Amino acid dipepetide frequency for Gillisia limnaea DSM 15749

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.73AlaAla: 4.73 ± 0.082
0.517AlaCys: 0.517 ± 0.023
3.048AlaAsp: 3.048 ± 0.051
4.507AlaGlu: 4.507 ± 0.073
3.311AlaPhe: 3.311 ± 0.052
4.698AlaGly: 4.698 ± 0.082
1.086AlaHis: 1.086 ± 0.034
5.394AlaIle: 5.394 ± 0.081
4.3AlaLys: 4.3 ± 0.069
6.228AlaLeu: 6.228 ± 0.08
1.619AlaMet: 1.619 ± 0.046
3.197AlaAsn: 3.197 ± 0.056
1.979AlaPro: 1.979 ± 0.053
2.389AlaGln: 2.389 ± 0.04
2.3AlaArg: 2.3 ± 0.051
4.1AlaSer: 4.1 ± 0.062
3.446AlaThr: 3.446 ± 0.084
4.369AlaVal: 4.369 ± 0.074
0.619AlaTrp: 0.619 ± 0.026
2.319AlaTyr: 2.319 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.381CysAla: 0.381 ± 0.019
0.085CysCys: 0.085 ± 0.008
0.398CysAsp: 0.398 ± 0.022
0.454CysGlu: 0.454 ± 0.025
0.367CysPhe: 0.367 ± 0.017
0.566CysGly: 0.566 ± 0.03
0.147CysHis: 0.147 ± 0.013
0.526CysIle: 0.526 ± 0.024
0.435CysLys: 0.435 ± 0.022
0.578CysLeu: 0.578 ± 0.023
0.132CysMet: 0.132 ± 0.01
0.351CysAsn: 0.351 ± 0.018
0.303CysPro: 0.303 ± 0.022
0.182CysGln: 0.182 ± 0.013
0.23CysArg: 0.23 ± 0.014
0.494CysSer: 0.494 ± 0.023
0.37CysThr: 0.37 ± 0.02
0.351CysVal: 0.351 ± 0.02
0.055CysTrp: 0.055 ± 0.007
0.254CysTyr: 0.254 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.393AspAla: 3.393 ± 0.059
0.337AspCys: 0.337 ± 0.018
2.587AspAsp: 2.587 ± 0.06
3.809AspGlu: 3.809 ± 0.071
3.646AspPhe: 3.646 ± 0.056
3.386AspGly: 3.386 ± 0.079
0.964AspHis: 0.964 ± 0.032
4.125AspIle: 4.125 ± 0.066
3.918AspLys: 3.918 ± 0.06
5.577AspLeu: 5.577 ± 0.07
1.093AspMet: 1.093 ± 0.034
2.528AspAsn: 2.528 ± 0.057
2.088AspPro: 2.088 ± 0.05
1.598AspGln: 1.598 ± 0.04
1.999AspArg: 1.999 ± 0.042
3.164AspSer: 3.164 ± 0.057
2.48AspThr: 2.48 ± 0.047
3.296AspVal: 3.296 ± 0.059
0.727AspTrp: 0.727 ± 0.029
2.56AspTyr: 2.56 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
4.633GluAla: 4.633 ± 0.072
0.333GluCys: 0.333 ± 0.021
4.045GluAsp: 4.045 ± 0.058
5.929GluGlu: 5.929 ± 0.094
3.408GluPhe: 3.408 ± 0.052
4.101GluGly: 4.101 ± 0.068
1.141GluHis: 1.141 ± 0.03
6.565GluIle: 6.565 ± 0.09
6.592GluLys: 6.592 ± 0.1
6.609GluLeu: 6.609 ± 0.093
1.86GluMet: 1.86 ± 0.043
5.264GluAsn: 5.264 ± 0.083
1.805GluPro: 1.805 ± 0.042
2.227GluGln: 2.227 ± 0.045
2.758GluArg: 2.758 ± 0.053
3.474GluSer: 3.474 ± 0.053
3.661GluThr: 3.661 ± 0.056
4.688GluVal: 4.688 ± 0.065
0.627GluTrp: 0.627 ± 0.025
2.564GluTyr: 2.564 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.066PheAla: 3.066 ± 0.055
0.408PheCys: 0.408 ± 0.02
3.051PheAsp: 3.051 ± 0.057
3.798PheGlu: 3.798 ± 0.059
2.87PhePhe: 2.87 ± 0.059
3.696PheGly: 3.696 ± 0.057
0.919PheHis: 0.919 ± 0.028
4.147PheIle: 4.147 ± 0.066
3.747PheLys: 3.747 ± 0.064
5.273PheLeu: 5.273 ± 0.077
1.146PheMet: 1.146 ± 0.031
3.121PheAsn: 3.121 ± 0.051
1.945PhePro: 1.945 ± 0.042
1.854PheGln: 1.854 ± 0.048
1.927PheArg: 1.927 ± 0.042
4.206PheSer: 4.206 ± 0.063
3.007PheThr: 3.007 ± 0.056
2.77PheVal: 2.77 ± 0.054
0.629PheTrp: 0.629 ± 0.027
2.038PheTyr: 2.038 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
4.163GlyAla: 4.163 ± 0.072
0.562GlyCys: 0.562 ± 0.024
3.35GlyAsp: 3.35 ± 0.067
4.131GlyGlu: 4.131 ± 0.069
3.79GlyPhe: 3.79 ± 0.063
4.579GlyGly: 4.579 ± 0.09
1.072GlyHis: 1.072 ± 0.03
5.941GlyIle: 5.941 ± 0.072
5.106GlyLys: 5.106 ± 0.065
5.972GlyLeu: 5.972 ± 0.081
1.711GlyMet: 1.711 ± 0.041
3.764GlyAsn: 3.764 ± 0.077
1.446GlyPro: 1.446 ± 0.039
1.802GlyGln: 1.802 ± 0.046
2.186GlyArg: 2.186 ± 0.049
4.152GlySer: 4.152 ± 0.069
3.934GlyThr: 3.934 ± 0.08
4.244GlyVal: 4.244 ± 0.068
0.794GlyTrp: 0.794 ± 0.03
2.687GlyTyr: 2.687 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
0.848HisAla: 0.848 ± 0.028
0.158HisCys: 0.158 ± 0.012
0.72HisAsp: 0.72 ± 0.03
0.935HisGlu: 0.935 ± 0.03
1.086HisPhe: 1.086 ± 0.033
1.078HisGly: 1.078 ± 0.029
0.45HisHis: 0.45 ± 0.025
1.338HisIle: 1.338 ± 0.038
1.186HisLys: 1.186 ± 0.032
1.85HisLeu: 1.85 ± 0.042
0.291HisMet: 0.291 ± 0.015
0.834HisAsn: 0.834 ± 0.03
0.954HisPro: 0.954 ± 0.035
0.702HisGln: 0.702 ± 0.027
0.706HisArg: 0.706 ± 0.021
1.163HisSer: 1.163 ± 0.04
0.871HisThr: 0.871 ± 0.028
0.833HisVal: 0.833 ± 0.03
0.224HisTrp: 0.224 ± 0.017
0.755HisTyr: 0.755 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.696IleAla: 5.696 ± 0.078
0.599IleCys: 0.599 ± 0.024
4.575IleAsp: 4.575 ± 0.061
5.575IleGlu: 5.575 ± 0.085
4.099IlePhe: 4.099 ± 0.069
5.187IleGly: 5.187 ± 0.075
1.376IleHis: 1.376 ± 0.041
6.206IleIle: 6.206 ± 0.084
5.7IleLys: 5.7 ± 0.072
8.068IleLeu: 8.068 ± 0.119
1.389IleMet: 1.389 ± 0.034
4.346IleAsn: 4.346 ± 0.065
3.526IlePro: 3.526 ± 0.054
2.649IleGln: 2.649 ± 0.051
2.921IleArg: 2.921 ± 0.06
6.129IleSer: 6.129 ± 0.07
4.606IleThr: 4.606 ± 0.081
4.347IleVal: 4.347 ± 0.074
0.721IleTrp: 0.721 ± 0.027
2.815IleTyr: 2.815 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
