Amino acid dipepetide frequency for Pseudactinotalea sp. HY158

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.367AlaAla: 22.367 ± 0.237	0.869AlaCys: 0.869 ± 0.029	9.121AlaAsp: 9.121 ± 0.107	8.412AlaGlu: 8.412 ± 0.114	3.378AlaPhe: 3.378 ± 0.054	15.859AlaGly: 15.859 ± 0.165	2.846AlaHis: 2.846 ± 0.057	5.405AlaIle: 5.405 ± 0.086	1.87AlaLys: 1.87 ± 0.054	13.597AlaLeu: 13.597 ± 0.153	2.638AlaMet: 2.638 ± 0.058	2.076AlaAsn: 2.076 ± 0.044	6.941AlaPro: 6.941 ± 0.096	3.579AlaGln: 3.579 ± 0.062	10.921AlaArg: 10.921 ± 0.151	6.347AlaSer: 6.347 ± 0.083	8.379AlaThr: 8.379 ± 0.119	11.013AlaVal: 11.013 ± 0.12	1.946AlaTrp: 1.946 ± 0.046	2.338AlaTyr: 2.338 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.763CysAla: 0.763 ± 0.03	0.063CysCys: 0.063 ± 0.009	0.364CysAsp: 0.364 ± 0.02	0.296CysGlu: 0.296 ± 0.018	0.152CysPhe: 0.152 ± 0.013	0.711CysGly: 0.711 ± 0.033	0.152CysHis: 0.152 ± 0.012	0.171CysIle: 0.171 ± 0.012	0.064CysLys: 0.064 ± 0.007	0.569CysLeu: 0.569 ± 0.027	0.091CysMet: 0.091 ± 0.01	0.099CysAsn: 0.099 ± 0.01	0.362CysPro: 0.362 ± 0.021	0.111CysGln: 0.111 ± 0.01	0.447CysArg: 0.447 ± 0.024	0.401CysSer: 0.401 ± 0.017	0.409CysThr: 0.409 ± 0.02	0.434CysVal: 0.434 ± 0.022	0.086CysTrp: 0.086 ± 0.009	0.127CysTyr: 0.127 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.061AspAla: 8.061 ± 0.101	0.326AspCys: 0.326 ± 0.018	4.061AspAsp: 4.061 ± 0.086	3.979AspGlu: 3.979 ± 0.062	1.631AspPhe: 1.631 ± 0.046	6.45AspGly: 6.45 ± 0.129	1.567AspHis: 1.567 ± 0.047	1.922AspIle: 1.922 ± 0.045	0.682AspLys: 0.682 ± 0.029	7.619AspLeu: 7.619 ± 0.09	0.811AspMet: 0.811 ± 0.031	0.824AspAsn: 0.824 ± 0.031	5.13AspPro: 5.13 ± 0.098	1.668AspGln: 1.668 ± 0.041	4.947AspArg: 4.947 ± 0.091	3.02AspSer: 3.02 ± 0.065	2.889AspThr: 2.889 ± 0.06	5.496AspVal: 5.496 ± 0.081	0.978AspTrp: 0.978 ± 0.035	1.413AspTyr: 1.413 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.699GluAla: 7.699 ± 0.103	0.295GluCys: 0.295 ± 0.019	2.863GluAsp: 2.863 ± 0.055	3.1GluGlu: 3.1 ± 0.067	1.757GluPhe: 1.757 ± 0.048	4.021GluGly: 4.021 ± 0.073	1.56GluHis: 1.56 ± 0.039	2.643GluIle: 2.643 ± 0.059	0.912GluLys: 0.912 ± 0.037	6.473GluLeu: 6.473 ± 0.098	0.906GluMet: 0.906 ± 0.034	1.15GluAsn: 1.15 ± 0.035	3.735GluPro: 3.735 ± 0.082	2.11GluGln: 2.11 ± 0.053	5.146GluArg: 5.146 ± 0.079	2.818GluSer: 2.818 ± 0.056	2.762GluThr: 2.762 ± 0.059	4.977GluVal: 4.977 ± 0.072	0.772GluTrp: 0.772 ± 0.029	1.13GluTyr: 1.13 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.764PheAla: 3.764 ± 0.06	0.168PheCys: 0.168 ± 0.014	2.198PheAsp: 2.198 ± 0.046	1.455PheGlu: 1.455 ± 0.04	0.893PhePhe: 0.893 ± 0.036	2.892PheGly: 2.892 ± 0.053	0.571PheHis: 0.571 ± 0.023	1.028PheIle: 1.028 ± 0.033	0.367PheLys: 0.367 ± 0.018	2.526PheLeu: 2.526 ± 0.055	0.438PheMet: 0.438 ± 0.02	0.587PheAsn: 0.587 ± 0.026	1.302PhePro: 1.302 ± 0.032	0.574PheGln: 0.574 ± 0.027	1.568PheArg: 1.568 ± 0.038	1.482PheSer: 1.482 ± 0.039	2.18PheThr: 2.18 ± 0.044	2.345PheVal: 2.345 ± 0.049	0.402PheTrp: 0.402 ± 0.019	0.61PheTyr: 0.61 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	12.309GlyAla: 12.309 ± 0.142	0.609GlyCys: 0.609 ± 0.028	5.629GlyAsp: 5.629 ± 0.083	5.645GlyGlu: 5.645 ± 0.094	2.741GlyPhe: 2.741 ± 0.055	8.778GlyGly: 8.778 ± 0.125	2.071GlyHis: 2.071 ± 0.05	4.251GlyIle: 4.251 ± 0.073	1.644GlyLys: 1.644 ± 0.048	9.435GlyLeu: 9.435 ± 0.094	2.06GlyMet: 2.06 ± 0.05	1.659GlyAsn: 1.659 ± 0.058	5.258GlyPro: 5.258 ± 0.092	2.588GlyGln: 2.588 ± 0.054	7.805GlyArg: 7.805 ± 0.105	6.104GlySer: 6.104 ± 0.101	6.226GlyThr: 6.226 ± 0.094	7.673GlyVal: 7.673 ± 0.111	1.583GlyTrp: 1.583 ± 0.034	2.208GlyTyr: 2.208 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.659HisAla: 2.659 ± 0.065	0.151HisCys: 0.151 ± 0.013	1.369HisAsp: 1.369 ± 0.039	1.27HisGlu: 1.27 ± 0.037	0.475HisPhe: 0.475 ± 0.022	2.187HisGly: 2.187 ± 0.056	0.629HisHis: 0.629 ± 0.027	0.66HisIle: 0.66 ± 0.027	0.238HisLys: 0.238 ± 0.016	2.327HisLeu: 2.327 ± 0.053	0.297HisMet: 0.297 ± 0.016	0.328HisAsn: 0.328 ± 0.017	1.616HisPro: 1.616 ± 0.046	0.514HisGln: 0.514 ± 0.021	1.921HisArg: 1.921 ± 0.047	1.022HisSer: 1.022 ± 0.031	1.241HisThr: 1.241 ± 0.034	1.851HisVal: 1.851 ± 0.039	0.333HisTrp: 0.333 ± 0.017	0.408HisTyr: 0.408 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.194IleAla: 6.194 ± 0.092	0.235IleCys: 0.235 ± 0.015	3.443IleAsp: 3.443 ± 0.057	2.675IleGlu: 2.675 ± 0.049	0.932IlePhe: 0.932 ± 0.033	4.158IleGly: 4.158 ± 0.079	0.718IleHis: 0.718 ± 0.025	1.38IleIle: 1.38 ± 0.051	0.595IleLys: 0.595 ± 0.025	3.183IleLeu: 3.183 ± 0.064	0.639IleMet: 0.639 ± 0.027	0.758IleAsn: 0.758 ± 0.029	2.042IlePro: 2.042 ± 0.048	0.764IleGln: 0.764 ± 0.027	2.613IleArg: 2.613 ± 0.05	2.129IleSer: 2.129 ± 0.043	2.708IleThr: 2.708 ± 0.051	3.941IleVal: 3.941 ± 0.07	0.46IleTrp: 0.46 ± 0.02	0.676IleTyr: 0.676 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	1.81LysAla: 1.81 ± 0.054	0.07LysCys: 0.07 ± 0.01	0.8LysAsp: 0.8 ± 0.029	0.763LysGlu: 0.763 ± 0.034	0.419LysPhe: 0.419 ± 0.018	1.077LysGly: 1.077 ± 0.039	0.32LysHis: 0.32 ± 0.015	0.644LysIle: 0.644 ± 0.03	0.483LysLys: 0.483 ± 0.034	1.313LysLeu: 1.313 ± 0.038	0.257LysMet: 0.257 ± 0.017	0.409LysAsn: 0.409 ± 0.019	0.833LysPro: 0.833 ± 0.037	0.414LysGln: 0.414 ± 0.021	1.109LysArg: 1.109 ± 0.035	0.877LysSer: 0.877 ± 0.033	0.902LysThr: 0.902 ± 0.036	1.38LysVal: 1.38 ± 0.043	0.176LysTrp: 0.176 ± 0.013	0.349LysTyr: 0.349 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.873LeuAla: 15.873 ± 0.161	0.567LeuCys: 0.567 ± 0.023	6.763LeuAsp: 6.763 ± 0.085	5.297LeuGlu: 5.297 ± 0.078	2.493LeuPhe: 2.493 ± 0.056	9.286LeuGly: 9.286 ± 0.112	1.941LeuHis: 1.941 ± 0.045	3.696LeuIle: 3.696 ± 0.066	1.187LeuLys: 1.187 ± 0.039	10.193LeuLeu: 10.193 ± 0.137	1.5LeuMet: 1.5 ± 0.044	1.547LeuAsn: 1.547 ± 0.041	5.834LeuPro: 5.834 ± 0.071	2.036LeuGln: 2.036 ± 0.046	7.69LeuArg: 7.69 ± 0.105	5.193LeuSer: 5.193 ± 0.069	7.329LeuThr: 7.329 ± 0.094	8.997LeuVal: 8.997 ± 0.122	1.169LeuTrp: 1.169 ± 0.035	1.476LeuTyr: 1.476 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.228MetAla: 2.228 ± 0.052	0.104MetCys: 0.104 ± 0.01	0.871MetAsp: 0.871 ± 0.031	0.637MetGlu: 0.637 ± 0.023	0.481MetPhe: 0.481 ± 0.023	1.287MetGly: 1.287 ± 0.038	0.334MetHis: 0.334 ± 0.016	0.863MetIle: 0.863 ± 0.034	0.332MetLys: 0.332 ± 0.018	1.729MetLeu: 1.729 ± 0.042	0.277MetMet: 0.277 ± 0.018	0.487MetAsn: 0.487 ± 0.023	1.065MetPro: 1.065 ± 0.028	0.425MetGln: 0.425 ± 0.022	1.451MetArg: 1.451 ± 0.042	1.446MetSer: 1.446 ± 0.04	1.616MetThr: 1.616 ± 0.038	1.363MetVal: 1.363 ± 0.043	0.233MetTrp: 0.233 ± 0.014	0.302MetTyr: 0.302 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.034AsnAla: 2.034 ± 0.044	0.104AsnCys: 0.104 ± 0.01	0.998AsnAsp: 0.998 ± 0.031	1.007AsnGlu: 1.007 ± 0.033	0.497AsnPhe: 0.497 ± 0.022	1.638AsnGly: 1.638 ± 0.047	0.39AsnHis: 0.39 ± 0.02	0.692AsnIle: 0.692 ± 0.027	0.317AsnLys: 0.317 ± 0.02	1.774AsnLeu: 1.774 ± 0.044	0.306AsnMet: 0.306 ± 0.016	0.448AsnAsn: 0.448 ± 0.023	1.399AsnPro: 1.399 ± 0.033	0.501AsnGln: 0.501 ± 0.023	1.287AsnArg: 1.287 ± 0.037	0.95AsnSer: 0.95 ± 0.035	1.048AsnThr: 1.048 ± 0.034	1.495AsnVal: 1.495 ± 0.047	0.29AsnTrp: 0.29 ± 0.017	0.45AsnTyr: 0.45 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	9.067ProAla: 9.067 ± 0.129	0.231ProCys: 0.231 ± 0.014	4.352ProAsp: 4.352 ± 0.079	4.027ProGlu: 4.027 ± 0.075	1.461ProPhe: 1.461 ± 0.039	6.711ProGly: 6.711 ± 0.093	1.221ProHis: 1.221 ± 0.036	2.116ProIle: 2.116 ± 0.044	0.785ProLys: 0.785 ± 0.034	4.576ProLeu: 4.576 ± 0.072	1.005ProMet: 1.005 ± 0.03	0.975ProAsn: 0.975 ± 0.026	3.196ProPro: 3.196 ± 0.074	1.437ProGln: 1.437 ± 0.038	3.836ProArg: 3.836 ± 0.071	3.089ProSer: 3.089 ± 0.057	3.851ProThr: 3.851 ± 0.088	4.917ProVal: 4.917 ± 0.068	0.922ProTrp: 0.922 ± 0.027	1.037ProTyr: 1.037 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.523GlnAla: 3.523 ± 0.068	0.106GlnCys: 0.106 ± 0.01	1.16GlnAsp: 1.16 ± 0.034	1.253GlnGlu: 1.253 ± 0.039	0.741GlnPhe: 0.741 ± 0.027	2.119GlnGly: 2.119 ± 0.062	0.546GlnHis: 0.546 ± 0.024	1.234GlnIle: 1.234 ± 0.034	0.377GlnLys: 0.377 ± 0.019	2.806GlnLeu: 2.806 ± 0.051	0.412GlnMet: 0.412 ± 0.018	0.497GlnAsn: 0.497 ± 0.024	1.43GlnPro: 1.43 ± 0.039	0.986GlnGln: 0.986 ± 0.037	2.197GlnArg: 2.197 ± 0.045	1.251GlnSer: 1.251 ± 0.033	1.225GlnThr: 1.225 ± 0.036	2.745GlnVal: 2.745 ± 0.06	0.429GlnTrp: 0.429 ± 0.02	0.554GlnTyr: 0.554 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	10.565ArgAla: 10.565 ± 0.156	0.447ArgCys: 0.447 ± 0.024	4.197ArgAsp: 4.197 ± 0.077	4.42ArgGlu: 4.42 ± 0.074	2.189ArgPhe: 2.189 ± 0.049	6.115ArgGly: 6.115 ± 0.085	1.818ArgHis: 1.818 ± 0.05	3.698ArgIle: 3.698 ± 0.068	1.075ArgLys: 1.075 ± 0.036	8.188ArgLeu: 8.188 ± 0.13	1.767ArgMet: 1.767 ± 0.042	1.249ArgAsn: 1.249 ± 0.033	4.684ArgPro: 4.684 ± 0.086	1.935ArgGln: 1.935 ± 0.047	7.839ArgArg: 7.839 ± 0.143	4.496ArgSer: 4.496 ± 0.069	4.623ArgThr: 4.623 ± 0.071	5.926ArgVal: 5.926 ± 0.079	1.272ArgTrp: 1.272 ± 0.037	1.577ArgTyr: 1.577 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	7.109SerAla: 7.109 ± 0.083	0.333SerCys: 0.333 ± 0.019	3.256SerAsp: 3.256 ± 0.088	2.862SerGlu: 2.862 ± 0.056	1.594SerPhe: 1.594 ± 0.044	6.077SerGly: 6.077 ± 0.071	1.052SerHis: 1.052 ± 0.034	2.263SerIle: 2.263 ± 0.043	0.826SerLys: 0.826 ± 0.035	4.715SerLeu: 4.715 ± 0.057	1.114SerMet: 1.114 ± 0.032	1.0SerAsn: 1.0 ± 0.035	3.299SerPro: 3.299 ± 0.066	1.432SerGln: 1.432 ± 0.039	3.891SerArg: 3.891 ± 0.063	3.246SerSer: 3.246 ± 0.072	3.59SerThr: 3.59 ± 0.073	4.307SerVal: 4.307 ± 0.074	0.861SerTrp: 0.861 ± 0.03	1.162SerTyr: 1.162 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	8.147ThrAla: 8.147 ± 0.117	0.385ThrCys: 0.385 ± 0.02	4.166ThrAsp: 4.166 ± 0.089	3.189ThrGlu: 3.189 ± 0.053	1.982ThrPhe: 1.982 ± 0.044	7.003ThrGly: 7.003 ± 0.105	1.179ThrHis: 1.179 ± 0.034	2.797ThrIle: 2.797 ± 0.058	0.979ThrLys: 0.979 ± 0.033	5.848ThrLeu: 5.848 ± 0.076	1.106ThrMet: 1.106 ± 0.034	1.195ThrAsn: 1.195 ± 0.039	4.045ThrPro: 4.045 ± 0.078	1.434ThrGln: 1.434 ± 0.04	4.231ThrArg: 4.231 ± 0.075	3.443ThrSer: 3.443 ± 0.054	4.082ThrThr: 4.082 ± 0.073	5.429ThrVal: 5.429 ± 0.085	1.072ThrTrp: 1.072 ± 0.033	1.393ThrTyr: 1.393 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	11.681ValAla: 11.681 ± 0.125	0.548ValCys: 0.548 ± 0.027	5.741ValAsp: 5.741 ± 0.062	4.723ValGlu: 4.723 ± 0.074	2.378ValPhe: 2.378 ± 0.055	6.963ValGly: 6.963 ± 0.102	1.858ValHis: 1.858 ± 0.046	3.59ValIle: 3.59 ± 0.075	1.168ValLys: 1.168 ± 0.041	9.374ValLeu: 9.374 ± 0.109	1.412ValMet: 1.412 ± 0.041	1.552ValAsn: 1.552 ± 0.037	4.892ValPro: 4.892 ± 0.072	1.955ValGln: 1.955 ± 0.044	6.288ValArg: 6.288 ± 0.077	4.561ValSer: 4.561 ± 0.066	5.934ValThr: 5.934 ± 0.091	8.284ValVal: 8.284 ± 0.127	0.988ValTrp: 0.988 ± 0.031	1.431ValTyr: 1.431 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.705TrpAla: 1.705 ± 0.04	0.124TrpCys: 0.124 ± 0.011	0.813TrpAsp: 0.813 ± 0.032	0.647TrpGlu: 0.647 ± 0.027	0.488TrpPhe: 0.488 ± 0.026	1.038TrpGly: 1.038 ± 0.029	0.384TrpHis: 0.384 ± 0.02	0.64TrpIle: 0.64 ± 0.023	0.215TrpLys: 0.215 ± 0.016	1.659TrpLeu: 1.659 ± 0.043	0.266TrpMet: 0.266 ± 0.016	0.402TrpAsn: 0.402 ± 0.021	0.759TrpPro: 0.759 ± 0.027	0.578TrpGln: 0.578 ± 0.023	1.305TrpArg: 1.305 ± 0.04	0.992TrpSer: 0.992 ± 0.036	0.918TrpThr: 0.918 ± 0.031	1.059TrpVal: 1.059 ± 0.031	0.342TrpTrp: 0.342 ± 0.019	0.309TrpTyr: 0.309 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.342TyrAla: 2.342 ± 0.047	0.137TyrCys: 0.137 ± 0.013	1.309TyrAsp: 1.309 ± 0.038	1.172TyrGlu: 1.172 ± 0.041	0.669TyrPhe: 0.669 ± 0.028	1.906TyrGly: 1.906 ± 0.046	0.341TyrHis: 0.341 ± 0.02	0.549TyrIle: 0.549 ± 0.024	0.29TyrLys: 0.29 ± 0.019	2.163TyrLeu: 2.163 ± 0.047	0.23TyrMet: 0.23 ± 0.015	0.383TyrAsn: 0.383 ± 0.019	0.99TyrPro: 0.99 ± 0.037	0.549TyrGln: 0.549 ± 0.037	1.59TyrArg: 1.59 ± 0.039	1.122TyrSer: 1.122 ± 0.033	1.19TyrThr: 1.19 ± 0.045	1.69TyrVal: 1.69 ± 0.04	0.329TyrTrp: 0.329 ± 0.018	0.432TyrTyr: 0.432 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3052 proteins (1062837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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