Amino acid dipepetide frequency for Intestinimonas butyriciproducens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.005AlaAla: 13.005 ± 0.158	1.605AlaCys: 1.605 ± 0.041	5.51AlaAsp: 5.51 ± 0.074	6.965AlaGlu: 6.965 ± 0.105	3.675AlaPhe: 3.675 ± 0.066	8.551AlaGly: 8.551 ± 0.092	1.598AlaHis: 1.598 ± 0.041	4.637AlaIle: 4.637 ± 0.08	3.843AlaLys: 3.843 ± 0.068	11.383AlaLeu: 11.383 ± 0.136	2.87AlaMet: 2.87 ± 0.052	2.281AlaAsn: 2.281 ± 0.05	3.928AlaPro: 3.928 ± 0.07	3.278AlaGln: 3.278 ± 0.063	5.685AlaArg: 5.685 ± 0.092	4.713AlaSer: 4.713 ± 0.086	3.802AlaThr: 3.802 ± 0.071	8.784AlaVal: 8.784 ± 0.105	1.023AlaTrp: 1.023 ± 0.038	2.899AlaTyr: 2.899 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.757CysAla: 1.757 ± 0.048	0.364CysCys: 0.364 ± 0.025	0.901CysAsp: 0.901 ± 0.031	0.814CysGlu: 0.814 ± 0.033	0.63CysPhe: 0.63 ± 0.028	1.91CysGly: 1.91 ± 0.048	0.326CysHis: 0.326 ± 0.018	0.815CysIle: 0.815 ± 0.03	0.619CysLys: 0.619 ± 0.028	1.452CysLeu: 1.452 ± 0.035	0.43CysMet: 0.43 ± 0.023	0.452CysAsn: 0.452 ± 0.026	0.839CysPro: 0.839 ± 0.03	0.412CysGln: 0.412 ± 0.02	1.127CysArg: 1.127 ± 0.035	0.868CysSer: 0.868 ± 0.029	0.91CysThr: 0.91 ± 0.029	1.133CysVal: 1.133 ± 0.035	0.186CysTrp: 0.186 ± 0.015	0.566CysTyr: 0.566 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	5.342AspAla: 5.342 ± 0.087	0.875AspCys: 0.875 ± 0.03	2.638AspAsp: 2.638 ± 0.066	3.624AspGlu: 3.624 ± 0.065	2.418AspPhe: 2.418 ± 0.053	5.077AspGly: 5.077 ± 0.093	1.026AspHis: 1.026 ± 0.033	3.263AspIle: 3.263 ± 0.064	2.303AspLys: 2.303 ± 0.058	5.328AspLeu: 5.328 ± 0.082	1.623AspMet: 1.623 ± 0.041	1.441AspAsn: 1.441 ± 0.045	2.728AspPro: 2.728 ± 0.05	1.559AspGln: 1.559 ± 0.039	3.353AspArg: 3.353 ± 0.068	2.59AspSer: 2.59 ± 0.057	2.98AspThr: 2.98 ± 0.058	3.854AspVal: 3.854 ± 0.064	0.711AspTrp: 0.711 ± 0.033	2.308AspTyr: 2.308 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	6.774GluAla: 6.774 ± 0.086	0.733GluCys: 0.733 ± 0.034	3.781GluAsp: 3.781 ± 0.067	5.594GluGlu: 5.594 ± 0.098	1.959GluPhe: 1.959 ± 0.049	5.053GluGly: 5.053 ± 0.072	1.413GluHis: 1.413 ± 0.041	3.669GluIle: 3.669 ± 0.066	3.989GluLys: 3.989 ± 0.078	6.819GluLeu: 6.819 ± 0.108	1.868GluMet: 1.868 ± 0.042	2.625GluAsn: 2.625 ± 0.058	2.296GluPro: 2.296 ± 0.046	2.773GluGln: 2.773 ± 0.068	4.669GluArg: 4.669 ± 0.09	3.08GluSer: 3.08 ± 0.058	3.633GluThr: 3.633 ± 0.068	4.145GluVal: 4.145 ± 0.066	0.64GluTrp: 0.64 ± 0.027	2.152GluTyr: 2.152 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.457PheAla: 3.457 ± 0.059	0.77PheCys: 0.77 ± 0.028	2.3PheAsp: 2.3 ± 0.049	1.996PheGlu: 1.996 ± 0.05	1.669PhePhe: 1.669 ± 0.044	3.08PheGly: 3.08 ± 0.065	0.835PheHis: 0.835 ± 0.031	1.792PheIle: 1.792 ± 0.047	1.154PheLys: 1.154 ± 0.041	4.092PheLeu: 4.092 ± 0.079	0.842PheMet: 0.842 ± 0.03	1.088PheAsn: 1.088 ± 0.031	1.695PhePro: 1.695 ± 0.045	1.436PheGln: 1.436 ± 0.039	2.187PheArg: 2.187 ± 0.05	2.775PheSer: 2.775 ± 0.061	2.361PheThr: 2.361 ± 0.054	2.473PheVal: 2.473 ± 0.049	0.454PheTrp: 0.454 ± 0.022	1.336PheTyr: 1.336 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	7.851GlyAla: 7.851 ± 0.101	1.576GlyCys: 1.576 ± 0.047	4.279GlyAsp: 4.279 ± 0.07	5.564GlyGlu: 5.564 ± 0.092	3.108GlyPhe: 3.108 ± 0.073	7.436GlyGly: 7.436 ± 0.105	1.48GlyHis: 1.48 ± 0.036	4.739GlyIle: 4.739 ± 0.076	4.185GlyLys: 4.185 ± 0.072	7.972GlyLeu: 7.972 ± 0.112	2.567GlyMet: 2.567 ± 0.046	2.482GlyAsn: 2.482 ± 0.064	2.32GlyPro: 2.32 ± 0.05	2.428GlyGln: 2.428 ± 0.054	4.996GlyArg: 4.996 ± 0.083	4.444GlySer: 4.444 ± 0.083	5.01GlyThr: 5.01 ± 0.096	6.544GlyVal: 6.544 ± 0.089	0.978GlyTrp: 0.978 ± 0.03	3.198GlyTyr: 3.198 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.454HisAla: 1.454 ± 0.037	0.329HisCys: 0.329 ± 0.018	0.897HisAsp: 0.897 ± 0.033	0.953HisGlu: 0.953 ± 0.032	0.876HisPhe: 0.876 ± 0.029	1.497HisGly: 1.497 ± 0.041	0.352HisHis: 0.352 ± 0.019	1.249HisIle: 1.249 ± 0.034	0.662HisLys: 0.662 ± 0.026	1.702HisLeu: 1.702 ± 0.046	0.533HisMet: 0.533 ± 0.024	0.566HisAsn: 0.566 ± 0.027	1.16HisPro: 1.16 ± 0.036	0.542HisGln: 0.542 ± 0.023	1.085HisArg: 1.085 ± 0.036	0.881HisSer: 0.881 ± 0.03	1.102HisThr: 1.102 ± 0.031	1.23HisVal: 1.23 ± 0.034	0.231HisTrp: 0.231 ± 0.017	0.631HisTyr: 0.631 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.076IleAla: 5.076 ± 0.078	0.977IleCys: 0.977 ± 0.029	2.85IleAsp: 2.85 ± 0.064	2.865IleGlu: 2.865 ± 0.06	1.935IlePhe: 1.935 ± 0.045	4.059IleGly: 4.059 ± 0.076	1.071IleHis: 1.071 ± 0.035	2.765IleIle: 2.765 ± 0.059	1.927IleLys: 1.927 ± 0.049	5.597IleLeu: 5.597 ± 0.083	1.245IleMet: 1.245 ± 0.039	1.535IleAsn: 1.535 ± 0.046	2.881IlePro: 2.881 ± 0.05	1.81IleGln: 1.81 ± 0.043	3.315IleArg: 3.315 ± 0.056	3.43IleSer: 3.43 ± 0.065	3.398IleThr: 3.398 ± 0.07	3.695IleVal: 3.695 ± 0.072	0.502IleTrp: 0.502 ± 0.023	1.76IleTyr: 1.76 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.287LysAla: 4.287 ± 0.08	0.509LysCys: 0.509 ± 0.024	2.332LysAsp: 2.332 ± 0.061	3.177LysGlu: 3.177 ± 0.071	1.172LysPhe: 1.172 ± 0.04	3.307LysGly: 3.307 ± 0.059	0.693LysHis: 0.693 ± 0.026	2.271LysIle: 2.271 ± 0.054	3.016LysLys: 3.016 ± 0.071	4.019LysLeu: 4.019 ± 0.07	1.287LysMet: 1.287 ± 0.039	1.7LysAsn: 1.7 ± 0.044	1.811LysPro: 1.811 ± 0.045	1.41LysGln: 1.41 ± 0.043	2.798LysArg: 2.798 ± 0.058	2.325LysSer: 2.325 ± 0.047	2.503LysThr: 2.503 ± 0.065	2.99LysVal: 2.99 ± 0.059	0.395LysTrp: 0.395 ± 0.023	1.519LysTyr: 1.519 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	9.761LeuAla: 9.761 ± 0.126	2.119LeuCys: 2.119 ± 0.054	5.706LeuAsp: 5.706 ± 0.082	6.728LeuGlu: 6.728 ± 0.111	4.032LeuPhe: 4.032 ± 0.086	7.713LeuGly: 7.713 ± 0.105	1.794LeuHis: 1.794 ± 0.043	4.867LeuIle: 4.867 ± 0.078	3.997LeuLys: 3.997 ± 0.064	10.962LeuLeu: 10.962 ± 0.168	2.78LeuMet: 2.78 ± 0.053	2.881LeuAsn: 2.881 ± 0.051	5.013LeuPro: 5.013 ± 0.09	2.753LeuGln: 2.753 ± 0.05	6.436LeuArg: 6.436 ± 0.102	7.264LeuSer: 7.264 ± 0.097	6.254LeuThr: 6.254 ± 0.092	6.442LeuVal: 6.442 ± 0.091	1.094LeuTrp: 1.094 ± 0.038	3.245LeuTyr: 3.245 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.813MetAla: 2.813 ± 0.052	0.363MetCys: 0.363 ± 0.021	1.822MetAsp: 1.822 ± 0.041	2.285MetGlu: 2.285 ± 0.057	0.785MetPhe: 0.785 ± 0.032	2.354MetGly: 2.354 ± 0.051	0.365MetHis: 0.365 ± 0.018	1.281MetIle: 1.281 ± 0.032	1.6MetLys: 1.6 ± 0.034	2.664MetLeu: 2.664 ± 0.055	0.733MetMet: 0.733 ± 0.032	1.023MetAsn: 1.023 ± 0.03	1.182MetPro: 1.182 ± 0.036	0.774MetGln: 0.774 ± 0.029	1.475MetArg: 1.475 ± 0.033	1.614MetSer: 1.614 ± 0.038	1.651MetThr: 1.651 ± 0.044	1.944MetVal: 1.944 ± 0.047	0.201MetTrp: 0.201 ± 0.012	0.64MetTyr: 0.64 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.951AsnAla: 2.951 ± 0.061	0.486AsnCys: 0.486 ± 0.023	1.46AsnAsp: 1.46 ± 0.042	1.643AsnGlu: 1.643 ± 0.045	1.101AsnPhe: 1.101 ± 0.037	2.873AsnGly: 2.873 ± 0.061	0.571AsnHis: 0.571 ± 0.03	1.893AsnIle: 1.893 ± 0.046	1.167AsnLys: 1.167 ± 0.038	2.921AsnLeu: 2.921 ± 0.061	0.87AsnMet: 0.87 ± 0.03	0.865AsnAsn: 0.865 ± 0.037	1.734AsnPro: 1.734 ± 0.047	0.953AsnGln: 0.953 ± 0.036	1.768AsnArg: 1.768 ± 0.045	1.481AsnSer: 1.481 ± 0.044	1.675AsnThr: 1.675 ± 0.049	2.133AsnVal: 2.133 ± 0.046	0.375AsnTrp: 0.375 ± 0.022	1.156AsnTyr: 1.156 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	4.736ProAla: 4.736 ± 0.085	0.627ProCys: 0.627 ± 0.029	2.918ProAsp: 2.918 ± 0.059	4.147ProGlu: 4.147 ± 0.062	1.639ProPhe: 1.639 ± 0.044	3.745ProGly: 3.745 ± 0.064	0.758ProHis: 0.758 ± 0.027	2.105ProIle: 2.105 ± 0.046	1.616ProLys: 1.616 ± 0.046	3.927ProLeu: 3.927 ± 0.076	1.149ProMet: 1.149 ± 0.036	1.194ProAsn: 1.194 ± 0.037	1.743ProPro: 1.743 ± 0.054	1.39ProGln: 1.39 ± 0.036	2.06ProArg: 2.06 ± 0.05	2.243ProSer: 2.243 ± 0.049	2.176ProThr: 2.176 ± 0.062	3.709ProVal: 3.709 ± 0.058	0.511ProTrp: 0.511 ± 0.027	1.489ProTyr: 1.489 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	3.253GlnAla: 3.253 ± 0.058	0.423GlnCys: 0.423 ± 0.024	1.464GlnAsp: 1.464 ± 0.038	2.181GlnGlu: 2.181 ± 0.056	1.062GlnPhe: 1.062 ± 0.033	2.341GlnGly: 2.341 ± 0.048	0.505GlnHis: 0.505 ± 0.022	1.774GlnIle: 1.774 ± 0.043	1.793GlnLys: 1.793 ± 0.046	2.75GlnLeu: 2.75 ± 0.047	1.006GlnMet: 1.006 ± 0.032	1.25GlnAsn: 1.25 ± 0.042	1.194GlnPro: 1.194 ± 0.037	1.066GlnGln: 1.066 ± 0.042	2.059GlnArg: 2.059 ± 0.051	1.782GlnSer: 1.782 ± 0.045	1.764GlnThr: 1.764 ± 0.049	2.354GlnVal: 2.354 ± 0.052	0.385GlnTrp: 0.385 ± 0.022	1.163GlnTyr: 1.163 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	5.522ArgAla: 5.522 ± 0.096	0.918ArgCys: 0.918 ± 0.033	3.177ArgAsp: 3.177 ± 0.057	4.929ArgGlu: 4.929 ± 0.093	2.39ArgPhe: 2.39 ± 0.062	4.179ArgGly: 4.179 ± 0.077	1.077ArgHis: 1.077 ± 0.033	3.236ArgIle: 3.236 ± 0.062	2.878ArgLys: 2.878 ± 0.063	6.346ArgLeu: 6.346 ± 0.094	1.77ArgMet: 1.77 ± 0.041	1.816ArgAsn: 1.816 ± 0.047	2.62ArgPro: 2.62 ± 0.062	2.173ArgGln: 2.173 ± 0.061	4.775ArgArg: 4.775 ± 0.103	2.943ArgSer: 2.943 ± 0.05	3.229ArgThr: 3.229 ± 0.063	3.999ArgVal: 3.999 ± 0.067	0.681ArgTrp: 0.681 ± 0.03	2.303ArgTyr: 2.303 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.726SerAla: 5.726 ± 0.086	0.809SerCys: 0.809 ± 0.03	2.952SerAsp: 2.952 ± 0.06	3.032SerGlu: 3.032 ± 0.054	2.397SerPhe: 2.397 ± 0.055	5.634SerGly: 5.634 ± 0.094	1.05SerHis: 1.05 ± 0.028	3.049SerIle: 3.049 ± 0.059	2.071SerLys: 2.071 ± 0.049	5.585SerLeu: 5.585 ± 0.078	1.594SerMet: 1.594 ± 0.042	1.563SerAsn: 1.563 ± 0.044	2.397SerPro: 2.397 ± 0.052	1.618SerGln: 1.618 ± 0.039	3.325SerArg: 3.325 ± 0.059	3.17SerSer: 3.17 ± 0.075	2.876SerThr: 2.876 ± 0.061	4.164SerVal: 4.164 ± 0.084	0.599SerTrp: 0.599 ± 0.024	1.995SerTyr: 1.995 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	6.021ThrAla: 6.021 ± 0.097	0.78ThrCys: 0.78 ± 0.032	3.003ThrAsp: 3.003 ± 0.069	3.361ThrGlu: 3.361 ± 0.063	2.162ThrPhe: 2.162 ± 0.054	5.316ThrGly: 5.316 ± 0.087	0.954ThrHis: 0.954 ± 0.04	2.984ThrIle: 2.984 ± 0.061	1.841ThrLys: 1.841 ± 0.051	5.698ThrLeu: 5.698 ± 0.083	1.429ThrMet: 1.429 ± 0.04	1.462ThrAsn: 1.462 ± 0.046	3.127ThrPro: 3.127 ± 0.062	1.506ThrGln: 1.506 ± 0.036	2.73ThrArg: 2.73 ± 0.043	2.728ThrSer: 2.728 ± 0.069	2.871ThrThr: 2.871 ± 0.062	5.265ThrVal: 5.265 ± 0.098	0.62ThrTrp: 0.62 ± 0.032	1.796ThrTyr: 1.796 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	6.201ValAla: 6.201 ± 0.087	1.481ValCys: 1.481 ± 0.039	4.147ValAsp: 4.147 ± 0.067	4.913ValGlu: 4.913 ± 0.081	2.866ValPhe: 2.866 ± 0.058	5.236ValGly: 5.236 ± 0.09	1.176ValHis: 1.176 ± 0.034	4.058ValIle: 4.058 ± 0.067	3.228ValLys: 3.228 ± 0.055	7.981ValLeu: 7.981 ± 0.108	1.946ValMet: 1.946 ± 0.043	2.284ValAsn: 2.284 ± 0.055	3.363ValPro: 3.363 ± 0.058	1.959ValGln: 1.959 ± 0.041	4.184ValArg: 4.184 ± 0.068	4.802ValSer: 4.802 ± 0.069	4.711ValThr: 4.711 ± 0.088	5.543ValVal: 5.543 ± 0.093	0.775ValTrp: 0.775 ± 0.029	2.393ValTyr: 2.393 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.958TrpAla: 0.958 ± 0.037	0.2TrpCys: 0.2 ± 0.015	0.588TrpAsp: 0.588 ± 0.027	0.746TrpGlu: 0.746 ± 0.027	0.473TrpPhe: 0.473 ± 0.026	0.903TrpGly: 0.903 ± 0.035	0.208TrpHis: 0.208 ± 0.014	0.451TrpIle: 0.451 ± 0.023	0.511TrpLys: 0.511 ± 0.025	1.131TrpLeu: 1.131 ± 0.036	0.3TrpMet: 0.3 ± 0.02	0.427TrpAsn: 0.427 ± 0.024	0.359TrpPro: 0.359 ± 0.019	0.4TrpGln: 0.4 ± 0.02	0.714TrpArg: 0.714 ± 0.028	0.675TrpSer: 0.675 ± 0.03	0.608TrpThr: 0.608 ± 0.029	0.638TrpVal: 0.638 ± 0.027	0.123TrpTrp: 0.123 ± 0.014	0.438TrpTyr: 0.438 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.091TyrAla: 3.091 ± 0.061	0.568TyrCys: 0.568 ± 0.026	2.317TyrAsp: 2.317 ± 0.056	2.15TyrGlu: 2.15 ± 0.049	1.443TyrPhe: 1.443 ± 0.04	2.893TyrGly: 2.893 ± 0.052	0.68TyrHis: 0.68 ± 0.023	1.799TyrIle: 1.799 ± 0.043	1.12TyrLys: 1.12 ± 0.036	3.51TyrLeu: 3.51 ± 0.071	0.725TyrMet: 0.725 ± 0.029	1.142TyrAsn: 1.142 ± 0.038	1.495TyrPro: 1.495 ± 0.04	1.326TyrGln: 1.326 ± 0.041	2.221TyrArg: 2.221 ± 0.048	1.796TyrSer: 1.796 ± 0.04	2.141TyrThr: 2.141 ± 0.058	2.209TyrVal: 2.209 ± 0.046	0.364TyrTrp: 0.364 ± 0.021	1.397TyrTyr: 1.397 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3358 proteins (986929 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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