4.727AlaAsp: 4.727 ± 0.263
5.405AlaGlu: 5.405 ± 0.285
3.459AlaPhe: 3.459 ± 0.194
4.649AlaGly: 4.649 ± 0.325
1.535AlaHis: 1.535 ± 0.139
4.916AlaIle: 4.916 ± 0.253
5.316AlaLys: 5.316 ± 0.286
6.818AlaLeu: 6.818 ± 0.291
2.558AlaMet: 2.558 ± 0.199
4.093AlaAsn: 4.093 ± 0.306
2.858AlaPro: 2.858 ± 0.188
2.525AlaGln: 2.525 ± 0.175
3.915AlaArg: 3.915 ± 0.191
4.682AlaSer: 4.682 ± 0.275
4.504AlaThr: 4.504 ± 0.285
5.094AlaVal: 5.094 ± 0.233
0.956AlaTrp: 0.956 ± 0.127
2.969AlaTyr: 2.969 ± 0.225
0.0AlaXaa: 0.0 ± 0.0
Cys
0.712CysAla: 0.712 ± 0.092
0.1CysCys: 0.1 ± 0.035
0.701CysAsp: 0.701 ± 0.095
0.734CysGlu: 0.734 ± 0.102
0.378CysPhe: 0.378 ± 0.071
0.734CysGly: 0.734 ± 0.11
0.311CysHis: 0.311 ± 0.062
0.456CysIle: 0.456 ± 0.069
0.856CysLys: 0.856 ± 0.115
0.845CysLeu: 0.845 ± 0.115
0.278CysMet: 0.278 ± 0.058
0.589CysAsn: 0.589 ± 0.094
0.534CysPro: 0.534 ± 0.075
0.378CysGln: 0.378 ± 0.06
0.612CysArg: 0.612 ± 0.087
0.5CysSer: 0.5 ± 0.074
0.456CysThr: 0.456 ± 0.069
0.701CysVal: 0.701 ± 0.091
0.133CysTrp: 0.133 ± 0.047
0.445CysTyr: 0.445 ± 0.08
0.0CysXaa: 0.0 ± 0.0
Asp
4.838AspAla: 4.838 ± 0.228
0.701AspCys: 0.701 ± 0.101
4.059AspAsp: 4.059 ± 0.266
4.771AspGlu: 4.771 ± 0.286
3.192AspPhe: 3.192 ± 0.23
4.916AspGly: 4.916 ± 0.271
0.923AspHis: 0.923 ± 0.116
4.26AspIle: 4.26 ± 0.238
3.703AspLys: 3.703 ± 0.216
5.583AspLeu: 5.583 ± 0.241
1.913AspMet: 1.913 ± 0.166
2.591AspAsn: 2.591 ± 0.154
2.358AspPro: 2.358 ± 0.167
1.546AspGln: 1.546 ± 0.126
2.547AspArg: 2.547 ± 0.186
3.47AspSer: 3.47 ± 0.173
3.392AspThr: 3.392 ± 0.2
4.649AspVal: 4.649 ± 0.228
1.301AspTrp: 1.301 ± 0.125
2.758AspTyr: 2.758 ± 0.185
0.0AspXaa: 0.0 ± 0.0
Glu
5.983GluAla: 5.983 ± 0.292
0.567GluCys: 0.567 ± 0.085
4.727GluAsp: 4.727 ± 0.217
6.428GluGlu: 6.428 ± 0.363
2.925GluPhe: 2.925 ± 0.181
4.916GluGly: 4.916 ± 0.244
2.046GluHis: 2.046 ± 0.171
4.482GluIle: 4.482 ± 0.187
4.304GluLys: 4.304 ± 0.249
7.062GluLeu: 7.062 ± 0.324
1.88GluMet: 1.88 ± 0.141
3.248GluAsn: 3.248 ± 0.208
2.102GluPro: 2.102 ± 0.186
2.691GluGln: 2.691 ± 0.195
3.592GluArg: 3.592 ± 0.252
3.87GluSer: 3.87 ± 0.23
4.727GluThr: 4.727 ± 0.223
5.683GluVal: 5.683 ± 0.265
1.212GluTrp: 1.212 ± 0.116
2.758GluTyr: 2.758 ± 0.169
0.0GluXaa: 0.0 ± 0.0
Phe
3.047PheAla: 3.047 ± 0.236
0.634PheCys: 0.634 ± 0.081
3.181PheAsp: 3.181 ± 0.211
