Amino acid dipepetide frequency for Velvet bean severe mosaic virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.448AlaAla: 3.448 ± 0.999
1.724AlaCys: 1.724 ± 1.109
1.149AlaAsp: 1.149 ± 0.62
2.874AlaGlu: 2.874 ± 1.775
1.724AlaPhe: 1.724 ± 0.651
1.149AlaGly: 1.149 ± 0.66
0.575AlaHis: 0.575 ± 0.461
2.874AlaIle: 2.874 ± 1.259
4.023AlaLys: 4.023 ± 1.179
5.747AlaLeu: 5.747 ± 1.837
0.575AlaMet: 0.575 ± 0.461
3.448AlaAsn: 3.448 ± 1.254
1.149AlaPro: 1.149 ± 0.546
3.448AlaGln: 3.448 ± 1.313
2.874AlaArg: 2.874 ± 1.046
3.448AlaSer: 3.448 ± 1.255
7.471AlaThr: 7.471 ± 1.475
1.149AlaVal: 1.149 ± 0.837
0.575AlaTrp: 0.575 ± 0.457
1.149AlaTyr: 1.149 ± 0.589
0.0AlaXaa: 0.0 ± 0.0
Cys
1.149CysAla: 1.149 ± 1.239
0.575CysCys: 0.575 ± 0.603
1.149CysAsp: 1.149 ± 0.62
1.724CysGlu: 1.724 ± 0.651
0.575CysPhe: 0.575 ± 0.755
1.149CysGly: 1.149 ± 0.723
0.0CysHis: 0.0 ± 0.0
1.724CysIle: 1.724 ± 1.109
1.149CysLys: 1.149 ± 0.923
0.575CysLeu: 0.575 ± 0.573
1.149CysMet: 1.149 ± 0.784
2.874CysAsn: 2.874 ± 1.098
0.575CysPro: 0.575 ± 0.581
0.575CysGln: 0.575 ± 0.581
1.724CysArg: 1.724 ± 0.896
2.874CysSer: 2.874 ± 1.329
1.724CysThr: 1.724 ± 0.933
0.575CysVal: 0.575 ± 0.573
0.0CysTrp: 0.0 ± 0.0
0.575CysTyr: 0.575 ± 0.595
0.0CysXaa: 0.0 ± 0.0
Asp
1.724AspAla: 1.724 ± 1.372
0.575AspCys: 0.575 ± 0.603
2.299AspAsp: 2.299 ± 1.105
2.299AspGlu: 2.299 ± 0.753
4.598AspPhe: 4.598 ± 1.678
2.874AspGly: 2.874 ± 1.49
1.724AspHis: 1.724 ± 0.755
2.299AspIle: 2.299 ± 0.937
2.299AspLys: 2.299 ± 0.99
2.874AspLeu: 2.874 ± 0.894
0.0AspMet: 0.0 ± 0.0
4.023AspAsn: 4.023 ± 0.83
2.299AspPro: 2.299 ± 0.711
0.575AspGln: 0.575 ± 0.495
2.299AspArg: 2.299 ± 1.26
4.598AspSer: 4.598 ± 0.872
2.874AspThr: 2.874 ± 1.771
5.747AspVal: 5.747 ± 1.678
0.575AspTrp: 0.575 ± 0.457
1.724AspTyr: 1.724 ± 0.806
0.0AspXaa: 0.0 ± 0.0
Glu
4.598GluAla: 4.598 ± 1.422
0.575GluCys: 0.575 ± 0.573
1.724GluAsp: 1.724 ± 0.755
4.598GluGlu: 4.598 ± 1.171
2.299GluPhe: 2.299 ± 1.829
1.724GluGly: 1.724 ± 0.896
1.724GluHis: 1.724 ± 1.033
2.874GluIle: 2.874 ± 1.884
2.299GluLys: 2.299 ± 0.962
5.172GluLeu: 5.172 ± 1.604
0.0GluMet: 0.0 ± 0.0
3.448GluAsn: 3.448 ± 1.873
1.724GluPro: 1.724 ± 0.612
2.874GluGln: 2.874 ± 1.028
1.724GluArg: 1.724 ± 0.931
5.747GluSer: 5.747 ± 1.282
2.874GluThr: 2.874 ± 2.182
1.724GluVal: 1.724 ± 1.177
1.149GluTrp: 1.149 ± 0.808
1.724GluTyr: 1.724 ± 1.245
0.0GluXaa: 0.0 ± 0.0
Phe
0.575PheAla: 0.575 ± 0.573
1.149PheCys: 1.149 ± 0.837
3.448PheAsp: 3.448 ± 1.688
2.874PheGlu: 2.874 ± 0.853
1.724PhePhe: 1.724 ± 0.961
2.874PheGly: 2.874 ± 1.351
1.149PheHis: 1.149 ± 0.686
2.874PheIle: 2.874 ± 1.58
4.023PheLys: 4.023 ± 0.77
4.598PheLeu: 4.598 ± 1.542
1.724PheMet: 1.724 ± 0.98
3.448PheAsn: 3.448 ± 1.076
2.299PhePro: 2.299 ± 1.773
2.299PheGln: 2.299 ± 1.157
4.023PheArg: 4.023 ± 1.473
2.299PheSer: 2.299 ± 1.071
2.299PheThr: 2.299 ± 1.222
1.724PheVal: 1.724 ± 1.486
1.149PheTrp: 1.149 ± 0.725
2.299PheTyr: 2.299 ± 1.018
0.0PheXaa: 0.0 ± 0.0
Gly
2.874GlyAla: 2.874 ± 1.49
2.299GlyCys: 2.299 ± 0.937
3.448GlyAsp: 3.448 ± 1.254
2.299GlyGlu: 2.299 ± 0.87
2.874GlyPhe: 2.874 ± 1.579
2.299GlyGly: 2.299 ± 0.878
0.575GlyHis: 0.575 ± 0.457
2.299GlyIle: 2.299 ± 0.928
5.747GlyLys: 5.747 ± 1.631
1.724GlyLeu: 1.724 ± 0.855
1.149GlyMet: 1.149 ± 0.732
2.299GlyAsn: 2.299 ± 0.91
1.724GlyPro: 1.724 ± 0.896
2.299GlyGln: 2.299 ± 1.162
2.874GlyArg: 2.874 ± 1.316
1.149GlySer: 1.149 ± 0.951
3.448GlyThr: 3.448 ± 1.31
3.448GlyVal: 3.448 ± 1.203
0.0GlyTrp: 0.0 ± 0.0
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
1.724HisAla: 1.724 ± 0.723
0.575HisCys: 0.575 ± 0.62
0.575HisAsp: 0.575 ± 0.461
0.575HisGlu: 0.575 ± 0.457
1.149HisPhe: 1.149 ± 0.915
2.874HisGly: 2.874 ± 1.316
1.724HisHis: 1.724 ± 0.959
1.149HisIle: 1.149 ± 0.963
0.575HisLys: 0.575 ± 0.595
2.299HisLeu: 2.299 ± 0.968
1.149HisMet: 1.149 ± 0.817
1.724HisAsn: 1.724 ± 1.002
1.149HisPro: 1.149 ± 0.642
1.724HisGln: 1.724 ± 0.853
2.299HisArg: 2.299 ± 1.35
1.149HisSer: 1.149 ± 0.725
1.724HisThr: 1.724 ± 1.384
2.874HisVal: 2.874 ± 0.769
0.0HisTrp: 0.0 ± 0.0
2.299HisTyr: 2.299 ± 1.172
0.0HisXaa: 0.0 ± 0.0
Ile
2.299IleAla: 2.299 ± 0.753
1.149IleCys: 1.149 ± 0.546
2.299IleAsp: 2.299 ± 0.99
4.598IleGlu: 4.598 ± 2.079
2.874IlePhe: 2.874 ± 1.345
1.149IleGly: 1.149 ± 0.62
1.724IleHis: 1.724 ± 1.808
3.448IleIle: 3.448 ± 1.189
6.322IleLys: 6.322 ± 1.764
5.747IleLeu: 5.747 ± 1.96
1.724IleMet: 1.724 ± 1.227
4.598IleAsn: 4.598 ± 1.309
1.149IlePro: 1.149 ± 0.915
2.299IleGln: 2.299 ± 1.182
4.023IleArg: 4.023 ± 1.141
6.322IleSer: 6.322 ± 1.552
2.874IleThr: 2.874 ± 1.243
2.874IleVal: 2.874 ± 1.345
0.0IleTrp: 0.0 ± 0.0
1.149IleTyr: 1.149 ± 0.749
0.0IleXaa: 0.0 ± 0.0
Lys
2.874LysAla: 2.874 ± 1.458
1.724LysCys: 1.724 ± 1.18
4.023LysAsp: 4.023 ± 1.355
5.747LysGlu: 5.747 ± 1.912
2.874LysPhe: 2.874 ± 0.995
1.149LysGly: 1.149 ± 0.915
2.874LysHis: 2.874 ± 1.063
4.023LysIle: 4.023 ± 1.399
2.874LysLys: 2.874 ± 0.846
5.747LysLeu: 5.747 ± 1.804
1.724LysMet: 1.724 ± 0.858
4.598LysAsn: 4.598 ± 1.334
4.023LysPro: 4.023 ± 1.371
2.299LysGln: 2.299 ± 1.151
2.874LysArg: 2.874 ± 1.287
4.598LysSer: 4.598 ± 1.173
1.149LysThr: 1.149 ± 0.84
4.023LysVal: 4.023 ± 1.262
0.0LysTrp: 0.0 ± 0.0
2.874LysTyr: 2.874 ± 1.151
0.0LysXaa: 0.0 ± 0.0
Leu
1.149LeuAla: 1.149 ± 0.66
3.448LeuCys: 3.448 ± 0.909
5.172LeuAsp: 5.172 ± 1.227
2.299LeuGlu: 2.299 ± 1.126
3.448LeuPhe: 3.448 ± 1.785
3.448LeuGly: 3.448 ± 0.811
2.874LeuHis: 2.874 ± 1.572
3.448LeuIle: 3.448 ± 1.258
4.598LeuLys: 4.598 ± 2.057
6.897LeuLeu: 6.897 ± 1.956
1.149LeuMet: 1.149 ± 1.186
5.172LeuAsn: 5.172 ± 1.909
4.598LeuPro: 4.598 ± 1.901
3.448LeuGln: 3.448 ± 1.007
6.322LeuArg: 6.322 ± 3.065
8.621LeuSer: 8.621 ± 2.133
3.448LeuThr: 3.448 ± 1.474
3.448LeuVal: 3.448 ± 2.045
1.149LeuTrp: 1.149 ± 0.589
3.448LeuTyr: 3.448 ± 1.352
0.0LeuXaa: 0.0 ± 0.0
Met
2.299MetAla: 2.299 ± 0.893
0.0MetCys: 0.0 ± 0.0
3.448MetAsp: 3.448 ± 1.076
1.149MetGlu: 1.149 ± 0.84
1.149MetPhe: 1.149 ± 0.842
1.724MetGly: 1.724 ± 0.851
1.149MetHis: 1.149 ± 0.91
2.299MetIle: 2.299 ± 1.425
1.724MetLys: 1.724 ± 0.858
1.724MetLeu: 1.724 ± 0.858
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
1.724MetPro: 1.724 ± 1.526
1.149MetGln: 1.149 ± 0.887
2.299MetArg: 2.299 ± 0.879
0.575MetSer: 0.575 ± 0.495
0.0MetThr: 0.0 ± 0.0
1.724MetVal: 1.724 ± 0.83
1.149MetTrp: 1.149 ± 0.755
0.575MetTyr: 0.575 ± 0.461
0.0MetXaa: 0.0 ± 0.0
Asn
7.471AsnAla: 7.471 ± 2.213
0.575AsnCys: 0.575 ± 0.495
4.023AsnAsp: 4.023 ± 0.722
1.724AsnGlu: 1.724 ± 0.841
2.299AsnPhe: 2.299 ± 0.983
2.874AsnGly: 2.874 ± 1.151
4.023AsnHis: 4.023 ± 2.033
4.023AsnIle: 4.023 ± 2.364
2.299AsnLys: 2.299 ± 1.071
4.023AsnLeu: 4.023 ± 1.828
2.299AsnMet: 2.299 ± 0.896
2.299AsnAsn: 2.299 ± 1.239
4.023AsnPro: 4.023 ± 1.46
3.448AsnGln: 3.448 ± 1.61
2.299AsnArg: 2.299 ± 0.953
5.172AsnSer: 5.172 ± 1.54
3.448AsnThr: 3.448 ± 1.147
5.172AsnVal: 5.172 ± 1.758
0.575AsnTrp: 0.575 ± 0.495
5.172AsnTyr: 5.172 ± 1.171
0.0AsnXaa: 0.0 ± 0.0
Pro
1.724ProAla: 1.724 ± 0.987
0.575ProCys: 0.575 ± 0.461
1.149ProAsp: 1.149 ± 0.63
2.874ProGlu: 2.874 ± 0.971
2.299ProPhe: 2.299 ± 0.53
2.299ProGly: 2.299 ± 1.251
1.724ProHis: 1.724 ± 1.372
3.448ProIle: 3.448 ± 1.636
5.747ProLys: 5.747 ± 2.017
5.172ProLeu: 5.172 ± 1.745
2.299ProMet: 2.299 ± 1.406
2.299ProAsn: 2.299 ± 0.805
1.724ProPro: 1.724 ± 0.737
0.575ProGln: 0.575 ± 0.62
3.448ProArg: 3.448 ± 0.88
3.448ProSer: 3.448 ± 1.076
2.874ProThr: 2.874 ± 1.24
2.874ProVal: 2.874 ± 1.187
0.575ProTrp: 0.575 ± 0.573
0.575ProTyr: 0.575 ± 0.495
0.0ProXaa: 0.0 ± 0.0
Gln
1.724GlnAla: 1.724 ± 0.858
1.149GlnCys: 1.149 ± 0.642
1.724GlnAsp: 1.724 ± 1.086
1.724GlnGlu: 1.724 ± 0.983
1.724GlnPhe: 1.724 ± 0.604
2.874GlnGly: 2.874 ± 1.394
1.149GlnHis: 1.149 ± 0.963
2.299GlnIle: 2.299 ± 1.291
1.149GlnLys: 1.149 ± 1.146
2.874GlnLeu: 2.874 ± 1.401
0.575GlnMet: 0.575 ± 0.595
2.299GlnAsn: 2.299 ± 1.05
2.299GlnPro: 2.299 ± 0.674
0.575GlnGln: 0.575 ± 0.595
2.299GlnArg: 2.299 ± 1.07
4.023GlnSer: 4.023 ± 1.503
1.724GlnThr: 1.724 ± 0.851
4.598GlnVal: 4.598 ± 1.419
0.0GlnTrp: 0.0 ± 0.0
2.299GlnTyr: 2.299 ± 1.233
0.0GlnXaa: 0.0 ± 0.0
Arg
2.299ArgAla: 2.299 ± 1.187
3.448ArgCys: 3.448 ± 1.217
3.448ArgAsp: 3.448 ± 1.226
1.724ArgGlu: 1.724 ± 1.123
5.747ArgPhe: 5.747 ± 1.825
2.874ArgGly: 2.874 ± 1.017
1.724ArgHis: 1.724 ± 1.266
3.448ArgIle: 3.448 ± 1.987
4.023ArgLys: 4.023 ± 1.054
5.172ArgLeu: 5.172 ± 1.86
2.299ArgMet: 2.299 ± 1.902
5.747ArgAsn: 5.747 ± 1.176
4.023ArgPro: 4.023 ± 1.05
1.149ArgGln: 1.149 ± 0.62
10.345ArgArg: 10.345 ± 4.015
5.172ArgSer: 5.172 ± 1.489
2.874ArgThr: 2.874 ± 1.225
2.874ArgVal: 2.874 ± 1.145
0.575ArgTrp: 0.575 ± 0.461
2.299ArgTyr: 2.299 ± 0.753
0.0ArgXaa: 0.0 ± 0.0
Ser
4.023SerAla: 4.023 ± 1.034
0.575SerCys: 0.575 ± 0.62
2.299SerAsp: 2.299 ± 0.767
2.874SerGlu: 2.874 ± 0.756
3.448SerPhe: 3.448 ± 0.947
3.448SerGly: 3.448 ± 1.907
0.575SerHis: 0.575 ± 0.595
5.747SerIle: 5.747 ± 1.41
4.598SerLys: 4.598 ± 1.305
5.747SerLeu: 5.747 ± 1.699
2.299SerMet: 2.299 ± 0.936
6.897SerAsn: 6.897 ± 1.335
4.023SerPro: 4.023 ± 1.161
2.299SerGln: 2.299 ± 1.761
7.471SerArg: 7.471 ± 1.453
12.644SerSer: 12.644 ± 3.155
8.621SerThr: 8.621 ± 1.794
5.172SerVal: 5.172 ± 1.629
0.575SerTrp: 0.575 ± 0.457
2.299SerTyr: 2.299 ± 1.178
0.0SerXaa: 0.0 ± 0.0
Thr
2.874ThrAla: 2.874 ± 1.162
2.299ThrCys: 2.299 ± 1.381
0.575ThrAsp: 0.575 ± 0.573
2.874ThrGlu: 2.874 ± 1.188
2.299ThrPhe: 2.299 ± 1.285
4.023ThrGly: 4.023 ± 1.443
2.874ThrHis: 2.874 ± 1.168
3.448ThrIle: 3.448 ± 0.871
2.299ThrLys: 2.299 ± 1.282
2.874ThrLeu: 2.874 ± 1.211
1.149ThrMet: 1.149 ± 0.756
4.598ThrAsn: 4.598 ± 1.046
4.023ThrPro: 4.023 ± 1.172
2.874ThrGln: 2.874 ± 1.512
2.874ThrArg: 2.874 ± 0.933
5.172ThrSer: 5.172 ± 1.222
2.299ThrThr: 2.299 ± 1.119
4.023ThrVal: 4.023 ± 1.855
2.299ThrTrp: 2.299 ± 0.91
2.874ThrTyr: 2.874 ± 1.707
0.0ThrXaa: 0.0 ± 0.0
Val
1.149ValAla: 1.149 ± 0.62
0.0ValCys: 0.0 ± 0.0
2.874ValAsp: 2.874 ± 1.16
4.023ValGlu: 4.023 ± 1.961
2.299ValPhe: 2.299 ± 1.366
2.299ValGly: 2.299 ± 0.942
0.575ValHis: 0.575 ± 0.495
4.598ValIle: 4.598 ± 1.021
4.023ValLys: 4.023 ± 1.804
5.172ValLeu: 5.172 ± 1.481
0.0ValMet: 0.0 ± 0.0
5.747ValAsn: 5.747 ± 1.633
2.874ValPro: 2.874 ± 0.745
2.874ValGln: 2.874 ± 1.323
3.448ValArg: 3.448 ± 0.858
4.598ValSer: 4.598 ± 1.886
4.023ValThr: 4.023 ± 1.494
4.023ValVal: 4.023 ± 2.131
0.575ValTrp: 0.575 ± 0.461
5.172ValTyr: 5.172 ± 1.385
0.0ValXaa: 0.0 ± 0.0
Trp
2.299TrpAla: 2.299 ± 1.359
0.0TrpCys: 0.0 ± 0.0
1.149TrpAsp: 1.149 ± 0.82
0.575TrpGlu: 0.575 ± 0.595
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.575TrpMet: 0.575 ± 0.461
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.149TrpGln: 1.149 ± 0.645
2.299TrpArg: 2.299 ± 1.068
1.724TrpSer: 1.724 ± 0.855
0.575TrpThr: 0.575 ± 0.461
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.575TrpTyr: 0.575 ± 0.457
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.299TyrAla: 2.299 ± 0.91
0.0TyrCys: 0.0 ± 0.0
2.299TyrAsp: 2.299 ± 1.488
1.149TyrGlu: 1.149 ± 0.63
3.448TyrPhe: 3.448 ± 1.295
1.724TyrGly: 1.724 ± 0.79
0.575TyrHis: 0.575 ± 0.457
2.299TyrIle: 2.299 ± 0.706
2.299TyrLys: 2.299 ± 1.126
4.023TyrLeu: 4.023 ± 1.494
3.448TyrMet: 3.448 ± 1.651
1.724TyrAsn: 1.724 ± 0.735
2.299TyrPro: 2.299 ± 0.835
1.149TyrGln: 1.149 ± 0.546
3.448TyrArg: 3.448 ± 1.271
2.299TyrSer: 2.299 ± 0.874
2.299TyrThr: 2.299 ± 0.64
2.299TyrVal: 2.299 ± 1.447
0.0TyrTrp: 0.0 ± 0.0
1.149TyrTyr: 1.149 ± 0.723
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (1741 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski