Amino acid dipepetide frequency for Brevibacillus laterosporus LMG 15441

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.211AlaAla: 5.211 ± 0.087	0.756AlaCys: 0.756 ± 0.028	3.607AlaAsp: 3.607 ± 0.051	4.891AlaGlu: 4.891 ± 0.065	3.183AlaPhe: 3.183 ± 0.055	5.227AlaGly: 5.227 ± 0.071	1.434AlaHis: 1.434 ± 0.033	5.69AlaIle: 5.69 ± 0.063	4.83AlaLys: 4.83 ± 0.071	7.375AlaLeu: 7.375 ± 0.081	2.174AlaMet: 2.174 ± 0.042	2.865AlaAsn: 2.865 ± 0.047	2.363AlaPro: 2.363 ± 0.049	2.764AlaGln: 2.764 ± 0.046	3.084AlaArg: 3.084 ± 0.047	4.482AlaSer: 4.482 ± 0.066	4.296AlaThr: 4.296 ± 0.093	5.178AlaVal: 5.178 ± 0.063	0.685AlaTrp: 0.685 ± 0.021	2.709AlaTyr: 2.709 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.511CysAla: 0.511 ± 0.022	0.116CysCys: 0.116 ± 0.01	0.382CysAsp: 0.382 ± 0.019	0.492CysGlu: 0.492 ± 0.018	0.398CysPhe: 0.398 ± 0.019	0.705CysGly: 0.705 ± 0.024	0.212CysHis: 0.212 ± 0.013	0.601CysIle: 0.601 ± 0.022	0.503CysLys: 0.503 ± 0.021	0.837CysLeu: 0.837 ± 0.027	0.263CysMet: 0.263 ± 0.013	0.323CysAsn: 0.323 ± 0.015	0.37CysPro: 0.37 ± 0.021	0.321CysGln: 0.321 ± 0.016	0.383CysArg: 0.383 ± 0.02	0.572CysSer: 0.572 ± 0.024	0.45CysThr: 0.45 ± 0.018	0.517CysVal: 0.517 ± 0.019	0.091CysTrp: 0.091 ± 0.008	0.329CysTyr: 0.329 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.167AspAla: 3.167 ± 0.054	0.381AspCys: 0.381 ± 0.017	2.197AspAsp: 2.197 ± 0.054	3.734AspGlu: 3.734 ± 0.059	2.206AspPhe: 2.206 ± 0.032	3.169AspGly: 3.169 ± 0.056	1.214AspHis: 1.214 ± 0.029	3.75AspIle: 3.75 ± 0.058	3.222AspLys: 3.222 ± 0.052	4.794AspLeu: 4.794 ± 0.071	1.42AspMet: 1.42 ± 0.033	1.678AspAsn: 1.678 ± 0.034	2.02AspPro: 2.02 ± 0.037	2.357AspGln: 2.357 ± 0.05	2.466AspArg: 2.466 ± 0.05	2.724AspSer: 2.724 ± 0.046	2.472AspThr: 2.472 ± 0.042	3.627AspVal: 3.627 ± 0.055	0.617AspTrp: 0.617 ± 0.022	1.935AspTyr: 1.935 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.583GluAla: 5.583 ± 0.075	0.48GluCys: 0.48 ± 0.019	3.151GluAsp: 3.151 ± 0.054	6.201GluGlu: 6.201 ± 0.092	2.234GluPhe: 2.234 ± 0.044	4.097GluGly: 4.097 ± 0.067	1.596GluHis: 1.596 ± 0.039	5.237GluIle: 5.237 ± 0.065	5.595GluLys: 5.595 ± 0.073	7.261GluLeu: 7.261 ± 0.086	2.277GluMet: 2.277 ± 0.035	2.922GluAsn: 2.922 ± 0.051	2.012GluPro: 2.012 ± 0.043	4.259GluGln: 4.259 ± 0.086	3.745GluArg: 3.745 ± 0.05	3.388GluSer: 3.388 ± 0.055	3.529GluThr: 3.529 ± 0.059	4.711GluVal: 4.711 ± 0.055	0.92GluTrp: 0.92 ± 0.024	2.271GluTyr: 2.271 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.03PheAla: 3.03 ± 0.05	0.415PheCys: 0.415 ± 0.017	2.219PheAsp: 2.219 ± 0.052	2.656PheGlu: 2.656 ± 0.061	2.106PhePhe: 2.106 ± 0.049	2.968PheGly: 2.968 ± 0.056	1.063PheHis: 1.063 ± 0.027	3.239PheIle: 3.239 ± 0.047	1.787PheLys: 1.787 ± 0.041	4.349PheLeu: 4.349 ± 0.083	1.089PheMet: 1.089 ± 0.031	1.443PheAsn: 1.443 ± 0.034	1.603PhePro: 1.603 ± 0.037	1.674PheGln: 1.674 ± 0.037	1.598PheArg: 1.598 ± 0.034	2.985PheSer: 2.985 ± 0.054	2.696PheThr: 2.696 ± 0.047	3.001PheVal: 3.001 ± 0.051	0.489PheTrp: 0.489 ± 0.019	1.566PheTyr: 1.566 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.824GlyAla: 4.824 ± 0.095	0.659GlyCys: 0.659 ± 0.022	3.147GlyAsp: 3.147 ± 0.058	4.319GlyGlu: 4.319 ± 0.067	3.121GlyPhe: 3.121 ± 0.055	4.535GlyGly: 4.535 ± 0.066	1.408GlyHis: 1.408 ± 0.029	5.637GlyIle: 5.637 ± 0.086	4.811GlyLys: 4.811 ± 0.07	6.312GlyLeu: 6.312 ± 0.074	2.126GlyMet: 2.126 ± 0.039	2.57GlyAsn: 2.57 ± 0.052	1.737GlyPro: 1.737 ± 0.07	2.424GlyGln: 2.424 ± 0.047	2.86GlyArg: 2.86 ± 0.05	3.843GlySer: 3.843 ± 0.06	4.012GlyThr: 4.012 ± 0.073	5.174GlyVal: 5.174 ± 0.064	0.836GlyTrp: 0.836 ± 0.023	2.681GlyTyr: 2.681 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.51HisAla: 1.51 ± 0.033	0.23HisCys: 0.23 ± 0.013	1.079HisAsp: 1.079 ± 0.028	1.455HisGlu: 1.455 ± 0.03	1.096HisPhe: 1.096 ± 0.028	1.359HisGly: 1.359 ± 0.032	0.718HisHis: 0.718 ± 0.029	1.672HisIle: 1.672 ± 0.035	1.141HisLys: 1.141 ± 0.028	2.399HisLeu: 2.399 ± 0.04	0.619HisMet: 0.619 ± 0.021	0.793HisAsn: 0.793 ± 0.025	1.218HisPro: 1.218 ± 0.028	1.103HisGln: 1.103 ± 0.036	1.056HisArg: 1.056 ± 0.031	1.433HisSer: 1.433 ± 0.031	1.171HisThr: 1.171 ± 0.03	1.697HisVal: 1.697 ± 0.037	0.231HisTrp: 0.231 ± 0.013	0.911HisTyr: 0.911 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.058IleAla: 6.058 ± 0.079	0.756IleCys: 0.756 ± 0.025	3.883IleAsp: 3.883 ± 0.054	5.032IleGlu: 5.032 ± 0.077	2.806IlePhe: 2.806 ± 0.055	5.455IleGly: 5.455 ± 0.082	1.688IleHis: 1.688 ± 0.034	4.706IleIle: 4.706 ± 0.078	3.834IleLys: 3.834 ± 0.062	6.752IleLeu: 6.752 ± 0.09	1.869IleMet: 1.869 ± 0.038	2.818IleAsn: 2.818 ± 0.048	3.334IlePro: 3.334 ± 0.049	3.007IleGln: 3.007 ± 0.054	3.367IleArg: 3.367 ± 0.051	5.007IleSer: 5.007 ± 0.068	4.478IleThr: 4.478 ± 0.074	5.151IleVal: 5.151 ± 0.059	0.716IleTrp: 0.716 ± 0.023	2.346IleTyr: 2.346 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.734LysAla: 4.734 ± 0.062	0.351LysCys: 0.351 ± 0.016	3.226LysAsp: 3.226 ± 0.055	5.893LysGlu: 5.893 ± 0.077	1.506LysPhe: 1.506 ± 0.037	4.063LysGly: 4.063 ± 0.061	1.353LysHis: 1.353 ± 0.028	4.054LysIle: 4.054 ± 0.054	4.968LysLys: 4.968 ± 0.094	5.509LysLeu: 5.509 ± 0.059	2.03LysMet: 2.03 ± 0.039	2.747LysAsn: 2.747 ± 0.049	2.302LysPro: 2.302 ± 0.044	3.482LysGln: 3.482 ± 0.055	3.38LysArg: 3.38 ± 0.046	3.16LysSer: 3.16 ± 0.052	3.379LysThr: 3.379 ± 0.055	4.185LysVal: 4.185 ± 0.062	0.818LysTrp: 0.818 ± 0.024	1.875LysTyr: 1.875 ± 0.042	0.001LysXaa: 0.001 ± 0.001
Leu	8.026LeuAla: 8.026 ± 0.089	0.963LeuCys: 0.963 ± 0.027	4.925LeuAsp: 4.925 ± 0.058	6.497LeuGlu: 6.497 ± 0.074	4.758LeuPhe: 4.758 ± 0.079	6.474LeuGly: 6.474 ± 0.076	2.645LeuHis: 2.645 ± 0.052	6.386LeuIle: 6.386 ± 0.081	5.128LeuLys: 5.128 ± 0.056	11.124LeuLeu: 11.124 ± 0.127	2.398LeuMet: 2.398 ± 0.037	3.221LeuAsn: 3.221 ± 0.054	4.435LeuPro: 4.435 ± 0.06	4.915LeuGln: 4.915 ± 0.059	4.462LeuArg: 4.462 ± 0.07	7.004LeuSer: 7.004 ± 0.078	5.913LeuThr: 5.913 ± 0.066	6.583LeuVal: 6.583 ± 0.067	0.852LeuTrp: 0.852 ± 0.027	3.26LeuTyr: 3.26 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.105MetAla: 2.105 ± 0.038	0.159MetCys: 0.159 ± 0.011	1.452MetAsp: 1.452 ± 0.029	2.026MetGlu: 2.026 ± 0.04	1.017MetPhe: 1.017 ± 0.029	1.848MetGly: 1.848 ± 0.039	0.507MetHis: 0.507 ± 0.016	2.139MetIle: 2.139 ± 0.04	2.264MetLys: 2.264 ± 0.042	2.855MetLeu: 2.855 ± 0.047	0.906MetMet: 0.906 ± 0.026	1.394MetAsn: 1.394 ± 0.032	1.085MetPro: 1.085 ± 0.03	1.268MetGln: 1.268 ± 0.034	1.292MetArg: 1.292 ± 0.027	1.718MetSer: 1.718 ± 0.038	1.548MetThr: 1.548 ± 0.031	1.973MetVal: 1.973 ± 0.04	0.23MetTrp: 0.23 ± 0.012	0.881MetTyr: 0.881 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.507AsnAla: 2.507 ± 0.043	0.304AsnCys: 0.304 ± 0.016	1.848AsnAsp: 1.848 ± 0.037	2.746AsnGlu: 2.746 ± 0.049	1.33AsnPhe: 1.33 ± 0.032	2.896AsnGly: 2.896 ± 0.051	0.991AsnHis: 0.991 ± 0.027	2.651AsnIle: 2.651 ± 0.051	2.605AsnLys: 2.605 ± 0.044	3.478AsnLeu: 3.478 ± 0.045	1.07AsnMet: 1.07 ± 0.03	1.721AsnAsn: 1.721 ± 0.043	2.116AsnPro: 2.116 ± 0.041	2.327AsnGln: 2.327 ± 0.047	2.077AsnArg: 2.077 ± 0.037	1.996AsnSer: 1.996 ± 0.039	2.059AsnThr: 2.059 ± 0.042	2.675AsnVal: 2.675 ± 0.044	0.476AsnTrp: 0.476 ± 0.02	1.33AsnTyr: 1.33 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	2.725ProAla: 2.725 ± 0.042	0.214ProCys: 0.214 ± 0.015	2.232ProAsp: 2.232 ± 0.038	3.05ProGlu: 3.05 ± 0.054	1.917ProPhe: 1.917 ± 0.036	2.234ProGly: 2.234 ± 0.047	0.955ProHis: 0.955 ± 0.028	3.072ProIle: 3.072 ± 0.05	2.136ProLys: 2.136 ± 0.043	3.805ProLeu: 3.805 ± 0.064	0.913ProMet: 0.913 ± 0.026	1.614ProAsn: 1.614 ± 0.031	1.128ProPro: 1.128 ± 0.043	1.464ProGln: 1.464 ± 0.038	1.306ProArg: 1.306 ± 0.03	2.438ProSer: 2.438 ± 0.052	2.468ProThr: 2.468 ± 0.074	2.975ProVal: 2.975 ± 0.052	0.344ProTrp: 0.344 ± 0.015	1.473ProTyr: 1.473 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.817GlnAla: 3.817 ± 0.067	0.24GlnCys: 0.24 ± 0.015	1.932GlnAsp: 1.932 ± 0.037	3.63GlnGlu: 3.63 ± 0.054	1.603GlnPhe: 1.603 ± 0.035	2.6GlnGly: 2.6 ± 0.048	1.007GlnHis: 1.007 ± 0.026	3.254GlnIle: 3.254 ± 0.051	3.233GlnLys: 3.233 ± 0.044	4.715GlnLeu: 4.715 ± 0.091	1.392GlnMet: 1.392 ± 0.031	1.798GlnAsn: 1.798 ± 0.042	1.632GlnPro: 1.632 ± 0.035	2.557GlnGln: 2.557 ± 0.056	2.033GlnArg: 2.033 ± 0.039	2.314GlnSer: 2.314 ± 0.046	2.394GlnThr: 2.394 ± 0.048	3.336GlnVal: 3.336 ± 0.055	0.439GlnTrp: 0.439 ± 0.019	1.391GlnTyr: 1.391 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.797ArgAla: 2.797 ± 0.05	0.344ArgCys: 0.344 ± 0.017	2.226ArgAsp: 2.226 ± 0.042	3.563ArgGlu: 3.563 ± 0.058	2.121ArgPhe: 2.121 ± 0.04	2.626ArgGly: 2.626 ± 0.05	0.976ArgHis: 0.976 ± 0.026	3.516ArgIle: 3.516 ± 0.053	2.957ArgLys: 2.957 ± 0.048	4.695ArgLeu: 4.695 ± 0.059	1.512ArgMet: 1.512 ± 0.033	1.939ArgAsn: 1.939 ± 0.037	1.548ArgPro: 1.548 ± 0.035	1.917ArgGln: 1.917 ± 0.041	2.073ArgArg: 2.073 ± 0.045	2.434ArgSer: 2.434 ± 0.036	2.417ArgThr: 2.417 ± 0.042	2.994ArgVal: 2.994 ± 0.05	0.506ArgTrp: 0.506 ± 0.018	1.811ArgTyr: 1.811 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.737SerAla: 3.737 ± 0.059	0.49SerCys: 0.49 ± 0.02	2.828SerAsp: 2.828 ± 0.049	3.641SerGlu: 3.641 ± 0.057	3.181SerPhe: 3.181 ± 0.048	4.28SerGly: 4.28 ± 0.057	1.311SerHis: 1.311 ± 0.029	4.842SerIle: 4.842 ± 0.06	3.695SerLys: 3.695 ± 0.056	6.537SerLeu: 6.537 ± 0.076	1.831SerMet: 1.831 ± 0.042	2.297SerAsn: 2.297 ± 0.042	2.278SerPro: 2.278 ± 0.039	2.373SerGln: 2.373 ± 0.04	2.482SerArg: 2.482 ± 0.043	4.117SerSer: 4.117 ± 0.068	3.5SerThr: 3.5 ± 0.056	4.132SerVal: 4.132 ± 0.056	0.644SerTrp: 0.644 ± 0.019	2.394SerTyr: 2.394 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.157ThrAla: 4.157 ± 0.053	0.442ThrCys: 0.442 ± 0.018	2.809ThrAsp: 2.809 ± 0.051	3.592ThrGlu: 3.592 ± 0.052	2.515ThrPhe: 2.515 ± 0.04	4.695ThrGly: 4.695 ± 0.19	1.202ThrHis: 1.202 ± 0.032	4.365ThrIle: 4.365 ± 0.056	3.241ThrLys: 3.241 ± 0.055	5.616ThrLeu: 5.616 ± 0.07	1.443ThrMet: 1.443 ± 0.028	2.384ThrAsn: 2.384 ± 0.039	2.637ThrPro: 2.637 ± 0.052	2.015ThrGln: 2.015 ± 0.039	2.108ThrArg: 2.108 ± 0.044	3.591ThrSer: 3.591 ± 0.052	3.246ThrThr: 3.246 ± 0.056	4.042ThrVal: 4.042 ± 0.063	0.559ThrTrp: 0.559 ± 0.023	2.148ThrTyr: 2.148 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	5.405ValAla: 5.405 ± 0.073	0.665ValCys: 0.665 ± 0.023	3.628ValAsp: 3.628 ± 0.049	4.947ValGlu: 4.947 ± 0.062	2.829ValPhe: 2.829 ± 0.048	4.785ValGly: 4.785 ± 0.052	1.473ValHis: 1.473 ± 0.031	5.263ValIle: 5.263 ± 0.063	4.383ValLys: 4.383 ± 0.06	6.693ValLeu: 6.693 ± 0.08	2.004ValMet: 2.004 ± 0.038	2.746ValAsn: 2.746 ± 0.043	2.795ValPro: 2.795 ± 0.052	2.708ValGln: 2.708 ± 0.044	2.901ValArg: 2.901 ± 0.055	4.659ValSer: 4.659 ± 0.062	4.355ValThr: 4.355 ± 0.055	5.118ValVal: 5.118 ± 0.065	0.705ValTrp: 0.705 ± 0.024	2.202ValTyr: 2.202 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.633TrpAla: 0.633 ± 0.021	0.091TrpCys: 0.091 ± 0.009	0.519TrpAsp: 0.519 ± 0.016	0.749TrpGlu: 0.749 ± 0.025	0.494TrpPhe: 0.494 ± 0.019	0.712TrpGly: 0.712 ± 0.023	0.214TrpHis: 0.214 ± 0.012	0.815TrpIle: 0.815 ± 0.028	0.77TrpLys: 0.77 ± 0.024	1.218TrpLeu: 1.218 ± 0.032	0.371TrpMet: 0.371 ± 0.016	0.55TrpAsn: 0.55 ± 0.02	0.253TrpPro: 0.253 ± 0.014	0.494TrpGln: 0.494 ± 0.022	0.478TrpArg: 0.478 ± 0.02	0.668TrpSer: 0.668 ± 0.026	0.535TrpThr: 0.535 ± 0.022	0.651TrpVal: 0.651 ± 0.021	0.154TrpTrp: 0.154 ± 0.011	0.357TrpTyr: 0.357 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.265TyrAla: 2.265 ± 0.036	0.321TyrCys: 0.321 ± 0.015	1.859TyrAsp: 1.859 ± 0.049	2.356TyrGlu: 2.356 ± 0.047	1.555TyrPhe: 1.555 ± 0.036	2.304TyrGly: 2.304 ± 0.046	0.922TyrHis: 0.922 ± 0.029	2.172TyrIle: 2.172 ± 0.041	1.913TyrLys: 1.913 ± 0.039	3.646TyrLeu: 3.646 ± 0.052	0.959TyrMet: 0.959 ± 0.029	1.38TyrAsn: 1.38 ± 0.034	1.598TyrPro: 1.598 ± 0.047	1.887TyrGln: 1.887 ± 0.042	1.818TyrArg: 1.818 ± 0.039	2.061TyrSer: 2.061 ± 0.039	1.887TyrThr: 1.887 ± 0.035	2.545TyrVal: 2.545 ± 0.049	0.418TyrTrp: 0.418 ± 0.019	1.376TyrTyr: 1.376 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4532 proteins (1432094 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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