4.665LysAla: 4.665 ± 0.075
0.318LysCys: 0.318 ± 0.017
4.5LysAsp: 4.5 ± 0.064
6.468LysGlu: 6.468 ± 0.098
3.148LysPhe: 3.148 ± 0.058
4.263LysGly: 4.263 ± 0.062
1.21LysHis: 1.21 ± 0.035
6.409LysIle: 6.409 ± 0.088
6.621LysLys: 6.621 ± 0.099
6.626LysLeu: 6.626 ± 0.09
2.146LysMet: 2.146 ± 0.047
5.33LysAsn: 5.33 ± 0.082
2.434LysPro: 2.434 ± 0.052
2.423LysGln: 2.423 ± 0.044
2.868LysArg: 2.868 ± 0.054
4.406LysSer: 4.406 ± 0.063
4.262LysThr: 4.262 ± 0.072
4.444LysVal: 4.444 ± 0.064
0.733LysTrp: 0.733 ± 0.022
2.855LysTyr: 2.855 ± 0.056
0.001LysXaa: 0.001 ± 0.001
Leu
6.047LeuAla: 6.047 ± 0.089
0.608LeuCys: 0.608 ± 0.023
5.172LeuAsp: 5.172 ± 0.069
6.871LeuGlu: 6.871 ± 0.092
5.1LeuPhe: 5.1 ± 0.085
6.18LeuGly: 6.18 ± 0.078
1.545LeuHis: 1.545 ± 0.038
7.605LeuIle: 7.605 ± 0.11
8.26LeuLys: 8.26 ± 0.101
9.26LeuLeu: 9.26 ± 0.124
2.266LeuMet: 2.266 ± 0.047
5.634LeuAsn: 5.634 ± 0.071
3.6LeuPro: 3.6 ± 0.063
3.411LeuGln: 3.411 ± 0.056
3.516LeuArg: 3.516 ± 0.061
6.787LeuSer: 6.787 ± 0.085
4.822LeuThr: 4.822 ± 0.073
5.533LeuVal: 5.533 ± 0.072
0.893LeuTrp: 0.893 ± 0.031
3.143LeuTyr: 3.143 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
1.761MetAla: 1.761 ± 0.039
0.109MetCys: 0.109 ± 0.01
1.342MetAsp: 1.342 ± 0.037
1.81MetGlu: 1.81 ± 0.041
0.876MetPhe: 0.876 ± 0.025
1.542MetGly: 1.542 ± 0.042
0.391MetHis: 0.391 ± 0.019
1.594MetIle: 1.594 ± 0.037
2.209MetLys: 2.209 ± 0.045
2.054MetLeu: 2.054 ± 0.044
0.607MetMet: 0.607 ± 0.024
1.278MetAsn: 1.278 ± 0.031
0.835MetPro: 0.835 ± 0.029
0.884MetGln: 0.884 ± 0.028
0.899MetArg: 0.899 ± 0.03
1.272MetSer: 1.272 ± 0.033
1.044MetThr: 1.044 ± 0.03
1.407MetVal: 1.407 ± 0.034
0.158MetTrp: 0.158 ± 0.012
0.641MetTyr: 0.641 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.588AsnAla: 3.588 ± 0.067
0.382AsnCys: 0.382 ± 0.022
2.782AsnAsp: 2.782 ± 0.053
3.786AsnGlu: 3.786 ± 0.058
3.399AsnPhe: 3.399 ± 0.06
3.496AsnGly: 3.496 ± 0.074
0.971AsnHis: 0.971 ± 0.031
4.548AsnIle: 4.548 ± 0.064
3.973AsnLys: 3.973 ± 0.068
5.839AsnLeu: 5.839 ± 0.067
1.287AsnMet: 1.287 ± 0.036
3.332AsnAsn: 3.332 ± 0.066
2.81AsnPro: 2.81 ± 0.061
2.028AsnGln: 2.028 ± 0.043
2.307AsnArg: 2.307 ± 0.045
4.027AsnSer: 4.027 ± 0.073
3.241AsnThr: 3.241 ± 0.067
3.139AsnVal: 3.139 ± 0.062
0.742AsnTrp: 0.742 ± 0.023
2.697AsnTyr: 2.697 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
2.214ProAla: 2.214 ± 0.054
0.187ProCys: 0.187 ± 0.012
2.135ProAsp: 2.135 ± 0.046
3.448ProGlu: 3.448 ± 0.057
1.93ProPhe: 1.93 ± 0.045
2.465ProGly: 2.465 ± 0.051
0.595ProHis: 0.595 ± 0.025
2.44ProIle: 2.44 ± 0.05
2.37ProLys: 2.37 ± 0.049
3.191ProLeu: 3.191 ± 0.052
0.737ProMet: 0.737 ± 0.029
2.046ProAsn: 2.046 ± 0.047
0.937ProPro: 0.937 ± 0.037
1.233ProGln: 1.233 ± 0.04
1.084ProArg: 1.084 ± 0.034
2.148ProSer: 2.148 ± 0.045
1.865ProThr: 1.865 ± 0.048
2.766ProVal: 2.766 ± 0.052
0.349ProTrp: 0.349 ± 0.019
1.365ProTyr: 1.365 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.066GlnAla: 2.066 ± 0.047
0.165GlnCys: 0.165 ± 0.012
1.728GlnAsp: 1.728 ± 0.037
2.61GlnGlu: 2.61 ± 0.051
1.609GlnPhe: 1.609 ± 0.039
1.861GlnGly: 1.861 ± 0.043
0.557GlnHis: 0.557 ± 0.02
2.656GlnIle: 2.656 ± 0.045
2.767GlnLys: 2.767 ± 0.057
3.531GlnLeu: 3.531 ± 0.066
0.816GlnMet: 0.816 ± 0.026
2.122GlnAsn: 2.122 ± 0.041
1.168GlnPro: 1.168 ± 0.034
1.444GlnGln: 1.444 ± 0.04
1.326GlnArg: 1.326 ± 0.035
1.831GlnSer: 1.831 ± 0.036
1.751GlnThr: 1.751 ± 0.043
1.977GlnVal: 1.977 ± 0.045
0.357GlnTrp: 0.357 ± 0.018
1.19GlnTyr: 1.19 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.157ArgAla: 2.157 ± 0.041
0.176ArgCys: 0.176 ± 0.013
2.06ArgAsp: 2.06 ± 0.041
2.917ArgGlu: 2.917 ± 0.052
2.004ArgPhe: 2.004 ± 0.046
2.132ArgGly: 2.132 ± 0.048
0.622ArgHis: 0.622 ± 0.026
3.259ArgIle: 3.259 ± 0.053
3.063ArgLys: 3.063 ± 0.058
3.409ArgLeu: 3.409 ± 0.066
0.93ArgMet: 0.93 ± 0.03
2.338ArgAsn: 2.338 ± 0.049
1.127ArgPro: 1.127 ± 0.032
1.153ArgGln: 1.153 ± 0.032
1.454ArgArg: 1.454 ± 0.038
2.275ArgSer: 2.275 ± 0.043
1.866ArgThr: 1.866 ± 0.044
2.113ArgVal: 2.113 ± 0.043
0.427ArgTrp: 0.427 ± 0.021
1.551ArgTyr: 1.551 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
3.94SerAla: 3.94 ± 0.062
0.586SerCys: 0.586 ± 0.023
3.109SerAsp: 3.109 ± 0.055
4.739SerGlu: 4.739 ± 0.072
3.838SerPhe: 3.838 ± 0.066
5.001SerGly: 5.001 ± 0.085
1.099SerHis: 1.099 ± 0.032
5.159SerIle: 5.159 ± 0.078
4.663SerLys: 4.663 ± 0.073
6.382SerLeu: 6.382 ± 0.088
1.297SerMet: 1.297 ± 0.039
3.611SerAsn: 3.611 ± 0.061
2.256SerPro: 2.256 ± 0.046
2.177SerGln: 2.177 ± 0.046
2.538SerArg: 2.538 ± 0.051
4.287SerSer: 4.287 ± 0.073
3.288SerThr: 3.288 ± 0.053
3.918SerVal: 3.918 ± 0.056
0.695SerTrp: 0.695 ± 0.025
2.625SerTyr: 2.625 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
3.825ThrAla: 3.825 ± 0.095
0.319ThrCys: 0.319 ± 0.018
2.826ThrAsp: 2.826 ± 0.066
3.379ThrGlu: 3.379 ± 0.06
2.788ThrPhe: 2.788 ± 0.054
4.292ThrGly: 4.292 ± 0.075
0.922ThrHis: 0.922 ± 0.031
4.235ThrIle: 4.235 ± 0.072
3.318ThrLys: 3.318 ± 0.055
4.871ThrLeu: 4.871 ± 0.063
0.937ThrMet: 0.937 ± 0.029
2.831ThrAsn: 2.831 ± 0.053
2.361ThrPro: 2.361 ± 0.05
1.709ThrGln: 1.709 ± 0.039
1.831ThrArg: 1.831 ± 0.045
3.771ThrSer: 3.771 ± 0.071
3.032ThrThr: 3.032 ± 0.07
3.402ThrVal: 3.402 ± 0.069
0.542ThrTrp: 0.542 ± 0.023
2.129ThrTyr: 2.129 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
4.103ValAla: 4.103 ± 0.062
0.443ValCys: 0.443 ± 0.022
3.19ValAsp: 3.19 ± 0.06
4.025ValGlu: 4.025 ± 0.068
3.274ValPhe: 3.274 ± 0.058
3.695ValGly: 3.695 ± 0.069
0.951ValHis: 0.951 ± 0.031
4.979ValIle: 4.979 ± 0.082
4.296ValLys: 4.296 ± 0.071
6.0ValLeu: 6.0 ± 0.076
1.394ValMet: 1.394 ± 0.042
3.425ValAsn: 3.425 ± 0.067
2.226ValPro: 2.226 ± 0.04
1.864ValGln: 1.864 ± 0.042
2.074ValArg: 2.074 ± 0.041
4.231ValSer: 4.231 ± 0.063
3.281ValThr: 3.281 ± 0.08
3.934ValVal: 3.934 ± 0.077
0.556ValTrp: 0.556 ± 0.024
2.185ValTyr: 2.185 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.622TrpAla: 0.622 ± 0.024
0.076TrpCys: 0.076 ± 0.008
0.597TrpAsp: 0.597 ± 0.028
0.742TrpGlu: 0.742 ± 0.028
0.595TrpPhe: 0.595 ± 0.025
0.638TrpGly: 0.638 ± 0.022
0.22TrpHis: 0.22 ± 0.014
0.828TrpIle: 0.828 ± 0.031
0.834TrpLys: 0.834 ± 0.024
0.963TrpLeu: 0.963 ± 0.029
0.355TrpMet: 0.355 ± 0.019
0.67TrpAsn: 0.67 ± 0.027
0.284TrpPro: 0.284 ± 0.018
0.38TrpGln: 0.38 ± 0.019
0.409TrpArg: 0.409 ± 0.021
0.599TrpSer: 0.599 ± 0.02
0.466TrpThr: 0.466 ± 0.022
0.635TrpVal: 0.635 ± 0.021
0.149TrpTrp: 0.149 ± 0.012
0.407TrpTyr: 0.407 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.262TyrAla: 2.262 ± 0.045
0.292TyrCys: 0.292 ± 0.017
2.059TyrAsp: 2.059 ± 0.038
2.354TyrGlu: 2.354 ± 0.047
2.478TyrPhe: 2.478 ± 0.05
2.529TyrGly: 2.529 ± 0.05
0.741TyrHis: 0.741 ± 0.028
2.579TyrIle: 2.579 ± 0.059
2.771TyrLys: 2.771 ± 0.056
3.973TyrLeu: 3.973 ± 0.075
0.699TyrMet: 0.699 ± 0.023
2.352TyrAsn: 2.352 ± 0.054
1.422TyrPro: 1.422 ± 0.039
1.423TyrGln: 1.423 ± 0.041
1.699TyrArg: 1.699 ± 0.044
2.691TyrSer: 2.691 ± 0.056
2.023TyrThr: 2.023 ± 0.048
1.961TyrVal: 1.961 ± 0.041
0.473TyrTrp: 0.473 ± 0.021
1.66TyrTyr: 1.66 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.001XaaThr: 0.001 ± 0.001
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.002
Statistics based on 3411 proteins (1128509 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski