Amino acid dipepetide frequency for Emergencia timonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.264AlaAla: 8.264 ± 0.109	1.33AlaCys: 1.33 ± 0.034	4.788AlaAsp: 4.788 ± 0.068	6.093AlaGlu: 6.093 ± 0.079	3.514AlaPhe: 3.514 ± 0.06	6.535AlaGly: 6.535 ± 0.097	1.111AlaHis: 1.111 ± 0.032	6.052AlaIle: 6.052 ± 0.079	5.093AlaLys: 5.093 ± 0.081	7.631AlaLeu: 7.631 ± 0.093	2.74AlaMet: 2.74 ± 0.051	2.441AlaAsn: 2.441 ± 0.045	2.062AlaPro: 2.062 ± 0.045	2.038AlaGln: 2.038 ± 0.039	2.867AlaArg: 2.867 ± 0.05	4.275AlaSer: 4.275 ± 0.066	3.271AlaThr: 3.271 ± 0.054	6.587AlaVal: 6.587 ± 0.08	0.553AlaTrp: 0.553 ± 0.026	2.794AlaTyr: 2.794 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.146CysAla: 1.146 ± 0.033	0.336CysCys: 0.336 ± 0.016	0.872CysAsp: 0.872 ± 0.027	0.957CysGlu: 0.957 ± 0.033	0.723CysPhe: 0.723 ± 0.025	1.638CysGly: 1.638 ± 0.04	0.303CysHis: 0.303 ± 0.015	1.23CysIle: 1.23 ± 0.033	0.878CysLys: 0.878 ± 0.025	1.319CysLeu: 1.319 ± 0.037	0.474CysMet: 0.474 ± 0.019	0.624CysAsn: 0.624 ± 0.024	0.667CysPro: 0.667 ± 0.027	0.505CysGln: 0.505 ± 0.021	0.831CysArg: 0.831 ± 0.028	0.975CysSer: 0.975 ± 0.027	0.816CysThr: 0.816 ± 0.029	1.004CysVal: 1.004 ± 0.029	0.144CysTrp: 0.144 ± 0.011	0.567CysTyr: 0.567 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.128AspAla: 4.128 ± 0.069	0.841AspCys: 0.841 ± 0.027	2.982AspAsp: 2.982 ± 0.072	4.317AspGlu: 4.317 ± 0.07	2.811AspPhe: 2.811 ± 0.045	4.421AspGly: 4.421 ± 0.074	0.995AspHis: 0.995 ± 0.03	4.553AspIle: 4.553 ± 0.073	3.639AspLys: 3.639 ± 0.066	5.028AspLeu: 5.028 ± 0.068	1.842AspMet: 1.842 ± 0.038	2.111AspAsn: 2.111 ± 0.05	1.782AspPro: 1.782 ± 0.046	1.775AspGln: 1.775 ± 0.037	2.37AspArg: 2.37 ± 0.047	2.854AspSer: 2.854 ± 0.058	2.82AspThr: 2.82 ± 0.052	3.83AspVal: 3.83 ± 0.057	0.532AspTrp: 0.532 ± 0.02	2.716AspTyr: 2.716 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.571GluAla: 5.571 ± 0.081	0.721GluCys: 0.721 ± 0.028	4.155GluAsp: 4.155 ± 0.06	6.886GluGlu: 6.886 ± 0.096	2.404GluPhe: 2.404 ± 0.051	4.58GluGly: 4.58 ± 0.064	1.173GluHis: 1.173 ± 0.029	5.763GluIle: 5.763 ± 0.078	6.673GluLys: 6.673 ± 0.08	6.115GluLeu: 6.115 ± 0.078	2.421GluMet: 2.421 ± 0.048	3.743GluAsn: 3.743 ± 0.053	1.828GluPro: 1.828 ± 0.044	2.418GluGln: 2.418 ± 0.05	3.279GluArg: 3.279 ± 0.054	3.28GluSer: 3.28 ± 0.06	3.726GluThr: 3.726 ± 0.047	4.227GluVal: 4.227 ± 0.067	0.479GluTrp: 0.479 ± 0.021	2.66GluTyr: 2.66 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.629PheAla: 3.629 ± 0.06	0.806PheCys: 0.806 ± 0.025	2.92PheAsp: 2.92 ± 0.048	2.547PheGlu: 2.547 ± 0.047	1.997PhePhe: 1.997 ± 0.058	3.322PheGly: 3.322 ± 0.061	0.774PheHis: 0.774 ± 0.022	2.975PheIle: 2.975 ± 0.055	2.048PheLys: 2.048 ± 0.044	3.907PheLeu: 3.907 ± 0.081	1.219PheMet: 1.219 ± 0.033	1.529PheAsn: 1.529 ± 0.037	1.412PhePro: 1.412 ± 0.033	1.246PheGln: 1.246 ± 0.031	1.61PheArg: 1.61 ± 0.033	2.867PheSer: 2.867 ± 0.062	2.537PheThr: 2.537 ± 0.051	2.955PheVal: 2.955 ± 0.051	0.4PheTrp: 0.4 ± 0.019	1.755PheTyr: 1.755 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.568GlyAla: 5.568 ± 0.088	1.375GlyCys: 1.375 ± 0.038	3.68GlyAsp: 3.68 ± 0.056	4.524GlyGlu: 4.524 ± 0.067	3.423GlyPhe: 3.423 ± 0.059	5.573GlyGly: 5.573 ± 0.104	1.195GlyHis: 1.195 ± 0.036	6.554GlyIle: 6.554 ± 0.087	5.407GlyLys: 5.407 ± 0.076	6.358GlyLeu: 6.358 ± 0.085	2.496GlyMet: 2.496 ± 0.056	2.986GlyAsn: 2.986 ± 0.058	1.498GlyPro: 1.498 ± 0.047	2.162GlyGln: 2.162 ± 0.045	3.264GlyArg: 3.264 ± 0.056	4.35GlySer: 4.35 ± 0.068	4.45GlyThr: 4.45 ± 0.076	5.22GlyVal: 5.22 ± 0.068	0.726GlyTrp: 0.726 ± 0.027	3.202GlyTyr: 3.202 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.02HisAla: 1.02 ± 0.027	0.344HisCys: 0.344 ± 0.016	0.946HisAsp: 0.946 ± 0.032	0.926HisGlu: 0.926 ± 0.028	0.832HisPhe: 0.832 ± 0.027	1.239HisGly: 1.239 ± 0.039	0.378HisHis: 0.378 ± 0.023	1.374HisIle: 1.374 ± 0.037	0.853HisLys: 0.853 ± 0.028	1.547HisLeu: 1.547 ± 0.037	0.52HisMet: 0.52 ± 0.021	0.658HisAsn: 0.658 ± 0.022	0.829HisPro: 0.829 ± 0.028	0.567HisGln: 0.567 ± 0.024	0.738HisArg: 0.738 ± 0.024	0.884HisSer: 0.884 ± 0.027	0.909HisThr: 0.909 ± 0.026	1.03HisVal: 1.03 ± 0.031	0.146HisTrp: 0.146 ± 0.011	0.686HisTyr: 0.686 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.548IleAla: 6.548 ± 0.085	1.495IleCys: 1.495 ± 0.034	4.578IleAsp: 4.578 ± 0.072	5.292IleGlu: 5.292 ± 0.075	3.285IlePhe: 3.285 ± 0.056	5.769IleGly: 5.769 ± 0.086	1.222IleHis: 1.222 ± 0.034	5.711IleIle: 5.711 ± 0.084	4.894IleLys: 4.894 ± 0.06	7.297IleLeu: 7.297 ± 0.092	2.27IleMet: 2.27 ± 0.044	3.092IleAsn: 3.092 ± 0.049	3.12IlePro: 3.12 ± 0.054	1.871IleGln: 1.871 ± 0.037	3.167IleArg: 3.167 ± 0.06	4.929IleSer: 4.929 ± 0.073	4.52IleThr: 4.52 ± 0.055	5.465IleVal: 5.465 ± 0.075	0.598IleTrp: 0.598 ± 0.024	2.685IleTyr: 2.685 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	5.348LysAla: 5.348 ± 0.088	0.774LysCys: 0.774 ± 0.026	3.992LysAsp: 3.992 ± 0.073	6.135LysGlu: 6.135 ± 0.09	1.975LysPhe: 1.975 ± 0.042	4.561LysGly: 4.561 ± 0.066	0.929LysHis: 0.929 ± 0.029	5.009LysIle: 5.009 ± 0.069	5.929LysLys: 5.929 ± 0.075	5.517LysLeu: 5.517 ± 0.062	2.327LysMet: 2.327 ± 0.047	3.278LysAsn: 3.278 ± 0.053	1.927LysPro: 1.927 ± 0.041	2.056LysGln: 2.056 ± 0.041	2.869LysArg: 2.869 ± 0.047	3.449LysSer: 3.449 ± 0.065	3.789LysThr: 3.789 ± 0.065	4.535LysVal: 4.535 ± 0.073	0.634LysTrp: 0.634 ± 0.022	2.744LysTyr: 2.744 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	7.704LeuAla: 7.704 ± 0.083	1.646LeuCys: 1.646 ± 0.04	4.895LeuAsp: 4.895 ± 0.065	5.903LeuGlu: 5.903 ± 0.09	3.994LeuPhe: 3.994 ± 0.07	6.155LeuGly: 6.155 ± 0.075	1.547LeuHis: 1.547 ± 0.036	6.772LeuIle: 6.772 ± 0.099	5.794LeuLys: 5.794 ± 0.066	8.941LeuLeu: 8.941 ± 0.14	2.906LeuMet: 2.906 ± 0.05	3.651LeuAsn: 3.651 ± 0.058	3.609LeuPro: 3.609 ± 0.061	2.923LeuGln: 2.923 ± 0.057	3.691LeuArg: 3.691 ± 0.059	6.309LeuSer: 6.309 ± 0.078	5.385LeuThr: 5.385 ± 0.066	5.55LeuVal: 5.55 ± 0.071	0.752LeuTrp: 0.752 ± 0.023	3.275LeuTyr: 3.275 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.793MetAla: 2.793 ± 0.049	0.372MetCys: 0.372 ± 0.017	1.894MetAsp: 1.894 ± 0.038	2.52MetGlu: 2.52 ± 0.05	1.024MetPhe: 1.024 ± 0.027	2.303MetGly: 2.303 ± 0.044	0.487MetHis: 0.487 ± 0.02	2.496MetIle: 2.496 ± 0.05	2.618MetLys: 2.618 ± 0.054	2.672MetLeu: 2.672 ± 0.046	1.058MetMet: 1.058 ± 0.031	1.497MetAsn: 1.497 ± 0.031	1.235MetPro: 1.235 ± 0.031	0.945MetGln: 0.945 ± 0.029	1.321MetArg: 1.321 ± 0.033	1.762MetSer: 1.762 ± 0.037	1.908MetThr: 1.908 ± 0.035	2.037MetVal: 2.037 ± 0.046	0.241MetTrp: 0.241 ± 0.017	0.881MetTyr: 0.881 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.971AsnAla: 2.971 ± 0.056	0.702AsnCys: 0.702 ± 0.024	1.992AsnAsp: 1.992 ± 0.045	2.45AsnGlu: 2.45 ± 0.047	1.57AsnPhe: 1.57 ± 0.038	3.073AsnGly: 3.073 ± 0.06	0.76AsnHis: 0.76 ± 0.024	3.302AsnIle: 3.302 ± 0.053	2.488AsnLys: 2.488 ± 0.051	4.026AsnLeu: 4.026 ± 0.059	1.298AsnMet: 1.298 ± 0.03	1.594AsnAsn: 1.594 ± 0.047	1.952AsnPro: 1.952 ± 0.041	1.375AsnGln: 1.375 ± 0.033	1.913AsnArg: 1.913 ± 0.039	2.101AsnSer: 2.101 ± 0.044	2.193AsnThr: 2.193 ± 0.053	2.789AsnVal: 2.789 ± 0.051	0.415AsnTrp: 0.415 ± 0.018	1.615AsnTyr: 1.615 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	2.731ProAla: 2.731 ± 0.045	0.509ProCys: 0.509 ± 0.023	2.112ProAsp: 2.112 ± 0.048	2.907ProGlu: 2.907 ± 0.056	1.576ProPhe: 1.576 ± 0.033	2.475ProGly: 2.475 ± 0.052	0.561ProHis: 0.561 ± 0.019	2.351ProIle: 2.351 ± 0.05	1.769ProLys: 1.769 ± 0.04	3.056ProLeu: 3.056 ± 0.058	0.971ProMet: 0.971 ± 0.029	1.148ProAsn: 1.148 ± 0.033	0.885ProPro: 0.885 ± 0.029	1.049ProGln: 1.049 ± 0.029	0.979ProArg: 0.979 ± 0.031	1.805ProSer: 1.805 ± 0.045	1.626ProThr: 1.626 ± 0.044	2.701ProVal: 2.701 ± 0.051	0.334ProTrp: 0.334 ± 0.019	1.475ProTyr: 1.475 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.191GlnAla: 2.191 ± 0.043	0.415GlnCys: 0.415 ± 0.017	1.339GlnAsp: 1.339 ± 0.03	2.135GlnGlu: 2.135 ± 0.045	1.193GlnPhe: 1.193 ± 0.034	1.933GlnGly: 1.933 ± 0.042	0.48GlnHis: 0.48 ± 0.017	2.502GlnIle: 2.502 ± 0.049	2.282GlnLys: 2.282 ± 0.049	2.809GlnLeu: 2.809 ± 0.055	1.131GlnMet: 1.131 ± 0.03	1.4GlnAsn: 1.4 ± 0.034	0.88GlnPro: 0.88 ± 0.026	1.072GlnGln: 1.072 ± 0.033	1.534GlnArg: 1.534 ± 0.037	1.679GlnSer: 1.679 ± 0.034	1.536GlnThr: 1.536 ± 0.037	2.075GlnVal: 2.075 ± 0.041	0.327GlnTrp: 0.327 ± 0.015	1.23GlnTyr: 1.23 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.655ArgAla: 2.655 ± 0.052	0.678ArgCys: 0.678 ± 0.025	2.222ArgAsp: 2.222 ± 0.05	3.584ArgGlu: 3.584 ± 0.055	1.759ArgPhe: 1.759 ± 0.045	2.633ArgGly: 2.633 ± 0.05	0.729ArgHis: 0.729 ± 0.024	3.377ArgIle: 3.377 ± 0.06	3.235ArgLys: 3.235 ± 0.054	3.843ArgLeu: 3.843 ± 0.066	1.389ArgMet: 1.389 ± 0.04	1.896ArgAsn: 1.896 ± 0.035	1.284ArgPro: 1.284 ± 0.037	1.605ArgGln: 1.605 ± 0.039	2.156ArgArg: 2.156 ± 0.046	2.054ArgSer: 2.054 ± 0.032	2.187ArgThr: 2.187 ± 0.043	2.435ArgVal: 2.435 ± 0.05	0.353ArgTrp: 0.353 ± 0.017	1.746ArgTyr: 1.746 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.462SerAla: 4.462 ± 0.061	0.866SerCys: 0.866 ± 0.031	3.177SerAsp: 3.177 ± 0.054	3.632SerGlu: 3.632 ± 0.067	2.666SerPhe: 2.666 ± 0.056	4.916SerGly: 4.916 ± 0.078	1.005SerHis: 1.005 ± 0.031	4.391SerIle: 4.391 ± 0.061	3.699SerLys: 3.699 ± 0.058	5.332SerLeu: 5.332 ± 0.073	1.807SerMet: 1.807 ± 0.039	2.117SerAsn: 2.117 ± 0.043	1.755SerPro: 1.755 ± 0.04	1.881SerGln: 1.881 ± 0.04	2.364SerArg: 2.364 ± 0.046	3.497SerSer: 3.497 ± 0.073	2.74SerThr: 2.74 ± 0.048	4.112SerVal: 4.112 ± 0.064	0.559SerTrp: 0.559 ± 0.022	2.297SerTyr: 2.297 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.942ThrAla: 4.942 ± 0.071	0.761ThrCys: 0.761 ± 0.026	3.027ThrAsp: 3.027 ± 0.054	3.699ThrGlu: 3.699 ± 0.058	2.337ThrPhe: 2.337 ± 0.044	4.722ThrGly: 4.722 ± 0.066	0.821ThrHis: 0.821 ± 0.029	4.336ThrIle: 4.336 ± 0.061	3.074ThrLys: 3.074 ± 0.061	5.027ThrLeu: 5.027 ± 0.061	1.604ThrMet: 1.604 ± 0.038	1.84ThrAsn: 1.84 ± 0.044	2.111ThrPro: 2.111 ± 0.041	1.26ThrGln: 1.26 ± 0.033	1.86ThrArg: 1.86 ± 0.043	2.91ThrSer: 2.91 ± 0.062	2.933ThrThr: 2.933 ± 0.066	4.379ThrVal: 4.379 ± 0.064	0.476ThrTrp: 0.476 ± 0.021	2.077ThrTyr: 2.077 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	5.028ValAla: 5.028 ± 0.073	1.265ValCys: 1.265 ± 0.035	3.732ValAsp: 3.732 ± 0.06	4.367ValGlu: 4.367 ± 0.074	3.167ValPhe: 3.167 ± 0.056	4.385ValGly: 4.385 ± 0.068	1.015ValHis: 1.015 ± 0.03	5.621ValIle: 5.621 ± 0.078	4.562ValLys: 4.562 ± 0.07	6.606ValLeu: 6.606 ± 0.086	2.238ValMet: 2.238 ± 0.043	2.888ValAsn: 2.888 ± 0.055	2.584ValPro: 2.584 ± 0.052	1.685ValGln: 1.685 ± 0.033	2.768ValArg: 2.768 ± 0.055	4.646ValSer: 4.646 ± 0.061	4.209ValThr: 4.209 ± 0.063	4.885ValVal: 4.885 ± 0.079	0.56ValTrp: 0.56 ± 0.022	2.559ValTyr: 2.559 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.541TrpAla: 0.541 ± 0.021	0.16TrpCys: 0.16 ± 0.011	0.443TrpAsp: 0.443 ± 0.019	0.523TrpGlu: 0.523 ± 0.02	0.387TrpPhe: 0.387 ± 0.02	0.679TrpGly: 0.679 ± 0.025	0.167TrpHis: 0.167 ± 0.01	0.703TrpIle: 0.703 ± 0.024	0.571TrpLys: 0.571 ± 0.02	0.859TrpLeu: 0.859 ± 0.03	0.288TrpMet: 0.288 ± 0.015	0.471TrpAsn: 0.471 ± 0.019	0.255TrpPro: 0.255 ± 0.015	0.375TrpGln: 0.375 ± 0.018	0.368TrpArg: 0.368 ± 0.021	0.462TrpSer: 0.462 ± 0.019	0.419TrpThr: 0.419 ± 0.018	0.539TrpVal: 0.539 ± 0.021	0.08TrpTrp: 0.08 ± 0.008	0.348TrpTyr: 0.348 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.799TyrAla: 2.799 ± 0.051	0.612TyrCys: 0.612 ± 0.023	2.599TyrAsp: 2.599 ± 0.063	2.706TyrGlu: 2.706 ± 0.054	1.819TyrPhe: 1.819 ± 0.033	3.102TyrGly: 3.102 ± 0.058	0.773TyrHis: 0.773 ± 0.024	2.735TyrIle: 2.735 ± 0.052	2.272TyrLys: 2.272 ± 0.05	3.51TyrLeu: 3.51 ± 0.06	1.062TyrMet: 1.062 ± 0.03	1.614TyrAsn: 1.614 ± 0.039	1.346TyrPro: 1.346 ± 0.037	1.338TyrGln: 1.338 ± 0.038	1.869TyrArg: 1.869 ± 0.042	2.187TyrSer: 2.187 ± 0.045	2.222TyrThr: 2.222 ± 0.051	2.42TyrVal: 2.42 ± 0.048	0.33TyrTrp: 0.33 ± 0.017	1.804TyrTyr: 1.804 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3841 proteins (1242610 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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