Amino acid dipepetide frequency for Caloramator fervidus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.405AlaAla: 4.405 ± 0.118
0.698AlaCys: 0.698 ± 0.04
2.526AlaAsp: 2.526 ± 0.069
3.516AlaGlu: 3.516 ± 0.076
2.9AlaPhe: 2.9 ± 0.093
3.832AlaGly: 3.832 ± 0.096
0.878AlaHis: 0.878 ± 0.041
6.038AlaIle: 6.038 ± 0.124
5.439AlaLys: 5.439 ± 0.11
6.378AlaLeu: 6.378 ± 0.127
1.564AlaMet: 1.564 ± 0.06
2.461AlaAsn: 2.461 ± 0.072
1.431AlaPro: 1.431 ± 0.059
1.47AlaGln: 1.47 ± 0.062
2.396AlaArg: 2.396 ± 0.071
3.06AlaSer: 3.06 ± 0.08
2.557AlaThr: 2.557 ± 0.066
4.496AlaVal: 4.496 ± 0.106
0.341AlaTrp: 0.341 ± 0.028
2.169AlaTyr: 2.169 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
0.649CysAla: 0.649 ± 0.034
0.165CysCys: 0.165 ± 0.02
0.64CysAsp: 0.64 ± 0.033
0.675CysGlu: 0.675 ± 0.033
0.527CysPhe: 0.527 ± 0.031
1.06CysGly: 1.06 ± 0.05
0.219CysHis: 0.219 ± 0.019
1.084CysIle: 1.084 ± 0.051
0.98CysLys: 0.98 ± 0.045
0.885CysLeu: 0.885 ± 0.043
0.232CysMet: 0.232 ± 0.023
0.562CysAsn: 0.562 ± 0.036
0.56CysPro: 0.56 ± 0.037
0.245CysGln: 0.245 ± 0.02
0.338CysArg: 0.338 ± 0.027
0.655CysSer: 0.655 ± 0.041
0.336CysThr: 0.336 ± 0.024
0.62CysVal: 0.62 ± 0.035
0.052CysTrp: 0.052 ± 0.01
0.431CysTyr: 0.431 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
2.891AspAla: 2.891 ± 0.073
0.579AspCys: 0.579 ± 0.033
2.587AspAsp: 2.587 ± 0.069
4.821AspGlu: 4.821 ± 0.11
3.223AspPhe: 3.223 ± 0.086
3.171AspGly: 3.171 ± 0.084
0.52AspHis: 0.52 ± 0.029
6.814AspIle: 6.814 ± 0.124
5.402AspLys: 5.402 ± 0.094
5.084AspLeu: 5.084 ± 0.099
1.436AspMet: 1.436 ± 0.047
2.451AspAsn: 2.451 ± 0.071
1.568AspPro: 1.568 ± 0.057
0.672AspGln: 0.672 ± 0.037
1.82AspArg: 1.82 ± 0.059
2.386AspSer: 2.386 ± 0.054
2.026AspThr: 2.026 ± 0.058
4.505AspVal: 4.505 ± 0.094
0.302AspTrp: 0.302 ± 0.024
2.605AspTyr: 2.605 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
4.494GluAla: 4.494 ± 0.106
0.657GluCys: 0.657 ± 0.038
4.563GluAsp: 4.563 ± 0.101
6.547GluGlu: 6.547 ± 0.132
3.335GluPhe: 3.335 ± 0.086
4.672GluGly: 4.672 ± 0.101
0.935GluHis: 0.935 ± 0.047
7.732GluIle: 7.732 ± 0.14
8.462GluLys: 8.462 ± 0.14
6.385GluLeu: 6.385 ± 0.129
1.973GluMet: 1.973 ± 0.063
4.802GluAsn: 4.802 ± 0.096
1.46GluPro: 1.46 ± 0.059
1.429GluGln: 1.429 ± 0.05
3.192GluArg: 3.192 ± 0.088
2.518GluSer: 2.518 ± 0.067
2.581GluThr: 2.581 ± 0.064
5.84GluVal: 5.84 ± 0.111
0.395GluTrp: 0.395 ± 0.027
3.14GluTyr: 3.14 ± 0.073
0.0GluXaa: 0.0 ± 0.0
Phe
2.459PheAla: 2.459 ± 0.084
0.523PheCys: 0.523 ± 0.029
2.752PheAsp: 2.752 ± 0.072
3.52PheGlu: 3.52 ± 0.079
2.075PhePhe: 2.075 ± 0.084
3.019PheGly: 3.019 ± 0.076
0.477PheHis: 0.477 ± 0.029
5.437PheIle: 5.437 ± 0.137
4.493PheLys: 4.493 ± 0.099
4.947PheLeu: 4.947 ± 0.133
1.106PheMet: 1.106 ± 0.049
2.722PheAsn: 2.722 ± 0.073
1.28PhePro: 1.28 ± 0.056
0.859PheGln: 0.859 ± 0.037
1.206PheArg: 1.206 ± 0.048
2.873PheSer: 2.873 ± 0.079
2.18PheThr: 2.18 ± 0.067
3.093PheVal: 3.093 ± 0.084
0.26PheTrp: 0.26 ± 0.025
2.058PheTyr: 2.058 ± 0.08
0.0PheXaa: 0.0 ± 0.0
Gly
4.168GlyAla: 4.168 ± 0.112
0.915GlyCys: 0.915 ± 0.048
3.182GlyAsp: 3.182 ± 0.076
3.991GlyGlu: 3.991 ± 0.09
3.322GlyPhe: 3.322 ± 0.083
4.3GlyGly: 4.3 ± 0.114
1.069GlyHis: 1.069 ± 0.048
7.28GlyIle: 7.28 ± 0.123
5.97GlyLys: 5.97 ± 0.103
5.654GlyLeu: 5.654 ± 0.111
1.637GlyMet: 1.637 ± 0.058
2.691GlyAsn: 2.691 ± 0.065
1.626GlyPro: 1.626 ± 0.063
1.568GlyGln: 1.568 ± 0.057
2.577GlyArg: 2.577 ± 0.078
3.038GlySer: 3.038 ± 0.076
2.978GlyThr: 2.978 ± 0.071
4.788GlyVal: 4.788 ± 0.117
0.421GlyTrp: 0.421 ± 0.031
3.151GlyTyr: 3.151 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
0.815HisAla: 0.815 ± 0.039
0.161HisCys: 0.161 ± 0.017
0.664HisAsp: 0.664 ± 0.038
0.813HisGlu: 0.813 ± 0.041
0.592HisPhe: 0.592 ± 0.036
0.976HisGly: 0.976 ± 0.048
0.26HisHis: 0.26 ± 0.021
1.215HisIle: 1.215 ± 0.048
0.985HisLys: 0.985 ± 0.045
1.121HisLeu: 1.121 ± 0.048
0.262HisMet: 0.262 ± 0.02
0.646HisAsn: 0.646 ± 0.039
0.707HisPro: 0.707 ± 0.042
0.297HisGln: 0.297 ± 0.024
0.488HisArg: 0.488 ± 0.029
0.703HisSer: 0.703 ± 0.038
0.579HisThr: 0.579 ± 0.032
0.95HisVal: 0.95 ± 0.049
0.074HisTrp: 0.074 ± 0.012
0.514HisTyr: 0.514 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.283IleAla: 6.283 ± 0.133
1.032IleCys: 1.032 ± 0.043
6.203IleAsp: 6.203 ± 0.121
7.931IleGlu: 7.931 ± 0.147
4.678IlePhe: 4.678 ± 0.126
6.042IleGly: 6.042 ± 0.116
1.13IleHis: 1.13 ± 0.04
10.145IleIle: 10.145 ± 0.188
10.54IleLys: 10.54 ± 0.15
10.226IleLeu: 10.226 ± 0.179
2.227IleMet: 2.227 ± 0.072
6.038IleAsn: 6.038 ± 0.13
3.758IlePro: 3.758 ± 0.092
2.216IleGln: 2.216 ± 0.069
3.537IleArg: 3.537 ± 0.086
6.27IleSer: 6.27 ± 0.108
4.45IleThr: 4.45 ± 0.101
6.504IleVal: 6.504 ± 0.109
0.507IleTrp: 0.507 ± 0.033
3.882IleTyr: 3.882 ± 0.099
0.0IleXaa: 0.0 ± 0.0
Lys
5.22LysAla: 5.22 ± 0.108
0.787LysCys: 0.787 ± 0.044
6.536LysAsp: 6.536 ± 0.113
9.484LysGlu: 9.484 ± 0.16
3.709LysPhe: 3.709 ± 0.086
6.161LysGly: 6.161 ± 0.118
1.117LysHis: 1.117 ± 0.047
9.696LysIle: 9.696 ± 0.173
8.801LysLys: 8.801 ± 0.161
8.074LysLeu: 8.074 ± 0.123
2.403LysMet: 2.403 ± 0.064
6.541LysAsn: 6.541 ± 0.154
2.275LysPro: 2.275 ± 0.067
2.347LysGln: 2.347 ± 0.072
4.006LysArg: 4.006 ± 0.086
4.34LysSer: 4.34 ± 0.092
3.882LysThr: 3.882 ± 0.091
6.972LysVal: 6.972 ± 0.116
0.488LysTrp: 0.488 ± 0.029
3.984LysTyr: 3.984 ± 0.088
0.0LysXaa: 0.0 ± 0.0
Leu
5.522LeuAla: 5.522 ± 0.116
1.009LeuCys: 1.009 ± 0.043
5.264LeuAsp: 5.264 ± 0.102
6.944LeuGlu: 6.944 ± 0.135
3.849LeuPhe: 3.849 ± 0.106
6.482LeuGly: 6.482 ± 0.121
1.043LeuHis: 1.043 ± 0.053
8.82LeuIle: 8.82 ± 0.159
10.64LeuLys: 10.64 ± 0.152
8.4LeuLeu: 8.4 ± 0.132
1.98LeuMet: 1.98 ± 0.064
6.265LeuAsn: 6.265 ± 0.114
3.066LeuPro: 3.066 ± 0.084
2.123LeuGln: 2.123 ± 0.065
3.472LeuArg: 3.472 ± 0.099
6.209LeuSer: 6.209 ± 0.126
4.415LeuThr: 4.415 ± 0.092
5.699LeuVal: 5.699 ± 0.123
0.479LeuTrp: 0.479 ± 0.032
3.481LeuTyr: 3.481 ± 0.087
0.0LeuXaa: 0.0 ± 0.0
Met
1.748MetAla: 1.748 ± 0.058
0.232MetCys: 0.232 ± 0.022
1.347MetAsp: 1.347 ± 0.047
1.716MetGlu: 1.716 ± 0.066
1.178MetPhe: 1.178 ± 0.053
1.583MetGly: 1.583 ± 0.06
0.336MetHis: 0.336 ± 0.024
2.195MetIle: 2.195 ± 0.064
2.182MetLys: 2.182 ± 0.051
2.457MetLeu: 2.457 ± 0.074
0.616MetMet: 0.616 ± 0.039
1.191MetAsn: 1.191 ± 0.049
0.956MetPro: 0.956 ± 0.045
0.692MetGln: 0.692 ± 0.033
0.839MetArg: 0.839 ± 0.043
1.163MetSer: 1.163 ± 0.043
1.002MetThr: 1.002 ± 0.043
1.57MetVal: 1.57 ± 0.054
0.126MetTrp: 0.126 ± 0.016
0.716MetTyr: 0.716 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.683AsnAla: 2.683 ± 0.077
0.625AsnCys: 0.625 ± 0.038
2.464AsnAsp: 2.464 ± 0.081
3.719AsnGlu: 3.719 ± 0.095
2.832AsnPhe: 2.832 ± 0.091
3.125AsnGly: 3.125 ± 0.076
0.581AsnHis: 0.581 ± 0.034
6.871AsnIle: 6.871 ± 0.147
5.435AsnLys: 5.435 ± 0.12
5.86AsnLeu: 5.86 ± 0.111
1.427AsnMet: 1.427 ± 0.054
3.156AsnAsn: 3.156 ± 0.104
2.21AsnPro: 2.21 ± 0.069
1.254AsnGln: 1.254 ± 0.053
1.7AsnArg: 1.7 ± 0.061
2.83AsnSer: 2.83 ± 0.095
2.229AsnThr: 2.229 ± 0.068
3.639AsnVal: 3.639 ± 0.088
0.341AsnTrp: 0.341 ± 0.028
2.388AsnTyr: 2.388 ± 0.073
0.0AsnXaa: 0.0 ± 0.0
Pro
1.492ProAla: 1.492 ± 0.06
0.358ProCys: 0.358 ± 0.026
1.637ProAsp: 1.637 ± 0.056
2.336ProGlu: 2.336 ± 0.081
1.631ProPhe: 1.631 ± 0.05
1.969ProGly: 1.969 ± 0.073
0.599ProHis: 0.599 ± 0.038
2.945ProIle: 2.945 ± 0.079
2.676ProLys: 2.676 ± 0.083
2.824ProLeu: 2.824 ± 0.075
0.653ProMet: 0.653 ± 0.038
1.577ProAsn: 1.577 ± 0.05
0.857ProPro: 0.857 ± 0.044
0.919ProGln: 0.919 ± 0.044
0.97ProArg: 0.97 ± 0.038
1.763ProSer: 1.763 ± 0.059
1.447ProThr: 1.447 ± 0.05
2.362ProVal: 2.362 ± 0.073
0.204ProTrp: 0.204 ± 0.024
1.572ProTyr: 1.572 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
1.47GlnAla: 1.47 ± 0.062
0.186GlnCys: 0.186 ± 0.019
1.201GlnAsp: 1.201 ± 0.044
1.731GlnGlu: 1.731 ± 0.06
0.818GlnPhe: 0.818 ± 0.039
1.418GlnGly: 1.418 ± 0.056
0.282GlnHis: 0.282 ± 0.022
2.271GlnIle: 2.271 ± 0.066
2.299GlnLys: 2.299 ± 0.071
1.807GlnLeu: 1.807 ± 0.058
0.588GlnMet: 0.588 ± 0.033
1.505GlnAsn: 1.505 ± 0.056
0.661GlnPro: 0.661 ± 0.038
0.653GlnGln: 0.653 ± 0.039
1.175GlnArg: 1.175 ± 0.052
1.061GlnSer: 1.061 ± 0.043
0.996GlnThr: 0.996 ± 0.049
1.499GlnVal: 1.499 ± 0.048
0.134GlnTrp: 0.134 ± 0.016
0.863GlnTyr: 0.863 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
2.037ArgAla: 2.037 ± 0.062
0.431ArgCys: 0.431 ± 0.028
1.883ArgAsp: 1.883 ± 0.064
3.012ArgGlu: 3.012 ± 0.083
1.739ArgPhe: 1.739 ± 0.061
2.221ArgGly: 2.221 ± 0.067
0.594ArgHis: 0.594 ± 0.032
3.837ArgIle: 3.837 ± 0.078
3.13ArgLys: 3.13 ± 0.082
3.568ArgLeu: 3.568 ± 0.086
1.002ArgMet: 1.002 ± 0.04
1.841ArgAsn: 1.841 ± 0.059
1.195ArgPro: 1.195 ± 0.052
1.071ArgGln: 1.071 ± 0.049
1.711ArgArg: 1.711 ± 0.063
1.446ArgSer: 1.446 ± 0.051
1.555ArgThr: 1.555 ± 0.06
2.609ArgVal: 2.609 ± 0.076
0.273ArgTrp: 0.273 ± 0.022
1.568ArgTyr: 1.568 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
2.706SerAla: 2.706 ± 0.083
0.661SerCys: 0.661 ± 0.034
2.485SerAsp: 2.485 ± 0.069
3.049SerGlu: 3.049 ± 0.08
2.978SerPhe: 2.978 ± 0.079
3.409SerGly: 3.409 ± 0.079
0.69SerHis: 0.69 ± 0.041
5.571SerIle: 5.571 ± 0.112
5.209SerLys: 5.209 ± 0.114
5.543SerLeu: 5.543 ± 0.115
1.318SerMet: 1.318 ± 0.048
2.672SerAsn: 2.672 ± 0.08
1.705SerPro: 1.705 ± 0.064
1.447SerGln: 1.447 ± 0.05
1.895SerArg: 1.895 ± 0.059
3.121SerSer: 3.121 ± 0.078
2.24SerThr: 2.24 ± 0.073
3.073SerVal: 3.073 ± 0.072
0.314SerTrp: 0.314 ± 0.025
2.138SerTyr: 2.138 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
2.739ThrAla: 2.739 ± 0.073
0.425ThrCys: 0.425 ± 0.032
1.926ThrAsp: 1.926 ± 0.063
2.418ThrGlu: 2.418 ± 0.07
2.11ThrPhe: 2.11 ± 0.068
3.325ThrGly: 3.325 ± 0.09
0.646ThrHis: 0.646 ± 0.036
4.166ThrIle: 4.166 ± 0.098
3.351ThrLys: 3.351 ± 0.095
4.556ThrLeu: 4.556 ± 0.093
0.919ThrMet: 0.919 ± 0.038
2.101ThrAsn: 2.101 ± 0.06
1.726ThrPro: 1.726 ± 0.055
1.078ThrGln: 1.078 ± 0.05
1.531ThrArg: 1.531 ± 0.053
2.49ThrSer: 2.49 ± 0.063
2.195ThrThr: 2.195 ± 0.078
2.98ThrVal: 2.98 ± 0.065
0.252ThrTrp: 0.252 ± 0.024
1.629ThrTyr: 1.629 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
4.398ValAla: 4.398 ± 0.113
0.883ValCys: 0.883 ± 0.04
4.194ValAsp: 4.194 ± 0.104
5.554ValGlu: 5.554 ± 0.111
3.195ValPhe: 3.195 ± 0.087
4.528ValGly: 4.528 ± 0.11
0.828ValHis: 0.828 ± 0.041
6.71ValIle: 6.71 ± 0.112
6.459ValLys: 6.459 ± 0.114
6.992ValLeu: 6.992 ± 0.129
1.516ValMet: 1.516 ± 0.055
3.448ValAsn: 3.448 ± 0.078
2.256ValPro: 2.256 ± 0.066
1.175ValGln: 1.175 ± 0.04
2.253ValArg: 2.253 ± 0.07
3.739ValSer: 3.739 ± 0.09
3.043ValThr: 3.043 ± 0.073
5.394ValVal: 5.394 ± 0.102
0.293ValTrp: 0.293 ± 0.024
2.796ValTyr: 2.796 ± 0.091
0.0ValXaa: 0.0 ± 0.0
Trp
0.328TrpAla: 0.328 ± 0.026
0.071TrpCys: 0.071 ± 0.012
0.308TrpAsp: 0.308 ± 0.026
0.354TrpGlu: 0.354 ± 0.027
0.301TrpPhe: 0.301 ± 0.025
0.445TrpGly: 0.445 ± 0.033
0.093TrpHis: 0.093 ± 0.014
0.585TrpIle: 0.585 ± 0.037
0.399TrpLys: 0.399 ± 0.026
0.466TrpLeu: 0.466 ± 0.034
0.156TrpMet: 0.156 ± 0.018
0.332TrpAsn: 0.332 ± 0.023
0.161TrpPro: 0.161 ± 0.017
0.18TrpGln: 0.18 ± 0.02
0.199TrpArg: 0.199 ± 0.021
0.236TrpSer: 0.236 ± 0.021
0.288TrpThr: 0.288 ± 0.022
0.364TrpVal: 0.364 ± 0.029
0.072TrpTrp: 0.072 ± 0.012
0.206TrpTyr: 0.206 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.047TyrAla: 2.047 ± 0.06
0.518TyrCys: 0.518 ± 0.029
2.503TyrAsp: 2.503 ± 0.071
2.982TyrGlu: 2.982 ± 0.088
2.347TyrPhe: 2.347 ± 0.076
2.587TyrGly: 2.587 ± 0.065
0.527TyrHis: 0.527 ± 0.028
4.186TyrIle: 4.186 ± 0.1
3.971TyrLys: 3.971 ± 0.103
3.932TyrLeu: 3.932 ± 0.105
0.831TyrMet: 0.831 ± 0.041
2.368TyrAsn: 2.368 ± 0.07
1.334TyrPro: 1.334 ± 0.047
0.924TyrGln: 0.924 ± 0.039
1.42TyrArg: 1.42 ± 0.044
2.32TyrSer: 2.32 ± 0.065
1.583TyrThr: 1.583 ± 0.06
2.698TyrVal: 2.698 ± 0.086
0.213TyrTrp: 0.213 ± 0.02
1.859TyrTyr: 1.859 ± 0.071
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1775 proteins (538899 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski