Amino acid dipepetide frequency for Natrinema pellirubrum (strain DSM 15624 / CIP 106293 / JCM 10476 / NCIMB 786 / 157)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.903AlaAla: 13.903 ± 0.173	0.722AlaCys: 0.722 ± 0.026	10.628AlaAsp: 10.628 ± 0.136	8.352AlaGlu: 8.352 ± 0.1	3.799AlaPhe: 3.799 ± 0.06	9.413AlaGly: 9.413 ± 0.111	1.681AlaHis: 1.681 ± 0.037	5.459AlaIle: 5.459 ± 0.074	1.812AlaLys: 1.812 ± 0.048	10.047AlaLeu: 10.047 ± 0.126	2.055AlaMet: 2.055 ± 0.046	2.331AlaAsn: 2.331 ± 0.05	3.706AlaPro: 3.706 ± 0.062	2.137AlaGln: 2.137 ± 0.046	5.9AlaArg: 5.9 ± 0.085	5.182AlaSer: 5.182 ± 0.073	7.312AlaThr: 7.312 ± 0.091	10.571AlaVal: 10.571 ± 0.13	1.066AlaTrp: 1.066 ± 0.03	2.689AlaTyr: 2.689 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.617CysAla: 0.617 ± 0.024	0.12CysCys: 0.12 ± 0.01	0.661CysAsp: 0.661 ± 0.024	0.675CysGlu: 0.675 ± 0.023	0.231CysPhe: 0.231 ± 0.016	0.91CysGly: 0.91 ± 0.03	0.197CysHis: 0.197 ± 0.012	0.254CysIle: 0.254 ± 0.015	0.145CysLys: 0.145 ± 0.011	0.628CysLeu: 0.628 ± 0.022	0.115CysMet: 0.115 ± 0.011	0.19CysAsn: 0.19 ± 0.013	0.57CysPro: 0.57 ± 0.026	0.185CysGln: 0.185 ± 0.014	0.538CysArg: 0.538 ± 0.021	0.472CysSer: 0.472 ± 0.02	0.479CysThr: 0.479 ± 0.021	0.452CysVal: 0.452 ± 0.019	0.129CysTrp: 0.129 ± 0.01	0.237CysTyr: 0.237 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	9.77AspAla: 9.77 ± 0.112	0.788AspCys: 0.788 ± 0.031	8.828AspAsp: 8.828 ± 0.134	8.693AspGlu: 8.693 ± 0.113	1.865AspPhe: 1.865 ± 0.041	8.51AspGly: 8.51 ± 0.109	2.167AspHis: 2.167 ± 0.041	3.047AspIle: 3.047 ± 0.062	0.994AspLys: 0.994 ± 0.032	7.619AspLeu: 7.619 ± 0.089	1.214AspMet: 1.214 ± 0.03	1.333AspAsn: 1.333 ± 0.039	4.683AspPro: 4.683 ± 0.068	1.654AspGln: 1.654 ± 0.042	7.312AspArg: 7.312 ± 0.101	3.838AspSer: 3.838 ± 0.064	4.019AspThr: 4.019 ± 0.065	7.211AspVal: 7.211 ± 0.097	1.06AspTrp: 1.06 ± 0.035	1.97AspTyr: 1.97 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.858GluAla: 8.858 ± 0.108	0.581GluCys: 0.581 ± 0.023	6.295GluAsp: 6.295 ± 0.1	6.641GluGlu: 6.641 ± 0.121	3.004GluPhe: 3.004 ± 0.06	5.742GluGly: 5.742 ± 0.08	1.559GluHis: 1.559 ± 0.04	4.572GluIle: 4.572 ± 0.078	1.798GluLys: 1.798 ± 0.056	7.414GluLeu: 7.414 ± 0.095	1.774GluMet: 1.774 ± 0.041	2.487GluAsn: 2.487 ± 0.053	4.686GluPro: 4.686 ± 0.076	2.786GluGln: 2.786 ± 0.059	8.266GluArg: 8.266 ± 0.106	5.543GluSer: 5.543 ± 0.074	7.233GluThr: 7.233 ± 0.092	5.222GluVal: 5.222 ± 0.072	1.181GluTrp: 1.181 ± 0.035	3.051GluTyr: 3.051 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.418PheAla: 3.418 ± 0.062	0.299PheCys: 0.299 ± 0.017	3.335PheAsp: 3.335 ± 0.046	3.115PheGlu: 3.115 ± 0.049	0.995PhePhe: 0.995 ± 0.03	2.984PheGly: 2.984 ± 0.063	0.626PheHis: 0.626 ± 0.023	1.014PheIle: 1.014 ± 0.033	0.435PheLys: 0.435 ± 0.019	2.818PheLeu: 2.818 ± 0.053	0.506PheMet: 0.506 ± 0.023	0.652PheAsn: 0.652 ± 0.024	1.264PhePro: 1.264 ± 0.033	0.799PheGln: 0.799 ± 0.029	1.761PheArg: 1.761 ± 0.043	1.58PheSer: 1.58 ± 0.039	1.801PheThr: 1.801 ± 0.04	3.11PheVal: 3.11 ± 0.049	0.394PheTrp: 0.394 ± 0.017	0.853PheTyr: 0.853 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	7.646GlyAla: 7.646 ± 0.1	0.775GlyCys: 0.775 ± 0.028	6.946GlyAsp: 6.946 ± 0.088	7.038GlyGlu: 7.038 ± 0.092	3.057GlyPhe: 3.057 ± 0.047	6.811GlyGly: 6.811 ± 0.097	1.631GlyHis: 1.631 ± 0.04	4.375GlyIle: 4.375 ± 0.072	1.79GlyLys: 1.79 ± 0.042	7.637GlyLeu: 7.637 ± 0.101	1.64GlyMet: 1.64 ± 0.037	1.92GlyAsn: 1.92 ± 0.043	3.328GlyPro: 3.328 ± 0.06	1.947GlyGln: 1.947 ± 0.047	4.805GlyArg: 4.805 ± 0.07	5.122GlySer: 5.122 ± 0.074	5.984GlyThr: 5.984 ± 0.087	7.067GlyVal: 7.067 ± 0.085	1.124GlyTrp: 1.124 ± 0.031	2.671GlyTyr: 2.671 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.933HisAla: 1.933 ± 0.042	0.229HisCys: 0.229 ± 0.015	1.779HisAsp: 1.779 ± 0.038	1.726HisGlu: 1.726 ± 0.042	0.502HisPhe: 0.502 ± 0.019	1.958HisGly: 1.958 ± 0.049	0.523HisHis: 0.523 ± 0.023	0.679HisIle: 0.679 ± 0.024	0.315HisLys: 0.315 ± 0.016	1.642HisLeu: 1.642 ± 0.036	0.304HisMet: 0.304 ± 0.017	0.435HisAsn: 0.435 ± 0.019	1.192HisPro: 1.192 ± 0.037	0.469HisGln: 0.469 ± 0.022	1.366HisArg: 1.366 ± 0.033	0.862HisSer: 0.862 ± 0.028	0.992HisThr: 0.992 ± 0.033	1.752HisVal: 1.752 ± 0.041	0.218HisTrp: 0.218 ± 0.015	0.588HisTyr: 0.588 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.422IleAla: 5.422 ± 0.07	0.318IleCys: 0.318 ± 0.016	4.641IleAsp: 4.641 ± 0.066	4.561IleGlu: 4.561 ± 0.072	0.973IlePhe: 0.973 ± 0.032	4.197IleGly: 4.197 ± 0.066	0.814IleHis: 0.814 ± 0.026	1.416IleIle: 1.416 ± 0.042	0.762IleLys: 0.762 ± 0.025	2.988IleLeu: 2.988 ± 0.056	0.553IleMet: 0.553 ± 0.022	1.017IleAsn: 1.017 ± 0.033	2.056IlePro: 2.056 ± 0.041	1.0IleGln: 1.0 ± 0.031	2.479IleArg: 2.479 ± 0.038	2.184IleSer: 2.184 ± 0.047	2.587IleThr: 2.587 ± 0.05	4.196IleVal: 4.196 ± 0.066	0.376IleTrp: 0.376 ± 0.019	0.988IleTyr: 0.988 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	1.703LysAla: 1.703 ± 0.042	0.127LysCys: 0.127 ± 0.011	1.118LysAsp: 1.118 ± 0.036	1.361LysGlu: 1.361 ± 0.04	0.47LysPhe: 0.47 ± 0.022	1.335LysGly: 1.335 ± 0.04	0.495LysHis: 0.495 ± 0.021	0.864LysIle: 0.864 ± 0.035	0.511LysLys: 0.511 ± 0.023	1.624LysLeu: 1.624 ± 0.044	0.33LysMet: 0.33 ± 0.019	0.534LysAsn: 0.534 ± 0.026	0.94LysPro: 0.94 ± 0.032	0.736LysGln: 0.736 ± 0.029	1.634LysArg: 1.634 ± 0.043	1.063LysSer: 1.063 ± 0.037	1.271LysThr: 1.271 ± 0.032	1.056LysVal: 1.056 ± 0.038	0.221LysTrp: 0.221 ± 0.014	0.556LysTyr: 0.556 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	11.043LeuAla: 11.043 ± 0.135	0.673LeuCys: 0.673 ± 0.026	5.756LeuAsp: 5.756 ± 0.083	10.98LeuGlu: 10.98 ± 0.106	3.037LeuPhe: 3.037 ± 0.059	7.116LeuGly: 7.116 ± 0.092	1.443LeuHis: 1.443 ± 0.038	3.099LeuIle: 3.099 ± 0.058	1.495LeuLys: 1.495 ± 0.042	8.766LeuLeu: 8.766 ± 0.112	1.196LeuMet: 1.196 ± 0.033	1.71LeuAsn: 1.71 ± 0.039	4.041LeuPro: 4.041 ± 0.062	2.088LeuGln: 2.088 ± 0.045	5.292LeuArg: 5.292 ± 0.069	5.532LeuSer: 5.532 ± 0.087	5.266LeuThr: 5.266 ± 0.068	8.001LeuVal: 8.001 ± 0.114	0.86LeuTrp: 0.86 ± 0.026	2.147LeuTyr: 2.147 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.876MetAla: 1.876 ± 0.04	0.111MetCys: 0.111 ± 0.01	1.16MetAsp: 1.16 ± 0.038	1.053MetGlu: 1.053 ± 0.032	0.491MetPhe: 0.491 ± 0.023	1.416MetGly: 1.416 ± 0.04	0.335MetHis: 0.335 ± 0.017	0.723MetIle: 0.723 ± 0.028	0.364MetLys: 0.364 ± 0.018	1.44MetLeu: 1.44 ± 0.041	0.325MetMet: 0.325 ± 0.016	0.611MetAsn: 0.611 ± 0.024	0.775MetPro: 0.775 ± 0.027	0.501MetGln: 0.501 ± 0.022	1.038MetArg: 1.038 ± 0.03	1.454MetSer: 1.454 ± 0.038	1.518MetThr: 1.518 ± 0.032	1.192MetVal: 1.192 ± 0.032	0.179MetTrp: 0.179 ± 0.013	0.373MetTyr: 0.373 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.452AsnAla: 2.452 ± 0.048	0.242AsnCys: 0.242 ± 0.014	1.812AsnAsp: 1.812 ± 0.045	1.971AsnGlu: 1.971 ± 0.051	0.616AsnPhe: 0.616 ± 0.024	2.063AsnGly: 2.063 ± 0.046	0.519AsnHis: 0.519 ± 0.021	0.851AsnIle: 0.851 ± 0.031	0.432AsnLys: 0.432 ± 0.02	1.814AsnLeu: 1.814 ± 0.043	0.403AsnMet: 0.403 ± 0.019	0.542AsnAsn: 0.542 ± 0.024	1.493AsnPro: 1.493 ± 0.038	0.615AsnGln: 0.615 ± 0.023	1.676AsnArg: 1.676 ± 0.039	0.942AsnSer: 0.942 ± 0.034	1.284AsnThr: 1.284 ± 0.033	2.143AsnVal: 2.143 ± 0.045	0.32AsnTrp: 0.32 ± 0.017	0.649AsnTyr: 0.649 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	5.042ProAla: 5.042 ± 0.071	0.245ProCys: 0.245 ± 0.015	5.114ProAsp: 5.114 ± 0.069	4.366ProGlu: 4.366 ± 0.064	1.507ProPhe: 1.507 ± 0.04	3.482ProGly: 3.482 ± 0.065	0.875ProHis: 0.875 ± 0.026	2.216ProIle: 2.216 ± 0.047	0.831ProLys: 0.831 ± 0.031	3.814ProLeu: 3.814 ± 0.058	0.842ProMet: 0.842 ± 0.025	1.12ProAsn: 1.12 ± 0.032	2.207ProPro: 2.207 ± 0.038	0.981ProGln: 0.981 ± 0.028	2.321ProArg: 2.321 ± 0.045	2.718ProSer: 2.718 ± 0.043	3.335ProThr: 3.335 ± 0.055	4.066ProVal: 4.066 ± 0.065	0.501ProTrp: 0.501 ± 0.02	1.136ProTyr: 1.136 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.344GlnAla: 2.344 ± 0.041	0.182GlnCys: 0.182 ± 0.013	1.381GlnAsp: 1.381 ± 0.038	1.729GlnGlu: 1.729 ± 0.044	1.014GlnPhe: 1.014 ± 0.033	1.644GlnGly: 1.644 ± 0.038	0.527GlnHis: 0.527 ± 0.02	0.981GlnIle: 0.981 ± 0.029	0.567GlnLys: 0.567 ± 0.023	2.465GlnLeu: 2.465 ± 0.052	0.514GlnMet: 0.514 ± 0.022	0.692GlnAsn: 0.692 ± 0.026	1.179GlnPro: 1.179 ± 0.036	1.087GlnGln: 1.087 ± 0.042	2.068GlnArg: 2.068 ± 0.05	1.653GlnSer: 1.653 ± 0.042	1.542GlnThr: 1.542 ± 0.043	1.65GlnVal: 1.65 ± 0.034	0.365GlnTrp: 0.365 ± 0.017	0.894GlnTyr: 0.894 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.395ArgAla: 6.395 ± 0.091	0.498ArgCys: 0.498 ± 0.021	5.278ArgAsp: 5.278 ± 0.084	6.786ArgGlu: 6.786 ± 0.097	2.3ArgPhe: 2.3 ± 0.044	4.365ArgGly: 4.365 ± 0.063	1.257ArgHis: 1.257 ± 0.038	3.153ArgIle: 3.153 ± 0.054	1.447ArgLys: 1.447 ± 0.038	6.615ArgLeu: 6.615 ± 0.099	1.178ArgMet: 1.178 ± 0.032	1.66ArgAsn: 1.66 ± 0.039	2.686ArgPro: 2.686 ± 0.051	1.781ArgGln: 1.781 ± 0.044	5.039ArgArg: 5.039 ± 0.089	3.836ArgSer: 3.836 ± 0.07	4.471ArgThr: 4.471 ± 0.071	4.952ArgVal: 4.952 ± 0.071	0.811ArgTrp: 0.811 ± 0.03	1.998ArgTyr: 1.998 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.258SerAla: 5.258 ± 0.068	0.387SerCys: 0.387 ± 0.019	4.658SerAsp: 4.658 ± 0.076	4.237SerGlu: 4.237 ± 0.066	1.798SerPhe: 1.798 ± 0.039	5.03SerGly: 5.03 ± 0.076	1.075SerHis: 1.075 ± 0.03	2.702SerIle: 2.702 ± 0.052	1.212SerLys: 1.212 ± 0.037	5.038SerLeu: 5.038 ± 0.074	1.139SerMet: 1.139 ± 0.033	1.335SerAsn: 1.335 ± 0.035	2.635SerPro: 2.635 ± 0.049	1.38SerGln: 1.38 ± 0.043	3.407SerArg: 3.407 ± 0.067	3.408SerSer: 3.408 ± 0.072	3.484SerThr: 3.484 ± 0.059	4.811SerVal: 4.811 ± 0.064	0.613SerTrp: 0.613 ± 0.022	1.437SerTyr: 1.437 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	7.498ThrAla: 7.498 ± 0.089	0.425ThrCys: 0.425 ± 0.02	6.157ThrAsp: 6.157 ± 0.084	4.966ThrGlu: 4.966 ± 0.079	1.97ThrPhe: 1.97 ± 0.04	5.848ThrGly: 5.848 ± 0.076	1.211ThrHis: 1.211 ± 0.032	3.328ThrIle: 3.328 ± 0.059	1.036ThrLys: 1.036 ± 0.033	5.628ThrLeu: 5.628 ± 0.068	1.071ThrMet: 1.071 ± 0.032	1.521ThrAsn: 1.521 ± 0.039	3.211ThrPro: 3.211 ± 0.063	1.37ThrGln: 1.37 ± 0.032	3.328ThrArg: 3.328 ± 0.057	2.965ThrSer: 2.965 ± 0.047	4.349ThrThr: 4.349 ± 0.067	7.09ThrVal: 7.09 ± 0.093	0.603ThrTrp: 0.603 ± 0.022	1.734ThrTyr: 1.734 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	9.856ValAla: 9.856 ± 0.121	0.715ValCys: 0.715 ± 0.024	7.509ValAsp: 7.509 ± 0.092	6.994ValGlu: 6.994 ± 0.081	2.818ValPhe: 2.818 ± 0.055	7.33ValGly: 7.33 ± 0.103	1.615ValHis: 1.615 ± 0.037	3.465ValIle: 3.465 ± 0.057	1.257ValLys: 1.257 ± 0.038	7.804ValLeu: 7.804 ± 0.096	1.198ValMet: 1.198 ± 0.033	1.768ValAsn: 1.768 ± 0.038	4.377ValPro: 4.377 ± 0.065	1.853ValGln: 1.853 ± 0.042	5.362ValArg: 5.362 ± 0.072	4.822ValSer: 4.822 ± 0.066	6.039ValThr: 6.039 ± 0.074	8.321ValVal: 8.321 ± 0.11	0.824ValTrp: 0.824 ± 0.026	2.111ValTyr: 2.111 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.931TrpAla: 0.931 ± 0.029	0.097TrpCys: 0.097 ± 0.009	0.808TrpAsp: 0.808 ± 0.027	0.844TrpGlu: 0.844 ± 0.03	0.469TrpPhe: 0.469 ± 0.022	0.842TrpGly: 0.842 ± 0.028	0.257TrpHis: 0.257 ± 0.014	0.554TrpIle: 0.554 ± 0.025	0.274TrpLys: 0.274 ± 0.017	1.257TrpLeu: 1.257 ± 0.037	0.208TrpMet: 0.208 ± 0.015	0.37TrpAsn: 0.37 ± 0.015	0.467TrpPro: 0.467 ± 0.02	0.387TrpGln: 0.387 ± 0.02	0.842TrpArg: 0.842 ± 0.032	0.602TrpSer: 0.602 ± 0.024	0.832TrpThr: 0.832 ± 0.031	0.788TrpVal: 0.788 ± 0.031	0.192TrpTrp: 0.192 ± 0.014	0.371TrpTyr: 0.371 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.802TyrAla: 2.802 ± 0.051	0.273TyrCys: 0.273 ± 0.015	2.711TyrAsp: 2.711 ± 0.05	2.603TyrGlu: 2.603 ± 0.055	0.842TyrPhe: 0.842 ± 0.027	2.319TyrGly: 2.319 ± 0.037	0.657TyrHis: 0.657 ± 0.023	0.777TyrIle: 0.777 ± 0.026	0.472TyrLys: 0.472 ± 0.021	2.484TyrLeu: 2.484 ± 0.049	0.37TyrMet: 0.37 ± 0.018	0.612TyrAsn: 0.612 ± 0.025	1.223TyrPro: 1.223 ± 0.033	0.722TyrGln: 0.722 ± 0.024	2.07TyrArg: 2.07 ± 0.043	1.266TyrSer: 1.266 ± 0.034	1.512TyrThr: 1.512 ± 0.035	2.387TyrVal: 2.387 ± 0.051	0.353TyrTrp: 0.353 ± 0.019	0.898TyrTyr: 0.898 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4138 proteins (1179910 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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