2.969PheGlu: 2.969 ± 0.17
2.135PhePhe: 2.135 ± 0.138
2.625PheGly: 2.625 ± 0.215
0.856PheHis: 0.856 ± 0.119
2.402PheIle: 2.402 ± 0.171
2.703PheLys: 2.703 ± 0.184
3.492PheLeu: 3.492 ± 0.192
1.257PheMet: 1.257 ± 0.126
2.213PheAsn: 2.213 ± 0.149
1.312PhePro: 1.312 ± 0.125
1.212PheGln: 1.212 ± 0.125
2.513PheArg: 2.513 ± 0.168
3.259PheSer: 3.259 ± 0.191
3.014PheThr: 3.014 ± 0.178
2.792PheVal: 2.792 ± 0.188
0.456PheTrp: 0.456 ± 0.071
1.524PheTyr: 1.524 ± 0.15
0.0PheXaa: 0.0 ± 0.0
Gly
4.693GlyAla: 4.693 ± 0.34
0.678GlyCys: 0.678 ± 0.091
3.948GlyAsp: 3.948 ± 0.237
4.56GlyGlu: 4.56 ± 0.223
2.814GlyPhe: 2.814 ± 0.221
4.371GlyGly: 4.371 ± 0.28
1.524GlyHis: 1.524 ± 0.16
3.759GlyIle: 3.759 ± 0.196
4.315GlyLys: 4.315 ± 0.212
5.372GlyLeu: 5.372 ± 0.277
1.757GlyMet: 1.757 ± 0.15
2.981GlyAsn: 2.981 ± 0.228
1.746GlyPro: 1.746 ± 0.16
2.436GlyGln: 2.436 ± 0.203
3.448GlyArg: 3.448 ± 0.238
4.159GlySer: 4.159 ± 0.24
4.526GlyThr: 4.526 ± 0.244
3.692GlyVal: 3.692 ± 0.243
1.057GlyTrp: 1.057 ± 0.112
2.602GlyTyr: 2.602 ± 0.184
0.0GlyXaa: 0.0 ± 0.0
His
1.535HisAla: 1.535 ± 0.139
0.234HisCys: 0.234 ± 0.059
1.146HisAsp: 1.146 ± 0.119
1.257HisGlu: 1.257 ± 0.126
1.201HisPhe: 1.201 ± 0.118
1.69HisGly: 1.69 ± 0.145
0.567HisHis: 0.567 ± 0.084
1.401HisIle: 1.401 ± 0.138
1.079HisLys: 1.079 ± 0.101
2.18HisLeu: 2.18 ± 0.131
0.556HisMet: 0.556 ± 0.081
0.89HisAsn: 0.89 ± 0.103
1.023HisPro: 1.023 ± 0.108
0.601HisGln: 0.601 ± 0.094
1.212HisArg: 1.212 ± 0.13
1.268HisSer: 1.268 ± 0.102
1.279HisThr: 1.279 ± 0.13
1.813HisVal: 1.813 ± 0.146
0.367HisTrp: 0.367 ± 0.06
1.079HisTyr: 1.079 ± 0.096
0.0HisXaa: 0.0 ± 0.0
Ile
4.404IleAla: 4.404 ± 0.228
0.656IleCys: 0.656 ± 0.089
3.97IleAsp: 3.97 ± 0.219
4.638IleGlu: 4.638 ± 0.24
1.813IlePhe: 1.813 ± 0.139
3.57IleGly: 3.57 ± 0.21
1.435IleHis: 1.435 ± 0.136
2.491IleIle: 2.491 ± 0.191
3.192IleLys: 3.192 ± 0.169
4.382IleLeu: 4.382 ± 0.214
1.357IleMet: 1.357 ± 0.137
2.536IleAsn: 2.536 ± 0.141
2.736IlePro: 2.736 ± 0.168
1.746IleGln: 1.746 ± 0.144
3.37IleArg: 3.37 ± 0.196
3.881IleSer: 3.881 ± 0.212
3.726IleThr: 3.726 ± 0.214
3.514IleVal: 3.514 ± 0.162
0.623IleTrp: 0.623 ± 0.077
1.969IleTyr: 1.969 ± 0.166
0.0IleXaa: 0.0 ± 0.0
Lys
5.294LysAla: 5.294 ± 0.291
0.456LysCys: 0.456 ± 0.071
4.126LysAsp: 4.126 ± 0.217
5.049LysGlu: 5.049 ± 0.275
2.313LysPhe: 2.313 ± 0.156
3.559LysGly: 3.559 ± 0.206
1.301LysHis: 1.301 ± 0.128
2.669LysIle: 2.669 ± 0.185
3.681LysLys: 3.681 ± 0.303
5.583LysLeu: 5.583 ± 0.302
1.59LysMet: 1.59 ± 0.131
2.28LysAsn: 2.28 ± 0.145
2.235LysPro: 2.235 ± 0.15
2.124LysGln: 2.124 ± 0.141
3.103LysArg: 3.103 ± 0.207
3.37LysSer: 3.37 ± 0.194
3.481LysThr: 3.481 ± 0.219
4.404LysVal: 4.404 ± 0.242
1.001LysTrp: 1.001 ± 0.115
1.824LysTyr: 1.824 ± 0.153
0.0LysXaa: 0.0 ± 0.0
Leu
7.029LeuAla: 7.029 ± 0.322
0.99LeuCys: 0.99 ± 0.115
5.861LeuAsp: 5.861 ± 0.267
7.007LeuGlu: 7.007 ± 0.328
3.37LeuPhe: 3.37 ± 0.196
5.338LeuGly: 5.338 ± 0.228
1.757LeuHis: 1.757 ± 0.143
3.982LeuIle: 3.982 ± 0.198
5.205LeuLys: 5.205 ± 0.268
6.54LeuLeu: 6.54 ± 0.293
2.347LeuMet: 2.347 ± 0.154
4.182LeuAsn: 4.182 ± 0.197
3.848LeuPro: 3.848 ± 0.209
2.747LeuGln: 2.747 ± 0.198
4.649LeuArg: 4.649 ± 0.277
6.206LeuSer: 6.206 ± 0.25
5.505LeuThr: 5.505 ± 0.253
5.071LeuVal: 5.071 ± 0.212
0.99LeuTrp: 0.99 ± 0.11
3.07LeuTyr: 3.07 ± 0.219
0.0LeuXaa: 0.0 ± 0.0
Met
2.425MetAla: 2.425 ± 0.181
0.311MetCys: 0.311 ± 0.058
1.69MetAsp: 1.69 ± 0.139
2.258MetGlu: 2.258 ± 0.184
1.123MetPhe: 1.123 ± 0.113
1.579MetGly: 1.579 ± 0.158
0.411MetHis: 0.411 ± 0.06
1.068MetIle: 1.068 ± 0.114
1.59MetLys: 1.59 ± 0.125
2.202MetLeu: 2.202 ± 0.144
0.612MetMet: 0.612 ± 0.097
1.212MetAsn: 1.212 ± 0.116
1.212MetPro: 1.212 ± 0.139
1.19MetGln: 1.19 ± 0.133
1.301MetArg: 1.301 ± 0.118
1.991MetSer: 1.991 ± 0.14
1.713MetThr: 1.713 ± 0.118
1.846MetVal: 1.846 ± 0.136
0.245MetTrp: 0.245 ± 0.047
0.879MetTyr: 0.879 ± 0.105
0.0MetXaa: 0.0 ± 0.0
Asn
4.048AsnAla: 4.048 ± 0.234
0.489AsnCys: 0.489 ± 0.077
2.769AsnAsp: 2.769 ± 0.154
2.669AsnGlu: 2.669 ± 0.167
1.88AsnPhe: 1.88 ± 0.121
3.526AsnGly: 3.526 ± 0.281
1.112AsnHis: 1.112 ± 0.111
2.925AsnIle: 2.925 ± 0.175
2.247AsnLys: 2.247 ± 0.184
4.293AsnLeu: 4.293 ± 0.24
1.157AsnMet: 1.157 ± 0.122
1.924AsnAsn: 1.924 ± 0.138
2.413AsnPro: 2.413 ± 0.148
1.49AsnGln: 1.49 ± 0.132
2.425AsnArg: 2.425 ± 0.173
2.358AsnSer: 2.358 ± 0.155
2.48AsnThr: 2.48 ± 0.165
3.314AsnVal: 3.314 ± 0.166
0.69AsnTrp: 0.69 ± 0.089
1.702AsnTyr: 1.702 ± 0.136
0.0AsnXaa: 0.0 ± 0.0
Pro
3.047ProAla: 3.047 ± 0.203
0.389ProCys: 0.389 ± 0.067
2.647ProAsp: 2.647 ± 0.164
3.381ProGlu: 3.381 ± 0.193
1.913ProPhe: 1.913 ± 0.129
2.291ProGly: 2.291 ± 0.188
0.69ProHis: 0.69 ± 0.074
2.302ProIle: 2.302 ± 0.128
2.491ProLys: 2.491 ± 0.168
3.159ProLeu: 3.159 ± 0.201
0.968ProMet: 0.968 ± 0.106
1.969ProAsn: 1.969 ± 0.153
1.001ProPro: 1.001 ± 0.095
1.257ProGln: 1.257 ± 0.116
1.724ProArg: 1.724 ± 0.164
2.458ProSer: 2.458 ± 0.152
2.536ProThr: 2.536 ± 0.176
2.78ProVal: 2.78 ± 0.2
0.578ProTrp: 0.578 ± 0.078
1.457ProTyr: 1.457 ± 0.147
0.0ProXaa: 0.0 ± 0.0
Gln
3.236GlnAla: 3.236 ± 0.19
0.356GlnCys: 0.356 ± 0.06
1.568GlnAsp: 1.568 ± 0.119
2.202GlnGlu: 2.202 ± 0.172
1.268GlnPhe: 1.268 ± 0.141
1.813GlnGly: 1.813 ± 0.146
0.856GlnHis: 0.856 ± 0.096
1.902GlnIle: 1.902 ± 0.15
1.713GlnLys: 1.713 ± 0.157
3.214GlnLeu: 3.214 ± 0.185
0.834GlnMet: 0.834 ± 0.096
1.368GlnAsn: 1.368 ± 0.116
1.368GlnPro: 1.368 ± 0.125
1.312GlnGln: 1.312 ± 0.135
1.857GlnArg: 1.857 ± 0.147
1.935GlnSer: 1.935 ± 0.162
1.868GlnThr: 1.868 ± 0.136
2.369GlnVal: 2.369 ± 0.181
0.612GlnTrp: 0.612 ± 0.093
1.223GlnTyr: 1.223 ± 0.117
0.0GlnXaa: 0.0 ± 0.0
Arg
3.559ArgAla: 3.559 ± 0.227
0.478ArgCys: 0.478 ± 0.074
3.281ArgAsp: 3.281 ± 0.199
3.781ArgGlu: 3.781 ± 0.229
2.547ArgPhe: 2.547 ± 0.163
3.025ArgGly: 3.025 ± 0.199
1.424ArgHis: 1.424 ± 0.132
3.303ArgIle: 3.303 ± 0.185
3.292ArgLys: 3.292 ± 0.265
4.371ArgLeu: 4.371 ± 0.237
1.468ArgMet: 1.468 ± 0.119
2.625ArgAsn: 2.625 ± 0.173
2.091ArgPro: 2.091 ± 0.146
1.657ArgGln: 1.657 ± 0.134
2.858ArgArg: 2.858 ± 0.189
2.847ArgSer: 2.847 ± 0.173
3.147ArgThr: 3.147 ± 0.182
3.448ArgVal: 3.448 ± 0.203
0.767ArgTrp: 0.767 ± 0.089
2.013ArgTyr: 2.013 ± 0.137
0.0ArgXaa: 0.0 ± 0.0
Ser
4.326SerAla: 4.326 ± 0.238
0.601SerCys: 0.601 ± 0.078
3.57SerAsp: 3.57 ± 0.236
4.337SerGlu: 4.337 ± 0.209
3.047SerPhe: 3.047 ± 0.175
4.204SerGly: 4.204 ± 0.274
1.412SerHis: 1.412 ± 0.143
3.781SerIle: 3.781 ± 0.209
3.459SerLys: 3.459 ± 0.191
5.461SerLeu: 5.461 ± 0.264
1.924SerMet: 1.924 ± 0.159
2.847SerAsn: 2.847 ± 0.156
2.336SerPro: 2.336 ± 0.183
2.002SerGln: 2.002 ± 0.158
2.925SerArg: 2.925 ± 0.168
4.248SerSer: 4.248 ± 0.228
3.815SerThr: 3.815 ± 0.238
4.638SerVal: 4.638 ± 0.203
0.901SerTrp: 0.901 ± 0.109
2.247SerTyr: 2.247 ± 0.133
0.0SerXaa: 0.0 ± 0.0
Thr
4.727ThrAla: 4.727 ± 0.296
0.534ThrCys: 0.534 ± 0.072
3.592ThrAsp: 3.592 ± 0.222
4.471ThrGlu: 4.471 ± 0.208
2.936ThrPhe: 2.936 ± 0.179
4.36ThrGly: 4.36 ± 0.318
1.39ThrHis: 1.39 ± 0.124
3.67ThrIle: 3.67 ± 0.227
3.336ThrLys: 3.336 ± 0.162
5.327ThrLeu: 5.327 ± 0.233
1.401ThrMet: 1.401 ± 0.126
2.58ThrAsn: 2.58 ± 0.174
2.614ThrPro: 2.614 ± 0.163
1.98ThrGln: 1.98 ± 0.138
2.803ThrArg: 2.803 ± 0.169
3.737ThrSer: 3.737 ± 0.245
3.759ThrThr: 3.759 ± 0.231
4.593ThrVal: 4.593 ± 0.203
1.023ThrTrp: 1.023 ± 0.155
2.491ThrTyr: 2.491 ± 0.174
0.0ThrXaa: 0.0 ± 0.0
Val
5.172ValAla: 5.172 ± 0.241
0.867ValCys: 0.867 ± 0.111
4.471ValAsp: 4.471 ± 0.222
5.338ValGlu: 5.338 ± 0.283
2.803ValPhe: 2.803 ± 0.189
4.026ValGly: 4.026 ± 0.226
1.557ValHis: 1.557 ± 0.123
3.637ValIle: 3.637 ± 0.186
4.171ValLys: 4.171 ± 0.236
5.127ValLeu: 5.127 ± 0.275
1.646ValMet: 1.646 ± 0.139
3.348ValAsn: 3.348 ± 0.205
3.259ValPro: 3.259 ± 0.187
2.235ValGln: 2.235 ± 0.162
3.77ValArg: 3.77 ± 0.204
4.682ValSer: 4.682 ± 0.248
4.415ValThr: 4.415 ± 0.296
4.582ValVal: 4.582 ± 0.248
0.901ValTrp: 0.901 ± 0.106
2.869ValTyr: 2.869 ± 0.205
0.0ValXaa: 0.0 ± 0.0
Trp
1.134TrpAla: 1.134 ± 0.112
0.145TrpCys: 0.145 ± 0.037
1.09TrpAsp: 1.09 ± 0.171
1.279TrpGlu: 1.279 ± 0.132
0.678TrpPhe: 0.678 ± 0.105
0.79TrpGly: 0.79 ± 0.098
0.345TrpHis: 0.345 ± 0.064
0.678TrpIle: 0.678 ± 0.095
0.834TrpLys: 0.834 ± 0.102
1.501TrpLeu: 1.501 ± 0.139
0.334TrpMet: 0.334 ± 0.062
0.612TrpAsn: 0.612 ± 0.091
0.512TrpPro: 0.512 ± 0.082
0.534TrpGln: 0.534 ± 0.091
0.767TrpArg: 0.767 ± 0.104
0.901TrpSer: 0.901 ± 0.108
0.801TrpThr: 0.801 ± 0.092
1.001TrpVal: 1.001 ± 0.096
0.2TrpTrp: 0.2 ± 0.052
0.445TrpTyr: 0.445 ± 0.084
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.547TyrAla: 2.547 ± 0.161
0.489TyrCys: 0.489 ± 0.077
2.347TyrAsp: 2.347 ± 0.166
2.669TyrGlu: 2.669 ± 0.182
1.802TyrPhe: 1.802 ± 0.155
2.458TyrGly: 2.458 ± 0.17
0.923TyrHis: 0.923 ± 0.111
1.924TyrIle: 1.924 ± 0.128
1.957TyrLys: 1.957 ± 0.137
3.192TyrLeu: 3.192 ± 0.181
1.012TyrMet: 1.012 ± 0.107
1.824TyrAsn: 1.824 ± 0.131
1.479TyrPro: 1.479 ± 0.121
1.212TyrGln: 1.212 ± 0.101
2.591TyrArg: 2.591 ± 0.226
2.258TyrSer: 2.258 ± 0.16
2.18TyrThr: 2.18 ± 0.165
2.892TyrVal: 2.892 ± 0.18
0.567TyrTrp: 0.567 ± 0.081
1.513TyrTyr: 1.513 ± 0.13
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 318 proteins (89916 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski